TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis

Leukemia

Volumn 9, Issue 12, 1995, Pages 1985-1989

  Shurtleff, S A ^a   Buijs, A ^a   Behm, F G ^a,b   Rubnitz, J E ^a,b   Raimondi, S C ^a,b   Hancock, M L ^a   Chan, G C F ^a   Pui, C H ^a,b   Grosveld, G ^a   Downing, J R ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Acute lymphoblastic leukemia; AML 1; TEL; Translocations

Indexed keywords

B LYMPHOCYTE ANTIGEN; CHIMERIC PROTEIN; DNA; DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; B LYMPHOCYTE; CANCER GENETICS; CHILDHOOD LEUKEMIA; CHROMOSOME 12P; CHROMOSOME 22Q; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOGENETICS; DNA CONTENT; GENE FUSION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; SHORT SURVEY;

EID: 13344282725     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (35)

1. Pui C-H. Childhood leukemias. New Engl J Med 1995; 332: 1618-1630.
2. Rabbits TH. Chromosomal translocations in human cancer. Nature 1994; 372: 143-149.
3. Raimondi SC. Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 1993; 81: 2237-2251.
4. Raimondi SC et al. Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia. Blood 1986; 68: 69-75.
5. Golub TR et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917-4921.
6. Romana SP et al. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 1995; 85: 3662-3670.
7. Nucifora G, Rowley JD. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 1995; 86: 1-14.
8. Liu P et al. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science 1993; 261: 1041-1044.
9. Golub TR, Barker GF, Lovett M, Gilliland DC. Fusion of PDCF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994; 77: 307-316.
10. Papadopoulos P et al. The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res 1995; 55: 34-38.
11. Wlodarska I et al. TEL gene is involved in myelodysplastic syndrome with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13). Blood 1995; 85: 2848-2852.
12. Buijs A et al. Translocation (12;22)(p13;q11) in myeloproliferative disorders results in the fusion of ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 1995; 10: 1511-1519.
13. Romana SP, Le Coniat M, Berger R. t(12;21): a new recurrent translocation in acute lymphoblastic leukemia. Genes Chromos Cancer 1994; 9: 186-191.
14. Kobayashi H, Rowley JD. Identification of cytogenetically undetected 12p13 translocations and associated deletions with fluorescence in situ hybridization. Genes Chromos Cancer 1995; 12: 66-69.
15. Stegmaier K et al. Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood 1995; 86: 38-44.
16. Kobayashi H et al. Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood 1994; 84: 3473-3482.
17. Romana SP et al. High frequency of t(12;21) in childhood B lineage acute lymphoblastic leukemia. Blood 1995; (in press).
18. Behm FG et al. Lack of CD45 antigen in blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features. Blood 1992; 79: 1011-1016.
19. Williams DL et al. A direct bone marrow chromosome technique for acute lymphoblastic leukemia. Cancer Genet Cytogenet 1984; 13: 239-243.
20. Shurtleff SA et al. Heterogeneity in CBFβ/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia. Blood 1995; 85: 3695-3703.
21. Downing JR et al. An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood 1993; 81: 2860-2865.
22. Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory, 1989.
23. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat 1958; 53: 457-481.
24. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. JCNI 1959; 22: 719-748.
25. Rivera GK et al. Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy. Lancet 1991; 337: 61-66.
26. Evans WE et al. Individualized dosages of chemotherapy as a strategy to improve response for acute lymphocytic leukemia. Semin Hematol 1991; 28: 15-21.
27. Pui C-H et al. L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins. Leukemia 1995; 9: 1680-1684.
28. Miyoshi H et al. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA 1991; 88: 10431-10435.
29. Ogawa E et al. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 1993; 194: 314-331.
30. Ogawa E et al. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the AML1 gene. Proc Natl Acad Sci USA 1993; 90: 6859-6963.
31. Meyers S, Downing JR, Hiebert SW. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA binding proteins: the runt homology domain is required for DNA-binding and protein-protein interactions. Mol Cell Biol 1993; 13: 6336-6345.
32. Shoemaker SG, Hromas R, Kaushansky K. Transcriptional regulation of interleukin 3 gene expression in T lymphocytes. Proc Natl Acad Sci USA 1990; 87: 9650-9654.
33. Nuchprayoon I et al. AML1/CBF, altered by chromosomal breaks in myeloid leukemia cells, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 1994; 14: 5558-5568.
34. Meyers S, Lenny N, Hiebert SW. The t(8;21) fusion protein interferes with AML-1 B-dependent transcriptional activation. Mol Cell Biol 1995; 15: 1974-1982.
35. Trueworthy R et al. Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell acute lymphoblastic leukemia of childhood: a Pediatric Oncology Group Study. J Clin Oncol 1992; 10: 606-608.