Adverse effects of iodine on the thyroid

Endocrinologist

Volumn 7, Issue 4, 1997, Pages 245-254

  Roti, Elio ^a   Colzani, Raffaella ^b   Braverman, Lewis E ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; CALCIDRINE; CLIOQUINOL; DIATRIZOATE; DIIODOHYDROXYQUIN; ECOTHIOPATE; IDOXURIDINE; IODINATED GLYCEROL; IODINE; IOPANOIC ACID; IOPODATE SODIUM; IOTALAMATE SODIUM; ISOPAQUE CORONAR; ISOPROPAMIDE IODIDE; LUGOL; METRIZAMIDE; PHENAZONE; PHOSPHOLINE; POVIDONE IODINE; SODIUM IODIDE; UNCLASSIFIED DRUG;

DRUG EFFECT; FUCUS; HUMAN; HYPERTHYROIDISM; REVIEW; THYROID FUNCTION; THYROID HORMONE SYNTHESIS;

EID: 0030741150     PISSN: 10512144     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019616-199707040-00008     Document Type: Review

References (89)

1. Wolff J. Chaikoff IL: Plasma inorganic iodide as homeostatic regulator of thyroid function. J Biol Chem. 1948; 174: 555-64.
2. Wolff J, Chaikoff IL, Goldberg Meier JR: The temporary nature of the inhibitory action of excess iodide on organic iodine synthesis in the normal thyroid. Endocrinology 1949; 45: 504-13.
3. Braverman LE, Ingbar SH: Changes in thyroidal function during adaptation to large doses of iodide. J Clin Invest 42: 1216-1231.
4. Dal G, Levy O, Carrasco N: Cloning and characterization of the thyroid iodide transporter. Nature 1996; 379: 458-9.
5. Vagenakis AG, Downs P, Braverman LE, Burger A, Ingbar SH: Control of thyroid hormone secretion in normal subjects receiving excess iodides. J Clin Invest 52: 528-532.
6. Safran M, Braverman LE: Effect of chronic douching with polyvinylpyrrolidone-iodine on iodine absorption and thyroid function. Obstet Gynecol 1982; 60: 35-40.
7. Ader AW, Paul TL, Reinhardt W, et al.: Effect of mouth rinsing with two polyvinylpyrrolidone-iodine mixtures on iodine absorption and thyroid function. J Clin Endocrinol Metab 1988; 66: 632-5.
8. Philippou G, Koutras DA, Piperingos G, Souvatzoglous A, Moulopoulos SD: The effect of iodide on serum thyroid hormone levels in normal persons, in hyperthyroid patients, and in hypothyroid patients on thyroxine replacement. Clin Endocrinol (Oxf) 1992; 36: 573-8.
9. LeMar HJ, Georgitis WJ, McDermott MT: Thyroid adaptation to chronic tetraglycine hydroperiodide water purification tablet use. J Clin Endocrinol Metab 1995; 80: 220-3.
10. Namba H, Yamashita S, Kimura H, et al.: Evidence of thyroid volume increase in normal subjects receiving excess iodide. J Clin Endocrinol Metab 1993; 76: 605-8.
11. Arntzenius AB, Smit LJ, Schipper J, van-der-Heide D, Meinders AE: Inverse relation between iodine intake and thyroid blood flow: color doppler flow imaging in euthyroid humans. J Clin Endocrinol Metab 1991; 73: 1051-5.
12. Paul T, Meyers B, Witorsch RJ, et al.: The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism 1988; 37: 12-4.
13. Jonckheer MH, Michotte Y, Van Steirteghem AC, Deconinck F: The adaptation of the human thyroid gland to a physiological regimen of iodide intake: evidence for a transitory inhibition of thyroid hormone secretion modulated by the intrathyroidal iodine stores. J Endocrinol Invest 1983; 6: 267-72.
14. Gardner DF, Centor RM, Utiger RD: Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin Endocrinol (Oxf) 1988; 28: 283-8.
15. Chow CC, Phillips DIW, Lazarus JH, Parkes AB: Effect of low dose iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable? Clin Endocrinol (Oxf) 1991; 34: 413-6
16. Braverman LE: Iodine and the thyroid: 33 years of study. Thyroid 1994; 4: 351-6.
17. Fisher DA, Klein AH: Thyroid development and disorders of thyroid function in the newborns. N Engl J Med 1981; 304: 702-12.
18. Roti E, Gnudi A, Braverman LE: The placental transport, synthesis and metabolism of hormones and drugs which affect thyroid function. Endocr Rev 1983; 4: 131-49.
19. De Wolf D, De Schepper J, Verhaaren H, Deneyer M, Smitz J, Sacre-Smits L: Congenital hypothyroid goiter and amiodarone. Acta Paediatr Scand 1988; 77: 616-8.
20. Magee LA, Downar E, Sermer M, Boulton BC, Allen LC, Koren G: Pregnancy outcome after gestational exposure to amiodarone in Canada. Am J Obstet Gynecol 1995; 172: 1307-11.
21. Robuschi G, Montermini M, Alboni A, et al.: Cord blood iodothyronine and thyrotropin concentrations in newborns of mothers exposed to povidone iodine in the last trimester. J Endocrinol Invest 1987; 10: 183-6.
22. Sakakura K, Iwata Y, Hayashi S: Study on the usefulness of povidone-iodine obstetric cream with special reference to the effect on the thyroid functions of mothers and the newborn. Postgrad Med J 1993; 69: S49-57.
23. Novaes M Jr, Biancalana MM, Garcia SA, Rassi I, Romaldini JH: Elevation of cord blood TSH concentration in newborn infants of mothers exposed to acute povidone iodine during delivery. J Endocrinol Invest 1994; 17: 805-8.
24. l'Allemand D, Gruters A, Heidemann P: Iodine-induced alterations of thyroid function in newborn infants after prenatal and perinatal exposure to povidone iodine. J Pediatr 1983; 102: 935-8.
25. Smerdely P, Boyages SC, Wu D, et al.: Topical iodine-containing antiseptics and neonatal hypothyroidism in very-low-birthweight infants. Lancet 1989; 2:661-4.
26. Barakat M, Carson D, Hetherton AM, Smyth P, Leslie H: Hypothyroidism secondary to topical iodine treatment in infants with spina bifida. Acta Paediatr 1994; 83: 741-3..
27. Brown RS, Bloomfield S, Bednarek FJ, Mitchell ML, Braverman LE: Routine skin cleansing with povidone-iodine is not a common cause of transient neonatal hypothyroidism in North America: A prospective, controlled study. Thyroid (in press).
28. Clemens PC, Neumann RSJ: Influence of iodine overloading on neonatal thyroid screening results. J Endocrinol Invest 1989; 12: 841-845.
29. L'Allemand D, Gruters AJ, Beyer P, Weber B: Iodine in contrast agents and skin disinfectants is the major cause for hypothyroidism in premature infants during intensive care. Horm Res 1987; 28: 42-9.
30. Chanoine JP, Boulvain M, Bourdoux P, et al.: Increased recall rate at screening for congenital hypothyroidism in breast fed infants born to iodine overloaded mothers. Arch Dis Child 1988; 63: 1207-10.
31. Momotani N, Hisaoka T, Noh J, Ishikawa N, Ito K: Effects of iodine on thyroid status of fetus versus mother in treatment of Graves' disease complicated by pregnancy. J Clin Endocrinol Metab 1992; 75: 738-44.
32. Nauman J, Wolff NJ: Iodide prophylaxis in Poland after the Chernobyl reactor accident: benefits and risks. Am J Med 1993; 94: 524-32.
33. Li M, Liu DR, Qu CY, et al.: Endemic goitre in Central China caused by excessive iodine intake. Lancet 1987; 2: 257-9.
34. Costigan DC, Holland FJ, Danerman D, Hesslein PS, Vogel M, Ellis G: Amiodarone therapy effects on childhood thyroid function. Pediatrics 1986; 77: 703-8.
35. Suzuki H, Higuchi T, Sawa K, Ohtaki S, Horinchi Y: Endemic coast goiter in Hokkaido, Japan. Acta Endocrinol (Copenh) 1965; 50: 161-76.
36. Konno N, Makita H, Yuri K, Izuka N, Kawasaki K: Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab 1994; 78: 393-7.
37. Mizukami Y, Michigishi T, Nonomura A, et al.: Iodine-induced hypothyroidism: a clinical and histological study of 28 patients. J Clin Endocrinol Metab 1993; 76: 466-71.
38. Tajiri J, Higashi K, Morita M, Umeda T, Sata T: Studies of hypothyroidism in patients with high iodine intake. J Clin Endocrinol Metab 1986; 63: 412-17-
39. Roti E, Montermini M, Robuschi G, et al.: Prevalence of hypothyroidism and Hashimoto's thyroiditis in two elderly population with different iodine intake. In Thyroid Autoimmunity, edited by Pinchera A, Ingbar SH, McKenzie JM, Fenzi GF, pp. 555-557, Plenum Publishing Corporation, New York, 1987.
40. Inada M, Nishikawa M, Kawai I: Hypothyroidism associated with positive results of the perchlorate discharge test in elderly patients. Am J Med 1983; 74: 1010-5.
41. Ordene KW, Pan C, Barzel US, Surks MI: Variable thyrotropin response to thyrotropin-releasing hormone after small decreases in plasma thyroid hormone concentrations in patients of advanced age. Metabolism 1983; 32: 881-8.
42. Jubiz W, Carlile S, Lagerquist LD: Serum thyrotropin and thyroid hormone levels in humans receiving chronic potassium iodide. J Clin Endocrinol Metab 1977; 44: 379-52.
43. Azizi F, Bentley D, Vagenakis A, et al.: Abnormal thyroid function and response to iodides in patients with cystic fibrosis. Trans Assoc Am Physicians 1974; 87: 111-9.
44. Vagenakis AG, Pagoni C, Georgopoulos N, Makri M, Alexandrides T: Alteration in thyroid function in patients with β-Thalassemia and iron overload (abstract). 6th International Thyroid Symposium, Graz, Austria. Thyroid 1996; 6: 142.
45. Sato K, Okamura K, Yoshinari M, et al.: Reversible primary hypothyroidism and elevated serum iodine level in patients with renal dysfunction. Acta Endocrinol (Copenh) 1992; 126: 253-9.
46. Takeda S, Michigishi T, Takazakura E: Iodine-induced hypothyroidim in patients on regular dialysis treatment. Nephron 1993; 65: 51-5.
47. Kaptein EM: Thyroid Hormone Metabolism and Thyroid Diseases in Chronic Renal Failure. Endoc Rev 1996; 17: 45-63.
48. Braverman LE, Ingbar SH, Vagenakis AG, Adams L, Maloof F: Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease. J Clin Endocrinol Metab 1971; 32: 51-5.
49. Fragu P, Schlumberger M, Tubiana M: Thyroid iodine content and serum thyroid hormone levels in autoimmune thyroiditis: effect of iodide supplementation. J Nucl Med 1985; 26: 133-9.
50. Perez B, Kraus A, Lopez G, Cifuentes M, Alarcon-Segovia D: Autoimmune thyroid disease in primary Sjogren's syndrome. Am J Med 1995; 99: 480-4.
51. Roti E, Emerson CH: Postpartum thyroiditis. J Clin Endocrinol Metab 1992; 74: 3-5.
52. Roti E, Minelli R, Gardini E, et al.: Impaired intrathyroidal iodine organification and iodine-induce hypothyroidism in euthyroid women with a previous episode of postpartum thyroiditis. J Clin Endocrinol Metab 1991; 73: 958-63.
53. 131I) treatment of Graves' hyperthyroidism. J Clin Endocrinol Metab 1983; 57: 250-3.
54. Braverman LE, Woeber KA, Ingbar SH: The induction of myxedema by iodide in patients euthyroid after radioiodine or surgical treatment of diffuse toxic goiter. N Engl J Med 1969; 281: 816-21.
55. Roti E, Gardini E, Minelli R, et al.: Effects of chronic iodine administration on thyroid status in euthyroid subjects previously treated with antithyroid drugs for Graves' hyperthyroidism. J Clin Endocrinol Metab 1993; 76:928-32.
56. Roti E, Minelli R, Gardini E, Bianconi L, Braverman LE: Iodineinduced hypothyroidism in euthyroid subjects with a previous episode of subacute thyroiditis. J Clin Endocrinol Metab 1990; 70: 1581-5.
57. Clark OH, Cavalieri RR, Moser C, Ingbar SH: Iodide-induced hypothyroidism in patients after thyroid resection. Eur J Clin Invest 1990; 20: 573-80.
58. Marcellin P, Pouteau M, Benhamou JP: Hepatitis C virus infection, alpha interferon therapy and thyroid dysfunction. J Hepatol 1995; 22: 364-9.
59. Roti E, Minelli R, Giuberti T, et al.: Multiple changes in thyroid function in patients with chronic active HCV hepatitis treated with recombinant interferon-alpha. Am J Med 1996; 101: 482-7.
60. Salvi M, Minelli R, Schianchi C, Valli A, Braverman LE, Rot E: Iodine-induced thyroid dysfunction in euthyroid subjects previously treated with recombinant human interferon-α (rIFNα (abstract). European Thyroid Association Meeting, Amsterdam, The Netherlands. J Endocrinol Invest 1996; 19: 62.
61. Roti E, Minelli R, Gardini E, et al.: Iodine induced hypothyroidism in euthyroid subjects with a previous episode of amiodarone induced thyrotoxicosis. J Clin Endocrinol Metab 1992; 75: 1273-77.
62. Belfiore A, Sava L, Runello F, Tomaselli L, Vigneri R: Solitary autonomously functioning thyroid nodules and iodine deficiency. J Clin Endocrinol Metabol 1983; 56: 283-7.
63. Roti E, Gardini E, D'Amato L, et al.: Goiter size and thyroid function in an endemic goiter area in Northern Italy. J Clin Endocrinol Metabol 1986; 63: 558-63.
64. Adams DP, Kennedy TH, Stewart JC, Utiger RD, Vidor GI: Hyperthyroidism in Tasmania following iodide supplementation: measurements of thyroid-stimulating autoantibodies and thyrotropin. J Clin Endocrinol 1975; 41: 221-8.
65. Lima N, Medeiros-Neto G: 1984 Transient thyrotoxicosis in endemic goitre patients following exposure to a normal iodine intake. Clin Endocrinol (Oxf) 21: 631-037.
66. Galofre JC, Fernandez-Calvet L, Rios M, Garcia-Mayor RV: Increased incidence of thyrotoxicosis after iodine supplementazion in an iodine sufficient area. J Endocrinol Invest 1994; 17: 23-7.
67. Elnagar B, Eltorn M, Karlsson FA, Ermans AM, Gebere-Medhin M, Bourdoux PP: The effects of different doses of oral iodized oil on goiter size, urinary iodine, and thyroid-related hormones. J Clin Endocrinol Metab 1995; 80: 891-7.
68. Bourdoux PP, Ermans AM, Mukalay A, Mukalay WA, Filetti S, Vigneri R: Iodine-induced thyrotooxicosis in Kivu, Zaire. Lancet 1996; 347: 552-3.
69. ToddCH, Allain T, Gomo ZA, Hasler JA, Ndiweni M, Oken E: Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe. Lancet 1995; 346: 1563-4-
70. Lazarus JH, Parkes AB, John R, N'Diaye M, Prysor-Iones SG: Endemic goitre in Senegal-thyroid function etiological factors and treatment with oral iodized oil. Acta Endocrinol (Copenh) 1992; 126: 149-54.
71. Fradkin JE, Wolff J: Iodide-induced thyrotoxicosis. Medicine 1983; 62: 1-20.
72. Vagenakis AG, Wang CA, Burger A, Maloof F, Braverman LE, Ingbar SH: Iodide induced thyrotoxicosis in Boston. N Engl J Med 1972; 287: 523-7.
73. Rajatanavin R, Safran M, Stoller W, Mordes JP, Braverman LE: Five patients with iodine-induced hyperthyroidism. Am J Med 1984; 77: 378-84.
74. Martin FIR, Tress BW, Colman PG, Deam DR: Iodine-induced hyperthyroidism due to nonionic contrast radiography in the elderly. Am J Med 1995; 95: 78-82.
75. Steidle B, Grehn S, SeifFJ: Jodinduzierte hyperthyreose durch kontrastmittel. Dtsch Med Wschr 1979; 104: 1435-8.
76. Conn JJ, Sebastian MJ, Dearn D, Tam M, Martin FTR: A prospective study of the effect of ionic contrast media on thyroid function. Thyroid 1996; 6: 107-10.
77. Nolte W, Müller R, Siggelkow H, Emrich D, Hübner M: prophylactic application of thyrostatic drugs during excessive iodine exposure in euthyroid patients with thyroid autonomy: a randomized study. Eur J Endocrinol 1996; 134: 337-41.
78. Lorberboym M, Mechanick JI: Accelerated thyrotoxicosis induced by iodinated contrast media in metastatic differentiated thyroid carcinoma. J Nucl Med 1996; 37: 532-5.
79. Harjai KJ, Licata AA: Effects of amiodarone on the thyroid. Ann Intern Med 1997; 126: 63-73.
80. Martino E, Safran M, Aghini-Lombardi F, et al.: Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Ann Intern Med 1984; 101: 28-34.
81. Martino E, Mariotti S, Aghini-Lombardi F, et al.: Short-term administration of potassium perchlorate restores euthyroidism in amiodarone-induced hypothyroidism. J Clin Endocrinol Metab 1986; 63: 1233-6.
82. Minelli R, Gardini E, Bianconi L, Salvi M, Roti E: Subclinical hypothyroidism, overt thyrotoxicosis and subclinical hypothyroidism: the subsequent phases of thyroid function in a patient chronically treated with amiodarone. J Endocrinol Invest 1992; 15: 853-5.
83. Roti E, Minelli R, Gardini E, Bianconi L, Braverman LE: Thyrotoxicosis followed by hypothyroidism in patients treated with amiodarone. A possible consequence of a destructive process in the thyroid. Arch Intern Med 1993; 886-92.
84. Bartalena L, Grasso L, Brogioni S, Aghini-Lombardi F, Braverman LE, Martino E: Serum interleukin-6 in amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab 1994; 78: 423-7.
85. Chiovato L, Martino E, Tonacchera M, et al.: Studies on the in vitro cytotoxic effect of amiodarone. Endocrinology 1994; 134: 2277-82.
86. Martino E, Aghini-Lombardi F, Mariotti S, et al.: Treatment of amiodarone associated thyrotoxicosis by simultaneous administration of potassium perchlorate and methimazole. J Endocrinol Invest 1986; 9: 201-7.
87. Bartalena L, Brogioni S, Grasso L, Bogazzi F, Burelli A, Martino E: Treatment of amiodarone-induced thyrotoxicosis, a difficult challenge: results of a prospective study. J Clin Endocrinol Metab 1996; 81: 2930-3.
88. Farwell AP, Abend SL, Huang SKS, Patwardhan N, Braverman LE: Thyroidectomy for amiodarone-induced thyrotoxicosis. JAMA 1990; 263: 1526-8.
89. Samaras K, Marel GM: Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis. Clin Endocrinol 1996; 45: 365-8.