Human immunodeficiency virus type 1 (HIV-1) protein Vif inhibits the activity of HIV-1 protease in bacteria and in vitro

Journal of Virology

Volumn 71, Issue 8, 1997, Pages 5774-5781

  Kotler, M ^a   Simm, M ^b   Zhao, Y S ^a   Sova, P ^b   Chao, W ^b   Ohnona, S F ^a   Roller, R ^a   Krachmarov, C ^b   Potash, M J ^b   Volsky, D J ^b  

^a HEBREW UNIVERSITY   (Israel)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; CORE PROTEIN; GAG PROTEIN; MATRIX PROTEIN; PROTEIN PRECURSOR; PROTEINASE; SYNTHETIC PEPTIDE; VIF PROTEIN;

ARTICLE; BACTERIUM TRANSFORMATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRINAE; PRIORITY JOURNAL; PROTEIN PROCESSING; VIRION; VIRUS CORE; VIRUS REPLICATION;

EID: 0030740060     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.8.5774-5781.1997     Document Type: Article

References (59)

1. Aldrovandi, G., and J. Zack. 1996. Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J. Virol. 70:1505-1511.
2. Pol-protease fusion protein is present in mature particles of human immunodeficiency virus type 1. J. Virol. 70:7228-7231.
3. Arrigo, S., and K. Huffman. 1995. Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers. J. Virol. 69:5988-5994.
4. Borman, A. M., C. Quillent, P. Charneau, C. Dauguet, and F. Clavel. 1995. HIV-1 Vif mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity. J. Virol. 69:2058-2067.
5. Camur, D., and D. Trono. 1996. Characterization of human immunodeficiency virus type 1 Vif particle incorporation. J. Virol. 70:6106-6111.
6. Casareale, D., M. Stevenson, K. Sakai, and D. J. Volsky. 1987. A human T-cell line resistant to cytopathic effects of the HIV-1. Virology 156:40-49.
7. Chowdhury, I. H., W. Chao, M. J. Potash, P. Sova, H. E. Gendelman, and D. J. Volsky. 1996. vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages producing attenuated progeny virus. J. Virol. 70:5336-5345.
8. Courcoul, M., C. Patience, F. Rey, D. Blanc, A. Harmache, J. Sire, R. Vigne, and B. Spire. 1995. Peripheral blood mononuclear cells produce normal amounts of Vif-defective human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps. J. Virol. 69:2068-2074.
9. Cullen, B. R. 1991. Regulation of human immunodeficiency virus replication. Annu. Rev. Microbiol. 45:219-250.
10. Debouck, C., and B. W. Metcalf, B. W. 1990. HIV protease: a target for AIDS therapy. Drug Dev. Res. 21:1-17.
11. Dougherty, W., and B. Semler. 1993. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes. Microbiol. Rev. 57:781-822.
12. Fisher, A. G., B. Ensoli, L. Ivanoff, M. Chamberlain, S. Petteway, L. Ratner, R. Gallo, and F. Wong-Staal. 1987. The sor gene of HIV-1 is required for efficient virus transmission in vitro. Science 237:888-892.
13. Fouchier, R. A. M., J. H. M. Simon, A. B. Jaffe, and M. H. Malim. 1996. Human immunodeficiency virus type 1 Vif does not influence expression or virion incorporation of gag-, pol-, or env-encoded proteins. J. Virol. 70:8263-8269.
14. + T lymphocytes. J. Virol. 66:6489-6495.
15. Gabuzda, D. H., H. Li, K. Lawrence, B. S. Vasir, K. Crawford, and E. Langhoff. Essential role of vif in establishing productive HIV-1 infection in peripheral blood lymphocytes and monocyte/macrophages. 1994. J. Acquired Immune Def. Synd. 7:908-915.
16. Garrett, E., L. Tiley, and B. Cullen. 1991. Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products. J. Virol 65:1653-1657.
17. Goncalves, J., P. Jallepalli, and D. H. Gabuzda. 1994. Subcellular localization of the Vif protein of human immunodeficiency virus type 1. J. Virol. 68:704-712.
18. Goodbar-Larsson, L., B. G. M. Luukkonen, T. Unge, S. Schwartz, G. Utter, B. Strandberg, and B. Oberg. 1995. Enhancement of HIV-1 proteinase activity by HIV-1 reverse transcriptase. Virology 206:387-394.
19. Hoglund, S., A. Ohagen, K. Lawrence, and D. H. Gabuzda. 1994. Role of vif during packing of the core of HIV-1. Virology 201:349-355.
20. Hunter, E. 1994. Macromolecular interactions in the assembly of HIV and other retroviruses. Semin. Virol. 5:71-83.
21. Kan, N., G. Franchini, F. Wong-Staal, G. DuBois, W. Robey, J. Lautenberger, and T. Papas. 1986. Identification of the HTLV-III/LAV sor gene product and detection of antibodies in human sera. Science 231:1553-1555.
22. Kaplan, A. H., M. Manchester, and R. Swanstrom. 1994. The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency. J. Virol. 68:6782-6786.
23. Kaplan, A. H., and R. Swanstrom. 1991. HIV-1 Gag proteins are processed in two cellular compartments. Proc. Natl. Acad. Sci. USA 88:4528-4532.
24. Karacostas, V., E. Wolffe, K. Nagashima, M. Gonda, and B. Moss. 1993. Overexpression of the HIV-1 Gag-Pol polyprotein results in intracellular activation of HIV-1 protease and inhibition of assembly and budding of virus-like particles. Virology 193:661-671.
25. Kotler, M., G. Arad, and S. H. Hughes. 1992. Human immunodeficiency virus type 1 Gag-protease fusion proteins are enzymatically active. J. Virol. 66:6781-6783.
26. Krausslich, H.-G. 1991. HIV proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity. Proc. Natl. Acad. Sci. USA 88:3213-3217.
27. Krausslich, H.-G., C. Ochsenbauer, A.-M. Traenckner, K. Mergener, M. Facke, H. Gelderblom, and V. Bosch. 1993. Analysis of protein expression and virus-like particle formation in mammalian cell lines stably expressing HIV-1 gag and env gene products with or without active HIV proteinase. Virology 192:605-617.
28. Lee, T.-H., J. Coligan, J. Allan, M. McLane, J. Groopman, and M. Essex. 1986. A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses. Science 231:1546-1549.
29. Liu, H., X. Wu, M. Newman, G. Shaw, B. Hahn, and J. Kappes. 1995. The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures. J. Virol. 69:7630-7638.
30. Louis, J., R. McDonald, N. Nashed, E. Wondrak, D. Jerrina, S. Oroszlan, and P. Mora. 1991. Autoprocessing of the HIV-1 protease using purified wild-type and mutated fusion proteins expressed at high levels in Escherichia coli. Eur. J. Biochem. 199:361-369.
31. Luukkonen, B. G. M., E. M. Fenyo, and S. Schwartz. 1996. Overexpression of human immunodeficiency virus type 1 protease increases intracellular cleavage of Gag and reduces virus infectivity. Virology 206:854-865.
32. Ma, X.-Y., P. Sova, W. Chao, and D. J. Volsky. 1994. Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity. J. Virol. 68:1714-1720.
33. Michaels, F., N. Hattori, R. Gallo, and G. Franchini. 1993. The HIV-1 Vif protein is located in the cytoplasm of infected cells and its effect on viral replication is equivalent in HIV-1. AIDS Res. Hum. Retroviruses 9:1025-1030.
34. Norrander, J., J. Vieira, I. Rubenstein, and J. Messing. 1985. Manipulation and expression of the maize zein storage proteins in Escherichia coli. J. Biotechnol. 2:157-175.
35. Oberste, M., and M. Gonda. 1992. Conservation of amino-acid sequence motifs in lentivirus Vif proteins. Virus Genes 6:95-102.
36. Pettit, S. C., M. Moody, R. Wehbie, A. Kaplan, P. Nantermet, C. Klein, and R. Swanstrom. The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions. 1994. J. Virol. 68:8017-8027.
37. Quillent, C., A. Borman, S. Paulois, C. Dauget, and F. Clavel. 1996. Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation. Virology 219:29-36.
38. Rhim, H., C. O. Echetebu, C. H. Herrman, and A. P. Rice. 1994. Wildtype and mutant HIV-1 and HIV-2 Tat proteins expressed in Escherichia coli as fusions with glutathione S-transferase. AIDS 7:1116-1121.
39. Roberts, N. A., J. Martin, D. Kinchington, A. V. Broadhurst, J. C. Craig, I. Duncan, S. A. Galpin, B. K. Handa. J. Kay, A. Krohn, R. W. Lambert, J. H. Merrett, J. S. Mills, K. E. B. Parkes, S. Redshaw, A. J. Ritchie, D. L. Taylor, G. J. Thomas, and P. J. Machin. 1990. Rational design of peptide-based HIV proteinase inhibitors. Science 248:358-361.
40. Sakai, H., R. Shibata, J. Sakuragi, M. Sakuragi, M. Kawamura, and A. Adachi. 1993. Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particles. J. Virol. 67:1663-1666.
41. Sakai, K., X. Ma, I. Gordienko, and D. J. Volsky. 1991. Recombinational analysis of a natural noncytopathic human immunodeficiency virus type 1 (HIV-1) isolate: role of the vif gene in HIV-1 infection kinetics and cytopathicity. J. Virol. 65:5765-5773.
42. Simm, M., M. Shahabuddin, W. Chao, J. S. Allan, and D. J. Volsky. 1995. Aberrant Gag protein composition of human immunodeficiency virus type 1 vif mutants produced in lymphocytes. J. Virol. 69:4582-4586.
43. Simm, M., G. Li, and D. J. Volsky. Unpublished observations.
44. Simon, J., and M. Malim. 1996. The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes. J. Virol. 70:5297-5305.
45. Gag-Pol expressed from a simian virus 40 late replacement vector are efficiently processed and assembled into viruslike particles. J. Virol. 64:2743-2750.
46. Sodroski, J., W. Goh, C. Rosen, A. Tartar, A., D. Portetelle, A. Burny, and W. Haseltine. 1986. Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions. Science 231:1549-1553.
47. Sova, P., M. Van Ranst, P. Gupta, R. Balachandran, W. Chao, S. Itescu, G. McKinley, and D. J. Volksy. 1995. Conservation of an intact human immunodeficiency virus type 1 vif gene in vitro and in vivo. J. Virol. 69:2557-2564.
48. Sova, P., and D. J. Volsky. 1993. Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1. J. Virol. 67:6322-6326.
49. Sova, P. Unpublished data.
50. Strebel, K., D. Daugherty, K. Clouse, D. Cohen, T. Folks, and M. Martin. 1986. The HIV-1 "A" gene product is essential for virus infectivily. Nature 328:728-730.
51. Studier, F. W., A. H. Rosenberg, J. J. Dunn, and J. W. Dubendorff. 1990. Use of T7 polymerase to direct expression of cloned genes. Methods Enzymol. 185:60-89.
52. Tomaszek, T. A., V. W. Magaard, H. G. Bryan, M. L. Moore, and T. D. Meek. 1990. Chromophoric peptide substrates for the spectrophotometric assay of HIV-1 protease. Biochem. Biophys. Res. Commun. 168:274-280.
53. Tritch, R., Y. Cheng, F. Yin, and S. Erickson-Vitanen. 1991. Mutagenesis of protease cleavage sites in the human immunodeficiency virus type 1 Gag polyprotein. J. Virol. 65:922-930.
54. Vieria, J., and J. Messing. 1982. The pUC plasmids, an M13amp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19:259-268.
55. Volsky, D. J., et al. Unpublished data.
56. Von Schwedler, U., J. Song, C. Aiken, and D. Trono. 1993. vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J. Virol. 67:4945-4955.
57. Wang, C.-T., and E. Barklis. 1993. Assembly, processing, and infectivity of human immunodeficiency virus type 1 Gag mutants. J. Virol. 67:4264-4273.
58. Willis, J., and R. Craven. 1991. Form, function, and use of retroviral Gag proteins. AIDS 5:639-654.
59. Zybarth, G., and C. Carter. 1995. Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing. J. Virol. 69:3878-3884.