Fetal pig neural cells as a restorative therapy for neurodegenerative disease

Artificial Organs

Volumn 21, Issue 11, 1997, Pages 1192-1198

  Jacoby, Douglas B ^a   Lindberg, Charles ^a   Ratliff, Judson ^a   Wunderlich, Michelle ^a   Bousquet, Joyce ^a   Wetzel, Kristie ^a   Beaulieu, Laura ^a   Dinsmore, Jonathan ^a  

^a GENVEC INC   (United States)

Author keywords

Brain; Immunosuppression; Pig; Transplantation; Xenotransplantation

Indexed keywords

CELLS; CYTOLOGY; DISEASE CONTROL; ELECTROPHYSIOLOGY; NEURODEGENERATIVE DISEASES; NEUROPHYSIOLOGY;

ATHYMIC; CENTRAL NERVOUS SYSTEMS; CYCLOSPORIN A; GABAERGIC; IMMUNOSUPPRESSION; NEURAL CELLS; PIG; PRECURSOR CELLS; TRANSPLANTATION; XENOTRANSPLANTATION;

RATS;

CONFERENCE PAPER; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; NERVE CELL; NERVE DEGENERATION; PRIORITY JOURNAL; SWINE; XENOGRAFT; XENOTRANSPLANTATION;

SUIDAE; SUS SCROFA;

EID: 0030735433     PISSN: 0160564X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1525-1594.1997.tb00474.x     Document Type: Conference Paper

References (34)

1. Dunnett SB. Functional repair of striatal systems by neural transplants: Evidence for circuit reconstruction. Behav Brain Res 1995;66:133-42.
2. Freed WJ. Neural transplantation: Prospects for clinical use. Cell Transplant 1993;2:13-31.
3. Björklund A. Neural transplantation - an experimental tool with clinical possibilities. Trends Neurosci 1991;14:319-22.
4. Gage FH, Fisher LJ. Intracerebral grafting: A tool for the neurobiologist. Neuron 1991;6:1-12.
5. Olanow CW, Kordower JH, Freeman TB. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci 1996;19:102-9.
6. Widner H, Rehncrona S. Transplantation and surgical treatment of parkinsonian syndromes. Curr Opin Neurol 1993;6: 344-9.
7. Pakzaban P, Deacon TW, Burns LH, Dinsmore J, Isacson O. A novel mode of immunoprotection of neural xenotransplants: Masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system. Neuroscience 1995;65:983-96.
8. Isacson O, Deacon TW, Pakzaban P, Galpern WR, Dinsmore J, Burns LH. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial axonal fibers. Nat Med 1995;1:1189-94.
9. Isacson O, Deacon TW. Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat. Neuroscience 1996;75:827-37.
10. Deacon TW, Pakzaban P, Burns LH, Dinsmore J, Isacson O. Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats. Exp Neurol 1994;130:151-67.
11. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med 1997;3:350-3.
12. Freeman TB, Olanow CW, Hauser RA, Nauert GM, Smith DA, Borlongan CV, Sanberg PR, Holt DA, Kordower JH, Vingerhoets FJ, Snow BJ, Calne D, Gauger LL. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann Neurol 1995;38:379-88.
13. Kordower JH, Freeman TB, Snow BJ, Vingerhoets FJ, Mufson EJ, Sanberg PR, Hauser RA, Smith DA, Nauert GM, Perl DP, Olanow W. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995;332:1118-24.
14. Kordower JH, Rosenstein JM, Collier TJ, Burke MA, Chen E, Li JM, Martel L, Levey AE, Mufson EJ, Freeman TB, Olanow CW. Functional fetal nigral grafts in a patient with Parkinson's disease: Chemoanatomic, ultrastructural, and metabolic studies. J Comp Neurol 1996;370:203-30.
15. Lindvall O, Sawle G, Widner H, Rothwell JC, Björklund A, Brooks D, Brundin P, Frackowiak R, Marsden CD, Odin P, Rehncrona S. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 1994;35:172-80.
16. Lindvall O, Odin P. Clinical application of cell transplantation and neurotrophic factors in CNS disorders. Curr Opin Neurobiol 1994;4:752-7.
17. Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, Åstedt B, Lindvall O, Björklund A. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: Immunological aspects, spontaneous and drug-induced behavior, and dopamine release. Exp Brain Res 1988;70:192-208.
18. Deacon TW, Pakzaban P, Isacson O. The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: Neural transplantation and developmental evidence. Brain Res 1994;668:211-9.
19. Freeman TB, Wojak JC, Brandeis L, Michel JP, Pearson J, Flamm ES. Cross-species intracerebral grafting of embryonic swine dopaminergic neurons. Prog Brain Res 1988;78:473-7.
20. Galpern WR, Burns LH, Deacon TW, Dinsmore J, Isacson O. Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: Functional recovery and graft morphology. Exp Neurol 1996;140:1-13.
21. Pakzaban P, Isacson O. Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers. Neuroscience 1994;62:989-1001.
22. Naimi S, Jeny R, Hantraye P, Peschanski M, Riche D. Ontogeny of human striatal DARPP-32 neurons in fetuses and following xenografting to the adult brain. Exp Neurol 1996; 137:15-25.
23. Brundin P, Fricker RA, Nakao N. Paucity of P-zones in striatal grafts prohibit commencement of clinical trials in Huntington's disease. Neuroscience 1996;71:895-7.
24. Pakzaban P, Deacon TW, Burns LH, Isacson O. Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence. Exp Brain Res 1993;97:13-22.
25. Wictorin K, Ouimet CC, Björklund A. Intrinsic organization and connectivity of intrastriatal striatal transplants in rats as revealed by DARPP-32 immunohistochemistry: Specificity of connections with the lesioned host brain. Eur J Neurosci 1989; 1:690-701.
26. Wictorin K. Anatomy and connectivity of intrastriatal striatal transplants. Prog Neurobiol 1992;38:611-39.
27. Steiner JP, Connolly MA, Valentine HL, Hamilton GS, Dawson TM, Hester L, Snyder SH. Neurotrophic actions of non-immunosuppressive analogues of immunosuppressive drugs FK-506, rapamycin, and cyclosporin A. Nat Med 1997;3:421-8.
28. Steiner JP, Hamilton GS, Ross DT, Valentine HL, Guo H, Connolly MA, Liang S, Ramsey C, Li JJ, Huand W, Howorth P, Soni R, Fuller M, Sauer H, Nowotnik AC, Suzdak PD. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc Natl Acad Sci USA 1997;94:2019-24.
29. Huffaker TK, Boss BD, Morgan AS, Neff NT, Strecker RE, Spence MS, Miao R. Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease. Exp Brain Res 1989;77:329-36.
30. Brundin P, Isacson O, Björklund A. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Res 1985;331: 251-9.
31. Ouimet CC, Miller PE, Hemmings HC, Walaas SI, Greengard P. DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated phosphoprotein enriched in dopamine innervated brain regions. III. Immunocytochemical localization. J Neurosci 1984;4:111-24.
32. Walaas SI, Greengard P. DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated phosphoprotein enriched in dopamine innervated brain regions. I. Regional and cellular distribution in the rat brain. J Neurosci 1984;4:84-98.
33. Oettinger HF, Sullivan JA, Horvalh KE, Kelley JA, Jacoby DB, Dinsmore J, Zawadzka A, Edge ASB. Species-specific detection of porcine xenografts with an antibody against a novel epitope of the lymphocyte homing receptor, CD44. Xenotransplant (in press).
34. Oettinger HF, Rodrigue-Way A, Bousquet JJ, Edge AS. Porcine repeat element DNA: In situ detection of xenotransplanted cells. Cell Transplant 1995;4:253-6.