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Volumn 18, Issue PK, 1995, Pages 43-154

A Historical Perspective of Morphine Syntheses

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EID: 77957814614     PISSN: 15725995     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1572-5995(96)80025-1     Document Type: Chapter
Times cited : (81)

References (167)
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    • An analogous opening with chloride followed by intramolecular Friedel-Crafts had served as a model study
    • An analogous opening with chloride followed by intramolecular Friedel-Crafts had served as a model studyEvans, D.A., Mitch, C.H., Thomas, R.C., Zimmerman, D.M., Robey, R.L., J. Am. Chem. Soc., 102, 1980, 5955.
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    • For an earlier, unsuccesful approach via anodic coupling, see
    • For an earlier, unsuccesful approach via anodic coupling, seeKlünenberg, H., Schäffer, C., Schäfer, H.J., Tetrahedron Lett., 23, 1982, 4581.
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    • Several model studies strengthened this approachToth, J.E., Fuchs, P.L., J. Org. Chem., 51, 1986, 2594.
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    • Preliminary investigations of this radical approach were presented in
    • Preliminary investigations of this radical approach were presented inParker, K.A., Spero, D.M., Van Epp, J., J. Org. Chem., 53, 1988, 4628.
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    • A full account of this work has recently appeared
    • A full account of this work has recently appearedParker, K.A., Fokas, D., J. Org. Chem., 59, 1994, 3927.
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    • This methodology has recently been extended to a palladium catalyzed biscyclization in which the furan ring is formed directly
    • This methodology has recently been extended to a palladium catalyzed biscyclization in which the furan ring is formed directlyHong, C.Y., Overman, L.E., Tetrahedron Lett., 35, 1994, 3453.
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    • For a successful application of this methodology to a total synthesis of O-methylpallidine, see
    • For a successful application of this methodology to a total synthesis of O-methylpallidine, seeMcMurry, J.E., Farina, V., Tetrahedron Lett., 24, 1983, 4653.
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    • For the utilization of this methodology in the synthesis of several morphinan, isomorphinan, normorphinan and hasubanan derivatives of potential pharmacological interest, see also
    • For the utilization of this methodology in the synthesis of several morphinan, isomorphinan, normorphinan and hasubanan derivatives of potential pharmacological interest, see alsoMonkovic, I., Wong, H., Can. J. Chem., 54, 1976, 883.
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    • citing the thesis of J.L. Bourgeois, Marseille 1980
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