Genexpression of matrix metalloproteinases and their inhibitors in lipodermatosclerosis;Genexpression von matrix-metalloproteinasen und deren inhibitoren bei dermatoliposklerose

Phlebologie

Volumn 26, Issue 5, 1997, Pages 150-154

  Herouy, Y ^a,c   May, A E ^a   Heisterkamp, T ^b   Hartmann, M ^b   Schopf E ^a   Norgauer, J ^a   Vanscheidt, W ^a  

^a KERCKHOFF HEART CENTER   (Germany)

^b Dermatologisch Phlebologischen G   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Lipodermatosclerosis (LDS); Matrix metalloproteinases (MMPs); Tissue inhibitors of metalloproteinases (TIMPs)

Indexed keywords

COLLAGENASE; GELATINASE A; GELATINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE;

AGED; ARTICLE; CLINICAL ARTICLE; ENZYME ANALYSIS; ENZYME INDUCTION; GENE EXPRESSION; HUMAN; LIPODERMATOSCLEROSIS; MULTIGENE FAMILY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCEROGENESIS;

EID: 0030728807     PISSN: 0939978X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Aimes RT, Quigley JP. Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem 1995; 270: 5872-6.
2. Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol 1995; 7: 728-35.
3. Henninger HP, Hoffmann R, Grewe M, Schulze-Specking A and Decker K. Purification and quantitative analysis of nucleic acids by anion-exchange high performance liquid chromatography. Biol Chem Hoppe-Seyler 1993; 373: 271-81.
4. Grewe M, Gyufko K, Schöpf E and Krutmann J. Lesional expression of interferon-gamma in atopic eczema. Lancet 1994; 343: 25-6.
5. Higley HR, Ksander GA, Gerhardt CO and Falanga V. Extravasation of macromolecules and possible trapping of transforming growth factor beta in venous ulceration. Br J Dermatol 1995; 132: 79-85.
6. Mackay AR, Hartzler JC, Pelina MD, Thorgeirsson UP. Studies on the ability of 65 kDa and 92 kDa tumor cell gelatinases to degrade type IV collagen. J Biol Chem 1990; 265: 21929-34.
7. Naschitz JE, Boss JH, Misselwevich I, Yeshurun D, Rosner I. The fasciitis-panniculitis syndromes. Clinical and pathologic features (Review). Medicine 1996; 75: 6-16.
8. Overall CM, Wrana IL, Sodek J. Transcriptional and posttranscriptional regulation of 72 kDa gelatinase/type IV collagenase by transforming growth factor beta 1 in human fibroblasts. Comparison wtih collagenase and tissue inhibitors of metalloproteinase gene expression. J Biol Chem 1991; 266: 14064-71.
9. Howard EW, Bullen EC and Banda MJ. Preferential inhibition of 72- and 92 kDa gelatinases by tissue inhibitor of metalloproteinase-2. J Biol Chem 1991; 266: 13070-5.
10. Weckroth M, Vaheri A, Lauharanta J, Sorsa T and Konttinen YT. Matrix metalloproteinases, gelatinases and collagenase in chronic leg ulcers. J Invest Dermatol 1996; 106: 1119-24.
11. Yager DR, Zhang LY, Liang HY, Diegelmann RF and Cohen IK. Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids. J Invest Dermatol 1996; 107: 743-8.