Effect of L-arginine on human coronary endothelium-dependent and physiologic vasodilation

Journal of the American College of Cardiology

Volumn 30, Issue 5, 1997, Pages 1220-1227

  Quyyumi, Arshed A ^a   Dakak, Nader ^a   Diodati, Jean G ^a   Gilligan, David M ^a   Panza, Julio A ^a   Cannon III, Richard O ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ARGININE; DEXTRO ARGININE;

ADULT; AGED; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTERY TONE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; EPICARDIUM; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

ACETYLCHOLINE; AGED; ARGININE; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; REGIONAL BLOOD FLOW; VASCULAR RESISTANCE; VASODILATION;

EID: 0030728034     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(97)00279-9     Document Type: Article

References (43)

1. Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med. 323:1990;27-36.
2. Palmer RMJ, Ferridge AG, Moncada S. Nitric oxide release amounts for the biological activity of endothelium-derived relaxing factor. Nature. 327:1987;524-526.
3. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 329:1993;2002-2012.
4. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 333:1988;664-666.
5. Palmer RMJ, Rees DD, Ashton DS, Moncada S. L-Arginine is the physiological precursor for the formation of nitric oxide in the endothelium-dependent relaxation. Biochem Biophys Res Commun. 153:1988;1251-1256.
6. Palmer RMJ, Moncada S. A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun. 158:1989;348-352.
7. Pollock JS, Forstermann U, Mitchell JA, et al. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci USA. 88:1991;10480-10484.
8. Hecker M, Sessa WC, Harris HJ, Anggard EE, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor cultured endothelial cells recycle L-citrulline to L-arginine . Proc Natl Acad Sci USA. 87:1990;8612-8616.
9. Forstermann U, Closs EI, Pollock JS, et al. Nitric oxide synthase isozymes characterization, purification, molecular cloning, and functions . Hypertension. 23:1994;1121-1131.
10. Girerd XJ, Hirsch AT, Cooke JP, Dzau VJ, Creager MA. L-Arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res. 67:1990;1301-1308.
11. Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest. 90:1992;1248-1253.
12. Cooke JP, Andon NA, Girerd XJ, Hirsch AT, Creager MA. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation. 83:1991;1057-1062.
13. Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet. 338:1991;1546-1550.
14. Panza JA, Casino PR, Badar DM, Quyyumi AA. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation. 87:1993;1475-1481.
15. Nakaki T, Hishikawa K, Suzuki H, Saruta T, Kato R. L-Arginine-induced hypotension [letter]. Lancet. 336:1990;696.
16. Imaizumi T, Hirooka Y, Masaki H, et al. Effects of L-arginine on forearm vessels and responses to acetylcholine. Hypertension. 20:1992;511-517.
17. Koifman B, Wollman Y, Bogomolny N, et al. Improvement of cardiac performance by intravenous infusion of L-arginine in patients with moderate congestive heart failure. J Am Coll Cardiol. 26:1995;1251-1256.
18. Adams MR, Forsyth CJ, Jessup W, Robinson J, Celermajer DS. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll Cardiol. 26:1995;1054-1061.
19. Egashira K, Hirooka Y, Kuga T, Mohri M, Takeshita A. Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. Circulation. 94:1996;130-134.
20. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation. 93:1996;2135-2141.
21. Hirooka Y, Egashira K, Imaizumi T, et al. Effect of L-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans. J Am Coll Cardiol. 24:1994;948-955.
22. Dubois-Randé J-L, Zelinsky R, Roudot F, et al. Effects of infusion of L-arginine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries. Am J Cardiol. 70:1992;1269-1275.
23. Quyyumi AA, Dakak N, Andrews NP, et al. Nitric oxide activity in the human coronary circulation impact of risk factors for coronary atherosclerosis . J Clin Invest. 95:1995;1747-1755.
24. Quyyumi AA, Dakak N, Andrews NP, Gilligan DM, Panza JA, Cannon RO III. Contribution of nitric oxide to metabolic vasodilation in the human heart. Circulation. 91:1995;320-326.
25. Quyyumi AA, Mulcahy D, Andrews NP, Husain S, Panza JA, Cannon RO III. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia comparison of acetylcholine and substance P . Circulation. 95:1997;104-110.
26. Doucette JW, Corl D, Payne HM, et al. Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation. 85:1992;1899-1911.
27. SAS Technical Report p-229 SAS/STST Software: Changes and Enhancements Release 6.07. 1992;SAS Institute, Cary (NC).
28. Arnal J-F, Münzel T, Venema RC, et al. Interactions between L-arginine and L-glutamine change endothelial nitric oxide production an effect independent of nitric oxide synthase substrate availability . J Clin Invest. 95:1995;2565-2572.
29. Mugge A, Harrison DG. L-Arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels. 28:1991;354-357.
30. Sessa WC, Hecker M, Mitchell JA, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor L-glutamine inhibits the generation of L-arginine by cultured endothelial cells . Proc Natl Acad Sci USA. 87:1990;8607-8611.
31. Minoder RL, Myers PR, Guerra R Jr, Bates JN, Harrison DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest. 86:1990;2109-2116.
32. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 91:1993;2546-2551.
33. Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inque M. Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci USA. 88:1991;10045-10048.
34. Kaiser L, Spickard RC, Oliver NB. Heart failure depresses endothelium-dependent responses in canine femoral artery. Am J Physiol. 25:1989;H72-H77.
35. Katusic ZS, Shepherd JT, Vanhoutte PM. Endothelium-dependent contractions to calcium ionophore A23187, arachidonic acid, and acetylcholine in canine basilar arteries. Stroke. 19:1988;476-479.
36. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients. J Am Coll Cardiol. 23:1994;844-850.
37. Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation. 88:1993;77-81.
38. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 81:1990;491-497.
39. Zeiher AM, Drexler H, Saubier B, Just H. Endothelium-mediated coronary blood flow modulation in humans effects of age, atherosclerosis, hypercholesterolemia, and hypertension . J Clin Invest. 92:1993;652-662.
40. Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR, Quyyumi AA. The contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation. 90:1994;2853-2858.
41. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest. 97:1996;1989-1994.
42. Lamontagne D, Pohl U, Busse R. Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ Res. 70:1992;123-130.
43. Cooke JP, Stamler J, Andon N, Davies PF, McKinley G, Loscalzo J. Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol. Am J Physiol. 259:1990;H804-H812.