Subchronic/chronic toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) in rats Part II. Biochemical effects

Toxicology and Applied Pharmacology

Volumn 146, Issue 2, 1997, Pages 217-226

  Viluksela, Matti ^a,b   Stahl, Bernhard U ^a,c   Birnbaum, Linda S ^d   Rozman, Karl K ^a,c  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ETHOXYRESORUFIN DEETHYLASE; PHOSPHOENOLPYRUVATE CARBOXYLASE; POLYCHLORINATED DIBENZODIOXIN;

ANIMAL EXPERIMENT; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INDUCTION; FEMALE; LIOTHYRONINE BLOOD LEVEL; LIVER; MALE; NONHUMAN; RAT; SEX DIFFERENCE; THYROXINE BLOOD LEVEL; TOXICOKINETICS;

EID: 0030727801     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8240     Document Type: Article

References (45)

1. Ahlborg U. G., Brouwer A., Fingerhut M. A., Jacobson J. L., Jacobson S. W., Kennedy S. W., Kettrup A. A. F., Koeman J. H., Poiger H., Rappe C., Safe S. H., Seegal R. F., Tuomisto J., van den Berg M. Impact of polychlorinated dibenzo-p. Eur. J. Pharmacol. 228:1992;179-199.
2. Bastomsky C. H. Enhanced thyroxine metabolism and high uptake goiter in rats after a single dose of 2,3,7,8-tetrachlorodibenzo-p. Endocrinology. 101:1977;292-296.
3. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
4. Christian B. J., Menahan L. A., Peterson R. E. Intermediary metabolism of the mature rat following 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 83:1986;360-378.
5. Dutton D. R., Parkinson A. Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P-450. Arch. Biochem. Biophys. 268:1989;605-616.
6. Fan F., Rozman K. K. Short- and long-term biochemical effects of TCDD in female Long-Evans rats. Toxicol. Lett. 75:1995;209-216.
7. Fan F., Wierda D., Rozman K. K. Effect of 2,3,7,8-tetrachlorodibenzo-p. Toxicology. 69:1995;547-551.
8. Fan F., Yan B., Wood G., Viluksela M., Rozman K. K. Cytokines (1L-1B and TNFx) in relation to biochemical and immunological effects of 2,3,7,8-tetrachlorodibenzo-p. Toxicology. 116:1997;9-16.
9. Fernandez-Salguero P. M., Hilbert D. M., Rudikoff S., Ward J. M., Gonzalez F. J. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 140:1996;173-179.
10. Gibaldi M., Perrier D. Pharmacokinetics. 1975;Dekker, New York. p. 329-.
11. Gorski J. R., Muzi G., Weber L. W. D., Pereira D. W., Arceo R. J., Iatropoulos M. J., Rozman K. K. Some endocrine and morphological aspects of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Pathol. 16:1988a;313-320.
12. Gorski J. R., Rozman K. K. Dose-response and time course of hypothyroxinemia and hypoinsulinemia and characterization of insulin hypersensitivity in 2,3,7,8-tetrachlorodibenzo-p. Toxicology. 44:1987;297-307.
13. Gorski J. R., Weber L. W. D., Rozman K. K. Tissue-specific alterations of de novo fatty acid synthesis in 2,3,7,8-tetrachlorodibenzo-p. Arch. Toxicol. 62:1988b;146-151.
14. Gorski J. R., Weber L. W. D., Rozman K. K. Reduced gluconeogenesis in 2,3,7,8-tetrachlorodibenzo-p. Arch. Toxicol. 64:1990;66-71.
15. Huuskonen H., Unkila M., Pohjanvirta R., Tuomisto J. Developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 124:1994;174-180.
16. Kutz F. W., Barnes D. G., Bretthauer E. W., Bottimore D. P., Greim H. The international toxicity equivalency factor (I-TEF) method for estimating risks associated with exposures to complex mixtures of dioxins and related compounds. Toxicol. Environ. Chem. 26:1990;99-109.
17. Li X., Johnson D. C., Rozman K. K. Reproductive effects of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 133:1995;321-327.
18. Lubet R. A., Nims R. W., Mayer R. T., Cameron J. W., Schechtman L. M. Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenoxazones in hepatic S9s and hepatocyte homogenates: Effects of dicoumarol. Mutat. Res. 142:1985;127-131.
19. Metzler H., Gebhardt R., Oberrauch W., Mecke D. A convenient and highly sensitive assay for tryptophan-2,3,-dioxigenase. Anal. Biochem. 121:1982;10-16.
20. Peterson R. E., Theobald H. M., Kimmel G. L. Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons. Crit. Rev. Toxicol. 23:1993;283-335.
21. Pohjanvirta R., Tuomisto J. Shot-term toxicity of 2,3,7,8-tetrachlorodibenzo-p. Pharmacol. Rev. 46:1994;483-549.
22. Potter C. L., Moore R. W., Inhorn S. L., Hagen T. C., Peterson R. E. Thyroid status and thermogenesis in rats treated with 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 84:1986;45-55.
23. Potter C. L., Sipes G. L., Haddock Russel D. Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 69:1983;89-95.
24. Rozman K. K., Pfeifer B., Kerecsen L., Alper R. H. Is a serotonergic mechanism involved in 2,3,7,8-tetrachlorodibenzo-p. Arch. Toxicol. 65:1991;124-128.
25. Rozman K. K., Roth W. L., Greim H., Stahl B. U., Doull J. Relative potency of chlorinated dibenzo-p. Toxicology. 77:1993;39-50.
26. Rozman K. K., Stahl B. U., Kerecsen L., Kettrup A. Comparative toxicity of four chlorinated dibenzo-p. Arch. Toxicol. 69:1995;547-551.
27. Safe S. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p. Annu. Rev. Pharmacol. Toxicol. 26:1986;371-399.
28. Skene S. A., Dewhurst I. C., Greenberg M. Polychlorinated dibenzo-p. Hum. Toxicol. 8:1989;173-203.
29. Stahl B. U., Beer D. G., Weber L. W. D., Rozman K. K. Reduction of hepatic phosphoenolpyruvate carboxykinase (PEPCK) activity by 2,3,7,8-tetrachlorodibenzo-p. Toxicology. 79:1993;81-95.
30. Stahl B. U., Kettrup A., Rozman K. K. Comparative toxicity of four chlorinated dibenzo-p. Arch. Toxicol. 66:1992;471-477.
31. Unkila M., Pohjanvirta R., MacDonald E., Tuomisto J. Differential effect of TCDD on brain serotonin metabolism in a TCDD-susceptible and a TCDD-resistant rat strain. Chemosphere. 27:1993;401-406.
32. Unkila M., Pohjanvirta R., MacDonald E., Tuomisto J. T., Tuomisto J. Dose response and time course of alterations in tryptophan metabolism by 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 128:1994;280-292.
33. Unkila M., Ruotsalainen M., Pohjanvirta R., Viluksela M., MacDonald E., Tuomisto J. T., Rozman K. K., Tuomisto J. Effect of 2,3,7,8-tetrachlorodibenzo-p. Arch. Toxicol. 69:1995;677-683.
34. Viluksela M., Stahl B. U., Birnbaum L. S., Schramm K.-W., Kettrup A., Rozman K. K. Subchronic/chronic toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p. Toxicol. Appl. Pharmacol. 146:1997a;207-216.
35. M. Viluksela, B. U. Stahl, L. S. Birnbaum, K.-W. Schramm, A. Kettrup, K. K. Rozman, 1997b, Subchronic/chronic toxicity of a mixture of four chlorinated dibenzo-p.
36. Viluksela M., Stahl B. U., Rozman K. K. Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 135:1995;308-315.
37. Weber L. W. D., Ernst S. W., Stahl B. U., Rozman K. K. Tissue distribution and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p. Fundam. Appl. Toxicol. 21:1993;523-534.
38. Weber L. W. D., Lebofsky M., Greim H., Rozman K. K. Key enzymes of gluconeogenesis are dose-dependently reduced in 2,3,7,8-tetrachlorodibenzo-p. Arch. Toxicol. 65:1991a;119-123.
39. Weber L. W. D., Lebofsky M., Stahl B. U., Gorski J. R., Muzi G., Rozman K. K. Reduced activities of key enzymes of gluconeogenesis as possible cause of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p. Toxicology. 66:1991b;133-144.
40. Weber L. W. D., Lebofsky M., Stahl B. U., Kettrup A., Rozman K. K. Comparative toxicity of four chlorinated dibenzo-p. Arch. Toxicol. 66:1992a;478-483.
41. Weber L. W. D., Lebofsky M., Stahl B. U., Kettrup A., Rozman K. K. Comparative toxicity of four chlorinated dibenzo-pO. Arch. Toxicol. 66:1992b;484-488.
42. Weber L. W. D., Palmer C. D., Rozman K. K. Reduced activity of tryptophan 2,3-dioxygenase in the liver of rats treated with chlorinated dibenzo-p. Toxicology. 86:1994;63-69.
43. Wimmer M. A bioluminescent assay for the determination of phosphoenolpyruvate carboxykinase activity in nanogram-sized tissue samples. Anal. Biochem. 170:1988;376-381.
44. Yamuda J., Sugimoto Y., Horisaka K. Simultaneous determination of tryptophan and its metabolites in mouse brain by high performance liquid chromatography with fluorometric determination. Anal. Biochem. 129:1983;460-463.
45. Zinkl J. G., Vos J. G., Moore J. A., Gupta B. N. Hematologic and clinical chemistry effects of 2,3,7,8-tetrachlorodibenzo-p. Environ. Health Perspect. 5:1973;111-118.