Functional evidence for tumor-suppressor activity on chromosome 15 in human skin carcinoma cells and thrombospondin-1 as the potential suppressor

Journal of Cellular Physiology

Volumn 173, Issue 2, 1997, Pages 256-260

  Boukamp, Petra ^a   Bleuel, Kerstin ^a   Popp, Susanne ^a   Vormwald Dogan, Vera ^a   Fusenig, Norbert E ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOSPONDIN;

CANCER INHIBITION; CARCINOGENESIS; CELL LINE; CHROMOSOME 15; CHROMOSOME LOSS; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; SKIN CARCINOMA;

CARCINOMA; CHROMOSOMES, HUMAN, PAIR 15; GENES, TUMOR SUPPRESSOR; HUMANS; SKIN NEOPLASMS; THROMBOSPONDIN 1;

EID: 0030727798     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199711)173:2<256::AID-JCP31>3.0.CO;2-B     Document Type: Conference Paper

References (13)

1. Ananthaswamy, H.N., and Pierceall, W.E. (1992) Molecular alterations in human skin tumors. Prog. Clin. Biol. Res., 376:61-84.
2. Bornstein, P. (1995) Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1. J. Cell Biol., 130:503-506
3. Boukamp, P., Tilgen, W., Dzarlieva, R.T., Breitkreutz, D., Haag, D., Riehl, R.K., Bohnert, A., and Fusenig, N.E. (1982) Phenotypic and genotypic characteristics of a cell line from a squamous cell carcinoma of human skin. J. Natl. Cancer Inst., 68:415-427
4. Boukamp, P., Petrussevska, R.T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig, N.E. (1988) Normal keratinization in a spontanously immortalized aneuploid human keratinocyte cell line. J. Cell Biol., 106:761-771.
5. Boukamp, P., Peter, W., Pascheberg, U., Altmeier, S., Fasching, C., Stanbridge, E.J., and Fusenig, N.E. (1995) Step wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53 H-ras oncogene activation and additional chromosome loss. Oncogene, 11:961-969
6. Boukamp, P., Popp, S., Altmeyer, S., Hülsen, A., Fasching, C., Cremer, T., and Fusenig, N.E. (1997) Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT. Genes Chromosom Cancer (in press).
7. Good, D.J., Polverini, P.J., Rastinejad, F., Le Beau, M.M., Lemons, R.S., Frazier, W.A., and Bouck, N.P. (1990) A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. USA, 87:6624-6628.
8. Lehman, T.A., Modali, R., Boukamp, P., Stanek, J., Bennett, W.P., Welsh, J.A., Metcalf, R.A., Stampfer, M.R., Fusenig, N., Rogan, E.M., et al. (1993) p53 mutations in human immortalized epithelial cell lines. Carcinogenesis, 14:833-839.
9. Quinn, A.G., Sikkink, S., and Rees, J.L. (1994) Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss. Cancer Res., 54:4756-4759.
10. Rastinejad, F., Polverini, P.J., and Bouck, N.P. (1989) Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene. Cell, 56:345-355.
11. Saxon, P.J., Srivatsan, E.S., Leipzig, G.V., Sameshima, J.H., and Stanbridge, E.J. (1985) Selective transfer of individual human chromosomes to recipient cells. Mol. Cell. Biol., 5:140-146.
12. Weinstat-Saslow, D.L., Zabrenetzky, V.S., VanHoutte, K., Frazier, W.A., Roberts, D.D., and Steeg, P.S. (1994) Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res., 54:6504-6511.
13. Ziegler, A., Jonason, A.S., Leffell, D.J., Simon, J.A., Sharma, H.W., Kimmelman, J., Remington, L., Jacks, T., and Brash, D.E. (1994) Sunburn and p53 in the onset of skin cancer. Nature, 372:773-776.