Heregulins and the ErbB-2/3/4 receptors in gliomas

Journal of Neuro-Oncology

Volumn 35, Issue 3, 1997, Pages 335-346

  Westphal, Manfred ^a   Meima, Leonie ^b   Szonyi, Eva ^b   Lofgren, Julie ^b   Meissner, Hildegard ^a   Hamel, Wolfgang ^a   Nikolics, Karoly ^b   Sliwkowski, Mark X ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b GENENTECH INC   (United States)

Author keywords

Growth factors; Neuro oncology; Neurobiology

Indexed keywords

CELL RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; MESSENGER RNA; NEU DIFFERENTIATION FACTOR; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN;

ARTICLE; AUTOCRINE EFFECT; AUTOPHOSPHORYLATION; CANCER GENETICS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHROMOSOME 8P; CONTROLLED STUDY; DNA SYNTHESIS; GENE ACTIVATION; GENE LOCATION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; ONCOGENE NEU; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; RNA SPLICING; SIGNAL TRANSDUCTION;

BRAIN NEOPLASMS; CULTURE MEDIA, CONDITIONED; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; GLYCOPROTEINS; NERVE GROWTH FACTORS; NEUREGULINS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; RNA, MESSENGER; RNA, NEOPLASM; TUMOR CELLS, CULTURED;

EID: 0030727788     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005837122181     Document Type: Article

References (60)

1. Aaronson SA: Growth factors and cancer. Science 254: 1146-1153, 1991
2. Alimandi M, Romano A, Curia MC, Muraro R, Fedi P, Aaronson SA, Di Fiore PP, Kraus MH: Cooperative signaling of ErbB-3 and ErbB-2 in neoplastic transformation and human mammary carcinomas. Oncogene 10: 1813-1821, 1995
3. Bacus SS, Gudkov AV, Zelnik CR, Chin D, Stern R, Stancovski I, Peles E, Ben-Baruch N, Farbstein H, Lupu R, Wen D, Sela M, Yarden Y: Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumors. Cancer Res 53: 5251-5261, 1993
4. Bargman CI, Hung MC, Weinberg RA: The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 310: 226-230, 1986
5. Bagelsa J, Tripathy D, Mendelsohn J, Baughman S, Benz CC, D antis L, Sklarin N, Moore J, Rosen P, Twaddell T, Henderson IC, Norton L: Treatment of metastatic breast cancer with an anti-p185HER-2 humanized monoclonal antibody. J Clin Oncol 14: 737-744
6. Bosenberg MW, Massague J: Juxtacrine cell signalling molecules. Curr Opin Cell Biol 5: 832-838, 1993
7. Burgess TL, Ross SL, Quian YX, Brankow D, Hu S: Biosynthetic processing of neu differentiation factor. Glycosylation, trafficking, and regulated cleavage from the cell surface. J Biol Chem 270: 19188-19196
8. Carraway KL, Sliwkowski MX, Akita RW, Platko JV, Guy PM, Nuijens A, Diamonti AJ, Vandlen RL, Cantley LC, Cerione RA : The ErbB3 gene product is a receptor for heregulin. J Biol Chem 269: 14303-14306, 1994
9. Corfas G, Falls DL, Fischbach GD: ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein. Proc Natl Acad Sci USA 90: 1624-1628, 1993
10. Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, Seeburg PH, Libermann TA, Schlessinger J, Francke U, Levinson A, Ullrich A : Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230: 1132-1139, 1985
11. Dèshane J, Loechel F, Conry RM, Siegal GP, King CR, Curiel DT: Intracellular single chain antibody directed against ErbB-2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines. Gene Therapy 1: 332-337, 1994
12. Fendly BM, Kotts C, Vetterlein D, Lewis GD, Winget M, Carver ME, Watson SR, Sarup J, Saks S, Ullrich A, Shepard M: The extracellular domain of HER-2/neu is a potential immunogen for active immunotherapy in breast cancer. J Biol Resp Mod 9: 449-455, 1990
13. Fendly BM, Winget M, Hudziak RM, Lipari MT, Napier MA, Ullrich A: Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER-2/neu oncogene product. Cancer Res 50: 1550-1558, 1990
14. Gamett DC, Greene T, Wagreich AR, Kim HH, Koland JG, Cerione RA: Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85. J Biol Chem 270: 19022-19027, 1995
15. Graus-Porta D, Beerli RR, Hynes N: Single chain antibody mediated intracellular retention of ErbB-2 impairs. Neu differentiation factor and epidermal growth factor signaling. Mol Cell Biol 15: 1182-1191, 1995
16. Goodearl AD, Davis JB, Mistry K, Minghetti L, Otsu M, Waterfield MD, Stroobant P: Purification of multiple forms of glial growth factor. J Biol Chem 268: 18095-18102, 1993
17. Hamel W, Westphal M, Shepard HM: Proto-oncogene expression in human glioma derived cell lines. Int J Oncol 1: 673-682, 1992
18. Hamel W, Westphal M, Szonyi E, Escandon E, Nikolics K: Neurotrophin gene expression by cell lines derived from human gliomas. J Neurosci Res 34: 147-157, 1993
19. Hayes C, Kelly D, Murayama S, Komiyama A, Suzuki K, Popko B: Expression of the Neu Oncogene under the transcriptional control of the myelin basic protein gene in transgenic mice: generation of transformed glial cells. J Neurosci Res 31: 175-187, 1992
20. Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, Park JW, Yansura D, Abadi N, Raab H, Lewis GD, Shepard HM, Kuang WJ, Wood WI, Goeddel DV, Vandlen RL: Identification of heregulin, a specific activator of p185erbB2. Science 256: 1205-1210, 1992
21. Ho WH, Armani MP, Nuijens A, Phillips HS, Osherhoff PL: Sensory and motor neuron-derived factor: A novel heregulin isoform highly expressed in sensory and motor neurons. J Biol Chem 270: 14523-14532, 1995
22. Hynes NE, Stern DF: The biology of ErbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 1198: 165-184, 1994
23. Jo SA, Zhu X, Marchionni MA, Burden SJ: Neuregulins are concentrated at nerve-muscle synapses and activate Achreceptor gene expression. Nature 373: 158-161, 1995
24. Lee J, Wood WI: Assigment of heregulin (HGL) to human chromosome 8p22-p11 by PCR analysis of somatic cell hybrid DNA. Genomics 16: 790-791, 1993
25. Leon SP, Zhu J, Black PMcL: Genetic aberrations in human brain tumors. Neurosurgery 24: 708-722, 1994
26. Levi ADO, Bunge RP, Lofgren JA, Meima L, Hefti F, Nikolics K, Sliwkowski MX: The influence of heregulins on human Schwann cell proliferation. J Neurosci 15: 1329-1340, 1995
27. Lewis GD, Figari I, Fendly B, Wong WL, Carter P, Gorman C, Shepard HM: Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies. Cancer Immunol Immunother 37: 255-263, 1993
28. Lewis GD, Lofgren JA, McMurtrey AE, Nuijens A, Fendly BM, Bauer KD, Sliwkowski MX: Growth regulation of breast and ovarian tumor cells by heregulin: evidence for the requirement of ErbB-2 as a critical component in mediating heregulin responsiveness. Cancer Res 56: 1457-1465, 1996
29. Liebermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J: Amplification, enhanced expression and possible rearrangement of EGF-receptor gene in human brain tumors of glial origin. Nature 313: 144-147, 1985
30. Marchionni MA, Goodearl ADJ, Chen MS, Bermingham-McDonogh O, Kirk C, Hendricks M, Danehy F, Misumi D, Sudhalter J, Kobayashi K, Wroblewski D, Lynch C et al.: Glial growth factors are alternatively spliced ErbB2 ligands expressed in the nervous system. Nature 362: 312-318, 1993
31. Marte BM, Jeschke M, Graus-Porta D, Taverna D, Hofer P, Groner B, Yarden Y, Hynes NE: Neu differentiation factor/ heregulin modulates growth and differentiation of HC11 mammary epithelial cells. Mol Endocrinol 9: 14-23, 1995
32. Meyer D, Birchmeyer C: Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development. Proc Natl Acad Sci USA 91: 1064-1068, 1994
33. Morrissey TK, Levi AD, Nuijens A, Sliwkowski MX, Bunge RP: Axon-induced mitogenesis of human Schwann cells involves heregulin and p185-erbB2. Proc Natl Acad Sci USA 92: 1431-1435, 1995
34. Morrison RS: Suppression of basic fibroblast growth factor expression by antisense oligodeoxynucleotides inhibits the growth of transformed human astrocytes. J Biol Chem 266: 728-734, 1991
35. Nakamura T, Ushijima T, Ishizaka Y, Nagao M, Nemoto T, Hara M, Ishikawa T: Neu proto-oncogene mutation is specific for the neurofibromatosis in a N-nitroso-N-ethyurea-induced hamster neurofibromatosis model but not for hamster melanomas and human Schwann cell tumors. Cancer Res 54: 976-980, 1994
36. Orr-Urtreger A, Trakhtenbrot L, Ben-Levy R, Wen D, Rechavi G, Lonai P, Yarden Y: Neural expression and chromosomal mapping of neu differentiation factor to 8p12-p21. Proc Natl Acad Sci USA 90: 1867-1871, 1993
37. Paterson JA, Privat A, Ling E, Leblond CP: Transformation of subependymal cells into glial cells as shown by radioautography after 3H-thymidine injection into the lateral ventricle of the brain of young rats. J Comp Neurol 149: 83-102, 1973
38. Peles E, Yarden Y: Neu and its ligands: from oncogene to neural factors. Bioessays 15: 815-824, 1993
39. Pinkas-Kramarski R, Ellam R, Spiegler O, Lavi S, Liu N, Chang D, and D, Schwartz M, Yarden Y: Brain neurons and glial cells express neu differentiation factor/heregulin: A survival factor for astrocytes. Proc Natl Acad Sci USA 91: 9387-9391, 1994
40. Plowman GD, Green JM, Culouscou JM, Carlton GW, Rothwell VM, Buckley S: Heregulin induces tyrosine phosphorylation of HER4/p2180ErbB-4. Nature 366: 473-475, 1993
41. Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M: Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci USA 90: 1746-1750, 1993
42. Press MF, Jones LA, Godolphin W, Edwards CL, Slamon DJ: HER-2/neu oncogene amplification and expression in breast and ovarian cancers. Prog Clin Biol Res 354A: 209-221, 1990
43. Press ME, Pike MC, Chazin VR, Hung C, Udove JA, Markowicz M, Danyluk J, Godolphin W, Sliwkowski M, Akita R,PatersonMC, Slamon DJ:Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease. Cancer Res 53: 4960-4970, 1993
44. Sadick MD, Sliwkowski MX, Nuijens A, Bald L, Chiang N, Lofgren JA, Wong WLT: Analysis of heregulin-induced ErbB-2 phosphorylation with high throughput 'Kinase-Receptor Activation' (KIRA) ELISA. Anal Biochem 235: 207-214, 1996
45. Sauter ER, Keller SM, Erner S, Goldberg M: HER-2/neu: a differentiation marker in adenocarcinoma of the esophagus. Cancer Lett 75:41-44, 1993
46. Schlegel J, Stumm G, Brandle K, Merdes A, Mechtersheimer G, Hynes NE, KiesslingM: Amplification and differential expression of members of the erbB-gene family in human glioblastoma. J Neuro-Oncol 22: 201-207, 1994
47. Schwechheimer K, Laufle RM, Schmahl W, Knodlseder M, Fischer H, Hofler H: Expression of neu/c-ErbB-2 in human brain tumors. Human Pathol 25: 772-780, 1994
48. Shah NM, Marchionni MA, Isaacs I, Stroobant P, Anderson DJ: Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell 77: 349-360, 1994
49. Sliwkowski MX, Schaefer G, Akita RW, Lofgren JA, Fitzpatrick VD, Nuijens A, Fendly BM, Cerione RA, Vandlen RL, Carraway KLr: Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J Biol Chem 269: 14661-14665, 1994
50. Smart I: The subependymal layer of the mouse brain and ist cell production as shown by radioautography after thydine-3H injection. J Comp Neurol 116: 325-347, 1961
51. Sugawa N, Ekstrand AJ, James CD, Collins VP: Identical splicing of aberrant epidermal growth factor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA 87: 8602-8606, 1990
52. Trachtenberg JT, Thompson WJ: Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature 379: 174-177, 1996
53. Ushio Y, Kuratsu JI: Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist on a glioma cell line in vitro. J Neurosurg 73: 436-440, 1990
54. Vartanian T, Corfas G, Li Y, Fischbach GD, Stefanson K: A role for the acetylcholine receptor inducing protein ARIA in oligodendrocyte development. Proc Natl Acad Sci USA 91: 11626-11630, 1994
55. Westphal M, Herrmann HD: Growth factor biology and oncogene activation in human gliomas and their implications for specific therapeutic concepts. Neurosurgery 25: 681-694, 1989
56. Westphal M, Ackermann E, Hoppe J, Herrmann HD: Receptors for platelet derived growth factor in human glioma cell lines and influence of suramin on cell proliferation. J Neuro-Oncol 11: 207-213, 1991
57. Westphal M, Hänsel M, Nausch H, Rohde E, Herrmann HD: Culture of human brain tumors on an extracellular matrix derived from bovine corneal endothelial cells and cultured human glioma cells. Methods in Molecular Biology Vol 5 (Eds. JW Pollard and JM Walker), Humana Press, Clifton, New Jersey, p 113-131, 1990
58. Westphal M, Hänsel M, Hamel W, Kunzmann R, Herrmann HD, Hölzel F: Karyotypic analysis of 20 glioma cell lines. Acta Neurochir 126: 17-26, 1994
59. Westphal M, Hänsel M, Nausch H, Rohde E, Herrmann HD, Cultuphal M, Hamel W, Zirkel D, Herrmann HD, Bilzer T, Reifenberger G et al.: Epidermal growth factor receptor expression in human malignant glioma: in vitro and in vivo effects of application of monoclonal antibodies to the epidermal growth factor receptor. Rec Res Cancer Res 135: 171-184, 1994
60. Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH: Localization of the human HER4/ErbB-4 gene to chromosome 2. Oncogene 10: 1235-1237, 1995