The endometrial approach in contraception

Annals of the New York Academy of Sciences

Volumn 828, Issue , 1997, Pages 59-83

  Levy, D ^a   Christin Maitre, S ^a   Leroy, I ^a   Bergeron, C ^b   Garcia, E ^c   Freitas, S ^a   Coelingh Bennink, H J C B ^d   Bouchard, P ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b Inst Pathol Cytologie Appl CERBA   (France)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; ENDOTHELIN 1; ESTRADIOL RECEPTOR; ESTROGEN; ETYNODIOL DIACETATE; GESTAGEN; GONADOTROPIN; LEVONORGESTREL; LYNESTRENOL; LYSOSOME ENZYME; MATRIX METALLOPROTEINASE; MEDROXYPROGESTERONE ACETATE; MESTRANOL PLUS NORETHISTERONE; MIFEPRISTONE; NORETHISTERONE; NORGESTREL; ORAL CONTRACEPTIVE AGENT; PLACENTA PROTEIN 14; PLASMINOGEN ACTIVATOR; PROGESTERONE RECEPTOR; PROSTAGLANDIN F2 ALPHA; SOMATOMEDIN C; STEROID; VASCULOTROPIN;

AMENORRHEA; ARTERIOLE; CELL DEGENERATION; CONCEPTION; CONFERENCE PAPER; CONTRACEPTION; DECIDUA; DRUG FORMULATION; EMERGENCY MEDICINE; ENDOMETRIUM; ENDOMETRIUM CANCER; FEMALE; GONADOTROPIN RELEASE; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; LUTEAL PHASE; LUTEOLYSIS; MENSTRUATION; MENSTRUATION DISORDER; MICROVASCULARIZATION; NIDATION; NONHUMAN; ORAL DRUG ADMINISTRATION; OVARY CYCLE; OVULATION; STROMA CELL; THROMBOSIS; UTERINE CERVIX MUCUS;

EID: 0030727754     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48524.x     Document Type: Conference Paper

References (100)

1. GIUDICE, L. 1995. The endometrial cycle. In Reproductive Endocrinology, Surgery and Technology. Vol. 1. E. Y. Adashi, J. A. Roch & Z. Rosenwaks, Eds. Lippincott-Raven. New York.
2. J. HOTCHKISS & E. KNOBIL. 1995. The hypothalamic pulse generator: The reproductive core. In Reproductive Endocrinology, Surgery and Technology. Vol. 1. E. Y. Adashi, J. A. Roch & Z. Rosenwaks, Eds. Lippincott-Raven. New York.
3. YEN, S. C. C., M. E. QUIGLEY, R. L. REID, J. F. ROPERT & N. S. CETEL. 1985. Neuroendocrinology of opioid peptides and their role in the control of gonadotropin and prolactin secretion. Am. J. Obstet. Gynecol. 152: 485-493.
4. ROPERT, J. F., M. E. QUIGLEY & S. S. C. YEN. 1981. Endogenous opiates modulate pulsatile luteinizing hormone release in humans. J. Clin. Endocrinol. Metab. 52: 583-585.
5. SPEROFF, L. 1995. Hormonal contraception. In Reproductive Endocrinology, Surgery and Technology. Vol. 1. E. Y. Adashi, J. A. Roch & Z. Rosenwaks, Eds. Lippincott-Raven. New York.
6. LOBO, R. A. & F. Z. STANCZYK. 1994. New knowledge in the physiology of hormonal contraceptives. Am. J. Obstet. Gynecol. 170: 1499-1507.
7. BROOME, M. & K. FOTHERBY. 1990. Clinical experience with progestin-only pill. Contraception 42: 489-495.
8. JOHANNISON, E., B.-M. LANDGREN & E. DICZFALUSY. 1982. Endometrial morphology and peripheral steroid levels in women with and without intermenstrual bleeding during contraception with 300 μg norethisterone minipill. Contraception 25: 13-30.
9. HELSA, J. S. & A. MURPHY. 1995. The effects of contraceptive agents on the endometrium. Infertil. Reprod. Med. Clin. N. Am. 6: 379-400.
10. WIENKE, E. C., JR., F. CAVAZOS, D. G. HALL & F. V. LUCAS. 1969. Ultrastructural effects of norethinodrel and mestranol on human endometrial stroma cell. Am. J. Obstet. Gynecol. 103: 102-111.
11. LANDGREN, B. M., E. JOHANNISSON, B. MASIRONI & E. DICZFALUSY. 1979. Pharmacokinetic and pharmacodynamic effects of small doses of norethisterone released from vaginal rings continuously during 90 days. Contraception 19: 253-271.
12. LANDGREN, B. M., E. JOHANNISSON, S. XING, A. R. AEDO & E. DICZFALUSY. 1985. A clinical pharmacological study of a new type of vaginal delivery system for levonorgestrel. Contraception 32: 581-601.
13. MARUFFO, C. A., L. CASAVILLIA, B. VAN NYNATTEN, et al. 1974. Modification of the human endometrial fine structure induced by low-dose progestogen therapy. Fertil. Steril. 25: 778.
14. KIM-BJORKLUND, T., B. M. LANDGREN & E. JOHANNISSON. 1991. Morphometric studies of the endometrium, the fallopian tube and the corpus luteum during contraception with 300 μg norethisterone (NET) minipill. Contraception 43: 459-474.
15. HOURIHAN, H. M., B. L. SHEPARD & J. BONNAR. 1986. A morphometric study of the effect of oral norethisterone or levonorgestrel on endometrium blood vessels. Contraception 34: 603-612.
16. PAW, R., C. L. AU & B. AFFANDI. 1993. Endometrial microvascular density during the normal menstrual cycle and following exposure to long-term levonorgestrel. Hum. Reprod. 8: 1396-1404.
17. FEDELE, L., M. MARCHINI, G. CAVALLI, A. BAGLIONI & G. L. TACAGNI. 1987. Marked deciliation and insufficient secretory modification of endometrial surface during treatment with a new progestogen-estrogen combination. Contraception 35: 497-505.
18. JOHANNISSON, E., B.-M. LANDGREN, H. P. ROHR & E. DICZFALUSY. 1987. Endometrial morphology and peripheral hormone levels in women with regular menstrual cycles. Fertil. Steril. 48: 401-408.
19. OBER, W. B. 1977. Effects of oral and intrauterine administration of contraceptives on the uterus. Hum. Pathol. 8: 513-527.
20. MAQUEO, M. 1980. Vascular and perivascular changes in the endometrium of women using steroidal contraception. In Endometrial Bleeding and Steroidal Contraception. E. Diczfalusy, I. S. Fraser & F. T. G. Webb, Eds.: 138-149. Pitman Press. Bath, England.
21. CHRISTIENSEN, K., P. A. ESTES, S. A. ONATE, C. A. BECK, A. DEMARZO, et al. 1991. Characterisation and functional properties of the A and B forms of human progesterone receptors synthetized in a baculovirus system. Mol. Endocrinol. 5: 1755-1770.
22. MACDONNELL, D. P. 1995. Unraveling the human progesterone receptor signal transduction pathways (insights into antiprogestin action). Trends Endocrinol. Metab. 6: 133-138.
23. SPITZ, I. M. 1996. Antiprogestins: Mechanisms of action and contraceptive potential. Annu. Rev. Pharmacol. Toxicol. 36: 47-81.
24. SLAYDEN, O. D. & R. M. BRENNER. 1994. RU 486 action after estrogen priming in the endometrium and oviducts of rhesus monkeys. J. Clin. Endocrinol. Metab. 78: 440.
25. CHWALISZ, K., C. HAGELE-HARTUNG, K.-H. FRITZEMEIER, et al. 1991. Inhibition of the estradiol mediated endometrial gland formation by the antigestagen onapristone in rabbits: Relationship to uterine estrogen receptors. Endocrinology 129: 213.
26. NEULEN, J., R. E. WILLIAMS, G. D. HODGEN, et al. 1990. RU 486 (mifepristone): Induction of dose-dependent elevation of estradiol receptor in endometrium from ovariectomized monkeys. J. Clin. Endocrinol. Metab. 74: 1074.
27. SPITZ, I. M., H. B. CROXATTO, A. M. SALVATIERRA & O. HEIKINHEIMO. 1993. Response to intermittent RU 486 in normal women. Fertil. Steril. 59: 971-975.
28. SWAHN, M. L., M. BYGDEMAN, S. CEKAN, et al. 1990. The effect of RU 486 administered during the early luteal phase on bleeding patterns, hormonal parameters and endometrium. Hum. Reprod. 5: 402-408.
29. GREENE, K. K. E., L. M. KETTEL & S. S. YEN. 1992. Interruption of endometrial maturation without hormonal changes by an antiprogesterone during the first half of luteal phase of the menstrual cycle: A contraceptive potential. Fertil. Steril. 58: 338-343.
30. GEMZELL-DANIELSSON, K., P. WESTLUND, E. JOHANNISSON, M. L. SWAHN, et al. 1996. Effect of low weekly doses of mifepristone on ovarian function and endometrial development. Hum. Reprod. 11: 256-264.
31. GEMZELL-DANIELSSON, K., M. L. SWAHN, P. SVALANDER & M. BYGDEMAN. 1993. Early luteal phase treatment with mifepristone (RU 486) for fertility regulation. Hum. Reprod. 8: 870-873.
32. LI, T. C., P. DOCKERY, A. M. ROGERS, et al. 1988. The effect of a single dose of RU 486 on endometrial histology around the time of implantation in infertile women. In Proceedings of the Fourth Meeting of the European Society of Human Reproduction and Embryology, Barcelona, July 3-6.
33. COUZINET, B., N. L. STRAT, L. SIVESTRE & G. SCHAISON. 1990. Late luteal administration of the antiprogesterone RU 486 in normal women: Effects on the menstrual cycle events and fertility control in a long-term study. Fertil. Steril. 54: 1039-1044.
34. WORLD HEALTH ORGANIZATION TASK FORCE ON POSTOVULATORY METHODS OF FERTILITY REGULATION. 1995. Menstrual regulation by mifepristone plus prostaglandin: Results form a multicentre trial. Hum. Reprod. 10: 308-314.
35. CRITCHLEY, H. O. D., D. A. BAILEY, C. L. AU, B. AFFANDI & P. A. ROGERS. 1993. Immunohistochemical sex steroid receptor distribution in endometrium from long-term subdermal levonorgestrel users and during the normal menstrual cycle. Hum. Reprod. 8: 1632-1639.
36. BATISTA, M. C., T. P. CARTLEDGE, A. W. ZELLMER, M. J. MERINO, C. AXIOTIS, et al. 1992. Delayed endometrial maturation induced by daily administration of the antiprogestin RU 486: A potential new contraceptive strategy. Am. J. Obstet. Gynecol. 167: 60-65.
37. GARCIA, E., P. BOUCHARD, J. DE BRUX, J. BERDAH, R. FRYDMAN, G. SCHAISON, et al. 1988. Use of immunocytochemistry of progesterone and estrogen receptors for endometrial dating. J. Clin. Endocrinol. Metab. 67: 80-87.
38. MASSAI, M. R., C. BERGERON, D. MARTEL, D. DE ZIEGLER, G. MEDURI, A. PSYCHOYOS, R. FRYDMAN & P. BOUCHARD. 1993. Physiological oestradiol and progesterone replacement cycles in women with ovarian failure: A model to study endometrial maturation and sex steroid receptor regulation by exogenous hormones. Hum. Reprod. 8: 1828-1834.
39. GEMZELL-DANIELSSON, K. & M. BYGDEMAN. 1996. Simpson Conference, Edinburgh.
40. MURPHY, A. A., L. M. KETTEL, A. J. MORALES, V. ROBERTS, T. PARMLEY & S. S. C. YEN. 1995. Endometrial effects of long-term low dose administration of RU 486. Fertil. Steril. 63: 761-766.
41. BATISTA, M. C., T. P. CARTLEDGE, A. W. ZELLMER, L. K. NIEMAN, G. R. MERRIEM & D. L. LORIAUX. 1992. Evidence for a critical role of progesterone in the regulation of the midcycle gonadotropin surge and ovulation. J. Clin. Endocrinol. Metab. 74: 565-570.
42. GLASIER, A. A., K. J. THONG, M. DEWAR, M. MACKIE & D. T. BAIRD. 1992. Mifepristone compared with high dose estrogen and progestogen for emergency post coital contraception. N. Engl. J. Med 37: 1041-1044.
43. WEBB, A., J. RUSSEL & M. ELSTEIN. 1992. Comparison of Yuzpe regimen, danazol, and mifepristone in oral post-coital contraception. BMJ 305: 927-931.
44. YUZPE, A. A. & W. J. LANCU. 1977. A combination of ethinyl estradiol and dl-norgestrel as a postcoital contraceptive. Fertil. Steril. 28: 932-936.
45. LING, W. Y., W. WRIXON, L. ZAYID, et al. 1983. Mode of action of dl-norgestrel and ethynil estradiol combination in post coital contraception. II. Effect of post-ovulatory administration on ovarian function and endometrium. Fertil. Steril. 39: 292.
46. VAN SANTEN, M. R. & A. A. HASPELS. 1980. Interfering with implantation by postcoital estrogen administration. I. Endometrium histology. Prog. Reprod. Biol. 7: 310.
47. DE ZIEGLER, D. & P. BOUCHARD. 1993. Understanding endometrial physiology and menstrual disorders in the 1990s. Curr. Opin. Obstet. Gynecol. 5: 378-388.
48. NEWTON, J. R. 1996. New hormonal methods of contraception. Baillere's Clin. Obstet. Gynecol. 10: 87-101.
49. NILSSON, C. G., P. LÄHTEENMÄKI & T. LUUKKAINEN. 1980. Patterns of ovulation and bleeding with low levonorgestrel-releasing intrauterine device. Contraception 21: 155-164.
50. ORTIZ, M. E. & H. B. CROXATTO. 1987. The mode of action of IUDs. Contraception 36: 37-53.
51. ANDERSSON, K., V. ODLIND & G. RYBO. 1994. LNG-releasing and copper-releasing IUDs. Contraception 42: 247-259.
52. LANDGREN, B. M. & E. DICZFALUSY. 1980. Hormonal effects of the 300 μg norethisterone (NET) minipill. Contraception 21: 87-113.
53. BELSEY, E. M. & TASK FORCE ON LONG-ACTING SYSTEMIC AGENTS FOR FERTILITY REGULATION. 1988. Vaginal bleeding patterns among women using one natural and eight hormonal methods of contraception. Contraception 38: 181-206.
54. VESSEY, M. P., M. LAWLESS, D. YEATES & K. MCPHERSON. 1985. Progestogen-only contraception: Findings in a large prospective study with special reference to effectiveness. Br. J. Fam. Plann. 10: 117-121.
55. SPEROFF, L. 1996. A Clinical Guide for Contraception. Williams & Wilkins. Baltimore, MD.
56. LANDGREN, B. M., S. LAGER & E. DICZFALUSY. 1981. Hormonal effects of 300 μg norethisterone (NET) minipill. 3. Comparison of short-term (2nd month) and medium-term (6th month) effects in 21 subjects. Contraception 23: 269-299.
57. FRASER, I. & M. HICKEY. 1996. Endometrial vasculature in Norplant users: Preliminary results from a hysteroscopic study. Hum. Reprod. 11(Suppl. 2): 35-44.
58. COLBURN, P. & V. BUONASSISI. 1978. Estrogen binding sites in endothelial cell culture. Science 201: 817-819.
59. PERROT-APPLANAT, M., M. T. GROYER-PICARD, E. GARCIA, F. LORENZO & E. MILGROM. 1988. Immunocytochemical demonstration of estrogen and progesterone receptors in muscle cells of uterine arteries in rabbits and humans. Endocrinology 123: 1511-1519.
60. PEEK, M. J., E. LANDGREN & E. JOHANNISSON. 1992. The endometrial capillaries during normal menstrual cycle: A morphometric study. Hum. Reprod. 7: 906-911.
61. FRASER, I. S. 1990. Towards a better understanding of effects of progestogens on the mechanisms of endometrial bleeding: Recommendation for research. In Contraception and Mechanisms of Endometrial Bleeding. C. d'Arcangues, I. S. Fraser, J. R. Newton & V. Odlind, Eds.: 491-533. Cambridge University Press.
62. CORNILLIE, et al. 1990. In Contraception and Mechanisms of Endometrial Bleeding. C. d'Arcangues, I. S. Fraser, J. R. Newton & V. Odlind, Eds.: 383. Cambridge University Press.
63. RODGERS, W. H., L. M. MATRISIAN, L. C. GIUDICE, et al. 1994. Patterns of matrix metalloproteinase expression in cyclic endometrium imply differential functions and regulation by steroid hormones. J. Clin. Invest. 946.
64. IRWIN, J. C., D. KIRK, R. B. L. GWATKIN, M. NAVRE, P. CANNON & L. C. GIUDICE. 1996. Human endometrial matrix metalloproteinase-2, a putative menstrual proteinase. JCI 97: 438-447.
65. 2 and P on prostaglandin production by human endometrium is maintained in organ culture. Endocrinology 106: 1599-1606.
66. 2 by fibroblasts from human endometrium in vitro. Prostaglandins 36: 17-30.
67. GURPIDE, E., F. SCHATZ & L. MARKIEWICZ. 1990. Steroid effects of endometrial prostaglandin production. In Contraception and Mechanisms of Endometrial Bleeding. C. d'Arcangues et al., Eds.: 267-274. Cambridge University Press.
68. 2 in human endometrium. Prostaglandins 27: 591-597.
69. GIUDICE, L. 1994. Growth factors and growth modulators in human uterine endometrium: Their potential relevance to reproductive medicine. Fertil. Steril. 61: 1-17.
70. ECONOMOS, K., P. C. MACDONALD & M. L. CASEY. 1992. Endothelin-1 gene expression and protein biosynthesis in human endometrium: Potential modulator of endometrial blood flow. J. Clin. Endocrinol. Metab. 74: 14-19.
71. HEAD, J. R., P. C. MACDONALD & M. L. CASEY. 1993. Cellular localization of membrane metalloendopeptidase (enkephalinase) in human endometrium during the menstrual cycle. J. Clin. Endocrinol. Metab. 76: 769-776.
72. TORRY, R. J. & B. J. RONGISH. 1992. Angiogenesis in the uterus: Potential regulation and relation to tumor angiogenesis. Am. J. Reprod. Immunol. 27: 171-179.
73. WILTING, J., B. CHRIST, M. BOKELOH & H. A. WEICH. 1993. In vivo effects of vascular endothelial growth factor on the chicken chorial-lantoic membrane. Cell Tissue Res. 247: 163-172.
74. TORRY, D. S., V. J. HOLT, J. A. KEENAN, G. HARRIS, M. R. CAUDLE & R. J. TORRY. 1996. Vascular endothelial growth factor expression in cycling human endometrium. Fertil. Steril. 66: 72-80.
75. COELINGH-BENNINK, H. J. C. D., et al. 1996. Submitted.
76. EDWARDS, R. G. 1994. Implantation, interception and contraception. Hum. Reprod. 9: 985-995.
77. BAULIEU, E. E. 1989. Contragestion and other clinical applications of RU 486, and antiprogesterone at the receptor. Science 245: 1351-1357.
78. BULUN, S. E., M. S. MAHENDROO & E. R. SIMPSON. 1993. Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua. J. Clin. Endocrinol. Metab. 76: 1458-1463.
79. LESSEY, B. A., A. P. KILLMAN, D. A. METZGER, A. F. HANEY, G. L. GREENE & K. S. MCCARTY, JR. 1988. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J. Clin. Endocrinol. Metab. 67: 334-340.
80. BERGERON, C., A. FERENCZY, D. O. TOFT, W. SCHNEIDER & G. SHYAMALA. 1988. Immuno-cytochemical study of progesterone receptors in the human endometrium during the menstrual cycle. Lab. Invest. 59: 862-869.
81. LESSEY, B. A., I. YEH, A. J. CASTELBAUM, M. A. FRITZ, A. O. ILESANMI, P. KORZENIOWSKI, J. SUN & K. CHWALISZ. 1996. Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation. Fertil. Steril. 65: 477-483.
82. TABIBZADEH, S. 1992. Patterns of expression of integrin molecules in human endometrium throughout the menstrual cycle. Hum. Reprod. 7: 876-882.
83. LESSEY, B. A., A. J. CASTELBAUM, C. A. BUCK, Y. LEI, C. W. YOWELL & J. SUN. 1994. Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil. Steril. 62: 497-506.
84. SOMKUTI, S. G., C. M. YOWELL & B. A. LESSEY. 1994. Effect of oral contraceptive pills on markers of uterine receptivity. American Fertility Society Annual Meeting, San Antonio, TX. Abstr. 0-139: 568.
85. TASKIN, O., R. W. BROWN, D. C. YOUNG, A. N. POINDEXTER & R. D. WIEHLE. High doses of oral contraceptives do not alter endometrial α1 and αvβ3 integrins in the late implantation window. Fertil. Steril. 61: 850-855.
86. WAITES, G. T., P. L. WOOD, R. A. WALKER & S. C. BELL. 1988. Immunohistological localization of human endometrial secretory protein, pregnancy-associated endometrial α2-globulin (α2-PEG) during the menstrual cycle. J. Reprod. Fertil. 82: 665-672.
87. WAITES, G. T., R. F. L. JAMES & S. C. BELL. 1988. Immunohistological localization of the human endometrial secretory protein pregnancy-associated endometrial α1-globulin, an IGFBP during the menstrual cycle. J. Clin. Endocrinol. Metab. 67: 1100-1104.
88. JULKUNEN, M., D. APTER, M. SEPPALA, et al. 1986. Serum levels of PP14 reflect ovulation in nonconceptional menstrual cycles. Fertil. Steril. 45: 47-50.
89. JOSHI, S. G., R. RAO, E. E. HENRIQUES, R. S. RAIKAR & M. GORDON. 1986. Luteal phase concentration of progestagen-associated endometrial protein (PEP) in the serum of cycling women with adequate or inadequate endometrium. J. Clin. Endocrinol. Metab. 63: 1247-1249.
90. CHECK, J. H., K. NOWROOZI, M. CHECK & B. VETTER. 1991. Correlation of serum progestagen-associated endometrial protein levels with endometrial biopsies, serum steroid levels and therapy for luteal phase defects. Hum. Reprod. 6: 511-514.
91. YDING-ANDERSEN, C., L. G. WESTERGAARD, B. TEISNER, A. G. BYSKOV, S. ZIEBE, L. HELLEDIE, K. PEDERSEN & J. G. WESTERGAARD. 1992. Changes induced in serum protein profiles by ovarian stimulation during in-vitro-fertilization-embryo transfer treatment: A comparison between conception and non-conception cycles. Hum. Reprod. 7: 585-591.
92. VAISSE, C., M. ATGER, B. POTIER & E. MILGROM. 1990. Human placental protein 14 gene: Sequence and characterization of a short duplication. DNA Cell Biol. 9: 401-413.
93. MACKENNA, A., T. C. LI, C. DALTON, A. BOLTON & I. COOKE. 1993. Placental protein 14 levels in uterine flushings and plasma of women with unexplained infertility. Fertil. Steril. 59: 577-582.
94. OEHNINGER, S., C. CODDINGTON & M. SEPPALA. 1993. Endometrial protein PP14 reduces sperm zona pellucida binding: A mechanism of endometriosis-related infertility? 49th Annual Meeting of the American Fertility Society. Montreal. Abstr. 0-039.
95. BELL, S. C., J. A. JACKSON, J. ASHMORE, H. H. ZHU & L. TSENG. 1991. Regulation of insulin-growth factor binding protein-1 synthesis and secretion by progestin and relaxin in long term cultures of human endometrial stromal cells. J. Clin. Endocrinol. Metab. 72: 1014-1024.
96. PEKONEN, F., T. NYMAN, P. LAHTEENMAKI, M. HAUKKAMAA & E. M. RUTANEN. 1992. Intra-uterine progestin induces continuous insulin-like growth factor binding protein-1 production in the human endometrium. J. Clin. Endocrinol. Metab. 75: 660-664.
97. GIUDICE, L. 1997. Multifaceted roles for IGFBP-1 in human endometrium during implantation and pregnancy. Ann. N. Y. Acad. Sci. This volume.
98. BELLER, F. K. & K. W. SCWEPPE. 1979. Review on the biology of menstrual blood. In The Biology of the Fluids of the Female Genital Tract. F. K. Beller & G. F. B. Schaumacher, Eds.: 231-245. Elsevier-North Holland. New York.
99. LITTLE, B. A. 1991. Plasminogen activators in endometrial physiology and embryo implantation: A review. Ann. N. Y. Acad. Sci. 626: 167-175.
100. STIKLAND, S. & W. G. RICHARDS. 1992. Invasion of the trophoblasts. Cell 71: 355-357.