Localization of CYP2D16 in the guinea pig adrenal cortex by immunohistochemistry and in situ hybridization

Molecular and Cellular Endocrinology

Volumn 134, Issue 2, 1997, Pages 139-146

  Yuan, Bing Bing ^a   Tchao, Ruy ^a   Voigt, Jeffrey M ^a   Colby, Howard D ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

P450 isozyme; Zona fasciculata; Zona glomerulosa

Indexed keywords

CYTOCHROME P450 ISOENZYME; HYDROCORTISONE; MESSENGER RNA;

ADRENAL CORTEX; ADRENAL MEDULLA; AGING; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; GUINEA PIG; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; XENOBIOTIC METABOLISM; ZONA GLOMERULOSA;

ADRENAL CORTEX; AGING; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; GUINEA PIGS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIXED FUNCTION OXYGENASES; ORGAN SPECIFICITY; STEROID 17-ALPHA-HYDROXYLASE;

EID: 0030727746     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(97)00177-9     Document Type: Article

References (31)

1. Adams J.B. Control of secretion and the function of C19-delta 5-steroids of the human adrenal gland. Mol. Cell. Endocrinol. 42:1985;1-17.
2. Black V.H., Barilla J.R., Russo J.J., Martin K.O. A cytochrome P450 immunochemically related to P450c,d (4501) located to smooth microsomes and inner zone of the guinea pig adrenal. Endocrinology. 124:1989;2480-2493.
3. Black V.H., Barilla J.R., Martin K.O. Effects of age, adrenocorticotropin, and dexamethasone on a male-specific cytochrome P450 localized in the inner zone of the guinea pig adrenal. Endocrinology. 124:1989;1494-1498.
4. Black V.H. The development of smooth-surfaced endoplasmic reticulum in adrenal cortical cells of fetal guinea pigs. Am. J. Anat. 135:1970;381-418.
5. Black V.H. Immunodetectable cytochromes P450I, II and III in guinea pig adrenal-hormone responsiveness and relationship to capacity for xenobiotic metabolism. Endocrinology. 127:1990;1153-1159.
6. Burstein S., Bhavani B.R. Effect of phenobarbital administration on the in vitro hydroxylation of cortisol and on over-all substrate and product metabolism in the guinea pig and rat. Endocrinology. 80:1967;351-356.
7. Colby, H.D., 1987. The adrenal cortex. In: Hedge, G.A., Colby, H.D., Goodman, R.L. (Eds.), Clinical Endocrine Physiology. Saunders, Philadelphia, PA, pp. 127-160.
8. Colby, H.D., Longhurst, P.A., 1992. Toxicology of the adrenal gland. In: Atterwill, C.K., Flack, J.D., (Eds.), Endocrine Toxicology. Cambridge University Press, Cambridge, pp. 243-284.
9. Colby, H.D., Rumbaugh, R.C., 1980. Adrenal drug metabolism. In: Gram, T.E. (Ed.), Extrahepatic Metabolism of Drugs and Other Foreign Compounds. Spectrum Publications, Jamaica, NY. pp. 239-266.
10. Colby H.D., Levitt M., Bergstrom J.M., Purcell H. Maturational changes in steroidogenesis in the inner and outer zones of the guinea pig adrenal cortex. J. Steroid. Biochem. Mol. Biol. 45:1993;501-507.
11. Colby, H.D., 1996. The adrenal cortex as a toxicological target organ. In: Harvey, P.W. (Ed.), The Adrenal in Toxicology. Taylor and Francis, London, pp. 131-163.
12. Eacho P.I., Colby H.D. Regional distribution of microsomal drug and steroid metabolism in the guinea pig adrenal cortex. Life. Sci. 32:1983;1119-1127.
13. Fajer A.B., Vogt M. Adrenocortical secretion in the guinea pig. J. Physiol. 169:1963;373-385.
14. Fazekas A.T.A., Homoki J., Teller W.M., Gaus W. Genetic differences in the cortisol concentration of the adrenal and other tissues of white and coloured guinea-pigs. J. Endocrinol. 66:1975;159-164.
15. Hallberg E. Metabolism and toxicity of xenobiotics in the adrenal cortex, with particular reference to 7, 12-dimethylbenz(a)anthracene. J. Biochem. Toxicol. 5:1990;71-90.
16. Hornsby, P.J., 1985. The regulation of adrenocortical function by control of growth and structure. In: Anderson, D.C., Winter, J.S.D. (Eds.), Adrenal Cortex. Butterworth, London, pp. 1-31.
17. c21) and steroidogenic activities in guinea-pig adrenal cortex. J. Endocrinol. 119:1988;191-200.
18. Ito T. Histology and histogenesis of the adrenal cortex in the guinea pig. Folia. Anat. Jap. 24:1952;269-291.
19. Jiang Q., Voigt J.M., Colby H.D. Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): High level expression in adrenal microsomes. Biochem. Biophys. Res. Commun. 209:1995;1149-1156.
20. Jiang Q., Huang Y., Voigt J.M., DeBolt K.M., Kominami S., Takemori S., Funae Y., Colby H.D. Differential effects of adrenocorticotropin in vivo on cytochromes P4502D16 and P450c17 in the guinea pig adrenal cortex. Endocrinology. 137:1996;4811-4816.
21. Jiang Q., Huang Y., Voigt J.M., DeBolt B.K., Kominasteti S., Takemori S., Colby H.D. Expression and zonal distribution of CYP2D16 in the guinea pig adrenal cortex: Relationship to xenobiotic metabolism. Mol. Pharmacol. 49:1996;458-464.
22. Kronbach T., Mathys D., Gut J., Catin T., Meyer U.A. High performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextrometorphan o-demethylase in microsomes and purified cytochrome P450 isozymes of human liver. Anal. Biochem. 162:1987;24-32.
23. 4-Hydrogenase in guinea pig adrenal: Evidence of localization in zona reticularis and age-related change. Endocrinology. 11:1982;1749-1757.
24. Martin K.O., Black V.H. Effects of age and adrenocorticotropin on microsomal enzymes in guinea pig adrenal inner and outer cortices. Endocrinology. 112:1983;573-579.
25. McKenna T.J., Cunningham T.J. The control of adrenal androgen secretion. J. Endocrinol. 129:1991;1-3.
26. Ohishi N., Imacka S., Suzuki T., Funae Y. Characterization of two P450 isozymes placed in the rat CYP2D subfamily. Biochim. Biophys. Acta. 1158:1993;227-236.
27. Parker L.N. Control of adrenal androgen secretion. Endocrinol. Metab. Clin. North Am. 20:1991;401-421.
28. Parker L.N. Adrenarche. Endocrinol. Metab. Clin. North Am. 20:1991;71-83.
29. Schenkman J.B. Steroid metabolism by constitutive cytochromes P450. J. Steroid Biochem. Mol. Biol. 43:1992;1023-1030.
30. Vinson G.P., Pudney J.A., Whitehouse B.J. The mammalian adrenal circulation and the relationship between adrenal blood flow and steroidogenesis. J. Endocrinol. 105:1985;285-294.
31. 16α) in mice. Organization, differential regulation, and chromosome localization. J. Biol. Chem. 264:1989;2920-2927.