Differential effects of adrenocorticotropin in vivo on cytochromes P4502D16 and P450c17 in the guinea pig adrenal cortex

Endocrinology

Volumn 137, Issue 11, 1996, Pages 4811-4816

  Jiang, Qinshi ^a   Huang, Yajue ^a   Voigt, Jeffrey M ^a   Debolt, Kristine M ^a   Kominami, Shiro ^b   Takemori, Shigeki ^b   Funae, Yoshihiko ^c   Colby, Howard D ^a,d  

^a UNIVERSITY OF THE SCIENCES   (United States)

^b HIROSHIMA UNIVERSITY   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CYTOCHROME P450; MESSENGER RNA; N DEMETHYLASE; OXYGENASE; PROTEIN; STEROID 17ALPHA MONOOXYGENASE; XENOBIOTIC AGENT;

ADRENAL CORTEX; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; MALE; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

EID: 0029803210     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895351     Document Type: Article

References (45)

1. Miller WL 1988 Molecular biology of steroid hormone synthesis. Endocr Rev 9:295-318
2. Hanukoglu I 1992 Steroidogenic enzymes: structure function and role in regulation of steroid hormone synthesis. J Steroid Biochem Mol Biol 43:779-804
3. Keeney DS, Waterman MR 1993 Regulation of steroid hydroxylase gene expression: importance to physiology and disease. Pharmacol Ther 58:301-317
4. Colby HD, Rumbaugh RC 1980 Adrenal drug metabolism. In: Gram TE (ed) Extrahepatic Metabolism of Drugs and Other Foreign Compounds. Spectrum, New York, pp 239-266
5. Hallberg E 1990 Metabolism and toxicity of xenobiotics in the adrenal cortex with particular reference to 7,12-dimethylbenz(a)anthracene. J Biochem Toxicol 5:71-90
6. Colby HD, Longhurst PA 1992 Toxicology of the adrenal gland. In: Atterwill CA, Flack JD (eds) Endocrine Toxicology. Cambridge University Press Cambridge, pp 243-281
7. Otto S, Marcus C, Pidgeon C, Jefcoate C 1991 A. novel adrenocorticotropin-inducible cytochrome P450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism. Endocrinology 129:970-982
8. Bhattacharyya KK, Brake PR, Eltom SE, Otto SA, Jefcoate CR 1995 Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. J Biol Chem 270:11596-11602
9. Black VH, Barilla JR, Martin KO 1989 Effects of age adrenocorticotropin and dexamethasone on a male-specific cytochrome P450 localized in the inner zone of the guinea pig adrenal. Endocrinology 124:2494-2498
10. Black VH, Barilla JR, Russe JJ, Martin KO 1989 A cytochrome P450 immunochemically related to P450c,d (P450I) localized to the smooth microsomes and inner zone of the guinea pig adrenal. Endocrinology 124:2480-2493
11. Eacho PI, Colby HD 1983 Regional distribution of microsomal drug and steroid metabolism in the guinea pig adrenal cortex. Life Sci 32:1119-1127
12. Martin KO, Black VH 1983 Effects of age and adrenocorticotropin on microsomal enzymes in guinea pig adrenal inner and outer cortices. Endocrinology 112:573-579
13. Jiang Q, Huang Y, Voigt JM, Debolt BK, Kominami S, Takemori S, Funae Y, Colby HD 1996 Expression and zonal distribution of CYP2D16 in the guinea pig adrenal cortex: relationship to xenobiotic metabolism. Mol Pharmacol 49:458-464
14. Jiang Q, Voigt JM, Colby HD 1995 Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes. Biochem Biophys Res Commun 209:1149-1156
15. Tremblay Y, Fleury A, Beaudoun C, Vallée M, Bélanger A 1994 Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17α-hydroxylase/17,20 lyase): tissue distribution regulation and substrate specificity of the expressed enzyme. DNA Cell Biol 13:199-1212
16. Ohishi N, Imaoka S, Suzuki T, Funae Y 1993 Characterization of two P-450 isozymes placed in the rat CYP2D subfamily. Biochim Biophys Acta 1156:227-236
17. Kominami S, Shinzawa K, Takemori S 1983 Immunochemical studies on cytochrome P-450 in adrenal microsomes. Biochim Biophys Acta 775:163-169
18. Eacho PI, Colby HD 1985 Differences in microsomal steroid metabolism between the inner and outer zones of the guinea pig adrenal cortex. Endocrinology 116:536-541
19. Towbin H, Staehelin T, Gordon J 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some ap-plications. Proc Natl Acad Sci USA 75:4350-4354
20. Chomcynski P 1993 A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques 15:532-537
21. Chomcynski P, Sacchi N 1987 Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-169
22. Chomcynski P 1992 One hour downward alkaline capillary transfer for blotting DNA and RNA. Anal Biochem 201:134-139
23. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Strahl K 1989 Current Protocols in Molecular Biology, vol 1, chapt 4. Greene and Wiley and Sons, pp 4.9.1-4.9.14
24. Clements JA, Matheson BA, Wines DR, Brady JM, McDonald RJ, Funder JW 1988 Androgen dependence of specific kallikrein gene family members expressed in rat prostate. J Biol Chem 263:16132-16137
25. Nebert DW, Gelboin HV 1968 Substrate-inducible microsomal aryl hydrocarbon hydroxylase in mammalian cell culture. J Biol Chem 243:6242-6249
26. Nash T 1953 The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem J 5:416-421
27. Kronback T, Mathys D, Gut J, Catin T, Meyer UA 1987 High performance liquid chromatographic assays for bufuralol 1′-hydroxylase debrisoquine 4-hydroxylase and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver. Anal Biochem 162:24-32
28. Gut J, Catin T, Dayer P, Kronbach T, Zanger U, Meyer UA 1986 Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol. J Biol Chem 261:11734-11743
29. Zanger UM, Vilbois F, Hardwick JP, Meyer UA 1988 Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man. Biochemistry 27:5447-5454
30. Colby HD, Levitt M, Pope MR, Johnson PB 1992 Differential effects of adrenocorticotropic hormone on steroid hydroxylase activities in the inner and outer zones of the guinea pig adrenal cortex. J Steroid Biochem Mol Biol 42:329-335
31. Kupfer D, Bruggeman LL, Munsell T 1969 Studies on the occurrence of N-demethylase activity in adrenal and hepatic preparations from guinea pigs and rats. The effect of various substances on the magnitude of this activity. Arch Biochem Biophys 129:189-195
32. Kupfer D, Orrenius S 1970 Characteristics of guinea pig liver and adrenal monooxygenase systems. Mol Pharmacol 6:221-230
33. Greiner JW, Kramer RE, Rumbaugh RC, Colby HD 1977 Differential control of adrenal drug and steroid metabolism in the guinea pig. Life Sci 20:1017-1026
34. Ichikawa T, Itakura T, Negishi M 1989 Functional characterization of two cytochrome P-450s within mouse male-specific steroid 16α-hydroxylase gene family: expression in mammalian cells and chimeric proteins. Biochemistry 28:4779-4784
35. 16α) in mice. Organization differential regulation and chromosome localization. J Biol Chem 264:2920-2927
36. Burstein S, Bhavani BR 1967 Effect of phenobarbital administration on the in vitro hydroxylation of cortisol and on over-all substrate and product metabolism in the guinea pig and rat. Endocrinology 80:351-356
37. Colby HD, Marquess ML, Johnson PB, Pope MR 1980 Effects of steroid hormones in vitro on adrenal xenobiotic metabolism in the guinea pig. Biochem Pharmacol 29:2372-2377
38. Provencher PH, Tremblay Y, Caron S, Bélanger A 1992 Effect of chronic ACTH treatment on guinea-pig adrenal steroidogenesis: steroid plasma levels steroid adrenal levels activity of steroidogenic enzymes and their steady-state mRNA levels. J Steroid Biochem Mol Biol 41:69-78
39. Provencher PH, Tremblay Y, Bélanger B, Bélanger A 1992 Steroidogenesis in guinea pig adrenal cortex: Effects of ACTH on steroid secretion and steroidogenic enzyme activities and expression. J Steroid Biochem Mol Biol 43:855-862
40. C21) and steroidogenic activities in guinea-pig adrenal cortex. J Endocrinol 119:191-200
41. Rainey WE, Naville D, Saez JM, Carr BR, Byrd W, Magness RR, Mason JI 1990 Transforming growth factor-β inhibits steroid 17α-hydroxylase cytochrome P-450 expression in ovine adrenocortical cells. Endocrinology 127:1910-1915
42. LeHoux J, Mason JI, Ducharme L 1992 In vivo effects of adrenocorticotropin on hamster adrenal steroidogenic enzymes. Endocrinology 131:1874-1882
43. Funkenstein B, McCarthy JC, Dus KM, Simpson ER, Waterman MR 1983 Effects of adrenocorticotropin on steroid 21-hydroxylase synthesis and activity in cultured bovine adrenocortical cells: increased synthesis in the absence of increased activity. J Biol Chem 258:9398-9495
44. Colby HD, Johnson PB, Zulkoski JS, Pope MR 1982 Differential effects of adrenocorticotropic hormone on adrenal microsomal xenobiotic and steroid metabolism in guinea pigs. Drug Metab Dispos 10:326-329
45. Vinson GP, Pudney JA, Whitehouse BJ 1985 The mammalian adrenal circulation and the relationship between adrenal blood flow and steroidogenesis. J Endocrinol 105:285-294