Health consequences of fat distribution

Hormone Research in Paediatrics

Volumn 48, Issue 5, 1997, Pages 88-92

  Jensen, Michael D ^a  

^a MAYO CLINIC   (United States)

Author keywords

Body composition; Diabetes mellitus; Dyslipidemia; Free fatty acids; Hypertension

Indexed keywords

FATTY ACID;

ADIPOSE TISSUE; BODY COMPOSITION; BODY FAT; CONFERENCE PAPER; DYSLIPIDEMIA; HEART DEATH; HUMAN; HYPERTENSION; INSULIN RESISTANCE; LIPOLYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; VISCERA;

ADIPOSE TISSUE; FATTY ACIDS, NONESTERIFIED; HUMANS; OBESITY;

EID: 0030727040     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000191335     Document Type: Article

References (39)

1. Vague J: The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease. Am J Clin Nutr 1956:4:20-34.
2. Kissebah AH, Vydelingum N, Murray R: Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1983;54:254-260.
3. Krotkiewski M, Bjomtorp P, Sjostrom L, Smith U: Impact of obesity on metabolism in men and women. J Clin Invest 1983:72:1150-1162.
4. Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebah AH: Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. Metabolism I984;33: 68-75.
5. Evans DJ, Hoffmann RG, Kalkhof TRK, Kissebah AH: Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab 1983:57:304-310.
6. Haffncr SM, Stern MP, Hazuda HP, Pugh J, Patterson JK: Do upper-body and centralized adiposity measure different aspects of regional body-fat distribution? Relationship to non-in-sulin-dependenl diabetes mellitus, lipids, and lipoproteins. Diabetes 1987;36:43-51.
7. Fontbonne A, Thibull N, Eschwcgc E, Ducimc-tiere P: Body fat distribution and coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes mellitus: the Paris Prospective Study, 15-year follow up. Diabetologia 1992;35:464-468.
8. Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ: Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of N1DDM. Diabetes 1996;45:633-638.
9. Clausen JO, Borch-Johnsen K, Ibsen H: Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. J Clin Invest 1996;98:1195-1209.
10. Seidell JC, Mensink RP, Katan MB: Measure of fat distribution as determinants of serum lipids in healthy volunteers consuming a uniform standardized diet. Eur J Clin Invest 1988,18: 243-249.
11. Fujioka S, Matsuzawa Y, Tokunaga K. Tarui S: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 1987;36:54-59.
12. Despres JP, Nadeau A, Tremblay A: Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 1989:38: 304-309.
13. Seidell JC, Bjomtorp P, Sjostrom L, Kvist H, Sannerstcdt R: Visceral fat accumulation in men is positively associated with insulin, glucose. and C-pcptide levels, but negatively with testosterone levels. Metabolism 1990:39:897-901.
14. Macor C, Ruggeri A, Mazzonetto P, Fedcrspil G, Cobelli C, Vettor R: Visceral adipose tissue impairs insulin secretion and insulin sensitivity but not energy expenditure in obesity. Metabolism 1997;46:123-129.
15. Abate N, Garg A, Peshock RM, Slray-Gunders-en J, Grundy SM: Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 1995:96:88-98.
16. Bonora E, Del Prato S, Bonadonna RC: Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobcse and obese nondiabetic women. Diabetes 1992;41:1151-1159.
17. Lcmieux S, Despres JP, Nadeau A, Prud'Homme D, Tremblay A, Bouchard C: Heterogeneous glycaemic and insulinacmic responses to oral glucose in non-diabetic men: interactions between duration of obesity, body fat distribution and family history of diabetes mellitus. Diabetologia 1992;35:653-659.
18. Rissanen J, Hudson R, Ross R: Visceral adiposity. androgens, and plasma lipids in obese men. Metabolism 1994,43:1318-1323.
19. Pouliot M, Despres JP, Moorjani S: Computed tomography -measured trunk fat and plasma lipoprotein levels in nonobcse women. Metabolism 1989:38:1244-1250.
20. Pouliot M, Despres JP, Nadeau A: Visceral obesity in men: associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 1992;41:826-834.
21. Despres JP, Vcrdon M, Moorjani S: Apolipo-protcin E polymorphism modifies relation of hyperinsulinemia to hypertriglyceridemia. Diabetes 1993;42:1474-1481.
22. Pouliot MC, Despres JP, Dionne FT, Vohl MC, Moorjani S, Prud'hommc D, Bouchard C, Lupien PJ: ApoB-100 Gene EcoRl polymorphism: relations to plasma lipoprotein changes associated with abdominal visceral obesity. Ar-terioscler Thromb 1994; 14:527-533.
23. Kisscbah AH, Peiris AN: Biology of regional body fat distribution: relationship to non-insu-lin-dcpendcnt diabetes mellitus. (Review). Diabetes Metab Rev 1989;5:83-109.
24. Kelley DE, Mokan M, Simoncau JA, Mandari-no LJ: Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 1993;92:91-98.
25. Saloranta C, Franssila-Kallunki A, Ekstrand A, Taskinen MR, Groop L: Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dcpcndcnt) diabetes mellitus. Diabetologia 1991;34:409-415.
26. Kissebah AH, Alfarsi S, Adams PW, Wynn V: Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hyper-triglyceridaemia in man. Diabetologia 1976; 12:563-571.
27. Roust LR, Jensen MD: Postprandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes 1993;42:1567-1573.
28. Lewis GF, Uffclman KD, Szcto LW. Weller B. Steiner G: Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 1995;95:158-166.
29. I-lennes MM, Shrago E, Kissebah AH: Receptor and postreceptor effects of free fatty acids (FFA) on hcpatocytc insulin dynamics. Int J Obes 1990;14:831-841.
30. Hcnnes MM. Dua A. Kissebah AH. Effects of free fatty acids and glucose on splanchnic insulin dynamics. Diabetes 1997:46:57-62.
31. Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatly acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994;93:870-876.
32. Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E: A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development ofNIDDM. Diabetologia 1995;38:1213-1217.
33. Egan BM, Hennes MM, Stepniakowski K, O’Shaughncssy IM, Kissebah AH, Goodfricnd TL: Obesity hypertension is related more to insulin’s fatty acid than glucose action. Hypertension 1996;27:723-728.
34. Hcnnes MM, O'Shaughnessy IM, Kelly TM, LaBellc P, Egan BM, Kissebah AH: Insulin-resistant lipolysis in abdominally obese hypertensive individuals: role of the renin-angioten-sin system. Hypertension 1996;28:120-126.
35. Jensen MD, Haymond MW, Rizza RA, Cryer PE, Miles JM: Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 1989;83: 1168-1173.
36. Martin ML, Jensen MD: Effects of body fat distribution on regional lipolysis in obesity. J Clin Invest 1991:88:609-613.
37. Nguyen TT, Mijares AH, Johnson CM, Jensen MD: Postprandial leg and splanchnic fatty acid metabolism in non-obesc men and women. Am J Physiol 1996;271:E965-E972.
38. Basso LV, Havel RJ: Hepatic metabolism of free fatty acids in normal and diabetic dogs. J Clin Invest 1970;49:537-547.
39. Bjomtorp P, Bengtsson B-A, Blohmc G: Adipose tissue fat cell size and number in relation to metabolism in randomly selected middle-aged men and women. Metabolism 1971:20: 927-935.