The GM-CSF analogue E21R induces apoptosis of normal and activated eosinophils

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 5, 1997, Pages 1628-1632

  Iversen, Per O ^b   Robinson, Douglas ^b   Ying, Sun ^b   Meng, Qiu ^b   Kay, A Barry ^b   Clark Lewis, Ian ^b   Lopez, Angel F ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; COLONY STIMULATING FACTOR RECEPTOR; CYTOKINE; E 21 R; EOSINOPHIL CATIONIC PROTEIN; EOTAXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PEROXIDASE; RANTES; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ASTHMA; CELL SURVIVAL; CONTROLLED STUDY; EOSINOPHIL; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; PRIORITY JOURNAL;

EID: 0030724555     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.5.9612097     Document Type: Article

References (22)

1. Gleich, G. J., and C. R. Adolphson. 1986. The eosinophilic leukocyte: structure and function. Adv. Immunol. 39:177.
2. Corrigan, C. J., and A. B. Kay. 1992. T cells and eosinophils in the pathogenesis of asthma. Immunol. Today 13:501-507.
3. Begley, C. G., A. F. Lopez, N. A. Nicola, D. J. Warren, M. A. Vadas, C. J. Sanderson, and D. Metcalf. 1986. Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors. Blood 68:162-166.
4. Owen W. F. Jr., M. E. Rothenberg, D. S. Silberstein, J. C. Gasson, R. L. Stevens, K. F. Austen, and R. J. Soberman. 1987. Regulation of human eosinophil viability, density, and function by granulucyte-macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J. Exp. Med. Med. 166:129-141.
5. Kita, H., and G. J. Gleich. 1996. Chemokines active on eosinophils: potential roles in allergic inflammation. J. Exp. Med. 183:2421-2426.
6. Simon, H.-U., and K. Blaser. 1995. Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia? Immunol. Today 16: 53-55.
7. Her, E., J. Frazer, K. F. Austen, and W. F. Owen, Jr. 1991. Eosinophil hematopoietins antagonize the programmed cell death of eosinophils: cytokine and glucocorticoid effects on eosinophils maintained by endothelial cell-conditioned medium. J. Clin. Invest. 88:1982-1987.
8. Hercus, T. R., C. J. Bagley, B. Cambareri, M. Dottore, J. Woodcock, M. A. Vadas, M. F. Shannon, and A. F. Lopez. 1994. Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proc. Natl. Acad. Sci. U.S.A. 91:5838-5842.
9. Iversen, P. O., L. B. To, and A. F. Lopez. 1996. Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R. Proc. Natl. Acad. Sci. U.S.A. 93:2785-2784.
10. Hansel, T. T., I. J. M. De Vries, T. Iff, S. Rihs, M. Wandzilak, S. Betz, K. Blaser, and C. Walker. 1991. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Methods 145:105-110.
11. Gong, J. H., M. Uguccioni, D. Dewald, M. Baggiolini, and I. Clark-Lewis. 1996. RANTES and MCP-3 antagonists bind multiple chemokine receptors. J. Biol. Chem. 271:10521-10527.
12. White, S. R., G. V. Kulp, S. M. Spaethe, E. Van Alstyne, and A. R. Leff. 1991. A kinetic assay for eosinophil peroxidase activity in eosinophils and eosinophil conditioned media. J. Immunol. Methods 144:257-263.
13. Winqvist, I., T. Olofsson, and I. Olsson. 1984. Mechanisms for eosinophil degranulation: release of the eosinophilic cationic protein. Immunology 51:1-7.
14. Kita, H., D. A. Weller, R. Abu-Ghazaleh, C. J. Sanderson, and G. J. Gleich. 1992. Release of granule proteins from eosinophils cultured with IL-5. J. Immunol. 149:629-635.
15. Kita, H., M. Kato, G. J. Gleich, and R. T. Abraham. 1994. Tyrosine phosphorylation and inositol phosphate production are early events in human eosinophil activation stimulated by immobilised secretory IgA and IgC. J. Allergy Clin. Immunol. 94:1272-1281.
16. Her, E., J. Frazer, K. F. Austen, and W. F. Owen, Jr. 1991. Eosinophil hematopoietins antagonize the programmed cell death of eosinophils. J. Clin. Invest. 88:1982-1987.
17. Boyce, J. A., D. Friend, M. F. Gurish, K. F. Austen, and W. F. Owen. 1996. Constitutive production of granulocyte-macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. Proc. Natl. Acad. Sci. U.S.A. 93:2436-2442.
18. Moqbel, R., Q. Hamid, S. Ying, J. Barkans, A. Hartnell, A. Tsicopoulos, A. J. Wardlaw, and A. B. Kay. 1991. Expression of mRNA and immunoreactivity for the granulocyte-macrophage colony-stimulating factor in activated human eosinophils. J. Exp. Med. 174:749-752.
19. Yousefi, S., D. C. Hoessli, K. Blaser, G. B. Mills, and H.-U. Simon. 1996. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J. Exp. Med. 183:1407-1414.
20. Daugherty B. L., S. J. Siciliano, J. A. DeMartino, L. Malkowitz, A. Sorotina, and M. S. Springer. 1996. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J. Exp. Med. 183:2349-2354.
21. Ponath, P. D., S. Qin, T. W. Post, J. Wang, L. Wu, N. P. Gerard, W. Newman, C. Gerard, and C. R. Mackay. 1996. Molecular cloning and charaeterization of a human eotaxin receptor expressed selectively on eosinophils. J. Exp. Med. 183:2437-2448.
22. Xing, Z., Y. Ohkawara, M. Jordana, F. L. Graham, and J. Gauldie. 1996. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. J. Clin. Invent. 97:1102-1110.