Preclinical evidence for a role of glutamatergic systems in opioid tolerance and dependence

Seminars in the Neurosciences

Volumn 9, Issue 3-4, 1997, Pages 110-119

  Inturrisi, Charles E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Excitatory amino acid; Morphine; Nitric oxide synthase inhibitor; NMDA receptor antagonist

Indexed keywords

DECAHYDRO 6 PHOSPHONOMETHYL 3 ISOQUINOLINECARBOXYLIC ACID; DIZOCILPINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE;

ANALGESIA; DRUG TOLERANCE; HUMAN; MORPHINE TOLERANCE; NERVE CELL PLASTICITY; NONHUMAN; OPIATE ADDICTION; REVIEW;

EID: 0030723968     PISSN: 10445765     EISSN: None     Source Type: Journal    
DOI: 10.1006/smns.1997.0111     Document Type: Article

References (58)

1. 1. Inturrisi, C. E. (1990) Opioid analgesic therapy in cancer pain. In Advances in Pain Research and Therapy (K. M. Foley, J. J. Bonica, and V. Ventafridda, Eds.), pp. 133-154. Raven Press, New York.
2. 2. Watkins, J. C. (1994) The NMDA receptor concept: Origins and development. In The NMDA Receptor (G. L. Collingridge, and J. C. Watkins, Eds.), pp. 1-30. Oxford Univ. Press, Oxford.
3. 3. Bredt, D. S., and Snyder, S. H. (1992) Nitric oxide a novel neuronal messenger. Neuron 8, 3-11.
4. 4. Bading, H., Ginty, D. D., and Greenberg, M. E. (1993) Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260, 181-186.
5. 5. Rasmussen, K., Brodksy, M., and Inturrisi, C. (1995) NMDA antagonists and clonidine block C-fos expression during morphine withdrawal. Synapse 20, 68-74.
6. 6. Meldrum, B., and Garthwaite, J. (1991) Excitatory amino acid neurotoxicity and neurodegenerative disease. In Trends in Pharmacological Sciences: The Pharmacology of Excitatory Amino Acids. A Special Report (D. Lodge, and L. Collingridge, Eds.), pp. 54-62. Elsevier, Cambridge.
7. 7. Himmelsbach, C. K. (1943) Symposium: Can the euphoric, analgetic and physical dependence effects of drugs be separated? Fed. Proc. 2, 201-203.
8. 8. Martin, W. R. (1984) Phenomenology and theoretical basis of tolerance and dependence. In Mechanism of Tolerance and Dependence, NIDA Monograph 54 (C. W. Scharp, Ed.), pp. 12-26. Dept. of Health & Human Services, Public Health Service, Rockville, MD.
9. 9. Nestler, E. J., Hope, B. T., and Widnell, K. L. (1993) Drug addition: A model for the molecular basis of neural plasticity. Neuron 11, 995-1106.
10. 10. Wang, Z., Bilsky, E. J., Porreca, F., and Sadee, W. (1994) Constitutive u opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci. 54, PL339-350.
11. 11. Mao, J., Price, D. D., and Mayer, D. J. (1995) Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions. Pain 62, 259-274.
12. 12. Ortiz, J., Harris, H. W., Guitart, X., Terwilliger, R. Z., Haycock, J. W., and Nestler, E. J. (1995) Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: Regional distribution and regulation by chronic morphine. J. Neurosci. 15, 1285-1297.
13. 13. Widnell, K. L., Russell, D. S., and Nestler, E. J. (1994) Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proc. Natl. Acad. Sci. USA 91, 10947-10951.
14. 14. Couceyro, P., and Douglass, J. (1995) Precipitated morphine withdrawal stimulates multiple activator protein-1 signaling pathways in rat brain. Mol. Pharmacol. 47, 29-39.
15. 15. Elliott, K., Kest, B., Man, A., Kao, B., and Inturrisi, C. E. (1995) N-Methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development. Neuropsychopharmacology 13, 347-356.
16. 16. Pasternak, G. W., and Inturrisi, C. E. (1995) Pharmacological modulation of opioid tolerance. Exp. Opin. Invest. Drugs. 4, 271-281.
17. 17. Herman, B. H., Vocci, F., and Bridge, P. (1995) The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Neuropsychopharmacology 13, 269-293.
18. 18. Trujillo, K. A., and Akil, H. (1991) Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251, 85-87.
19. 19. Marek, P., Ben-Eliyahu, S., Gold, M., and Liebeskind, J. C. (1991) Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat. Brain Res. 547, 77-81.
20. 20. Ben-Eliyahu, S., Marek, P., Vaccarino, A. L., Mogil, J. S., Sternberg, W. F., and Liebeskind, J. C. (1992) The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat. Brain Res. 575, 304-308.
21. 21. Lutfy, K., Hurlbut, D. E., and Weber, E. (1993) Blockade of morphine-induced analgesia and tolerance in mice by MK-801. Brain Res. 616, 83-88.
22. 22. Koyuncuoglu, H., Gungor, M., Sagduyu, and Aricioglu, F. (1990) Suppression by ketamine and dextromethorphan of precipitated abstinence syndrome in rats. Pharmacol. Biochem. Behav. 35, 829-832.
23. 23. Elliott, K. J., Hynansky, A., and Inturrisi, C. E. (1994b) Dextromethorphan attenuates and reverses analgesic tolerance to morphine. Pain 59, 361-368.
24. 24. Manning, B. H., Mao, J., Frenk, H., Price, D. D., and Mayer, D. J. (1996) Continuous co-administration of dextromethorphan or MK-801 with morphine: Attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance. Pain 67, 79-88.
25. 25. Trujillo, K. A., and Akil, H. (1994) Inhibition of opiate tolerance by non-competitive N-methyl-D-aspartate receptor antagonists. Brain Res. 633, 178-188.
26. 26. Gorman, A. L., Elliott, K. J., and Inturrisi, C. E. (1997) The d-and 1-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord. Neurosci. Lett. 223, 5-8.
27. 27. Shimoyama, N., Shimoyama, M., Elliott, K. J., and Inturrisi, C. E. (1996) D-Methadone is antinociceptive in the rat formalin test. J. Pharmacol. Exp. Ther., in press.
28. 28. Inturrisi, C. E., Davis, A. M., Shimoyama, N., Shimoyama, M., Gorman, A. L., and Elliott, K. J. (1997) d-Methadone has NMDA receptor antagonist activity and prevents the development of tolerance to morphine. APS Abstract.
29. 29. Shimoyama, N., Shimoyama, M., Inturrisi, C. E., and Elliott, K. J. (1996) Ketamine attenuates and reverses morphine tolerance. Anesthesiology 85, 1357-1366.
30. 30. Rasmussen, K., Fuller, R. W., Stockton, M. E., Perry, K. W., Swinford, R. M., and Ornstein, P. L. (1991) NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal. Eur. J. Pharmacol. 197, 9-16.
31. 31. Tiseo, P. J., and Inturrisi, C. E. (1993) Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614. J. Pharmacol. Exp. Ther. 264, 1090-1096.
32. 32. Rasmussen, K. (1995) The role of the locus coeruleus and N-methyl-D-aspartic acid (NMDA) and AMPA receptors in opiate withdrawal. Neuropsychopharmacology 13, 295-300.
33. 1 opioid analgesic tolerance by NPC17742, a novel NMDA antagonist. Life Sci. 53, 1489-1494.
34. 34. Kolesnikov, Y. A., Maccechini, M. L., and Pasternak, G. W. (1994) 1-Aminocyclopropate carboxylic acid (ACPC) prevents mu and delta opioid tolerance. Life Sci. 55, 1393-1398.
35. 35. Lutfy, K., Shen, K. Z., Kwon, I. S., Cai, S. X., Woodward, R. M., Keana, J. F., and Weber, E. (1995) Blockade of morphine tolerance by ACEA-1328, a novel NMD A receptor/glycine site antagonist. Eur. J. Pharmacol. 273, 187-189.
36. 36. Ornstein, P. L., Arnold, M. B., Augenstein, N. K., Lodge, D., Leander, J. D., and Schoepp, D. D. (1993) (3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)-ethyl]decahydroisoquinoline -3-carboxylic acid: A structurally novel, systemically active, competitive AMPA receptor antagonist. J. Med. Chem. 36, 2046-2048.
37. 37. Kest, B., McLemore, G., Kao, B., and Inturrisi, C. E. (1997) The competitive α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor antagonist LY293558 attenuates and reverses analgesic tolerance to morphine but not to delta or kappa opioids. J. Pharmacol. Exp. Ther., in press.
38. 38. Kolesnikov, Y. A., Pick, C. G., Ciszewska, G., and Pasternak, G. W. (1993b) Blockade of tolerance to morphine but not to κ opioids by a nitric oxide synthase inhibitor. Proc. Natl. Acad. Sci. USA 90, 5162-5166.
39. 39. Vaupel, D. B., Kimes, A. S., London, E. D. (1995) Nitric oxide synthase inhibitors. Neuropsychopharmacology 13, 315-322.
40. 40. Tiseo, P. J., Cheng, J., Pasternak, G. W., and Inturrisi, C. E. (1994) Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: Assessment of opioid receptor changes. J. Pharmacol. Exp. Ther. 268, 195-201.
41. 41. Yoburn, B. C., Chen, J., Huang, T., and Inturrisi, C. E. (1985) Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat. J. Pharmacol Exp. Ther. 235, 282-286.
42. 42. Elliott, K., Minami, N., Kolesnikov, Y. A., Pasternak, G. W., and Inturrisi, C. E. (1994a) The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain 56, 69-75.
43. 43. Gutstein, H. B., and Trujillo, K. A. (1993) MK-801 inhibits the development of morphine tolerance at spinal sites. Brain Res. 626, 332-334.
44. 44. Trujillo, K. A. (1995) Effects of noncompetitive N-methyl-D-aspartate receptor antagonists on opiate tolerance and physical dependence. Neuropsychopharmacology 13, 301-307.
45. 45. Watkins, L. R., Kinscheck, I. B., and Mayer, D. J. (1984) Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. Science 224, 395-396.
46. 46. Wahlestedt, C., Golanov, E., Yamamoto, S., Yee, F., Ericson, H., Yoo, H., Inturrisi, C. E., and Reis, D. J. (1993) Antisense oligodeoxynucleotides to the NMDAR1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature 363, 260-263.
47. 47. Inturrisi, C. E., Shimoyama, N., Shimoyama, M., Foley, K., and Elliott, K. (1996) NMDA-R1 antisense attenuates morphine tolerance. Soc. Neurosci. 22, 1760.
48. 48. Yaksh, T. L. (1986) The effects of intrathecally administered opioid and adrenergic agents on spinal function. In Spinal Afferent Processing (T. L. Yaksh, Ed.), pp. 505-539. Plenum, New York.
49. 49. Mao, J., Price, D. D., and Mayer, D. J. (1995) Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions. Pain 62, 259-274.
50. 50. Chen, L., and Huang, L.-Y. M. (1991) Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid. Neuron 7, 319-326.
51. 51. Chen, L., and Huang, L. Y. M. (1992) Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356, 521-523.
52. 52. Bilsky, E. J., Inturrisi, C. E., Sadee, W., Hruby, V. J., and Porreca, F. (1996) Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice. Pain 68, 229-237.
53. 53. Olney, J. W., Labruyere, J., and Price, M. T. (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244, 1360-1362.
54. 54. Olney, J. W., Labruyere, J., Wang, G., Wozniak, D. F., Price, M. T., and Sesma, M. A. (1991) NMDA antagonist neurotoxicity: Mechanism and Prevention. Science 254, 1515-1518.
55. 55. Olney, J. W., and Farber, N. B. (1995) NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia. Neuropsychopharmacology 13, 335-345.
56. 56. Auer, R. N., and Coulter, K. C. (1994) The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK801. Acta Neuropathol 87, 1-7.
57. 57. Bhargava, H. N., and Matwyshyn, G. A. (1993) Dizocilpine (MK-801) blocks tolerance to the analgesic but not to the hyperthermic effect of morphine in the rat. Pharmacology 47, 344-350.
58. 58. Tzschentke, T. M., and Schmidt, W. J. (1995) N-Methyl-D-aspartic acid-receptor antagonists block morphine-induced conditioned place preference in rats. Neurosci. Lett. 193, 37-40.