Longitudinal study of fasting proinsulin in 148 siblings of patients with insulin-dependent diabetes mellitus

European Journal of Endocrinology

Volumn 137, Issue 5, 1997, Pages 490-494

  Hartling, Svend G ^a,b   Knip, Mikael ^c   Røder, Michael E ^a   Dinesen, Bo ^a   Åkerblom, Hans K ^d   Binder, Christian ^a  

^a STENO DIABETES CENTER   (Denmark)

^b AMAGER HOSPITAL   (Denmark)

^c UNIVERSITY OF OULU   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; PROINSULIN;

ARTICLE; CHILD; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; FINLAND; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0030722427     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1370490     Document Type: Article

References (28)

1. Hartling SG, Lindgren F, Dahlqvist G, Persson B & Binder C. Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes 1989 38 1271-1274.
2. Heaton DA, Millward BA, Gray P, Tun Y, Hales CN, Pyke DA & Leslie RDG. Evidence of beta-cell dysfunction which does not lead to diabetes: a study of identical twins of insulin dependent diabetics. British Medical Journal 1987 294 145-146.
3. Lindgren FA, Hartling SG, Dahlquist GG, Binder C, Efendic S & Persson BE. Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients. Diabetic Medicine 1991 8 638-643.
4. Melani F, Rubenstein AH & Steiner DF. Human serum proinsulin. Journal of Clinical Investigation 1970 49 497-507.
5. Koivisto VA, Yki-Järvinen H, Hartling SG & Pelkonen R. The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects and patients with insulinoma. Journal of Clinical Endocrinology and Metabolism 1986 63 1117-1120.
6. Saad MF, Kahn SE, Nelson RG, Pettitt DJ, Knowler WC, Schwartz MW, Kowalyk SM Bennett PH & Porte D Jr. Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 1990 70 1247-1253.
7. Nauck MA, Siegel EG & Creutzfeldt W. Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin. Pancreas 1991 6 645-652.
8. Hartling SG, Røder ME, Dinesen B & Binder C. Proinsulin, C-peptide and insulin in normal subjects during an 8-h hyperglycemic clamp. European Journal of Endocrinology 1996 134 197-200.
9. Spinas GA, Snorgaard O, Hartling SG, Oberholzer M & Berger W. Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients. Diabetes Care 1992 15 632-637.
10. Røder ME, Knip M, Hartling SG, Karjalainen J, Åkerblom HK, Binder C & the Childhood Diabetes in Finland Study Group. Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. Journal of Clinical Endocrinology and Metabolism 1994 79 1570-1575.
11. Tuomilehto J, Lounamaa R, Tuomilehto-Wolf E, Reumanen E, Virtala E, Kaprio EA, Åkerblom HK & the Childhood Diabetes in Finland (DiMe) Study Group. Epidemiology of childhood diabetes mellitus in Finland - background of a nationwide study of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1992 35 70-76.
12. Knip M, Vähäsalo P, Karjalainen J, Lounamaa R, Åkerblom HK & the Childhood Diabetes in Finland Study Group. Natural history of preclinical IDDM in high risk siblings. Diabetologia 1994 37 388-393.
13. Hartling SG, Dinesen B, Kappelgård AM, Faber OK & Binder C. ELISA for human proinsulin. Clinica Chimica Acta 1986 156 289-298.
14. Hartling SG, Garne S, Binder C, Heilman C, Petersen W, Petersen KE & Koch C. Proinsulin, insulin and C-peptide in cystic fibrosis after an oral glucose tolerance test. Diabetes Research 1988 7 165-169.
15. Heding LG. Radioimmunological determination of human C-peptide in serum. Diabetologia 1975 11 541-548.
16. Hjelm M. Enzymatic determination of hexoses in blood and urine. Scandinavian Journal of Clinical and Laboratory Investigation 1966 192 (Suppl) 85-98.
17. Bottazzo GF, Dean BM, Gorsuch AN, Cudworth AG & Doniach D. Complement-fixing islet cell antibodies in type 1 diabetes: possible monitors of active beta-cell damage. Lancet 1980 1 668-672.
18. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK & Paquette TL. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983 222 1337-1339.
19. Heaton DA, Millward BA, Gray IP, Tun Y, Hales CN, Pyke DA & Leslie RDG. Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of Type 1 (insulin-dependent) diabetic patients. Diabetologia 1988 31 182-184.
20. Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstrom RW & Fujimoto WY. Proinsulin as a marker for the development of NIDDM in Japanese-American men. Diabetes 1995 44 173-179.
21. Mykkänen L, Haffner SM, Kuusisto J, Pyörälä K, Hales CN & Laakso M. Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects. Diabetologia 1995 38 1176-1182.
22. Røder ME, Eriksson J, Hartling SG, Groop L & Binder C. Proportional proinsulin responses in first-degree relatives of patients with type 2 diabetes mellitus. Acta Diabetologica 1993 30 132-137.
23. Røder ME, Vaag A, Harling SG, Dinesen B, Lanng S, Beck-Nielsen H & Binder C. Proinsulin immunoreactivity in identical twins discordant for noninsulin-dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 1995 80 2359-2363.
24. Lindgren F, Hartling SG, Persson B, Røder ME, Snellman K, Dahlquist G & Binder C. Proinsulin levels in newborn siblings of type 1 (insulin-dependent) diabetic children and mothers. Diabetologia 1993 36 560-563.
25. Heding LG, Persson B & Stangenberg M. B-cell function in newborn infants of diabetic mothers. Diabetologia 1980 19 427-432.
26. Heding LG, Ludvigsson J & Kasperska-Czyzykowa T. B-cell secretion in non-insulin and insulin-dependent-diabetics. Acta Medica Scandinavica 1981 656 (Suppl) 5-9.
27. Snorgaard O, Hartling SG & Binder C, Proinsulin and C-peptide at onset and during 12 months cyclosporin treatment of Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1990 33 36-42.
28. Snorgaard O. Kjems LL, Røder ME, Hartling SG, Dinesen B & Binder C. Proinsulin immunoreactivity in recent-onset IDDM. The significance of insulin antibodies and insulin autoantibodies. Diabetes Care 1996 19 146-150.