Proinsulin immunoreactivity in recent-onset IDDM: The significance of insulin antibodies and insulin autoantibodies

Diabetes Care

Volumn 19, Issue 2, 1996, Pages 146-150

  Snorgaard, Ole ^a,b   Kjems, Lise L ^a   Røder, Micheal E ^a   Hartling, Svend G ^a   Dinesen, Bo ^a   Binder, Christian ^a  

^a STENO DIABETES CENTER   (Denmark)

^b FREDERIKSBERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN ANTIBODY; ISOPHANE INSULIN; NEUTRAL INSULIN; PIG INSULIN; PROINSULIN;

ADULT; ANTIGEN BINDING; ARTICLE; BODY MASS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; RADIOIMMUNOASSAY;

EID: 0030069902     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.19.2.146     Document Type: Article

References (18)

1. Snorgaard O, Hartling SG, Binder C, The Canadian-European Randomized Control Trial Group: Proinsulin and C-peptide at onset and during 12 months cyclosporin treatment of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 33:36-42, 1990
2. Ludvigsson J, Heding LG: Abnormal proinsulin/C-pepdde ratio in juvenile diabetes. Acta Diabetol Lat 19:351-358, 1982
3. The Canadian-European Randomized Control Trial Group: Cyclosporin-induced remission of IDDM after early intervention: association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 37:1574-1582, 1988
4. Mandrup-Poulsen T, Mølvig J, Andersen HU, Helqvist S, Spinas GA, Munck M, the Canadian-European Randomized Control Trial Group Lack of predictive value of islet cell antibodies, insulin antibodies, and HLA-DR phenotype for remission in cyclosporin-treated IDDM patients. Diabetes 39:204-210, 1990
5. Snorgaard O, Lassen LH, Binder C: Homogeneity in the pattern of decline of β-cell function in IDDM: prospective study of 204 consecutive cases followed for 7.4 yrs. Diabetes Care 15:1009-1013, 1992
6. Agner T, Damm P, Binder C: Remission in IDDM: prospective study of basal C-peptide and insulin dose in 268 consecutive patients Diabetes Care 10:164-169, 1987
7. Kjems LL, Røder ME, Dinesen B, Hartling SG, Jørgensen PN, Binder C: Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies. Clin Chem 39.2146-2150, 1993
8. Faber OK, Markussen J, Naithani VK, Binder C: Production of antisera to synthetic benzyloxycarbonyl-C-peptide of human proinsulin Hoppe-Seylers Z Physiol Chem 357:751-757, 1976
9. Heding LG: Radioimmunological determination of human C-peptide in serum. Diabetologia 11:541-548, 1975
10. Svendsen PA, Christiansen JS, Søegaard U, Welinder BA, Nerup J: Rapid changes in chromatographically determined haemoglobin A1c induced by short-term changes in glucose concentrations. Diabetologia 19.130-136, 1980
11. Lauritzen T, Pramming S, Gale EAM, Decken T, Binder C: Absorption of isophane (NPH) insulin and its clinical implications. Br Med J 285:159-162, 1982
12. Hartling SG, Dinesen B, Kappelgard AM, Faber OK, Binder C: ELISA for human proinsulin. Clin Chim Acta 156:289-298, 1986
13. Böhmer K, Keilacker H, Kuglin B, Hubinger A, Bertrams J, Gries FA, Kolb H: Proinsulin autoantibodies are more closely associated with type 1 (insulin-dependent) diabetes mellitus than insulin antibodies. Diabetologia 34:830-834, 1991
14. Greenbaum CJ, Palmer JP, Kuglin B, Kolb H: Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement. J Clin Endocrinol Metab 74:1040-1044, 1992
15. Ludvigsson J, Binder C, Mandrup-Poulsen T: Insulin auto-antibodies are associated with islet cell antibodies: their relation to insulin antibodies and B-cell function in diabetic children. Diabetologia 31:647-651, 1988
16. Greenbaum CJ, Palmer JP: Insulin antibodies and insulin autoantibodies. Diabetic Med 8:97-105, 1991
17. Van Haeften T: Clinical significance of insulin antibodies in insulin-treated diabetic patients. Diabetes Care 12.641-648, 1989
18. Zinman B. The physiologic replacement of insulin N Engl J Med 321:363-370, 1989