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Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF: Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 1997, 386:284-288. Homer is identified as a single PDZ containing protein that binds the carboxyl terminus of the metabotropic glutamate (mGlu) receptor. Homer might function to modify signal transduction or to spatially localize the mGlu receptors.
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Nature
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Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL: GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 1997, 386:279-284. Presents the identification of GRIP, which has seven PDZ domains and can bind to the carboxyl terminus of subunits in the AMPA receptor at excitatory neurosynapses. Overexpression of the carboxyl terminus of a subunit of the AMPA receptor prevents its localization to the synapse, suggesting that GRIP may function in receptor localization.
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Dong, H.1
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2+ entry through the transient receptor potential (TRP) channel. The paper shows that the TRP channel, phospholipase C, eye-specific protein kinase C and InaD can be isolated in one protein complex.
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Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex
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Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E. Becker A, Socolich M, Zuker C: A multivalent PDZ-domain protein assembles signaling complexes in a G-protein-coupled cascade. Nature 1997, 388:242-249. An outstanding paper showing that InaD is involved in localizing the transient receptor potential (TRP) channel to the rhabdomere and acts as a scaffold for signaling proteins in the photoreceptor cell in the fly. The authors isolate two new InaD alleles using an impressive genetic screen InaD has five PDZ domains, and three of these PDZ domains bind to different signaling molecules, namely, phospholipase C, TRP channel and protein kinase C.
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Nature
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Tsunoda, S.1
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Zuker, C.8
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