-
1
-
-
0025272187
-
Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse
-
Kaneda, N., Nagata, H., Furuta, T., and Yokokura, T. Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse. Cancer Res., 50: 1715-1720, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 1715-1720
-
-
Kaneda, N.1
Nagata, H.2
Furuta, T.3
Yokokura, T.4
-
2
-
-
0025996996
-
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
-
Kawato, Y., Aonuma, M., Hirota, Y., Kuga, H., and Sato, K. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res., 51: 4187-4191, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 4187-4191
-
-
Kawato, Y.1
Aonuma, M.2
Hirota, Y.3
Kuga, H.4
Sato, K.5
-
3
-
-
0025827281
-
CPT-11 converting enzyme from rat serum: Purification and some properties
-
Tsuji, T., Kaneda, N., Kado, K., Yokokura, T., Yoshimoto, T., and Tsuru, D. CPT-11 converting enzyme from rat serum: purification and some properties. J. Pharmacobio-Dyn., 14: 341-349, 1991.
-
(1991)
J. Pharmacobio-Dyn.
, vol.14
, pp. 341-349
-
-
Tsuji, T.1
Kaneda, N.2
Kado, K.3
Yokokura, T.4
Yoshimoto, T.5
Tsuru, D.6
-
4
-
-
0028364014
-
Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase
-
Satoh, T., Hosokawa, M., Atsumi, R., Suzuki, W., Hakusi, H., and Nagai, E. Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase. Biol. Pharm. Bull., 17: 662-664, 1994.
-
(1994)
Biol. Pharm. Bull.
, vol.17
, pp. 662-664
-
-
Satoh, T.1
Hosokawa, M.2
Atsumi, R.3
Suzuki, W.4
Hakusi, H.5
Nagai, E.6
-
5
-
-
0030580064
-
Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase
-
Rivory, L. P., Bowles, M. R., Robert, J., and Pond, S. M. Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase. Biochem. Pharmacol., 52: 1103-1111, 1996.
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 1103-1111
-
-
Rivory, L.P.1
Bowles, M.R.2
Robert, J.3
Pond, S.M.4
-
6
-
-
0025858296
-
Identification of the metabolites of irinotecan, a new derivative camptothecin, in rat bile and its biliary excretion
-
Atsumi, R., Suzuki, W., and Hakusui, H. Identification of the metabolites of irinotecan, a new derivative camptothecin, in rat bile and its biliary excretion. Xenobiotica, 21: 1159-1169, 1991.
-
(1991)
Xenobiotica
, vol.21
, pp. 1159-1169
-
-
Atsumi, R.1
Suzuki, W.2
Hakusui, H.3
-
7
-
-
15144351640
-
Multiplicity and toxicological implications of liver microsomal carboxylesterase
-
E. Hodgson, R. M. Roe, and N. Motoyama (eds.), Raleigh, NC: North Carolina State University
-
Satoh, T., Maki, T., Kobayashi, S., and Hosokawa, M. Multiplicity and toxicological implications of liver microsomal carboxylesterase. In: E. Hodgson, R. M. Roe, and N. Motoyama (eds.), Pesticides and Future: Toxicological Studies of Risk and Benefit, pp. 137-148. Raleigh, NC: North Carolina State University, 1991.
-
(1991)
Pesticides and Future: Toxicological Studies of Risk and Benefit
, pp. 137-148
-
-
Satoh, T.1
Maki, T.2
Kobayashi, S.3
Hosokawa, M.4
-
8
-
-
0023658320
-
Involvement of the esterase active site of egasyn in compartmentalization of β-glucuronidase within the endoplasmic reticulum
-
Medda, S., Stevens, A. M., and Swank, R. T. Involvement of the esterase active site of egasyn in compartmentalization of β-glucuronidase within the endoplasmic reticulum. Cell, 50: 301-310, 1987.
-
(1987)
Cell
, vol.50
, pp. 301-310
-
-
Medda, S.1
Stevens, A.M.2
Swank, R.T.3
-
9
-
-
0019127534
-
Significance of phosphorylation in organophosphate-mediated β-glucuronidase release from the rat liver
-
Keadtisuke, S., and Nakatsugawa, T. Significance of phosphorylation in organophosphate-mediated β-glucuronidase release from the rat liver. Pestic. Biochem. Physiol., 73: 213-219, 1980.
-
(1980)
Pestic. Biochem. Physiol.
, vol.73
, pp. 213-219
-
-
Keadtisuke, S.1
Nakatsugawa, T.2
-
10
-
-
0021265070
-
Paraoxon-induced release of β-glucuronidase from rat hepatocytes in vitro
-
Leng, X-F., and Nakatsugawa, T. Paraoxon-induced release of β-glucuronidase from rat hepatocytes in vitro. Pestic. Biochem. Physiol., 21: 207-212, 1984.
-
(1984)
Pestic. Biochem. Physiol.
, vol.21
, pp. 207-212
-
-
Leng, X.-F.1
Nakatsugawa, T.2
-
11
-
-
0027461221
-
Inhibition of β-glucuronidase by natural glucuronides of Kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate
-
Narita, M., Nagai, E., Hagiwara, H., Aburada, M., Yokoi, T., and Kamataki, T. Inhibition of β-glucuronidase by natural glucuronides of Kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate. Xenobiotica, 23: 5-10, 1993.
-
(1993)
Xenobiotica
, vol.23
, pp. 5-10
-
-
Narita, M.1
Nagai, E.2
Hagiwara, H.3
Aburada, M.4
Yokoi, T.5
Kamataki, T.6
-
12
-
-
85004809753
-
Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in Kampo medicines using SN-38 as a substrate
-
Yokoi, T., Narita, M., Nagai, E., Hagiwara, H., Aburada, M., and Kamataki, T. Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in Kampo medicines using SN-38 as a substrate. Jpn. J. Cancer Res., 86: 985-989, 1995.
-
(1995)
Jpn. J. Cancer Res.
, vol.86
, pp. 985-989
-
-
Yokoi, T.1
Narita, M.2
Nagai, E.3
Hagiwara, H.4
Aburada, M.5
Kamataki, T.6
-
13
-
-
0029741368
-
Involvement of β-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats
-
Takasuna, K., Hagiwara, T., Hirohashi, M., Kato, M., Nomura, M., Nagai, E., Yokoi, T., and Kamataki, T. Involvement of β-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res., 56: 3752-3757, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 3752-3757
-
-
Takasuna, K.1
Hagiwara, T.2
Hirohashi, M.3
Kato, M.4
Nomura, M.5
Nagai, E.6
Yokoi, T.7
Kamataki, T.8
-
14
-
-
0025342506
-
Nonlinear pharmacokinetics of CPT-11 in rats
-
Kaneda, N., and Yokokura, T. Nonlinear pharmacokinetics of CPT-11 in rats. Cancer Res., 50: 1721-1725, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 1721-1725
-
-
Kaneda, N.1
Yokokura, T.2
-
15
-
-
0023180455
-
Multiplicity and regulation of hepatic microsomal carboxylesterases in rats
-
Hosokawa, M., Maki, T., and Satoh, T. Multiplicity and regulation of hepatic microsomal carboxylesterases in rats. Mol. Pharmacol., 31: 579-584, 1987.
-
(1987)
Mol. Pharmacol.
, vol.31
, pp. 579-584
-
-
Hosokawa, M.1
Maki, T.2
Satoh, T.3
-
16
-
-
0019739895
-
Carboxylesterases-amidases
-
W. B. Jakoby (ed.), New York: Academic Press
-
Heymann, E., and Mentlein, R. Carboxylesterases-amidases. In: W. B. Jakoby (ed.), Methods in Enzymology, Vol. 77, Detoxification and Drug Metabolism: Conjugation and Related Systems, pp. 333-344. New York: Academic Press, 1981.
-
(1981)
Methods in Enzymology, Vol. 77, Detoxification and Drug Metabolism: Conjugation and Related Systems
, vol.77
, pp. 333-344
-
-
Heymann, E.1
Mentlein, R.2
-
17
-
-
0022486166
-
Identity of esterase-22 and egasyn, the protein which complexes with microsomal β-glucuronidase
-
Medda, S., Deimling, O. V., and Swank, R. T. Identity of esterase-22 and egasyn, the protein which complexes with microsomal β-glucuronidase. Biochem. Genet., 24: 229-243, 1986.
-
(1986)
Biochem. Genet.
, vol.24
, pp. 229-243
-
-
Medda, S.1
Deimling, O.V.2
Swank, R.T.3
-
18
-
-
0023664443
-
An accessory protein identical to mouse egasyn is complexed with rat microsomal β-glucuronidase and is identical to rat esterase-3
-
Medda, S., Takeuchi, K., Devore-Carter, D., Deimling, O. V., Heymann, E., and Swank, R. T. An accessory protein identical to mouse egasyn is complexed with rat microsomal β-glucuronidase and is identical to rat esterase-3. J. Biol. Chem., 262: 7248-7253, 1987.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 7248-7253
-
-
Medda, S.1
Takeuchi, K.2
Devore-Carter, D.3
Deimling, O.V.4
Heymann, E.5
Swank, R.T.6
-
19
-
-
0025029946
-
The propeptide of β-glucuronidase. Further evidence of its involvement in compartmentalization of β-glucuronidase and sequence similarity with portions of the reactive site region of the serpin superfamily
-
Li, H., Takeuchi, K. H., Manly, K., Chapman, V., and Swank, R. T. The propeptide of β-glucuronidase. Further evidence of its involvement in compartmentalization of β-glucuronidase and sequence similarity with portions of the reactive site region of the serpin superfamily. J. Biol. Chem., 265: 14732-14735, 1990.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 14732-14735
-
-
Li, H.1
Takeuchi, K.H.2
Manly, K.3
Chapman, V.4
Swank, R.T.5
-
20
-
-
0022379558
-
Egasyn, a protein which determines the subcellular distribution of β-glucuronidase, has esterase activity
-
Medda, S., and Swank, R. T. Egasyn, a protein which determines the subcellular distribution of β-glucuronidase, has esterase activity. J. Biol. Chem., 260: 15802-15808, 1985.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 15802-15808
-
-
Medda, S.1
Swank, R.T.2
-
21
-
-
0027933519
-
Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients
-
de Forni, M., Bugat, R., Chabot, G. G., Culine, S., Extra, J-M., Gouyette, A., Madelaine, I., Marty, M. E., and Mathieu-Boué, A. Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients. Cancer Res., 54: 4347-4354, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 4347-4354
-
-
De Forni, M.1
Bugat, R.2
Chabot, G.G.3
Culine, S.4
Extra, J.-M.5
Gouyette, A.6
Madelaine, I.7
Marty, M.E.8
Mathieu-Boué, A.9
-
22
-
-
0028158012
-
Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-hydroxy-[4-(piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks
-
Rowinsky, E. K., Grochow, L. B., Ettinger, D. S., Sartorius, S. E., Lubejko, B. G., Chen, T-L., Rock, M. K., and Donehower, R. C. Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-hydroxy-[4-(piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks. Cancer Res., 54: 427-436, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 427-436
-
-
Rowinsky, E.K.1
Grochow, L.B.2
Ettinger, D.S.3
Sartorius, S.E.4
Lubejko, B.G.5
Chen, T.-L.6
Rock, M.K.7
Donehower, R.C.8
-
23
-
-
0010917253
-
Pharmacokinetics and pharmacodynamics of irinotecan during a Phase II clinical trial in colorectal cancer
-
Canal, P., Gay, C., Dezeuze, A., Douillard, J. Y., Bugat, R., Brunet, R., Adenis, A., Herait, P., Lokiec, F., and Mathieu-Boue, A. Pharmacokinetics and pharmacodynamics of irinotecan during a Phase II clinical trial in colorectal cancer. J. Clin. Oncol., 14: 2688-2695, 1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 2688-2695
-
-
Canal, P.1
Gay, C.2
Dezeuze, A.3
Douillard, J.Y.4
Bugat, R.5
Brunet, R.6
Adenis, A.7
Herait, P.8
Lokiec, F.9
Mathieu-Boue, A.10
-
24
-
-
0028022585
-
Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
-
Gupta, E., Lestingi, T. M., Mick, R., Ramirez, J., Yokes, E. E., and Ratain, M. J. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res., 54: 3723-3725, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 3723-3725
-
-
Gupta, E.1
Lestingi, T.M.2
Mick, R.3
Ramirez, J.4
Yokes, E.E.5
Ratain, M.J.6
-
25
-
-
0042478012
-
Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), in patients with previously treated colorectal cancer
-
Schaaf, L., Ichhpurani, N., Elfring, G., Wolf, D., Rothenberg, M., and Von Hoff, D. Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), in patients with previously treated colorectal cancer. Proc. Am. Soc. Clin. Oncol., 16: 202a, 1997.
-
(1997)
Proc. Am. Soc. Clin. Oncol.
, vol.16
-
-
Schaaf, L.1
Ichhpurani, N.2
Elfring, G.3
Wolf, D.4
Rothenberg, M.5
Von Hoff, D.6
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