Cytokine mRNA expression in tolerant heart allografts after immunosuppression with cyclosporine, sirolimus or brequinar

Transplant Immunology

Volumn 5, Issue 3, 1997, Pages 189-198

  Tian, Ling ^a   Stepkowski, Stanislaw M ^a   Qu, Xiumei ^a   Wang, Mou Er ^a   Wang, Min ^a   Yu, Jiang ^a   Kahan, Barry D ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREQUINAR; CYCLOSPORIN; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; RAPAMYCIN;

ANIMAL EXPERIMENT; CONFERENCE PAPER; HEART TRANSPLANTATION; HELPER CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RECIPIENT;

EID: 0030715635     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(97)80037-8     Document Type: Conference Paper

References (38)

1. Sherman LA, Chattopadhyay S. The molecular basis of allorecognition. Annu Rev Immunol. 11:1993;385-402.
2. Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 136:1986;2348-2357.
3. Stepkowski SM, Duncan WR. The role of TDTH and Tc population in organ graft rejection. I. Functional analysis of graft infiltrating T cells. Transplantation. 42:1986;406-412.
4. Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems. The differential activation of Th2-like effector cells in peripheral tolerance. Transplantation. 53:1992;1281-1294.
5. + T cells in vivo. J Immunol. 148:1992;1308-1314.
6. Kupiec-Weglinski JW, Wasowska B, Papp I, et al. CD4 MAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines. J Immunol. 151:1993;5053-5061.
7. Chen N, Field EH. Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance. Transplantation. 59:1995;933-941.
8. Nickerson P, Pacheco-Silva A, O'Connell PJ, et al. Analysis of cytokine transcripts in pancreatic islet cell allografts during rejection and tolerance induction. Transplant Proc. 25:1993;984-985.
9. Hancock WW, Sayegh MH, Kwok CA, Weiner HL, Carpenter CB. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation. 55:1993;1112-1118.
10. Ferraresso M, Tian L, Ghobrial R, Stepkowski SM, Kahan BD. Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart allografts in rats. J Immunol. 153:1994;3307-3318.
11. Lee MS, Wogensen L, Shizuru J, Oldstone MB, Sarvetnick N. Pancreatic islet production of murine IL-10 does not inhibit immune-mediated tissue destruction. J Clin Invest. 93:1994;1332-1338.
12. Nickerson P, Steurer W, Steiger J, Zheng X, Steel AW, Strom TB. Cytokine and Th1/Th2 paradigm in transplantation. Curr Opin Immunol. 6:1994;757-764.
13. Platzer C, Richter G, Uberla K, et al. Analysis of cytokine mRNA levels in interleukin-4 transgenic mice by quantitative polymerase chain reaction. Eur J Immunol. 22:1992;1179-1184.
14. Platzer C, Richter G, Uberla K, Hock H, Dimantstein T, Blankenstein T. Interleukin-4 mediated tumor suppression in nude mice involves interferon-γ Eur J Immunol. 22:1992;1729-1733.
15. Miyagawa S, Stepkowski SM, Lawen JG, Rutzky LP, Kahan BD. In vitro correlates of in vivo therapy with cyclosporine to immunosuppress rejection of heterotopic rat cardiac allografts across strong (RT 1) plus weak (non-RT 1) histocompatibility differences. Transplantation. 52:1991;851-857.
16. Cramer DV, Chapman FA, Jaffee BD, et al. The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat. Transplantation. 53:1992;303-308.
17. Kronke M, Leonard WJ, Depper JM, et al. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci USA. 81:1984;5214-5218.
18. Metcalfe SM, Richards FM. Cyclosporine, FK506, and rapamycin: Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cell. Transplantation. 49:1990;798-802.
19. Henderson DJ, Nava I, Bundick RV, et al. Comparison of the effects of FK506, cyclosporin A and rapamycin on IL-2 production. Immunology. 73:1991;316-321.
20. Sehgal SN, Baker H, Vezina C. Rapamycin (AV-22,989), a new antifungal antibiotic. II Fermentation, isolation and characterization. J Antibiot (Tokyo). 28:1975;727-732.
21. Kimball PM, Kerman RH, Kahan BD. Production of synergistic but nonidentical mechanisms of immunosuppression by rapamycin and cyclosporine. Transplantation. 51:1991;486-490.
22. Bierer BE, Mattila PS, Standaert RF, et al. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci USA. 87:1990;9231-9235.
23. Dumont FJ, Staruch MJ, Koprak SL, et al. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin. J Immunol. 144:1990;251-258.
24. Peters GJ, Sharma SL, Laurensse E, et al. Inhibition of pyrimidine de novo synthesis by DUP-785 (NS 368390). Invest New Drugs. 5:1987;235-244.
25. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 57:1969;225-229.
26. Chirgwin JM, Przybyla AE, Macdonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:1979;5294-5299.
27. Nudel U, Zakut R, Yaffe D, et al. The nucleotide sequence of the rat cytoplasmic beta-actin gene. Nucleic Acids Res. 11:1983;1759-1771.
28. McKnight AJ, Mason DW, Barclay AN. Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin 2 cDNA probe to rat MHC class II-associated invariant chain mRNA. Immunogenetics. 30:1989;145-147.
29. Richter G, Blankenstein T, Diamantstein T. Evolutionary aspects. Structure and expression of rat interleukin 4 gene. Cytokine. 2:1990;221-228.
30. Uberla K, Li WQ, Qin ZH, Richter G, Raabe T, Diamantstein T, Blankenstein T. The rat interleukin-5 gene: Characterization and expression by retroviral gene transfer and polymerase chain reaction. Cytokine. 3:1991;72-81.
31. Goodman RE, Oblak J, Bell RG. Synthesis and characterization of rat IL-10 cDNA clones from the RNA of cultured OX8-OX22-thoracic duct T cell. Biochem Biophys Res Commun. 189:1992;1-7.
32. Wasowska B, Wieder KJ, Hancock WW, Strom TB, Kupiec-Weglinski JW. Cytokine and alloantibody networks in long term cardiac allografts in rapamycin-treated sensitizes rat recipients. J Immunol. 156:1996;395-404.
33. Zheng XX, Strom TB, Steele AW. Quantitative comparison of rapamycin and cyclosporin effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction. Transplantation. 58:1994;87-92.
34. Granelli-Piperno A. Lymphokine gene expression in vivo is inhibited by cyclosporin A. J Exp Med. 171:1990;533-544.
35. Batiuk TD, Pazderka F, Halloran PF. Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients. Transplantation. 59:1995;1400-1404.
36. Francalancia NA, Wang SC, Thai NL, et al. Graft cytokine mRNA activity in rat single lung transplants by reverse transcription-polymerase chain reaction: effect of cyclosporine. J Heart Lung Transplant. 11:1992;1041-1045.
37. Shirwan H, Cosenza CA, Wang HK, Wu GD, Makowka L, Cramer DV. Prevention of orthotopic liver allograft rejection in rats with a short-term brequinar sodium therapy. Transplantation. 57:1994;1072-1080.
38. Nisco SJ, Hissink RJ, Vriens PW, Hoyt EG, Reitz BA, Clayberger C. In vivo studies of the maintenance of peripheral transplant tolerance after cyclosporine. Radiosensitive antigen specific suppressor cells mediate lasting graft protection against primed effector cells. Transplantation. 59:1995;1444-1452.