Evidence for a common active site for cleavage of an AP site and the benzene-derived exocyclic adduct, 3,N4-benzetheno-dC, in the major human AP endonuclease

Biochemistry

Volumn 36, Issue 49, 1997, Pages 15411-15418

  Hang, B ^a   Rothwell, D G ^b   Sagi, J ^a,c   Hickson, I D ^b   Singer, B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CTRL RES INSTITUTE FOR CHEMISTRY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

3,N4 BENZETHENO 2' DEOXYCYTIDINE; ADENOSINE PHOSPHATE; BENZENE DERIVATIVE; DNA; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; MAGNESIUM ION; MANGANESE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; ZINC;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA NICK TRANSLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR MODEL; PH; PRIORITY JOURNAL;

BINDING SITES; CARBON-OXYGEN LYASES; DEOXYCYTIDINE MONOPHOSPHATE; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA ADDUCTS; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HELA CELLS; HUMANS; HYDROLYSIS; MOLECULAR STRUCTURE;

FELIS CATUS;

EID: 0030708824     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971367s     Document Type: Article

References (45)

1. Barzilay, G., & Hickson, I. D. (1995) BioEssays 17, 713-719.
2. Barzilay, G., Mol, C. D., Robson C. N., Walker, L. J., Cunninghan, R. P., Tainer J.A., & Hickson, I. D. (1995a) Nature Struct. Biol. 2, 561-568.
3. Barzilay, G., Walker, L. J., Robson, C. N., & Hickson, I. D. (1995b) Nucleic Acids Res. 23, 1544-1550.
4. Chenna, A., & Singer, B. (1995) Chem. Res. Toxicol. 8, 865-874.
5. Chenna, A., & Singer, B. (1997) Chem. Res. Toxicol. 10, 165-171.
6. Chenna, A., Hang, B., Rydberg, B., Kim, E., Pongracz, K., Bodell, W. J., & Singer, B. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 5890-5894.
7. Cuniasse, Ph., Fazakerley, G. V., Guschlbauer, W., Kaplan, B. E., & Sowers, L. C. (1990) J. Mol. Biol. 213, 303-314.
8. Demple, B., & Harrison, L. (1994) Annu. Rev. Biochem. 63, 915-948.
9. Demple, B., Herman, T., & Chen, D. S. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 11450-11454.
10. Dosanjh, M. K., Chenna, A., Kim, E., Fraenkel-Conrat, H., Samson, L., & Singer, B. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1024-1028.
11. Goljer, I., Kumar, S., & Bolton, P. H. (1995) J. Biol. Chem. 270, 22980-22987.
12. Gorman, M. et al. Crystal structure of the human DNA repair endonuclease, HAP1/Ref-1. (Manuscript in preparation.)
13. Habraken, Y., Carter, C. A., Sekiguchi, M., & Ludlum, D. B. (1991) Carcinogenesis 12, 1971-1973.
14. Hakura, A., Mochida, H., Tsutsui, Y., & Yamatsu, K. (1995) Mutat. Res. 347, 37-43.
15. Hang, B., Chenna, A., Rao, S., & Singer, B. (1996a) Carcinogenesis 17, 155-157.
16. Hang, B., Chenna, A., Fraenkel-Conrat, H., & Singer, B. (1996b) Proc. Natl. Acad. Sci. U.S.A. 93, 13737-13741.
17. Hricko, A. (1994) Environ. Health Perspect. 102, 276-81.
18. Huff, J. E., Haseman, J. K., DeMarini, D. M., Eustis, S., Maronpot, R. R., Peters, A. C., Persing, R. L., Chrisp, C. E., & Jacobs, A. C. (1989) Environ. Health Perspect. 82, 125-163.
19. IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans. (1987) International Agency for Research on Cancer, Lyon, France.
20. Jowa, L., Winkle, S., Kalf, G., Witz, G., & Snyder, R. (1986) Adv. Exp. Med. Biol. 197, 825-832.
21. Jowa, L., Witz, G., Snyder, R., Winkle, S., & Kalf, G. (1990) J. Applied Toxicol. 10, 47-54.
22. Kalnik, M. W., Chang, C. N., Grollman, A. P., & Patel, D. J. (1988) Biochemistry 27, 924-931.
23. Kane, C. M., & Linn, S. (1981) J. Biol. Chem. 256, 3405-3414.
24. Kow, Y. W. (1989) Biochemistry 28, 3280-3287.
25. Landt, O., Grunert, H. P., & Hahn, U. (1990) Gene 96, 125-128.
26. Marnett, L. J., & Burcham, P. C. (1993) Chem. Res. Toxicol. 6, 771-785.
27. Matijasevic, Z., Sekiguchi, M., & Ludlum, D. B. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 9331-9334.
28. Melamede, R. J., Hatabet, Z., Kow, Y. W., Ide, H., & Wallace, S. S. (1994) Biochemistry 33, 1255-1264.
29. Mol, C. D., Kuo, C. F., Thayer, M. M., Cunningham, R. P., & Tainer, J. A. (1995) Nature 374, 381-386.
30. Pongracz, K., & Bodell, W. J. (1991) Chem. Res. Toxicol. 4, 199-202.
31. Pongracz, K., Kaur, S., Burlingame, A. L., & Bodell, W. J. (1990) Carcinogenesis 11, 1469-1472.
32. Robson, C. N., & Hickson, I. D. (1991) Nucleic Acids Res. 19, 5519-5523.
33. Rothwell, D. G., & Hickson, I. D. (1996) Nucleic Acids Res. 24, 4217-4221.
34. Rydberg, B., Dosanjh, M. K., & Singer, B. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 6839-6842.
35. Rydberg, B., Qiu, Z.-H., Dosanjh, M. K., & Singer, B. (1992) Cancer Res. 52, 1377-1379.
36. Seki, S., Hatsushika, M., Watanabe, S., Akiyama, K., Nagao, K., & Tsutsui, K. (1992) Biochim. Biophys. Acta 1131, 287-299.
37. Singer, B. (1996) Regulat. Toxicol. Pharmacol. 23, 2-13.
38. Singer, B., & Bartsch, H. (1986) Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis, Vol. 70, IARC Scientific Publications, Oxford University Press, Oxford.
39. Singer, B., & Hang, B. (1997) Chem. Res. Toxicol. 10, 713-732.
40. Singer, B., Antoccia, A., Basu, A. K., Dosanjh, M. K., Fraenkel-Conrat, H., Gallagher, P. E., Kusmierek, J. T., Qiu, Z.-H., & Rydberg, B. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 9386-9390.
41. Walker, L. J., Robson, C. N., Black, E., Gillespie, D., & Hickson, I. D. (1993) Mol. Cell. Biol. 13, 5370-5376.
42. Weiss, B. (1976) J. Biol. Chem. 251, 1896-1901.
43. Withka, J. M., Wilde, J. A., & Bolton, P. H. (1991) Biochemistry 30, 9931-9940.
44. Xanthoudakis, S., & Curran, T. (1992) EMBO J. 11, 653-665.
45. Xanthoudakis, S., Miao, G. G., Wang, F., & Pan, Y.-C. E. (1992) EMBO J. 11, 3323-3335.