The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibberellin responses

Genes and Development

Volumn 11, Issue 23, 1997, Pages 3194-3205

  Peng, Jinrong ^a   Carol, Pierre ^a,b   Richards, Donald E ^a   King, Kathryn E ^a   Cowling, Rachel J ^a,c   Murphy, George P ^a   Harberd, Nicholas P ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b UNIV GRENOBLE ALPES   (France)

^c CEMAGREF   (France)

Author keywords

Arabidopsis thaliana; gai; Gibberellin; Mutant; Signal transduction

Indexed keywords

GIBBERELLIN;

ARABIDOPSIS; ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE MUTATION; NONHUMAN; PLANT GROWTH; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ARABIDOPSIS; ARABIDOPSIS THALIANA;

EID: 0030708651     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.23.3194     Document Type: Article

References (69)

1. Altschul, S.F., G. Warren, W. Gish, E.W. Myers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
2. Avery, L. and S. Wasserman. 1992. Ordering gene function: The interpretation of epistasis in regulatory hierarchies. Trends Genet. 8: 312-316.
3. Balcells, L., J. Swinburne, and G. Coupland. 1991. Transposons as tools for the isolation of plant genes. Trends Biotechnol. 9: 31-37.
4. Bancroft, I. and C. Dean. 1993. Transposition pattern of the maize element Ds in Arabidopsis thaliana. Genetics 134: 1221-1229.
5. Bleeker, A.B., M.A. Estelle, C. Somerville, and H. Kende. 1988. Insensitivity to ethylene conferred by a dominant mutation in Arabidopsis thaliana. Science 241: 1086-1089.
6. Boehm, U., M. Heinlein, U. Behrens, and R. Kunze. 1995. One of the three nuclear localization signals of maize Activator (Ac) transposase overlaps the DNA-binding domain. Plant J. 7: 441-451.
7. Boguski, M.S., T.M. Lowe, and C.M. Tolstoshev. 1993. dbEST: Database for "expressed sequence tags." Nature Genet. 4: 332-333.
8. Boulikas, T. 1994. Putative nuclear localization signals (NLS) in protein transcription factors. J. Cell. Biochem. 55: 32-58.
9. Brian, P.W. 1957. The effects of some microbial metabolic products on plant growth. Symp. Soc. Exp. Biol. 11: 166-182.
10. Carol, P., J. Peng, and N.P. Harberd. 1995. Isolation and preliminary characterization of gas1-1, a mutation causing partial suppression of the phenotype conferred by the gibberellin-insensitive (gai) mutation in Arabidopsis thaliana (L.) Heyhn. Planta 197: 414-417.
11. Chandler, P.M. 1988. Hormonal regulation of gene expression in the "slender" mutant of barley (Hordeum vulgare L.). Planta 175: 115-120.
12. Chang, C., S.F. Kwok, A.B. Bleecker, and E.M. Meyerowitz. 1993. Arabidopsis ethylene-response gene ETR1: Similarity of product to two-component regulators. Science 262: 539-544.
13. Chiang, H-H., I. Hwang, and H.M. Goodman. 1995. Isolation of the Arabidopsis GA4 locus. Plant Cell 7: 195-201.
14. Croker, S.J., P. Hedden, J.R. Lenton, and J.L. Stoddart. 1990. Comparison of gibberellins in normal and slender barley seedlings. Plant Physiol 94: 194-200.
15. Davis, T.D. and E.A. Curry. 1991. Chemical regulation of vegetative growth. Crit. Rev. Plant Sci. 10: 151-188.
16. Di Laurenzio, L., J. Wysocka-Diller, J.E. Malamy, L. Pysh, Y. Helariutta, G. Freshour, M.G. Hahn, K.A. Feldmann, and P.N. Benfey. 1996. The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root. Cell 86: 423-433.
17. Dingwall, C. and R.A. Laskey. 1991. Nuclear targeting sequences - A consensus? Trends Biochem. Sci. 16: 478-481.
18. Fujioka, S., H. Yamane, C.R. Spray, M. Katsumi, B.O. Phinney, P. Gaskin, J. MacMillan, and N. Takahashi. 1988. The dominant non-gibberellin-responding dwarf mutant (D8) of maize accumulates native gibberellins. Proc. Natl. Acad. Sci. 85: 9031-9035.
19. Gale, M.D., C.N. Law, G.A. Marshall, and A.J. Worland. 1975. The genetic control of gibberellic acid insensitivity and co-leoptile length in a "dwarf" wheat. Heredity 34: 393-399.
20. Gale, M.D. and S. Youssefian. 1985. Dwarfing genes in wheat. In Progress in plant breeding (ed. G.E. Russell), pp. 1-35. Butterworths, London, UK.
21. Gilroy, S. and R.L. Jones. 1994. Perception of gibberellin and abscisic acid at the external face of the plasma membrane of barley (Hordeum vulgare L.) aleurone protoplasts. Plant Physiol. 104: 1185-1192.
22. Grossi, M., M. Gulli, A.M. Stanca, and L. Cattivelli. 1995. Characterization of two barley genes that respond rapidly to dehydration stress. Plant Sci. 105: 71-80.
23. Harberd, N.P. and M. Freeling. 1989. Genetics of dominant gibberellin-insensitive dwarfism in maize. Genetics 121: 827-838.
24. Hedden, P. and J.E. Graebe. 1985. Inhibition of gibberellin biosynthesis by paclobutrazol in cell-free homogenates of Cucurbita maxima endosperm and Malus pumila embryos. J. Plant Growth Regul. 4: 111-122.
25. Heery, D.M., E. Kalkhoven, S. Hoare, and M.G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387: 733-736.
26. Hooley, R. 1994. Gibberellins: Perception, transduction and responses. Plant. Mol. Biol. 26: 1529-1555.
27. Hooley, R., M.H. Beale, and S.J. Smith. 1991. Gibberellin perception at the plasma membrane of Avena fatua aleurone protoplasts. Planta 183: 271-280.
28. Hua, J., C. Chang, Q. Sun, and E.M. Meyerowitz. 1995. Ethylene insensitivity conferred by Arabidopsis ERS gene. Science 269: 1712-1714.
29. Jacobsen, J.V., F. Gubler, and P.M. Chandler. 1995. Gibberellin action in germinated cereal grains. In Plant hormones: Physiology, biochemistry and molecular biology (ed. P.J. Davies), pp. 246-271. Kluwer Academic Publishers, Dordrecht, The Netherlands.
30. Jacobsen, S.E. and N.E. Olszewski. 1993. Mutations at the SPINDLY locus of Arabidopsis alter gibberellin signal transduction. Plant Cell 5: 887-896.
31. Jacobsen, S.E., K.A. Binkowski, and N.E. Olszewski. 1996. SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction in Arabidopsis. Proc. Natl. Acad. Sci. 93: 9292-9296.
32. Jans, D.A., L.J. Briggs, S.E. Gustin, P. Jans, S. Ford, and I.G. Young. 1997. A functional bipartite nuclear localization signal in the cytokine interleukine-5. FEBS Lett. 406: 315-320.
33. Jones, D.A., C.M. Thomas, K.E. Hammond-Kosack, P.J. Balint-Kurti, and J.D.G. Jones. 1994. Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science 266: 789-793.
34. Kieber, J.J., M. Rothenberg, G. Roman, K.A. Feldmann, and J.R. Ecker. 1993. CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the Raf family of protein kinases. Cell 72: 1-20.
35. Koornneef, M. and J.H. van der Veen. 1980. Induction and analysis of gibberellin sensitive mutants in Arabidopsis thaliana (L.) Hehyn. Theor. Appl. Genet. 58: 257-263.
36. Koornneef, M., A. Elgersma, C.J. Hanhart, E.P. van Loenen-Martinet, L. van Rign, and J.A.D. Zeevaart. 1985. A gibberellin insensitive mutant of Arabidopsis thaliana. Physiol. Plant 65: 33-39.
37. Kreppel, L.K., M.A. Blomberg, and G.W. Hart. 1997. Dynamic glycosylation of nuclear and cytosolic proteins: Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J. Biol. Chem. 272: 9308-9315.
38. LaCasse, E.C. and Y.A. Lefebvre. 1995. Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins. Nucleic Acids Res. 23: 1647-1656.
39. Lanahan, M.B. and T.-H.D. Ho. 1988. Slender barley: A constitutive gibberellin response mutant. Planta 175: 107-114.
40. Lenton, J.R., P. Hedden, and M.D. Gale. 1987. Gibberellin insensitivity and depletion in wheat - consequences for development. In Hormone action in plant development: A critical appraisal (ed. G.V. Hoad, J.R. Lenton, M.B. Jackson, and R.K. Atkin), pp. 145-160. Butterworths, London, UK.
41. Long, D., M. Martin, E. Sundberg, J. Swinburne, P. Puangsomlee, and G. Coupland. 1993. The maize transposable element system Ac/Ds as a mutagen in Arabidopsis: Identification of an albino mutation induced by Ds insertion. Proc. Natl. Acad. Sci. 90: 10370-10374.
42. Lubas, W.A., D.W. Frank, M. Krause, and J.A. Hanover. 1997. O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. J. Biol. Chem. 272: 9316-9324.
43. Macknight, R., I. Bancroft, T. Page, C. Lister, R. Schmidt, C. Love, L. Westphal, G. Murphy, S. Sherson, C. Cobbett, and C. Dean. 1997. FCA, a gene controlling flowering time in Arabidopsis, encodes a protein containing RNA-binding domains. Cell 89: 737-745.
44. Montminy, M. 1997. Something new to hang your HAT on. Nature 387: 654-655.
45. Nakai, K. and M. Kanehisa. 1992. A knowledge base for predicting protein localization sites in eukaryotic cells. Genomics 14: 897-911.
46. Peng, J. and N.P. Harberd. 1993. Derivative alleles of the Arabidopsis gibberellin-insensitive (gai) mutation confer a wild-type phenotype. Plant Cell 5: 351-360.
47. _. 1997. Gibberellin deficiency and response mutations suppress the stem elongation phenotype of phytochrome-deficient mutants of Arabidopsis. Plant Physiol. 113: 1051-1058.
48. Phillips, A.L., D.A. Ward, S. Uknes, N.E.J. Appleford, T. Lange, A.K. Huttly, P. Gaskin, J.E. Graebe, and P. Hedden. 1995. Isolation and expression of three gibberellin 20-oxidase cDNA clones from Arabidopsis. Plant Physiol. 108: 1049-1057.
49. Potts, W.C., J.B. Reid, and I.C. Murfet. 1985. Internode length in Pisum. Gibberellins and the slender phenotype. Physiol Plant. 63: 357-364.
50. Putterill, J., F. Robson, K. Lee, and G. Coupland. 1993. Chromosome walking with YAC clones in Arabidopsis: Isolation of 1700 kb of contiguous DNA on chromosome 5, including a 300-kb region containing the flowering-time gene CO. Mol. Gen. Genet. 239: 145-157.
51. Putterill, J., F. Robson, K. Lee, R. Simon, and G. Coupland. 1995. The CONSTANS gene of Arabidopsis promotes flowering and encodes a protein showing similarities to zinc finger transcription factors. Cell 80: 847-857.
52. Raikhel, N. 1992. Nuclear targeting in plants. Plant Physiol. 100: 1627-1632.
53. Robbins, J., S.M. Dilworth, R.A. Laskey, and C. Dingwall. 1991. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence. Cell 64: 615-623.
54. Roe, J.L., C.J. Rivin, R.A. Sessions, K.A. Feldmann, and P.C. Zambryski. 1993. The Tousled gene in A. thaliana encodes a protein kinase homolog that is required for leaf and flower development. Cell 75: 939-950.
55. Roe, J.L., T. Durfee, J.R. Zupan, P.P Repetti, B.G. McLean, and P.C. Zambryski. 1997. TOUSLED is a nuclear serine/threonine protein kinase that requires a coiled-coil region for oligomerization and catalytic activity. J. Biol. Chem. 272: 5838-5845.
56. Ross, J.J. 1994. Recent advances in the study of gibberellin mutants. Plant Growth Regul. 15: 193-206.
57. Schaller, G.E. and A.B. Bleecker. 1995. High-affinity binding sites for ethylene are generated in yeast expressing the Arabidopsis ETR1 gene. Science 270: 1809-1811.
58. Silverstone, A.L., P.Y.A. Mak, E.G. Martínez, and T.-p. Sun. 1997. The new RGA locus encodes a negative regulator of gibberellin response in Arabidopsis thaliana. Genetics 146: 1087-1099.
59. Smith, S.J., R.P. Walker, M.H. Beale, and R. Hooley. 1993. Biological activity of some gibberellins and gibberellin derivatives in aleurone cells and protoplasts of Avena fatua. Phytochemistry 33: 17-20.
60. Sun, T.-p. and Y. Kamiya. 1994. The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. Plant Cell 6: 1509-1518.
61. Swain, S.M. and N.E. Olszewski. 1996. Genetic analysis of gibberellin signal transduction. Plant Physiol. 112: 11-17.
62. Talon, M., M. Koornneef, and J.A.D. Zeevaart. 1990a. Endogenous gibberellins in Arabidopsis thaliana and possible steps blocked in the biosynthetic pathways of the semidwarf ga4 and ga5 mutants. Proc. Natl. Acad. Sci. 87: 7983-7987.
63. Talon, M., M. Koornneef, and J.A.D. Zeevaart. 1990b. Accumulation of C19-gibberellins in the gibberellin-insensitive dwarf mutant gai of Arabidopsis thaliana (L.) Hehyn. Planta 182: 501-505.
64. Torchia, J., D.W. Rose, J. Inostroza, Y. Kamei, S. Westin, C.K. Glass, and M.G. Rosenfeld. 1997. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677-684.
65. Whitelam, G.C., E. Johnson, J. Peng, P. Carol, M.L. Anderson, J.S. Cowl, and N.P. Harberd. 1993. Phytochrome A null mutants of Arabidopsis display a wild-type phenotype in white light. Plant Cell 5: 757-768.
66. Wilson, R.N. and C. Somerville. 1995. Phenotypic suppression of the gibberellin-insensitive mutant (gai) of Arabidopsis. Plant Physiol. 108: 495-502.
67. Wilson, R.N., J.W. Heckman, and C. Somerville. 1992. Gibberellin is required for flowering in Arabidopsis thaliana under short days. Plant Physiol. 100: 403-408.
68. Winkler, R.G. and M. Freeling. 1994. Physiological genetics of the dominant gibberellin-nonresponsive maize dwarfs, Dwarf8 and Dwarf9. Planta 193: 341-348.
69. Xu, Y-L., L. Li, K. Wu, A.J.M. Peeters, D.A. Gage, and J.A.D. Zeevaart. 1995. The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: Molecular cloning and functional expression. Proc. Natl. Acad. Sci 92: 6640-6644.