Protein and amino acid metabolism in splanchnic organs in metabolic acidosis

Mineral and Electrolyte Metabolism

Volumn 23, Issue 3-6, 1997, Pages 229-233

  Deferrari, Giacomo ^a   Garibotto, Giacomo ^b   Robaudo, Cristina ^b   Saffioti, Stefano ^b   Russo, Rodolfo ^b   Sofia, Antonella ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b NONE

Author keywords

Amino acids; Ammonia; Proteins; Splanchnic organs; Urea

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

AMINO ACID TRANSPORT; AMMONIA FORMATION; CONFERENCE PAPER; HUMAN; LIVER METABOLISM; METABOLIC ACIDOSIS; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPLANCHNIC NERVE; UREA CYCLE;

ACIDOSIS; AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; GLUTAMINE; GROWTH HORMONE; HUMANS; PROTEINS; UREA; VISCERA;

EID: 0030707590     PISSN: 03780392     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (38)

1. Halperin ML, Etheir JH, Kamel KS: Ammonium excretion in chronic metabolic acidosis: Benefits and risks. Am J Kidney Dis 1989;14:267-271.
2. Reaich D, Price SR, England BK, Mitch WE: Mechanisms causing muscle loss in chronic renal failure. Am J Kidney Dis 1995;26:242-247.
3. Alpern RJ: Trade-off in the adaptation to acidosis. Kidney Int 1995;47:1205-1215.
4. Cohen PP: Regulation of the ornithine-urea cycle enzymes; in Waterlow JC, Stephen JML (eds): Nitrogen Metabolism in Man. London, Applied Science, 1981, pp 215-228.
5. Keeton RW: Ammonia excretion following experimental administration of acids via the stomach and peripheral vein. J Biol Chem 1921;49:411-427.
6. Oliver J, Bourke E: Adaptations in urea and ammonium excretion in metabolic acidosis in the rat: A reinterpretation. Clin Sci Mol Med 1975;48:515-520.
7. 3 on the excretion of urea and ammonium in man. Eur J Clin Invest 1977;7:587-589.
8. Meijer AJ, Lamers WH, Chamuleau RAFM: Nitrogen metabolism and ornithine cycle function. Physiol Rev 1990;70:701-748.
9. Kamemoto ES, Atkinson DE: Modulation of the activity of rat liver acetylglutamate synthase by pH and arginine concentration. Arch Biochem Biophys 1985;243:100-107.
10. -, pH and the activity of carbonic anhydrase. Eur J Biochem 1985;152:381-386.
11. Rémésy C, Demigné C, Fafournoux P: Control of ammonia distribution ratio across the liver cell membrane and of ureagenesis by extracellular pH. Eur J Biochem 1986;158:283-288.
12. Sobol S, Lenzen C, Haussinger A: Regulation of glutamine transport in isolated perfused rat liver. J Hepatol 1987;4(suppl 1):44.
13. Atkinson DE, Bourke E: The role of ureagenesis in pH homeostasis. Trends Biochem Sci 1984;9:297-300.
14. Dubose TD Jr, Cogan MG, Rector FC Jr: Acid-base disorders; in Brenner BM (ed): The Kidney. Philadelphia, Saunders, 1996, vol 22, pp 929-998.
15. Kilberg MS, Handlogten ME, Christensen HN: Characteristics of an amino acid transport system in rate liver for glutamine, asparagine, histidine, and closely related analogs. J Biol Chem 1980;225:4011-4019.
16. Sestoft LP, Bartels PO, Folke M: Pathophysiology of metabolic acidosis: Effect of low pH on the hepatic uptake of lactate, pyruvate and alanine. Clin Physiol 1982;2:51-58.
17. Cupisti A, Baker F, Brown J, Lock C, Bevington A, Harris KPG, Walls J: Effects of acid loading on serum amino acid profiles and muscle composition in normal fed rats. Clin Sci 1993;85:445-449.
18. Boon L, Blommaart PJE, Meijer AJ, Lamers WH, Schoolwerth AC: Effect of chronic acidosis on hepatic amino acid uptake and gene regulation: Implication for control of acid-base balance. Contrib Nephrol, Basel, Karger, vol 110, pp 138-143.
19. Garibotto G, Deferrari G, Robaudo C, Saffioti S, Salvidio G, Paoletti E, Tizianello A: Effect of amino acid ingestion on blood amino acid levels in patients with chronic renal failure. Am J Clin Nutr 1987;46:949-954.
20. Garibotto G, Deferrari G, Robaudo C, Saffioti S, Paoletti E, Pontremoli R, Tizianello A: Effects of a protein meal on blood amino acid profile in patients with chronic renal failure. Nephron 1993;64:216-225.
21. Deferrari G, Garibotto G, Robaudo C, Sala MR, Tizianello A: Splanchnic exchange of amino acid after amino acid ingestion in patients with chronic renal insufficiency. Am J Clin Nutr 1988;48:72-83.
22. Young VR, Yu Y: Protein and amino acid metabolism; in Fischer JE (ed): Nutritional and Metabolism in the Surgical Patients. Boston, Little, Brown, 1996, pp 159-201.
23. Ballmer PE, Ballmer-Hofer K, Repond F, Kohler H, Studer H: Acute suppression of albumin synthesis in systemic inflammatory disease: An individual graded response of rat hepatocytes. J Histochem Cytochem 1992;40:201.
24. Deferrari G, Garibotto G, Robaudo C, Saffioti S, Russo R, Sala MR, Bruzzone M, Tizianello A: Renal ammoniagenesis and interorgan flow of glutamine in chronic metabolic acidosis. Contrib Nephrol. Basel, Karger, vol 110, pp 144-149.
25. Garibotto G, Deferrari G, Robaudo C, Saffioti S, Sofia A, Russo R, Tizianello A: Disposal of exogenous amino acids by muscle in patients with chronic renal failure. Am J Clin Nutr 1995;62:136-142.
26. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Bruzzone M, Passerone GC: Renal ammoniagenesis during the adaptation to metabolic acidosis in man; in Tannen RL, Goldstein L, Lemieux G, Simpson D, Vinay P (eds): Renal Ammonia Metabolism. Contrib Nephrol. Basel, Karger, vol 31, pp 40-46.
27. Welbourne TC, Joshi S: Interorgan glutamine metabolism during acidosis. J Parent Enter Nutr 1990;14:778-858.
28. Schrock H, Goldstein L: Interorgan relationships for glutamine metabolism in normal and acidotic rats. Am J Physiol 1981;240:E519-E525.
29. Tizianello A, Deferrari G, Garibotto G, Gurreri G: Effects of chronic renal insufficiency and metabolic acidosis on glutamine metabolism in man. Clin Sci Mol Med 1978;55:391-397.
30. Tessari P, Garibotto G, Inchiostro S, Robaudo C, Saffioti S, Vettore M, Zanetti M, Russo R, Deferrari G: Kidney, splanchnic, and leg protein turnover in humans: Insight from leucine and phenylalanine kinetics. J Clin Invest 1996;98:1481-1492.
31. Garlick PJ: The effect of protein deprivation and starvation on the rate of protein synthesis in tissues of the rat. Biochem Biophys Acta 1975;414:71-79.
32. Levenson SM, Imegwu OJ, Cang TH: Starvation: Metabolic and physiologic responses; in Fischer JE (ed): Nutrition and Metabolism in the Surgical Patient. Boston, Little, Brown, 1996, pp 523-576.
33. Addis T, Poo LJ, Lew W: The quantities of protein lost by the various organs and tissues of the body during a fast. J Biol Chem 1936;115:111-116.
34. Ballmer PE, McNurlan MA, Hulter HN, Anderson SE, Garlick PJ, Krapf R: Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans. J Clin Invest 1995;95:39-45.
35. May RC, Masud T, Logue B, Bailey J, England B: Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats. Kidney Int 1992;41:1535-1542.
36. Krieg RJ Jr, Santos F, Chan JCM: Growth hormone, insulin-like growth factor and the kidney. Kidney Int 1995;48:321-336.
37. Fryburg DA: Insulin-like growth factor-1 exerts growth hormone- and insulin-like actions on human muscle protein metabolism. Am J Physiol 1994;267:E331-E336.
38. Challa A, Chan W, Krieg RJ Jr, Thabet MA, Liu F, Hintz RL, Chan JCM: Effect of metabolic acidosis on the expression of insulin-like growth factor and growth hormone receptor. Kidney Int 1993;44:1224-1227.