Aerosolized surfactant inhibits acetylcholine-induced airway obstruction in rats

European Respiratory Journal

Volumn 10, Issue 10, 1997, Pages 2198-2203

  Hohlfeld, J ^a,b   Hoymann, H G ^a   Molthan, J ^a   Fabel, H ^b   Heinrich, U ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Aerosol; asthma; Bronchoconstriction; Inhalation; Obstructive lung disease; Pulmonary surfactant

Indexed keywords

ACETYLCHOLINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; LUNG SURFACTANT; SURFACTANT; TERBUTALINE;

AEROSOL; AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; FEMALE; GUINEA PIG; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRACHEA MUSCLE;

ACETYLCHOLINE; ADMINISTRATION, INHALATION; ADRENERGIC BETA-AGONISTS; AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ANALYSIS OF VARIANCE; ANIMALS; BRONCHOCONSTRICTION; DISEASE MODELS, ANIMAL; FEMALE; LIPIDS; PHOSPHOLIPIDS; PULMONARY SURFACTANTS; RATS; RATS, WISTAR; REFERENCE VALUES; RESPIRATORY FUNCTION TESTS; SURFACE PROPERTIES; TERBUTALINE;

EID: 0030702771     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.97.10102198     Document Type: Article

References (34)

1. Macklem PT, Proctor DF, Hogg JC. The stability of peripheral airways. Respir Physiol 1970; 8: 191-203.
2. Liu M, Wang L, Li E, Enhorning G. Pulmonary surfactant will secure free airflow through a narrow tube. J Appl Physiol 1991; 71: 742-748.
3. Enhorning G, Duffy LC, Welliver RC. Pulmonary surfactant maintains patency of conducting airways in the rat. Am J Respir Crit Care Med 1995; 151: 554-556.
4. Hohlfeld J, Fabel H, Hamm H. The role of pulmonary surfactant in obstructive airways disease. Eur Respir J 1997; 10: 482-491.
5. Schürch S, Gehr P, Im Hof V, Geiser M, Green F. Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol 1990; 80: 17-32.
6. van Iwaarden JF. Surfactant and the pulmonary defense system. In: Robertson B, van Golde LMG, Batenburg JJ, eds. Pulmonary Surfactant. From Molecular Biology to Clinical Practice. Amsterdam-London-New York-Tokyo, Elsevier, 1992; pp. 215-227.
7. McFadden ERJ, Gilbert IA. Asthma. N Engl J Med 1992; 327: 1928-1937.
8. Seeger W, Grube C, Günther A, Schmidt R. Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations. Eur Respir J 1993; 6: 971-977.
9. Becher G. Lung surfactant prevents allergic bronchial constriction in ovalbumin sensitized guinea-pigs. Biomed Biochim Acta 1985; 44: K57-K61.
10. Liu M, Wang L, Li E, Enhorning G. Pulmonary surfactant given prophylactically alleviates an asthma attack in guinea-pigs. Clin Exp Allergy 1996; 26: 270-275.
11. Kurashima K, Ogawa H, Ohka T, Fujimura M, Matsuda T, Kobayashi T. A pilot study of surfactant inhalation in the treatment of asthmatic attack. Aerugi (Jpn J Allergol) 1991; 40: 160-163.
12. Hoymann HG, Heinrich U, Beume R, Kilian U. Comparative investigation of the effects of zardaverine and theophylline on pulmonary function in rats. Exp Lung Res 1994; 20: 235-250.
13. Flüge T, Hoymann HG, Hohlfeld J, et al. Type A natriuretic peptide exhibits different bronchoprotective effects in rats. Eur J Pharmacol 1994; 271: 395-402.
14. Enhorning G. Pulsating bubble technique for evaluating pulmonary surfactant. J Appl Physiol: Respirat Environ Exercise Physiol 1977; 43: 198-203.
15. Snedecor GW, Cochran WG. One-way classifications: analysis of variance. In: Statistical methods. 6th Edn. Ames (Iowa), Iowa State University Press, 1967; pp. 258-298.
16. Wright JR, Wager RE, Hamilton RL, Huang M, Clements JA. Uptake of lung surfactant subfractions into lamellar bodies of adult rabbit lungs. J Appl Physiol 1986; 60: 817-825.
17. Pettenazzo A, Jobe A, Ikegami M, Abra R, Hogue E, Mihalko P. Clearance of phosphatidylcholine and cholesterol from liposomes, liposomes loaded with metaproterenol and rabbit surfactant from adult rabbit lungs. Am Rev Respir Dis 1989; 139: 752-758.
18. Jacobs H, Jobe A, Ikegami M, Jones S. Surfactant phosphatidylcholine sources, fluxes, and turnover times in 3 day old, 10 day old, and adult rabbits. J Biol Chem 1982; 257: 1805-1810.
19. So KL, Gommers D, Lachmann B. Bronchoalveolar surfactant and intratracheal adrenaline. Lancet 1993; 341: 120-121.
20. Schürmann WHT, Hohlfeld J, Muhle H, Fabel H. Oxidative damage of rat type II pneumocytes and alveolar macrophages: protective effect of surfactant. Eur Respir J 1995; 8: 464s.
21. Lichtenberger LM, Graziani LA, Dial EJ, Butler BD, Hills BA. Role of surface active phospholipids in gastric cytoprotection. Science 1983; 219: 1327-1329.
22. Lugea A, Mourelle M, Guarner F, Domingo A, Salas A, Malagelada JR. Phosphatidylcholines as mediators of adaptive cytoprotection of the rat duodenum. Gastroenterology 1994; 107: 720-727.
23. Hills BA. Oesophageal surfactant: evidence for a possible mucosal barrier on oesophageal epithelium. Aust NZ J Med 1994; 24: 41-46.
24. Goddard PJ, Kao YJ, Lichtenberger LM. Luminal surface hydrophobicity of canine gastric mucosa is dependent on a surface mucous gel. Gastroenterology 1990; 98: 361-370.
25. Gerde P, Muggenburg BA, Sabourin PJ, et al. Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog. II. The conducting airways. Toxicol Appl Pharmacol 1993; 121: 319-327.
26. Hills BA. Asthma: is there an airway receptor barrier? Thorax 1996; 51: 773-776.
27. van't Veen A, Mouton JW, Gommers D, Kluytmans JA, Dekkers P, Lachmann B. Influence of pulmonary surfactant on in vitro bactericidal activities of amoxycillin, ceftazidime and tobramycin. Antimicrob Agents Chemother 1995; 39: 329-333.
28. Bredenberg CE, Paskanik AM, Nieman GF. High surface tension pulmonary edema. J Surg Res 1983; 34: 515-523.
29. Kaneko T, Sato T, Katsuya H, Miyauchi Y. Surfactant therapy for pulmonary edema due to intratracheally-injected bile acid. Crit Care Med 1990; 18: 77-83.
30. Oetomo SB, Dorrepaal C, Bos H, et al. Surfactant nebulization does not alter airflow obstruction and bronchial responsiveness to histamine in asthmatic children. Am J Respir Crit Care Med 1996; 153: 1148-1152.
31. Raabe OG, Al-Bayati MA, Teague SV, Rasolt A. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann Occup Hyg 1988; 32: 53-63.
32. Jobe A, Ikegami M. Surfactant for the treatment of respiratory distress syndrome. Am Rev Respir Dis 1987; 136: 1256-1275.
33. Mason RJ. Surfactant secretion. In: Robertson B, van Golde LMG, Batenburg JJ, eds. Pulmonary Surfactant: From Molecular Biology to Clinical Practice. Amsterdam-London-New York-Tokyo, Elsevier, 1992: pp. 295-312.
34. Effros RM, Feng NH, Mason G, Sietsema K, Silverman P, Hukkanen J. Solute concentrations of pulmonary epithelial lining fluid of anesthetized rats. J Appl Physiol 1990; 68: 275-281.