-
1
-
-
0001102999
-
Liquefaction of viscous purulent exudates by deoxyribonuclease
-
Amstrong JB, White JC. Liquefaction of viscous purulent exudates by deoxyribonuclease. Lancet 1950; 11: 739-42
-
(1950)
Lancet
, vol.11
, pp. 739-742
-
-
Amstrong, J.B.1
White, J.C.2
-
2
-
-
0004418587
-
Deoxyribonuclease in the treatment of purulent bronchitis
-
Elmes PC, White JC. Deoxyribonuclease in the treatment of purulent bronchitis. Thorax 1953; 8: 295-300
-
(1953)
Thorax
, vol.8
, pp. 295-300
-
-
Elmes, P.C.1
White, J.C.2
-
3
-
-
0001307488
-
Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis
-
Chernick WS, Barbero GJ. Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis. Pediatrics 1959; 24: 739-45
-
(1959)
Pediatrics
, vol.24
, pp. 739-745
-
-
Chernick, W.S.1
Barbero, G.J.2
-
4
-
-
0001513063
-
Composition of pulmonary secretions from patients with and without cystic fibrosis
-
Potter J, Matthews LW, Lemm J, et al. Composition of pulmonary secretions from patients with and without cystic fibrosis. Am J Dis Child 1960; 100: 493-5
-
(1960)
Am J Dis Child
, vol.100
, pp. 493-495
-
-
Potter, J.1
Matthews, L.W.2
Lemm, J.3
-
5
-
-
75549102827
-
Studies on pulmonary secretions. I. the overall composition of secretions from patients with cystic fibrosis. bronchiectasis, and laryngectomy
-
Matthews LW, Spector S, Lemm J, et al. Studies on pulmonary secretions. I. The overall composition of secretions from patients with cystic fibrosis. bronchiectasis, and laryngectomy. Am Rev Respir Dis 1963; 88: 199-204
-
(1963)
Am Rev Respir Dis
, vol.88
, pp. 199-204
-
-
Matthews, L.W.1
Spector, S.2
Lemm, J.3
-
6
-
-
0017892815
-
Pus deoxyribonucleic acid and sputum viscosity
-
Picot R, Das I, Reid L. Pus deoxyribonucleic acid and sputum viscosity. Thorax 1978; 33: 235-42
-
(1978)
Thorax
, vol.33
, pp. 235-242
-
-
Picot, R.1
Das, I.2
Reid, L.3
-
7
-
-
0025181636
-
The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum
-
Lethem MI, James SL, Marriott C, et al. The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum. Eur Respir J 1990; 3: 19-23
-
(1990)
Eur Respir J
, vol.3
, pp. 19-23
-
-
Lethem, M.I.1
James, S.L.2
Marriott, C.3
-
8
-
-
0014434254
-
Dornase aerosol effect on sputum viscosity in cases of cystic fibrosis
-
Lieberman J. Dornase aerosol effect on sputum viscosity in cases of cystic fibrosis. J Am Med Assoc 1968; 205: 312-13
-
(1968)
J Am Med Assoc
, vol.205
, pp. 312-313
-
-
Lieberman, J.1
-
9
-
-
0014340449
-
Bronchospasm after inhalation of pancreatic dornase
-
Raskin P. Bronchospasm after inhalation of pancreatic dornase. Am Rev Respir Dis 1968; 98: 697-8
-
(1968)
Am Rev Respir Dis
, vol.98
, pp. 697-698
-
-
Raskin, P.1
-
10
-
-
0025647882
-
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum
-
Shak S, Capon DJ, Hellmiss R, et al. Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. Proc Natl Acad Sci USA 1990; 87: 9188-92
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 9188-9192
-
-
Shak, S.1
Capon, D.J.2
Hellmiss, R.3
-
11
-
-
0028901356
-
Dose-dependent in vitro effect of recombinant human DNase on rheological and transport properties of cystic fibrosis respiratory mucus
-
Zahm JM, Girod de Bentzmann S, Deneuville E, et al. Dose-dependent in vitro effect of recombinant human DNase on rheological and transport properties of cystic fibrosis respiratory mucus. Eur Respir J 1995; 8: 381-6
-
(1995)
Eur Respir J
, vol.8
, pp. 381-386
-
-
Zahm, J.M.1
Girod de Bentzmann, S.2
Deneuville, E.3
-
12
-
-
0030027655
-
In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis
-
Shah PL, Scott SF, Knight RA, et al. In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis. Thorax 1996; 51: 119-25
-
(1996)
Thorax
, vol.51
, pp. 119-125
-
-
Shah, P.L.1
Scott, S.F.2
Knight, R.A.3
-
13
-
-
0016726156
-
Physical properties of sputum. VII. Rheologic properties and mucociliary transport
-
Dulfano MJ, Adler KB. Physical properties of sputum. VII. Rheologic properties and mucociliary transport. Am Rev Respir Dis 1975; 112: 341-7
-
(1975)
Am Rev Respir Dis
, vol.112
, pp. 341-347
-
-
Dulfano, M.J.1
Adler, K.B.2
-
14
-
-
0019171071
-
Drug effects on visco-elasticity of mucus
-
Puchelle E, Zahm JM, Polu JM, et al. Drug effects on visco-elasticity of mucus. Eur J Respir Dis 1980; 61 Suppl. 110: 195-208
-
(1980)
Eur J Respir Dis
, vol.61
, Issue.110 SUPPL.
, pp. 195-208
-
-
Puchelle, E.1
Zahm, J.M.2
Polu, J.M.3
-
15
-
-
0017406248
-
Effect of nondialyzable solids concentration and viscoelasticity on ciliary transport of tracheal mucus
-
Shih CK, Litt M, Khan MA, et al. Effect of nondialyzable solids concentration and viscoelasticity on ciliary transport of tracheal mucus. Am Rev Respir Dis 1977; 115: 989-95
-
(1977)
Am Rev Respir Dis
, vol.115
, pp. 989-995
-
-
Shih, C.K.1
Litt, M.2
Khan, M.A.3
-
16
-
-
0016311999
-
On the transport of mucus and its rheologic stimulants in ciliated systems
-
King M, Gilboa A, Meyer FA, et al. On the transport of mucus and its rheologic stimulants in ciliated systems. Am Rev Respir Dis 1974; 110: 740-5
-
(1974)
Am Rev Respir Dis
, vol.110
, pp. 740-745
-
-
King, M.1
Gilboa, A.2
Meyer, F.A.3
-
17
-
-
0030034674
-
Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis
-
Laube BL, Auci RA, Shields DE, et al. Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis. Am J Respir Crit Care Med 1996; 153: 752-60
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 752-760
-
-
Laube, B.L.1
Auci, R.A.2
Shields, D.E.3
-
18
-
-
0028129568
-
Effect of aerosolised recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis
-
Fuchs HJ, Borowitz DS, Christiansen DH, et al. Effect of aerosolised recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. N Engl J Med 1994; 331: 637-42
-
(1994)
N Engl J Med
, vol.331
, pp. 637-642
-
-
Fuchs, H.J.1
Borowitz, D.S.2
Christiansen, D.H.3
-
19
-
-
0027181325
-
Efficacy and safety of short-term administration of aerosolised recombinant human DNase 1 in adults with stable stage cystic fibrosis
-
Ranasinha C, Assoufi B, Shak S, et al. Efficacy and safety of short-term administration of aerosolised recombinant human DNase 1 in adults with stable stage cystic fibrosis. Lancet 1993; 342: 199-202
-
(1993)
Lancet
, vol.342
, pp. 199-202
-
-
Ranasinha, C.1
Assoufi, B.2
Shak, S.3
-
20
-
-
0027278897
-
Efficacy and safety of short-term administration of aerosolised recombinant human deoxyribonuclease in patients with cystic fibrosis
-
Ramsey BW, Astley SJ, Aitken ML, et al. Efficacy and safety of short-term administration of aerosolised recombinant human deoxyribonuclease in patients with cystic fibrosis. Am Rev Respir Dis 1993; 148: 145-51
-
(1993)
Am Rev Respir Dis
, vol.148
, pp. 145-151
-
-
Ramsey, B.W.1
Astley, S.J.2
Aitken, M.L.3
-
21
-
-
0027395872
-
The changing epidemiology of cystic fibrosis
-
FitzSimmons SC. The changing epidemiology of cystic fibrosis. J Pediatr 1991; 122: 1-9
-
(1991)
J Pediatr
, vol.122
, pp. 1-9
-
-
Fitzsimmons, S.C.1
-
22
-
-
0029067641
-
Recombinant human DNase 1 (rhDNase) in cystic fibrosis patients with severe pulmonary disease: A short-term double-blind study followed by six months open-label treatment
-
Shah PL, Bush A, Canny GJ, et al. Recombinant human DNase 1 (rhDNase) in cystic fibrosis patients with severe pulmonary disease: a short-term double-blind study followed by six months open-label treatment. Eur Respir J 1995; 8: 954-8
-
(1995)
Eur Respir J
, vol.8
, pp. 954-958
-
-
Shah, P.L.1
Bush, A.2
Canny, G.J.3
-
23
-
-
9844247887
-
A multicentre, double-blind, placebo controlled study to evaluate the safety and efficacy of aerosolized rhDNase therapy in patients with cystic fibrosis who have advanced lung disease
-
Pulmozyme Severe Lung Disease Study Group
-
Johnson C, Pulmozyme Severe Lung Disease Study Group. A multicentre, double-blind, placebo controlled study to evaluate the safety and efficacy of aerosolized rhDNase therapy in patients with cystic fibrosis who have advanced lung disease [abstract]. Pediatr Pulmonol 1994; Suppl. 10: 115
-
(1994)
Pediatr Pulmonol
, Issue.10 SUPPL.
, pp. 115
-
-
Johnson, C.1
-
24
-
-
1542659481
-
Use of aerosolised dornase alfa in cystic fibrosis: Safety, patient selection and dosing
-
Schidlow DV. Use of aerosolised dornase alfa in cystic fibrosis: safety, patient selection and dosing. Dornase alfa Clin Ser 1994; 1 (3): 1-6
-
(1994)
Dornase Alfa Clin Ser
, vol.1
, Issue.3
, pp. 1-6
-
-
Schidlow, D.V.1
-
25
-
-
1542449822
-
Aerosolised dornase alfa in cystic fibrosis patients with clinically mild lung disease
-
Accurso FJ. Aerosolised dornase alfa in cystic fibrosis patients with clinically mild lung disease. Dornase alfa Clin Ser 1995; 2 (1): 1-6
-
(1995)
Dornase Alfa Clin Ser
, vol.2
, Issue.1
, pp. 1-6
-
-
Accurso, F.J.1
-
26
-
-
0026548151
-
A preliminary study of aerosolised recombinant human deoxyribonuclease I in the treatment of cystic fibrosis
-
Hubbard RC, McElvaney NG, Birrer P, et al. A preliminary study of aerosolised recombinant human deoxyribonuclease I in the treatment of cystic fibrosis. N Engl J Med 1992; 326: 812-5
-
(1992)
N Engl J Med
, vol.326
, pp. 812-815
-
-
Hubbard, R.C.1
McElvaney, N.G.2
Birrer, P.3
-
27
-
-
0028281360
-
Characterisation of aerosol of recombinant deoxyribonuclease I (rhDNase) generated by jet nebulisers
-
Cipolla D, Gonda I, Shire SJ. Characterisation of aerosol of recombinant deoxyribonuclease I (rhDNase) generated by jet nebulisers. Pharm Res 1994; 11: 491-8
-
(1994)
Pharm Res
, vol.11
, pp. 491-498
-
-
Cipolla, D.1
Gonda, I.2
Shire, S.J.3
-
28
-
-
0029046164
-
Comparison of three jet nebuliser aerosol delivery systems used to administer recombinant human DNase 1 to patients with cystic fibrosis
-
Fiel SB, Fuchs HJ, Johnson C, et al. Comparison of three jet nebuliser aerosol delivery systems used to administer recombinant human DNase 1 to patients with cystic fibrosis. Chest 1995; 108: 153-6
-
(1995)
Chest
, vol.108
, pp. 153-156
-
-
Fiel, S.B.1
Fuchs, H.J.2
Johnson, C.3
-
29
-
-
0030923835
-
An evaluation of two aerosol delivery systems for rhDNase
-
Shah PL, Scott SF, Geddes DM, et al. An evaluation of two aerosol delivery systems for rhDNase. Eur Respir J 1997; 10: 1261-6
-
(1997)
Eur Respir J
, vol.10
, pp. 1261-1266
-
-
Shah, P.L.1
Scott, S.F.2
Geddes, D.M.3
-
30
-
-
0028241757
-
Pharmaco-toxicological expert report: Pulmozyme (rhDNase)
-
Genentech Inc.
-
Green JD. Pharmaco-toxicological expert report: Pulmozyme (rhDNase), Genentech Inc. Hum Exp Toxicol 1994; 13 Suppl 1: S1-S42
-
(1994)
Hum Exp Toxicol
, vol.13
, Issue.1 SUPPL.
-
-
Green, J.D.1
-
31
-
-
8944262191
-
Aerosolised recombinant human DNase in hospitalised cystic fibrosis patients with acute pulmonary exacerbations
-
Wilmott RW, Amin RS, Colin AA, et al. Aerosolised recombinant human DNase in hospitalised cystic fibrosis patients with acute pulmonary exacerbations. Am J Respir Crit Care Med 1996; 153: 1914-7
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 1914-1917
-
-
Wilmott, R.W.1
Amin, R.S.2
Colin, A.A.3
-
32
-
-
0028283405
-
Lobar atelectasis in cystic fibrosis and treatment with recombinant human DNase I
-
Shah PL, Scott SF, Hodson ME. Lobar atelectasis in cystic fibrosis and treatment with recombinant human DNase I. Respir Med 1994; 88: 313-5
-
(1994)
Respir Med
, vol.88
, pp. 313-315
-
-
Shah, P.L.1
Scott, S.F.2
Hodson, M.E.3
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