Design and analysis of epidemiological studies of excess cancer among children exposed to Chernobyl radionuclides

Stem Cells

Volumn 15, Issue SUPPL. 2, 1997, Pages 211-230

  Peterson, Leif E ^a   Dreyer, ZoAnn E ^b   Plon, Sharon E ^b   Smith, Janice L ^c   Weinberg, Armin D ^a   Mccarthy, Philip L ^d  

^a Center for Cancer Immunology Research   (United States)

^b TEXAS CHILDREN S CANCER CENTER   (United States)

^c Lab for Genetic Services Inc   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Chernobyl; Childhood cancer; Cytogenetics; Dosimetry; Epidemiology

Indexed keywords

CHERNOBYL ACCIDENT; CHILDHOOD CANCER; CONFERENCE PAPER; CYTOGENETICS; ENVIRONMENTAL RADIOACTIVITY; EPIDEMIOLOGY; FALLOUT; GENETIC SUSCEPTIBILITY; HUMAN; RADIATION DOSE; RADIATION EXPOSURE;

EID: 0030697071     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.5530150730     Document Type: Conference Paper

References (82)

1. Plon SE, Peterson LE. Childhood Cancer, Heredity and the Environment. Chapter 2. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott-Raven, 1997.
2. Bender MA. Significance of chromosome abnormalities. In: Boice JD Jr., Fraumeni JF, eds. Radiation Carcinogenesis: Epidemiology and Biological Significance . New York: Raven Press, 1984.
3. Awa AA. Directly exposed survivors - chromosomal aberrations in peripheral blood lymphocytes. In: Shigematsu I, Ito C, Kamada N et al., eds. Effects of A-Bomb Radiation on the Human Body. Tokyo: Harwood, 1995.
4. Edwards AA, Lloyd DC, Prosser JS. Chromosome aberrations in human lymphocytes - a radiobiological review. In: Baverstock KF, Stather JW, eds. Low Dose Radiation: Biological Basis of Risk Assessment. London: Taylor and Francis, 1989.
5. Akiyama M, Nakamura N, Masayuki H et al. Somatic cell mutations in atomic bomb survivors. J Radiat Res 1991;32(suppl):278-282.
6. Miller RC, Brenner DJ, Randers-Pehrson G et al. The effects of temporal distribution of dose on oncogenic transformation by neutrons and charged particles of intermediate LET. Radiat Res 1990;124:562-567.
7. Schull WJ. Effects of atomic radiation: a half-century of studies from Hiroshima and Nagasaki. New York: Wiley-Liss 1995.
8. Neel JV, Schull WJ. The children of atomic bomb survivors. Washington, DC: National Academy Press, 1991.
9. Stewart A, Webb J, Giles D et al. Malignant disease in childhood and diagnostic irradiation in-utero. Lancet 1956;2:447.
10. Monson RR, MacMahon B. Prenatal x-ray exposure and cancer in children. In: Boice JD Jr., Fraumeni JF, eds. Radiation Carcinogenesis: Epidemiology and Biological Significance . New York: Raven, 1984.
11. Preston DL, Kusimi S, Tomonaga M et al. Cancer incidence in atomic bomb survivors. Part III: Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res 994;137:S68-S97.
12. Ron E, Lubin JH, Shore RE et al. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 1995;141:259-277.
13. Thompson DE, Mabuchi K, Ron E et al. Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987. Radiat Res 1994;137:S17-S67.
14. Bhatia S, Robisin LL, Oberlin O et al. Breast cancer and other second neoplasms after childhood Hodgkin's disease. New Engl J Med 1996;334:745-751.
15. Hawkins MM, Draper GJ, Kingston JE. Incidence of second primary tumors among childhood cancer survivors. Br J Cancer 1987;56:339-347.
16. Neglia JP, Meadows AT, Robison LL et al. Second neoplasms after acute lymphoblastic leukemia in childhood. New Engl J Med 1991;325:1330-1336.
17. Otake M, Schull WJ, Yoshimaru H. A Review Of Radiation-Related Brain Damage In The Prenatally Exposed Atomic Bomb Survivors. CR 4-89, Radiation Effects Research Foundation, Hiroshima, 1989.
18. Dunn K, Yoshimaru H, Otake M et al. Prenatal exposure to ionizing radiation and subsequent development of seizures. TR 13-88, Radiation Effects Research Foundation, Hiroshima, 1988.
19. Yoshimoto Y, Kato H, Schull WJ. Risk of cancer among in-utero children exposed to a-bomb radiation, 1950-84. TR 4-88, Radiation Effects Research Foundation, Hiroshima, 1988.
20. Prisyazhniuk A, Fedorenko Z, Okeanov A et al. Epidemiology of cancer in populations living in contaminated territories of Ukraine, Belarus, Russia after the Chernobyl accident. In: Karaoglou A, Desmet G, Kelly GN et al., eds. The Radiological Consequences of The Chernobyl Accident. European Commission Report EUR 16544 EN. European Commission, Luxembourg, 1996:909-921.
21. Cardis E, Okeanov AE. What is feasible and desirable in the epidemiologic follow-up of Chernobyl. In: Karaoglou A, Desmet G, Kelly GN et al., eds. The Radiological Consequences of theChernobyl Accident. European Commission Report EUR 16544 EN. European Commission, Luxembourg, 1996:835-850.
22. Yarilin AA, Belyakov IM, Kusmenok OI et al. Late T-cell deficiency in victims of the Chernobyl radiation accident: possible mechanisms of induction. Int J Radiat Biol 1993:519-528.
23. Padovani L, Appolloni M, Anzidei P et al. Do human lymphocytes exposed to the fallout of the Chernobyl accident exhibit adaptive response? Challenge with ionizing radiation. Mutat Res 1995;332:33-38.
24. Jensen RH, Langlois RG, Bigbee WL et al. Elevated frequency of Glycophorin A mutations in erythrocytes from Chernobyl accident victims. Radiat Res 1995;141:129-135.
25. Ivanov EP, Tolochko G, Lazarev VS et al. Child leukaemia after Chernobyl. Nature 1993;365:702.
26. Hjalmars Y, Kulldorff M, Gustafsson G. Risk of acute leukaemia in Sweden after the Chernobyl reactor accident. Br Med J 1994;309:154-157.
27. Auvinen A, Hakama M, Arvela H et al. Fallout from Chernobyl and incidence of childhood leukaemia in Finland, 1976-1992. Br Med J 1994;309:151-154.
28. Parkin DM, Cardis E, Masuyere E. Childhood leukaemia following the Chernobyl accident: the European Childhood Leukaemia-Lymphoma Incidence Study (ECLIS). Eur J Cancer 1992;29A:87-95.
29. Durkheim E. Suicide. New York: Free Press, 1951.
30. Robinson WS. Ecologic correlations and the behaviour of individuals. Am Sociol Rev 1950;15:351-357.
31. Machado SG, Land CE, McKay FW. Cancer mortality and radioactive fallout in southwestern Utah. Am J Epidemiol 1987;125:44-61.
32. Simon SL, Till JE, Lloyd RD et al. The Utah leukemia case-control study: dosimetry, methodology, and results. Health Phys 1995;68:460-471.
33. Stevens WS, Thomas DC, Lyon JL et al. Leukemia in Utah and radioactive fallout from the Nevada Test Site: a case-control study. J Am Med Assoc 1990;264:585-591.
34. Till JE, Simon SL, Kerber RL et al. The Utah thyroid cohort study: analysis of the dosimetry results. Health Phys 1995;68:472-483.
35. Kerber RA, Till JE, Simon SL et al. A cohort study of thyroid disease in relation to fallout from nuclear weapons testing. J Am Med Assoc 1993;270:2076-2082.
36. Land CE. The hazards of fallout or of epidemiological research? N Engl J Med 1979;300:431-432.
37. Land CE. Epidemiological studies of populations downwind from atmospheric weapons tests. Proceedings of the Annual Meeting of the National Council on Radiation Protection and Measurements. Bethesda, MD: National Council on Radiation Protection and Measurements. 1995.
38. Yoshimoto ZY, Ezaki H, Etoh R. Prevalence rate of thyroid diseases among autopsy cases of the atomic bomb survivors in Hiroshima, 1951-85. Radiat Res 1995;131:278-286.
39. Holm LE, Wiklund KE, Lundell GE et al. Cancer risk in a population examined with diagnostic doses of 131-I. J Natl Cancer Inst 1989;81:302-306.
40. Shore RE. Issues and epidemiological evidence regarding radiation-induced thyroid cancer. Radiat Res 1992;131:98-111.
41. Nikiforov Y, Gnepp DR. Pediatric thyroid cancer after the Chernobyl disaster. Pathomorphologic study of 84 cases (1991-1992) from the Republic of Belarus. Cancer 1994;74:748-766.
42. Mettler FA, Williamson MR, Royal HD et al. Thyroid nodules in the population living around Chernobyl. J Am Med Assoc 1992;268:616-619.
43. Tsyb AF, Parshkov EM, Ivanov VK et al. Disease indices of thyroid and their dose dependence in children and adolescents affected as a result of the Chernobyl accident. In: Nagataki S, ed. Nagasaki Symposium on Chernobyl: Update and Future. Amsterdam: Elsevier, 1994.
44. Demidchik EP, Kazakov VS, Astakhova LN et al. Thyroid cancer in children after the Chernobyl accident: clinical and epidemiological evaluation of 251 cases in the Republic of Belarus. In: Nagataki S, ed. Nagasaki Symposium on Chernobyl: Update and Future. Amsterdam: Elsevier, 1994.
45. Sobolev B, Likhtarev IA, Kairo I et al. Radiation risk assessment of thyroid cancer in Ukrainian children exposed due to Chernobyl. In: Karaoglou A, Desmet G, Kelly GN et al., eds. The Radiological Consequences of the Chernobyl accident. European Commission Report EUR 16544 EN. European Commission, Luxembourg, 1996:741-748.
46. Ito M, Yamashita S, Ashizawa K et al. Childhood thyroid diseases around Chernobyl evaluated by ultrasound examination and fine needle aspiration cytology. Thyroid 1995;5:365-368.
47. Hamilton TE, van Belle G, LoGerfo JP. Thyroid neoplasia in Marshall Islanders exposed to nuclear fallout. J Am Med Assoc 1987;258:629-636.
48. Spitalnik PF, Strauss FH. Patterns of human thyroid parenchymal reaction following low-dose childhood irradiation. Cancer 1978;41:1098-1105.
49. Becker FO, Economou SG, Southwick HW et al. Adult thyroid cancer after head and neck irradiation in infancy and childhood. Ann Intern Med 1975;83:347-351.
50. Tokunaga M, Land CE, Tokuoka S et al. Incidence of female breast cancer among atomic bomb survivors, 1950-1985. Radiat Res 1994;138:209-223.
51. Land CE. Studies of cancer and radiation dose among atomic bomb survivors - the example of breast cancer. J Am Med Assoc 1995;274:402-407.
52. Peltomaki P, Aaltonen LA, Sistonen P et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science 1993;260:810-812.
53. Vogel F, Motulsky AG. Human Genetics. Berlin: Springer-Verlag, 1996:438.
54. Swift M, Reitnauer P, Morrell D et al. Breast and other cancers in families with ataxia-telangiectasia. N Engl J Med 1987;316:1289-1294.
55. Savitsky K, Bar-Shira A, Gilad S et al. A single ataxia telangiectasia gene with a product similar to P1-3 kinase. Science 1995;268:1749-1753.
56. Swift M, Morrell D, Massey R et al. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 1991;325:1831-1836.
57. Malkin D, Li FP, Strong LC et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990;250:1233-1238.
58. Weinert T, Lydall D. Cell cycle checkpoints, genetic instability and cancer. Semin Cancer Biol 1993;4:129-140.
59. Liu B, Nicolaides NC, Markowitz S et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet 1995;9:48-55.
60. Ries LAG, Miller BA, Hankey BF et al. SEER Cancer Statistics Review, 1973-1991: Tables and Graphs, National Cancer Institute. No. 94-2789. Bethesda, MD: National Cancer Institute, 1994.
61. Peterson LE, Schull WJ, Davis BR et al. Information Bias and Lifetime Mortality Risks of Radiation-Induced Cancer. U. S. NRC NUREG Report GR-0011. Nuclear Regulatory Commission, Washington, DC, 1994.
62. Schlesselman JJ. Sample Size. Chap. 6. In: Case-Control Studies: Design, Conduct, Analysis. Oxford, New York, 1982.
63. Bailiff IK, Stepanenko V. Retrospective Dosimetry and Dose Reconstruction. Report EUR 16540 EN. European Commission, Brussels, 1996.
64. Skryabin AM, Masyakin VB, Osypenko et al. Distribution of doses received in rural areas affected by the Chernobyl accident. Report R277, National Radiological Protection Board, Chilton, 1995.
65. Likhtarev IA, Kovgan LN, Novak D et al. Effective doses due to external irradiation from the Chernobyl accident for different population groups of Ukraine. Health Phys 1996;70:87-98.
66. 137Cs after the Chernobyl accident. Report 1. General model: ingestion doses and countermeasure effectiveness for the adults of Rovno Oblast of Ukraine. Health Phys 1996;70:297-317.
67. Straume T, Lucas JN. A comparison of the yields of translocations and dicentrics measured using fluorescence in situ hybridization. Int J Radiat Biol 1993;64:185-187.
68. Heinze B, Arnold R, Rutzenloesevitz L et al. The role of stable chromosome aberrations as biological indicators of radiation effect - studies in patients after total body irradiation and bone marrow transplantation. STEM CELLS 1995;13(suppl 1):191-198.
69. Pilinskaya MA. The results of selective cytogenetic monitoring of Chernobyl accident victims in the Ukraine. Health Phys 1996;71:29-33.
70. Durante M, George K, Yang TC. Biological dosimetry by interphase chromosome painting. Radiat Res 1996;145:53-60.
71. Kulka U, Huber R, Muller P et al. Combined FISH painting and harlequin staining for cell cycle-controlled chromosome analysis inhuman lymphocytes. Int J Radiat Biol 1995;68:25-27.
72. Finnon P, Lloyd DC, Edwards AA. Fluorescence in situ hybridization detection of chromosomal aberrations in human lymphoctyes - applicability to biological dosimetry. Int J Radiat Biol 1995;68:429-435.
73. Blakely WF, Prasanna PGS, Kolanko CJ et al. Application of the premature chromosome condensation assay in simulated partial-body radiation exposures - evaluation of the use of an automated metaphase-finder. STEM CELLS 1995;13(suppl 1):223-230.
74. Evan JW, Liu XF, Kirchgessner CU et al. Induction and repair of chromosome aberrations in scid cells measured by premature chromosome condensation. Radiat Res 1996;145:39-46.
75. Peterson LE, Rosenstein M. Computer Program for Tissue Doses in Diagnostic Radiology (for VAX and PC Systems). Center for Devices and Radiological Health. Rockville, MD: Food and Drug Administration, 1989.
76. ICRP, Radiation Dose to Patients from Radiopharmaceuticals. Publication 53, Annals of the ICRP, International Commission on Radiological Protection. Oxford: Pergamon Press, 1988;18:14.
77. Peterson LE, Pepper LJ, Hamm PB et al. Longitudinal study of astronaut health: mortality in the years 1959-91. Radiat Res 1993;133:257-264.
78. Atwell WC, Hardy AC, Peterson LE. Organ radiation doses and lifetime risk of excess cancer for several Space Shuttle missions. Adv Space Res 1996;18.
79. Breslow NE, Day NE. Case-control sampling within a cohort, Section 7. 6, Chapter 7: Design Considerations. In: Statistical Methods in Cancer Research. Vol. II - The Design and Analysis of Cohort Studies. International Agency for Research on Cancer, Lyon, 1987.
80. Pike MC, Hill AP, Smith PG. Bias and efficiency in logistic analyses of stratified case-control studies. Int J Epidemiol 1980;9:89-95.
81. Hirji KF, Mehta CR, Patel NR. Exact inference for matched case-control studies. Biometrics 1988;44:803-814.
82. Preston DL, Pierce DA. EPICURE User's Guide and Command Language Summary. Seattle, WA: Hirosoft International Corporation, 1993.