Falsely high ionized magnesium results by an ion-selective electrode method in severe hypomagnesemia

European Journal of Clinical Chemistry and Clinical Biochemistry

Volumn 35, Issue 9, 1997, Pages 701-709

  Csako, Gyorgy ^a   Rehak, Nadja N ^a   Elin, Ronald J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM ION; CISPLATIN; INTERLEUKIN 2; MAGNESIUM; MAGNESIUM ION;

ADULT; ANALYTICAL ERROR; ARTICLE; CALCIUM BLOOD LEVEL; CALIBRATION; CHEMOMETRICS; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HYPOMAGNESEMIA; ION SELECTIVE ELECTRODE; MAGNESIUM BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PH; PRIORITY JOURNAL;

ADULT; CALCIUM; CALIBRATION; FEMALE; HUMANS; ION-SELECTIVE ELECTRODES; MAGNESIUM; MAGNESIUM DEFICIENCY; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; PHOSPHATES; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 0030695285     PISSN: 09394974     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Elin RJ. Magnesium metabolism in health and disease. Dis Month 1988; 34:161-219.
2. Romani A, Scarpa A. Regulation of cell magnesium. Arch Biochem Biophys 1992; 298:1-12.
3. 2+ and vascular contractility. Miner Electrolyte Metab 1993; 19:323-36.
4. Iseri LT, French JH. Magnesium: nature's physiologic calcium blocker. Am Heart J 1984; 208:188-93.
5. Speich M, Bousquet B, Nicolas G. Reference values for ionized, complexed, and protein-bound plasma magnesium in men and women. Clin Chem 1981; 27:246-8.
6. Altura BT, Altura BM. A method for distinguishing ionized, complexed and protein-bound Mg in normal and diseased subjects. Scand J Clin Lab Invest 1994; 54 Suppl 217:83-7.
7. Huijgen HJ, van Ingen HE, Kok WT, Sanders GTB. Magnesium fractions in serum of healthy individuals and CAPD patients, measured by an ion-selective electrode and ultrafiltration. Clin Biochem 1996; 29:261-6.
8. Greenway DC, Hindmarsh JT, Wang J, Khodadeen JA, Herbert PC. Reference interval for whole blood ionized magnesium in a healthy population and the stability of ionized magnesium under varied laboratory conditions. Clin Biochem 1996; 29:515-20.
9. Uesch U, Amman D, Simon W. Ion-selective electrodes for clinical use. Clin Chem 1986; 32:1448-59.
10. Ross JW. Calcium-selective electrode with liquid ion exchange. Science 1967; 156:1378-9.
11. Mueller M, Rouilly M, Rusterholz B, Maj-Zurawska M, Hu Z, Simon W. Magnesium selective electrodes for blood serum studies and water hardness measurement. Microchim Acta 1988; 1988111:283-90.
12. Rouilly M, Rusterholz B, Spichiger UE, Simon W. Neutral ionophore-based selective electrode for assaying the activity of ionized magnesium in undiluted blood serum. Clin Chem 1990; 36:466-9.
13. Marsoner HJ, Spichiger UE, Ritter C, Sachs C, Ghahramani M, Offenbacher H, et al. Measurement of ionized magnesium with neutral carrier based ISEs. Progress and results with the AVL 988-4 magnesium analyzer. Scand J Clin Lab Invest 1994; 54 Suppl 217:45-51.
14. Douzdjian V, Filos D, Okorodudu AO. Serum ionized magnesium changes during and immediately after liver transplantation. Ann Clin Lab Sei 1995; 25:297-305.
15. Cecco SA, Rehak NN. NOVA 8, NOVA 8+ analyzer comparison for ionized calcium, normalized calcium and pH [abstract], Clin Chem 1994; 40:1097-8.
16. Hristova EN, Cecco SA, Niemela JE, Rehak NN, Elin RJ. Analyzer-dependent differences in results for ionized calcium, ion-ized magnesium, sodium and pH. Clin Chem 1995; 41:1649-53.
17. Rehak NN, Cecco SA, Niemela JE, Hristova EN, Elin RJ. Linearity and stability of the AVL and NOVA magnesium and calcium ion-selective electrodes. Clin Chem 1996; 42:880-7.
18. Hristova EN, Rehak NN, Cecco S, Ruddel M, Herion D, Eckhardt M, et al. Serum ionized magnesium in chronic alcoholism: is it really decreased? Clin Chem 1997; 43:394-9.
19. Maj-Zurawska M, Kewenstam A. Fully automated potentiometric determination of ionized magnesium in blood serum. Anal Chim Acta 1990; 236:331-5.
20. Maj-Zurawska M, Hulanicki A, Drygieniec D, Pertkiewicz M. Ionized and total magnesium level in blood serum and plasma of healthy and ill adults. Elektroanalysis 1993; 5:713-7.
21. 2+. Scand J Clin Lab Invest 1994; 54 Suppl 217:37-43.
22. van Ingen HE, Huijgen HJ, Kok WT, Sanders TB. Analytical evaluation of KONE Microlyte determination of ionized magnesium. Clin Chem 1994; 40:52-5.
23. 2+. Scand J Clin Lab Invest 1994; 54 Suppl 217:69-76.
24. 2+. Scand J Clin Lab Invest 1994; 54 Suppl 217:77-81.
25. Külpmann WR, Rossler J, Brunkhorst R, Schuler A. Ionized and total magnesium serum concentrations in renal and hepatic diseases. Eur J Clin Chem Clin Biochem 1996; 34:257-64.
26. 2+ in whole blood, serum and plasma. Meth Find Exp Clin Pharmacol 1992; 14:297-304.
27. Handwerker SM, Altura BT, Royo B, Altura BM. Ionized serum magnesium levels in umbilical cord blood of normal pregnant women at delivery: relationship to calcium, demographics, and birthweight. Am J Perinatol 1993; 10:392-7.
28. Markell MS, Altura BT, Barbour RL, Altura BM. Ionized and total magnesium levels in cyclosporin-treated renal transplant recipients: relationship with cholesterol and cyclosporin levels. Clin Sei 1993; 85:315-8.
29. Altura Bt, Shirey TL, Young CC, Dell'Orfano K, Hiti J, Welsh R, et al. Characterization of a new ion-selective electrode for magnesium in whole blood, plasma, serum, and aqueous samples. Scand J Clin Lab Invest 1994; 54 Suppl 217:21-36.
30. 2+. Scand J Clin Lab Invest 1994; 54 Suppl 217:53-67.
31. Chernow B, Bamberger S, Stoiko M, Vadnais M, Mills S, Hoellerich V, et al. Hypomagnesemia in patients in postoperative intensive care. Chest 1989; 95:391-7.
32. Salem M, Kasinski N, Andrei AM, Brüssel T, Gold MR, Conn A, et al. Hypomagnesemia is a frequent finding in the emergency department in patients with chest pain. Arch Intern Med 1991; 151:2185-90.
33. Salem M, Muiz R, Chernow B. Hypomagnesemia in critical illness. A common and critically important problem. Crit Care Clin 1991; 7:225-52.
34. Ramage IJ, Ray M, Paton RD, Logan RW, Beattie TJ. Hypomagnesemic tetany. J Clin Pathol 1996; 49:343-4.
35. Niemela JE, Csako G, Bui MN, Elin RJ. Gender-specific correlation of platelet ionized magnesium and serum low-densitylipoprotein cholesterol concentrations in apparently healthy subjects. J Lab Clin Med 1997; 129:89-96.
36. Thode J, Holmegaard SN, Transbol I, Siggaard-Andersen O. Adjusted ionized calcium (at pH 7.4) and actual ionized calcium (at actual pH) in capillary blood compared for clinical evaluation of patients with disorders of calcium metabolism. ClinChem 1990; 3:541-4.
37. Broner CW, Stidham GL, Westenkirchner DF, Tolley EA. Hypermagnesemia and hypocalcemia as predictors of high mortality in critically ill pédiatrie patients. Crit Care Med 1990; 18:921-8.
38. Wong ET, Rude RK, Singer FR, Shaw ST Jr. A high prevalence of hypomagnesemia in hospitalized patients. Am J Clin Pathol 1983; 79:348-52.
39. Whang R. Magnesium deficiency: pathogenesis, prevalence and clinical implications. Am J Med 1987; 82 Suppl A:24-9.
40. Lum G. Hypomagnesemia in acute and chronic care patient populations. Am J Clin Pathol 1992; 92:827-30.
41. Schilsky RL, Anderson T. Hypomagnesemia and renal magnesium wasting in patients receiving cisplatin. Ann Intern Med 1979; 90:929-31.
42. Kozenyi GA, Nicolas JD, Creekmore S, Sticklin L, Hano JE, Fisher RI. Effects of interleukin-2 immunotherapy on renal function. J Clin Oncol 1988; 6:1170-6.
43. Webb DE, Austin HA III., Belldegrun A, Vaughan E, Linehan WM, Rosenberg SA. Metabolic and renal effects of interleukin-2 immunotherapy for metastatic cancer. Clin Nephrol 1988; 30:141-5.