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Papadopoulos I, Rudolph P, Weichert-Jacobsen K, Thiemann O, Papadopoulou D: Prognostic indicators for response to therapy and survival in patients with metastatic renal cell cancer treated with interferon alfa-2 beta and vinblastin. Urology 1996, 48:373-378.
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Natural immune reactivity-associated therapeutic response in patients with metastatic renal cell carcinoma receiving tumor-infiltrating lymphocytes and interleukin-2-based therapy
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Belldegrun A, Tso CL, Kaboo R, Pang S, Pierce W, Dekernion JB, Figlin R: Natural immune reactivity-associated therapeutic response in patients with metastatic renal cell carcinoma receiving tumor-infiltrating lymphocytes and interleukin-2-based therapy. J Immunother 1996, 19:149-161. The patient's baseline natural immune status seems to predict the clinical response to TIL and IL-2-based immunotherapy. The percentage of circulating NK cells and the presence of serum NK-cell-enhancing factors may serve as predictors of response.
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Cytogenetic studies in renal cell carcinoma patients receiving low-dose recombinant interleucin-2-based immunotherapy
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Therapy of locally recurrent renal cell carcinoma after nephrectomy
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Tanquay S, Pisters LL, Lawrence DD, Dinney CPN: Therapy of locally recurrent renal cell carcinoma after nephrectomy. J Urol 1996, 155:26-29. A retrospective evaluation of 16 patients with local tumour recurrence comparing surgical resection with a combined treatment with immunotherapy followed by surgery. A survival advantage for the combined therapy was seen.
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A phase I randomized study of subcutaneous adjuvant IL-2 in combination with an autologous tumor vaccine in patients with advanced renal cell carcinoma
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Fenton RG, Steis RG, Madara K, Zea AH, Ochoa AC, Janik JE, Smith JW, Gause BL, Sharfman WH, Urba WJ et al.: A phase I randomized study of subcutaneous adjuvant IL-2 in combination with an autologous tumor vaccine in patients with advanced renal cell carcinoma. J Immunother 1996, 19:364-374.
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Cytokines and tumor vaccination
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Anton P, Kirchner H, Jonas U, Atzpodien J: Cytokines and tumor vaccination. Cancer Biother & Radiopharmaceut 1996, 11:315-318. A total of 208 patients with locally advanced renal cell carcinoma were given adjuvant treatment with autologous, Newcastle disease virus-modified and lethally irradiated tumour cells in combination with low-dose IL-2 and IFN-α Compared with historical results, the data showed evidence for an improvement in disease-free survival.
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Walker LG, Wesnes KP, Heys SD, Walker MB, Lolley J, Eremin O: The cognitive effects of recombinant interleukin-2 (rIL-2) therapy: a controlled clinical trial using computerised assessments. Eur J Cancer 1996, 32A:2275-2283.
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Multiple cerebral lesions complicating therapy with interleukin-2
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Karp BI, Yang JC, Khorsand M, Wood R, Merigan TC: Multiple cerebral lesions complicating therapy with interleukin-2. Neurology 1996, 47:417-424.
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Khanna C, Hasz DE, Klausner JS, Anderson PM: Aerosol delivery of interleukin 2 liposomes is nontoxic and biologically effective: canine studies. Clin Cancer Res 1996, 2:721-734. By the use of aerosolized IL-2 liposomes, a favourable toxicity profile was obtained, which might be of value in increasing the tolerability of immunotherapy.
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Khanna, C.1
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