Modulation of the expression of integrins on glial cells during experimental autoimmune encephalomyelitis: A central role for TNF-α

American Journal of Pathology

Volumn 151, Issue 5, 1997, Pages 1425-1435

  Previtali, Stefano C ^a,b   Archelos, Juan J ^a   Hartung, Hans Peter ^a,c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTEGRIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; AUTOIMMUNITY; BRAIN BLOOD FLOW; CELL INFILTRATION; CELL INTERACTION; CENTRAL NERVOUS SYSTEM; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GLIA CELL; MONONUCLEAR CELL; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT;

ANIMALS; ASTROCYTES; BLOOD VESSELS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CEREBRAL CORTEX; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; INTEGRINS; NEUROGLIA; OLIGODENDROGLIA; RATS; RATS, INBRED LEW; REFERENCE VALUES; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030691752     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Raine CS: The neuropathology of multiple sclerosis. Multiple Sclerosis. Edited by CS Raine, HF McFarland, WW Tourtellotte. London, Chapman & Hall, 1997, pp 151-172
2. Adams CWM, Poston RN, Buk SJ: Pathology, histochemistry, and immunocytochemistry of lesions in acute multiple sclerosis. J Neurol Sci 1989, 92:291-306
3. Swanborg RH: Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clinical Immunol Immunopathol 1995, 77:4-13
4. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994, 76:301-314
5. Hynes RO: Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992, 69:11-25
6. Miyake S, Yagita H, Maruyama T, Hashimoto H, Miyasaka N, Okomura K: β1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients. J Exp Med 1993, 177:863-868
7. Yamada KM, Miyamoto S: Integrin transmembrane signaling and cytoskeletal control. Curr Opin Cell Biol 1995, 7:681-689
8. Archelos JJ, Jung S, Maurer M, Schmied M, Lassman H, Tamatani T, Miyasaka M, Toyka KV, Hartung H-P: Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. Ann Neurol 1993, 34:145-154
9. Yednock T, Cannon C, Fritz L, Sanchez-Madrid F, Steinman L, Karin N: Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature 1992, 356:63-66
10. Kent SJ, Karlik SJ, Cannon C, Hines DK, Yednock TA, Fritz LC, Horner HC: A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis. J Neuroimmunol 1995, 58:1-10
11. Kawai K, Kobayashi Y, Shiratori M, Sobue G, Tamatani T, Miyasaka M, Yoshikai Y: Intrathecal administration of antibodies against LFA-1 and against ICAM-1 suppresses experimental allergic encephalomyelitis in rats. Cell Immunol 1996, 171:262-268
12. Milner R, ffrench-Constant C: A developmental analysis of oligodendroglial integrins in primary cells: changes in αv-associated β subunits during differentiation. Development 1994, 120:3497-3506
13. Malek-Hedayat S, Rome LH: Expression of a β(1)-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination. J Cell Biol 1994, 124:1039-1046
14. Clark RAF, Tonnesen MG, Gailit J, Cheresh DA: Transient functional expression of αvβ3 on vascular cells during wound repair. Am J Pathol 1996, 148:1407-1421
15. Merrill JE, Benveniste EN: Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 1996, 19:331-338
16. Lider O, Hershkoviz R, Kachalsky SG: Interactions of migrating T lymphocytes, inflammatory mediators, and the extracellular matrix. Crit Rev Immunol 1995, 15:271-283
17. Issazadeh S, Ljungdahl A, Höjeberg B, Mustafa M, Olsson T: Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for IL-10, IL-12, cytolysin, TNF-α and TNF-β. J Neuroimmunol 1995, 61:205-212
18. Zitron I, Praveen Reddy B, Gould K, Stepaniak J, Swanborg R: Regulation of cytokine gene expression in experimental autoimmune encephalomyelitis. J Neurosci Res 1996, 46:438-444
19. Cannella B, Raine CS: The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 1995, 37:424-435
20. Rentzos M, Nikolau C, Rombos A, Voumvourakis K, Segditsa I, Papageorgiou C: Tumour necrosis factor-α is elevated in serum and cerebrospinal fluid in multiple sclerosis and inflammatory neuropathies. J Neurol 1996, 243:165-170
21. Kennedy MK, Torrance DS, Picha KS, Mohler KM: Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol 1992, 149: 2496-2505
22. Villarroya H, Violleau K, Younes-Chennoufi AB, Baumann N: Myelin-induced experimental allergic encephalomyelitis in Lewis rats: tumor necrosis factor-α levels in serum and cerebrospinal fluid immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord. J Neuroimmunol 1996, 64:55-61
23. Eylar E, Jackson J: Myelin basic protein. Methods Enzymol 1974, 32:323-341
24. McCarthy KD, De Vellis J: Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980, 85:890-902
25. Jefferies WA, Brandon MR, Hunt SV, Williams AF, Gatter KC, Mason DY: Transferrin receptor on endothelium of brain capillaries. Nature 1984, 312:162-163
26. Umezawa K, Asakura S, Jin Y, Matsuda M: Localization of vitronectin-and fibronectin-receptors on cultured human gliomas cells. Brain Res 1994, 659:23-32
27. Previtali S, Quattrini A, Nemni R, Truci G, Ducati A, Wrabetz L, Canal N: α6β4, and α6β1 integrins in astrocytomas, and other CNS tumors. J Neuropathol Exp Neurol 1996, 55:456-465
28. Paulus W, Baur I, Schuppan D, Roggendorf W: Characterization of integrin receptors in normal and neoplastic human brain. Am J Pathol 1993, 143:154-163
29. Tawil NJ, Wilson P, Carbonetto S: Expression and distribution of functional integrins in rat CNS glia. J Neurosci Res 1994, 39:436-447
30. Grooms SY, Terracio L, Sargent Jones L: Anatomical localization of β1 integrin-like immunoreactivity in rat brain. Exp Neurol 1993, 122: 253-259
31. Shaw CE, Milner R, Compston AS, ffrench-Constant C: Analysis of integrin expression on oligodendrocytes during axo-glial interaction by using rat-mouse xenocultures. J Neurosci 1996, 16:1163-1172
32. Haring HA, Akamine P, Habermann R, Koziol JA, Del Zoppo GJ: Distribution of integrin-like immunoreactivity on primate brain microvasculature. J Neuropathol Exp Neurol 1996, 55:236-245
33. Rothwell NJ, Hopkins SJ: Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci 1995, 3:130-136
34. Inoue A, Koh C-S, Yahikozawa H, Yanagisawa N, Yagita H, Ishihara Y, Kim BS: The level of tumor necrosis factor-a producing cells in the spinal cord correlates with the degree of Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int Immunol 1996, 8:1001-1008
35. Selmaj K, Farooq M, Norton WT, Raine CS, Brosnan CF: Proliferation of astrocytes in vitro in response to cytokines: a primary role for tumor necrosis factor. J Immunol 1990, 144:129-135
36. Agresti C, D'Urso D, Levi G: Reversible inhibitory effects of interferon-γ and tumor necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro. Eur J Neurosci 1996, 8:1106-1116
37. Frohman EM, Frohman TC, Dustin ML, Vayuvegula B, Choi B, Gupta A, van den Noort S, Gupta S: The induction of intracellular adhesion molecule 1 (ICAM-1) and expression of human fetal astrocytes by interferon-γ, tumor necrosis factor-α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation. J Neuroimmunol 1989, 23:117-124
38. Hurwitz AA, Lyman WD, Guida MP, Calderon TM, Berman JW: Tumor necrosis factor-α induces adhesion molecule expression on human fetal astrocytes. J Exp Med 1992, 176:1631-1636
39. Cannella B, Cross A, Raine C: Adhesion-related molecules in the central nervous system: upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis. Lab Invest 1991, 65:23-31
40. Hirsch E, Gullberg D, Balzac F, Altruda F, Silengo L, Tarone G: αv integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development. Dev Dyn 1994, 201:108-120
41. Fernandez-Valle C, Gwynn L, Wood P, Carbonetto S, Bunge M: Anti β1 integrin antibody inhibits Schwann cell myelination. J Neurobiol 1994, 25:1207-1226
42. Tomaselli KJ, Doherty P, Emmett CJ, Damsky CH, Walsh FS, Reichardt LF: Expression of β1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms. J Neurosci 1993, 13:4880-4888
43. Sobel RA, Chen M, Maeda A, Hinojoza JR: Vitronectin and integrin vitronectin receptor localization in multiple sclerosis lesions. J Neuropathol Exp Neurol 1995, 54:202-213
44. Gelding-Habermann B, Cheresc DA: Vitronectin and its receptors. Curr Opin Cell Biol 1993, 5:864-868
45. Sturmhofel K, Brando C, Martinon F, Shevach EM, Coligan JE: Antigen-independent, integrin-mediated T cell activation. J Immunol 1995, 154:2104-2111
46. Roberts K, Yokoyama WM, Kehn PJ, Shevach EM: The vitronectin receptor serves as an accessory molecule for the activation of a subset of γ/δ T cells. J Exp Med 1991, 173:231-240
47. Previtali S, Quattrini A, Nemni R, Truci G, Wrabetz L, Canal N: α6β4 integrin expression in ENU-induced gliomas. J Neurooncol 1996, 30s:148
48. Mainiero F, Pepe A, Mitchell Y, Ren Y, Giancotti FG: The intracellular functions of α6β4 integrin are regulated by EGF. J Cell Biol 1996, 134:241-253
49. Pacifici R, Carano A, Santoro SA, Rifas L, Jeffrey JJ, Malone JD, McCracken R, Avioli LV: Bone matrix constituents stimulate interleukin-1 release from human blood mononuclear cells. J Clin Invest 1991, 87:221-228
50. Riikonen T, Westermarck J, Koivisto L, Brogerg A, Kahari VM, Heino J: Integrin α2β1 is a positive regulator of collagenase (MMP-1), and collagen α1 (I) gene expression. J Biol Chem 1995, 270:13548-13552
51. Langholz O, Roeckel D, Mauch C, Kozlowska E, Bank I, Krieg T, Eckes B: Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by α1β1 and α2β1 integrins. J Cell Biol 1995, 31:1903-1915
52. Maeda A, Sobel RA: Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions. J Neuropathol Exp Neurol 1996, 55:300-309
53. Fambrough D, Pan D, Rubin F, Goodman C: The cell surface metalloprotease/disintegrin kuzbanian is required for axonal extension in Drosophila. Proc Natl Acad Sci USA 1996, 93:13233-13238
54. McGeer PL, Zhu SG, Dedhar S: Immunostainmg of human brain capillaries by antibodies to very late antigens. J Neuroimmunol 1990, 26:213-218
55. Stroemblad S, Cheresh D: Cell adhesion and angiogenesis. Trends Cell Biol 1996, 6:462-468