No association or linkage to IDDM of an interferon regulatory factor-1 gene polymorphism in a Danish population

European Journal of Immunogenetics

Volumn 24, Issue 5, 1997, Pages 377-383

  Johannesen, J ^a   Karlsen, A E ^a   Nerup, J ^a   Pociot, F ^a  

^a STENO DIABETES CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INDUCTION; GENE DELETION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INTRON; MAJOR CLINICAL STUDY; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; POPULATION GENETICS; PRIORITY JOURNAL; TANDEM REPEAT;

EID: 0030678477     PISSN: 09607420     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2370.1997.d01-113.x     Document Type: Article

References (37)

1. AKABANE, A., KATO, I., TAKASAWA, S., UNNO, M., YONEKURA, H., YOSHIMOTO, T. & OKAMOTO, H. (1995) Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta induced nitric oxide synthase expression in pancreatic beta-cells. Biochemical and Biophysical Research Communications, 215, 524.
2. BERGHOLDT, R., KARLSEN, A.E., JOHANNESEN, J., HANSEN, P.M., DINARELLO, C.A., NERUP, J., POCIOT, F. & THE DANISH STUDY GROUP OF DIABETES IN CHILDHOOD (1995) Characterization of polymorphisms of an interleukin-1 receptor type 1 gene (ILIRI) promoter region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). Cytokine, 7, 727.
3. CAMPBELL, I.L., KAY, T.W.H., OXBROW, L. & HARRISON, L.C. (1991) Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. Journal of Clinical Investigations. 87, 739.
4. CETKOVIC-CVRLJE, M. & EIZIRIK, D.L. (1994) TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine, 6, 399.
5. CHA, Y., SIMS, S.H., ROMINE, M.F., KAUFMANN, M. & DEISSEROTH, A.B. (1992) Human interferon regulatory factor 1: intron-exon organization. DNA and Cell Biology, 11, 605.
6. CORBETT, J.A. & MCDANIEL, M.L. (1992) Does nitric oxide mediate autoimmune destruction of B-cells? Possible therapeutic interventions in IDDM. Diabetes, 41, 897.
7. CORBETT, J.A., WANG, J.L., SWEETLAND, M.A., LANCASTER, J.R. & MCDANIEL, M.L. (1992) IL-1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans: evidence for the beta-cell as a source and site of action of nitric oxide. Journal of Clinincal Investigation 90, 2384.
8. DEBRAY-SACHS, M., CARNAUD, C., BOITARD, C., COHEN, H., GRESSER, I., BEDOSSA, P. & BACH, J.-F. (1991) Prevention of diabetes in NOD mice treated with antibody to murine IFNγ. Journal of Autoimmunity, 4, 237.
9. EIZIRIK, D.L. & LEIJERSTAM, F. (1994) The inducible form of nitric oxide synthase (iNOS) in insulin-producing cells. Diabetic Metabolism 20, 116.
10. EIZIRIK, D.L., FLODSTROEM, M., KARLSEN, A.E. & WELSH, N. (1996) The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia, 39, 875.
11. EIZIRIK, D.L., SANDLER, S., WELSH, N., CETKOVIC-CVRLJE, M., NIEMAN, A., GELLER, D.A., PIPELEERS, D.G., BENDTZEN, K. & HELLERSTRÖM, C. (1994) Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. Journal of Clinincal Investigation, 93, 1968.
12. FLODSTROEM, M. & EIZIRIK, D.L. (1996) Cytokines induce expression of Interferon regulatory factor-1 (IRF-1) in insulin-producing cells. Diabetologia, 39 (Suppl. 1), A102 (abstract).
13. FOULIS, A.K., MCGILL, M. & FARQUHARSON, M.A. (1991) Insulitis in type 1 (insulin-dependent) diabetes mellitus in man: macrophages, lymphocytes, and interferon-γ containing cells. Journal of Pathology, 165, 97.
14. FUJITA, T., SAKAKIHAKA, J., SUDO, Y., MIYAMOTO, M., KIMUKA, Y. & TANIGUCHI, T. (1988) Evidence for a nuclear factor (s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements. EMBO Journal, 7, 3397.
15. HARADA, H., FUJITA, T., MIYAMOTO, M., KIMURA, Y., MARUYAMA, M., FURIA, A., MIYATA, T. & TANIGUCHI, T. (1989) Structurally similar, but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell, 58, 729.
16. HERBERT, A. & RICH, A. (1996) The biology of left-handed Z-DNA. Journal of Biological Chemistry, 271, 11595.
17. KAMIJO, R., HARADA, H., MATSIYAMA, T., BOSLAND, M., GERECITANO, J., SHAPIRO, D., LE, J., KOH, S.I., KIMURA, T., GREEN, S.J., MAK, T.W., TANIGUCHI, T. & VILCEK, J. (1994) Requirement of transcription factor IRF-1 in NO synthase induction in macrophages. Science, 263, 1612.
18. KROEF, M.J.P.L., WILLEMZE, R. & LANDEGENT, J.E. (1993) Dinucleotide repeat polymorphism in the interferon regulatory factor 1 (IRF1) gene. Human Molecular Genetics, 2, 1748.
19. KRONCKE, K.-D., BRENNER, H.-H., RODRIGUEZ, M.-L., ETZKORN, K., NOACK, E.A. & KOLB-BACHOFEN, V. (1993) Pancreatic islets cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide. Biochemica et Biophysica Acta, 1182, 221.
20. LINDSAY, R.M., SMITH, W., ROSSIER, S.P., MCINTYRE, M.A., WILLIAMS, B.C. & BAIRD, J.D. (1995) N-nitro-1-arginine methyl ester reduces the incidence of IDDM in BB/E rats. Diabetes, 44, 335.
21. LOWENSTEIN, C.J., ALLEY, R.W., RAVAL, P., SNOWMAN, A.M., SNYDER, S.H., RUSSELL, S.W. & MURPHY, W.J. (1993) Macrophage nitric oxide synthase gene: two up-stream regions mediate induction by interferon gamma and lipopolysaccharide. Proceeding of the National Academy of Sciences USA, 90, 9730.
22. MANDRUP-POULSEN, T., HELQVIST, S., MØLVIG, J., WoGENSEN, L.D. & NERUP, J. (1989) Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin dependent diabetes mellitus. Autoimmunity, 4, 191.
23. MANDRUP-POULSEN, T., HELQVIST, S., WOGENSEN, L.D., MØLVIG, J., POCIOT, F., JOHANNESEN, J. & NERUP, J. (1990) Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells. Current Topics in Microbiological Immunology, 164, 169.
24. MARTIN, E., NATHAN, C. & XIE, Q. (1994) Role of Interferon regulatory factor 1 in induction of nitric oxide synthase. Journal of Experimental Medicine, 180, 977.
25. NERUP, J., MANDRUP-POULSEN, T., MOELVIG, J., HELQVIST, S., WOGENSEN, L. & EGEBERG, J. (1988) Mechanisms of pancretic beta-cell destruction in type 1 diabetes. Diabetes Care, 11 (Suppl. 1), 16.
26. POCIOT, F., MØLVIG, J., WOGENSEN, L., WORSAAE, H., DALBØGE, H., BAEK, L. & NERUP, J. (1991) A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus. Journal of Scandinavian Immunlogy, 33, 37.
27. POCIOT, F., NØRGAARD, K., HOBOLTH, N., ANDERSEN, O., NERUP, J. & THE DANISH STUDY GROUP OF DIABETES IN CHILDHOOD (1993) A nationwide population-based study of the familial aggregation of insulin-dependent diabetes in Denmark. Diabetologia, 36, 870.
28. POCIOT, F., RØNNINGEN, K.S., BERGHOLDT, R., LORENZEN, T., JOHANNESEN, J., YE, K., DINARELLO, C.A., NERUP, J. & THE DANISH STUDY GROUP OF DIABETES IN CHILDHOOD (1994) Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes: evidence for polygenecity in man. Autoimmunity, 19, 169.
29. RABINOVITCH, A. (1993) Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Reviews, 1, 215.
30. SARVETNICK, N., LIGGITT, D., PITTS, S.L., HANSEN, S.E. & STEWART, T.A. (1988) Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell, 52, 773.
31. SHAM, P.C. & CURTIS, D. (1995) An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Annals of Human Genetics, 59, 323.
32. SOUTHERN, C., SCHULSTER, D. & GREEN, I.C. (1990) Inhibition of insulin secretion by interleukin-1 beta and tumor necrosis factor-alfa via an L-argenine dependent nitric oxide generating mechanism. FEBS Letters, 276, 42.
33. SPIELMAN, R.S., MCGINNIS, R.E. & EWENS, W.J. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics, 52, 506.
34. TAMURA, T., ISHIHARA, M., LAMPHIER, M.S., TANAKA, N., OISHI, I., AIZAWA, S., MATSUYAMA, T., MAK, T.W., TAKI, S. & TANIGUCHI, T. (1995) An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T-lymphocytes. Nature, 376, 596.
35. TANAKA, N., ISHIHARA, M., KITAGWA, M., HARADA, H., KIMURA, T., MATSUYAMA, T., LAMPHIER, M.S., AIZAWA, S., MAK, T.W. & TANIGUCHI, T. (1994) Cellular commitment, to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell, 77, 829.
36. WIKKMAN, C.L., SERVER, C.E., PALLAVICINI, M.G., HARADA, H., TANAKA, N., SLOVAK, M.L., YAMAMOTO, H., HARADA, K., MEEKER, T.C., LIST, A.F. & TANIGUCHI, T. (1993) Deletion of IRF-1, mapping to chromosome 5q.31.1 in human leukemia and pleleukamic myelodyplasia. Science, 259, 968.
37. XIE, Q., WHISNANT, R. & NATHAN, C. (1993) Promotor of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. Journal of Experimental Medicine, 177, 1779.