Hyperglycemia and hypercapnia suppress BDNF gene expression in vulnerable regions after transient forebrain ischemia in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 12, 1997, Pages 1303-1308

  Uchino, H ^a   Lindvall, O ^a   Siesjo B K ^a   Kokaia, Zaal ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

BDNF; Cerebral ischemia; Gene expression; Hypercapnia; Hyperglycemia; In situ hybridization

Indexed keywords

BRAIN DERIVED GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CINGULATE GYRUS; CONTROLLED STUDY; FOREBRAIN; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GRANULE CELL; HYPERCAPNIA; HYPERGLYCEMIA; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; RECEPTOR UPREGULATION;

EID: 0030670532     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199712000-00005     Document Type: Article

References (46)

1. Balastrino M, Somjen G (1988) Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat. J Physiol 396:247-266
2. Ballarín M, Ernfors P, Lindefors N, Persson H (1991) Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Exp Neurol 114:35-43
3. Beck T, Lindholm D, Castrén E, Wree A (1994) Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J Cereb Blood Flow Metab 14:689-692
4. Cheng B, Mattson MP (1994) NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res 640:56-67
5. Combs DJ, Dempsey RJ, Donaldson D, Kindy MS (1992) Hyperglycemia suppresses c-fos mRNA expression following transient cerebral ischemia in gerbils. J Cereb Blood Flow Metab 12:169-172
6. Comelli MC, Guidolin D, Seren MS, Zanoni R, Canella R, Rubini R, Manev H (1993) Time course, localization and pharmacological modulation of immediate early inducible genes, brain-derived neurotrophic factor and trkB messenger RNAs in the rat brain following photochemical stroke. Neuroscience 55:473-490
7. Elmér E, Kokaia Z, Kokaia M, Carnahan J, Nawa H, Lindvall O (1997) Dynamic changes of BDNF protein levels in the rat forebrain after single and recurring kindling-induced seizures. Neuroscience (in press)
8. Ernfors P, Wetmore C, Olson L, Persson H (1990) Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 5:511-526
9. Ernfors P, Bengzon J, Kokaia Z, Persson H, Lindvall O (1991) Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron 7:165-176
10. Ghosh A, Greenberg ME (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268:239-247
11. Ghosh A, Carnahan J, Greenberg ME (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263:1618-1623
12. Hofer M, Paglusi SR, Hohn A, Leibrock J, Barde Y-A (1990) Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J 9:2459-2464
13. Hughes P, Beilharz E, Gluckman P, Dragunow M (1993) Brain-derived neurotrophic factor is induced as an immediate early gene following N-methyl-D-aspartate receptor activation. Neuroscience 57: 319-328
14. Isackson PJ, Huntsman MM, Murray KD, Gall CM (1991) BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron 6:937-948
15. Kang H, Schuman EM (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658-1662
16. Katsura K, Tibor K, Smith M-L, Siesjö BK (1994) Acidosis induced by hypercapnia exaggerates ischemic brain damage. J Cereb Blood Flow Metab 14:243-250
17. Knipper M, Beck A, Rylett J, Breer H (1993) Neurotrophin induced second messenger responses in rat brain synaptosomes. Neuroreport 4:483-486
18. Kokaia Z, Bengzon J, Metsis M, Kokaia M, Persson H, Lindvall O (1993a) Coexpression of neurotrophins and their receptors in neurons of the central nervous system. Proc Natl Acad Sci USA 90: 6711-6715
19. Kokaia Z, Gidö G, Ringstedt T, Bengzon J, Kokaia M, Siesjö BK, Persson H, Lindvall O (1993b) Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Mol Brain Res 19:277-286
20. Kokaia Z, Othberg A, Kokaia M, Lindvall O (1994) BDNF makes cultured dentate granule cells more resistant to hypoglycemic damage. Neuroreport 5:1241-1244
21. Kokaia Z, Zhao Q, Kokaia M, Elmér E, Metsis M, Smith M-L, Siesjö BK, Lindvall O (1995) Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage. Exp Neurol 136:73-88
22. Kokaia Z, Nawa H, Uchino H, Elmér E, Kokaia M, Carnahan J, Smith M-L, Siesjö BK, Lindvall O (1996) Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat. Mol Brain Res 38:139-144
23. Kristián T, Gidö G, Siesjö BK (1995) The influence of acidosis on hypoglycemic brain damage. J Cereb Blood Flow Metab 15:78-87
24. Leßmann V, Gottmann K, Heumann R (1994) BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. Neuroreport 6:21-25
25. Li P-A, Shamloo M, Smith M-L, Katsura K, Siesjö BK (1994) The influence of plasma glucose concentrations on ischemic brain damage is a threshold function. Neurosci Lett 177:63-65
26. Li P-A, Kristián T, Siesjö BK (1995a) Brief periods of ischemia in hyperglycemic rats induce hippocampal CAl damage in the absence of cell membrane depolarization and calcium influx. Neurosci Res Comm 17:217-220
27. Li P-A, Shamloo M, Katsura K, Smith M-L, Siesjö BK (1995b) Critical values of plasma glucose in aggravating ischemic brain damage: correlation to extracellular pH. Neurobiol Dis 2:97-108
28. Li P-A, Kristián T, Shamloo M, Siesjö BK (1996) Effects of preischemic hyperglycemia on the brain damage incurred by rats subjected to 2.5 and 5 minutes of forebrain ischemia. Stroke 27:1592-1601
29. Lindsay RM, Wiegand SJ, Altar CA, DiStefano PS (1994) Neurotrophic factors: from molecule to man. Trends Neurosci 17:182-190
30. Lindvall O, Ernfors P, Bengzon J, Kokaia Z, Smith M-L, Siesjö BK, Persson H (1992) Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci USA 89:646-652
31. Lohof AM, Ip NY, Poo M-m (1993) Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 363:350-353
32. Mudó G, Persson H, Timmusk T, Funakoshi H, Bindoni M, Belluardo N (1993) Increased expression of trkB and trkC messenger RNAs in the rat forebrain after focal mechanical injury. Neuroscience 57:901-912
33. Nakao N, Brundin P, Funa K, Lindvall O, Odin P (1995a) Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro. Dev Brain Res 90:92-101
34. Nakao N, Kokaia Z, Odin P, Lindvall O (1995b) Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Exp Neurol 131:1-10
35. Nawa H, Carnahan J, Gall C (1995) BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disaccordance with mRNA levels. Eur J Neurosci 7:1527-1535
36. Ou-Yang Y, Kristian T, Mellergård P, Siesjö BK (1994) The influence of pH on glutamate- and depolarization-induced increases of intracellular calcium concentration in cortical neurons in primary culture. Brain Res 646:65-72
37. 2. J Cereb Blood Flow Metab 9:65-70
38. Siesjö BK (1988) Acidosis and ischemic brain damage. Neurochem Pathol 9:31-88
39. Siesjö BK, Katsura K, Mellergård P, Ekholm A, Lundgren J, Smith M-L (1993) Acidosis related brain damage. In: Progress in Brain Research. (Kogure K, Hossman K-A, Siesjö BK, eds) Amsterdam, Elsevier Science, pp 23-48
40. Siesjö B, Katsura K, Kristián T (1996) Acidosis-related damage. In: Advances in Neurology. (Siesjö B, Wieloch T, eds) New York, Raven Press, pp 209-236
41. Smith M-L, Bendek G, Dahlgren N, Rosén I, Wieloch T, Siesjö BK (1984) Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model. Acta Neurol Scand 69:385-401
42. Takeda A, Onodera H, Sugimoto A, Kogure K, Obinata M, Shibahara S (1993) Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus following transient forebrain ischemia. Neuroscience 55:23-31
43. +. Proc Natl Acad Sci USA 87:6445-6449
44. Zafra F, Hengerer B, Leibrock J, Thoenen H, Lindholm D (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9:3545-3550
45. Zafra F, Castérn E, Thoenen H, Lindholm D (1991) Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in the hippocampal neurons. Proc Natl Acad Sci USA 88:10037-10041
46. Zafra F, Lindholm D, Castrén E, Hartikka J, Thoenen H (1992) Regulation of brain-derived neurotrophic factor and nerve growth factor rnRNA in primary cultures of hippocampal neurons and astrocytes. J Neurosci 12:4793-4799