Progress in determining the genes for hypertension, insulin resistance, and dyslipidemia

Annals of the New York Academy of Sciences

Volumn 827, Issue , 1997, Pages 110-117

  Caulfield, Mark ^a   Bouloux, Pierre Marc ^b   Munroe, Patricia ^c  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; INSULIN RECEPTOR; LIPOPROTEIN LIPASE;

CARDIOVASCULAR DISEASE; CONFERENCE PAPER; DYSLIPIDEMIA; ESSENTIAL HYPERTENSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYPERTENSION; INSULIN RESISTANCE; LIDDLE SYNDROME; MAJOR CLINICAL STUDY; POPULATION GENETICS; RECEPTOR GENE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYSTOLIC BLOOD PRESSURE;

EID: 0030670428     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb51826.x     Document Type: Conference Paper

References (26)

1. WARD, R. 1990. Familial aggregation and genetic epidemiology of blood pressure. In Hypertension: Pathophysiology, Diagnosis, and Management, p. 81-100. Raven Press. New York.
2. LANDER, E. S. & N. J. SCHORK. 1994. Genetic dissection of complex traits. Science 265:2037-2048.
3. LIFTON, R. P., R. G. DLUHY, M. POWERS, G. M. RICH, S. COOK, S. ULICK & J. M. LALOUEL. 1992. A chimaeric 11-beta-hydroxylase/aldosterone synthase gene causes glucocorticoidremediable aldosteronism and human hypertension. Nature 355: 262-265.
4. SHIMKETS, R., D. G. WARNOCK, C. M. Bosms, C. NELSON-WILLIAMS, J. H. HANSSON, M. SCHAMBELAN, J. R. GlLL, S. UtlCK, R. V, MlLORA, J. W. FINDLING, C. M. CANESSA, B. C. ROSSIER & R. P. LIFTON. 1994. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407-414.
5. SUTHERLAND, D. J., J. L. RUSE & J. C. LAIDLAW. 1966. Hypertension, increased aldosterone secretion, and low plasma renin activity relieved by dexamethasone. Can. Med. Assoc. J. 95: 1109-1119.
6. OGISHIMA, T., H. SHIBATA, H. SIIIMADA, F. MITANI, H. SUZUKI & T. I. Y. SARUTA. 1991. Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism. J. Biol. Chem. 266: 10731-10734.
7. LIFTON, R. P., R. G. DLUHY, M. POWERS, G. M. RICH, M. GUTKIN, F. FALLO, J. R. J. GILL, L. FELD, A. GANGULY, J. C. LAIDLAW, et al. 1992. Hereditary hypertension caused by chimeric gene duplications and ectopic expression of aldosterone synthase. Nat. Genet. 2:66-74.
8. LIDDLE, G. W., T. BLEDSOE & W. S. COPPAGE. 1963. A familial renal disorder stimulating primary aldosteronism, but with negligible aldosterone secretion. Trans. Assoc. Am. Physicians 76: 199-213.
9. SCHUSTER, H., T. F. WIENKER, S. BAHRING, N. BILGINTURAN, H. R. TOKA, E. J. NEITZEL, O. TOKA, D. GILBERT, A. LOWE, J. Orr, H. HALLER & F. C. LUFT. 1996. Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nat. Genet. 13: 98-100.
10. MACGREGOR, G. A., N. D. MARKANDU, J. E. ROULSTON, J. C. JONES & J. J. MORTON. 1981. Maintenance of blood pressure by the renin angiotensin system in normal man. Nature 291: 329-331.
11. WATT, G. C., S. B. HARRAP, C. J. FOY, D. W. HOLTON, H. V. EDWARDS, H. R. C. DAVIDSON, A. F. LEVER & R. FRASER. 1992. Abnormalities of glucocorticoid metabolism and the reninangiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. J. Hypertens. 10: 473-482.
12. JEUNEMAITRE, X., F. SOUBRIER, Y. V. KOTELEVTSEV, R. P. LIFTON, C. S. WILLIAMS, S. C. HUNT, P. N. HOPKINS, R. R. WILLIAMS, J. M. LALOUEL, et al. 1992. Molecular basis of human hypertension: role of angiotensinogen. Cell 71: 169-180.
13. CAULFIELD, M., P. LAVENDER, M. FARRALL, P. MUNROE, M. LAWSON, P. C. TURNER & A. J. L. CLARK. 1994. Linkage of the angiotensinogen gene to essential hypertension. N. Engl. J. Med. 330: 1629-1633.
14. CAULFIELD, M., P. LAVENDER, J. NEWELL-PRICE, M. FARRALL, S. KAMDAR, H. DANIEL, M. LAWSON, P. DE FREITAS, P. FOGARTY & A. J. L. CLARK. 1995. Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J. Clin. Invest. 95:687-692.
15. REAVEN, G. M. & B. B. HOFFMAN. 1987. A role for insulin in the aetiology and course of hypertension. Lancet ii: 435-437.
16. HAFFNER, S. M., M. W. BRANDS, H. P. HAZUDA & M. P. STERN. 1992. Clustering of risk factors in confirmed prehypertensive individuals. Hypertension 20(1): 38-55.
17. HARRIS, C. L., E. BOERWINKLE, R. CHAKRABORTY, etal. 1996. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat. Genet. 13(2): 161-166.
18. OELBAUM, R. S., P. M. G. BOULOUX, S. R. Li, M. G. BARONI, J. STOCKS & D. J. GALTON. 1991. Insulin receptor gene polymorphisms in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34: 260-264.
19. YING, L-H., R. Y. L. ZEE, L. R. GRIFFITHS & B. J. MORRIS. 1991. Association of a RFLP for the insulin receptor gene, but not insulin with essential hypertension. Biochem. Biophys. Res. Commun. 181: 486-492.
20. MUNROE, P. B., H. I. DANIEL, M. FARRALL, M. LAWSON, P. M. BOULOUX & M. J. CAULFIELD. 1995. Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension. J. Hum. Hypertens. 9: 669-670.
21. WILLIAMS, R. R., S. C. HUNT, P. N. HOPKINS, B. M. STULTS, L. L. WU, S. J. HASSTEDT, G. K. BARLOW, M. C. SCHUMACHER, R. P. LIFTON & J. M. LALOUEL. 1988. Familial dyslipidemic hypertension: evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension. JAMA 259(24): 3579-3586.
22. WU, D-A..X. BU, C. H. WARDEN, etal. 1996. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J. Clin. Invest. 97: 2111-2118.
23. DAMMERMAN, M. & J. L. BRESLOW. 1995. Genetic basis of lipoprotein disorders. Circulation 91: 505-512.
24. HEGELE, R. A., L-S. HUANG, P. N. HERBERT, B. B. CONRAD, J. E. BURING, C. H. HENNEKENS & J. L. BRESLOW. 1986. Apolipoprotein B gene DNA polymorphisms associated with myocardial infarction. N. Engl. J. Med. 315: 1509-1515.
25. MENDIS, S., J. SHEPARD, C. J. PACKARD & D. GAFFNEY. 1991. Restriction fragment length polymorphisms in the apo B gene in relation to coronary heart disease in a southern Asian population. Clin. Chim. Acta 196: 107-117.
26. MUNROE, P. B., A. JOHNSTON, H. DANIEL, M. LAWSON, P. BOULOUX & M. CAULFIELD. 1995. Linkage of the apolipoprotein B gene to hypercholesterolemia in patients with essential hypertension. Abstract: Proc. Eur. Soc. Hypertens. J. Hypertens.