Simple cis-epoxide-based inhibitors of HIV-1 protease

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 22, 1997, Pages 2853-2856

  Abell, Andrew D ^a   Hoult, Deborah A ^a   Bergman, Douglas A ^b   Fairlie, David P ^b  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPOXIDE; PROTEINASE; PROTEINASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; EPOXIDATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030670333     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10106-8     Document Type: Article

References (13)

1. Kempf, D. J.; Sham, H. L. Current Pharmaceutical Design 1996, 2, 225. March, D. R.; Fairlie, D. P. In HIV-1 Protease and its Inhibitors; Wise, R., Ed.; R. G. Landes: Austin, 1996; pp 1-88.
2. Kempf, D. J.; Sham, H. L. Current Pharmaceutical Design 1996, 2, 225. March, D. R.; Fairlie, D. P. In HIV-1 Protease and its Inhibitors; Wise, R., Ed.; R. G. Landes: Austin, 1996; pp 1-88.
3. Erickson, J. W. Nature Structural Biology 1995, 2, 523.
4. Day, M. New Scientist 1997, 4.
5. Meek, T. D.; Dayton, B. D.; Metcalf, B. W.; Dreyer, G. B.; Strickler, J. E.; Gorniak, J. G.; Rosenberg, M.; Moore, M. L.; Magaard, V. W.; Debouck, C. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 1841.
6. Grant, S. K.; Moore, M. L.; Fakhoury, S. A.; Tomaszek, T. A.; Meek, T. D. Bioorg. Med. Chem. Lett. 1992,2, 1441.
7. Lee, C. S.; Choy, N.; Park, C.; Choi, H.; Son. Y. C.; Kim, S.; Ok, J. H.; Yoon, H.; Kim, S. C. Bioorg. Med. Chem. Lett. 1996, 6, 589.
8. Park, C.; Koh, J. S.; Son. Y. C.; Choi, H.; Lee, C. S.; Choy, N.; Moon K. Y.; Jung, W. H.; Kim, S. C.; Yoon, H. Bioorg. Med. Chem. Lett. 1995, 5, 1843.
9. Yu, Z.; Caldera, P.; De Voss, J. J.; Jones, P. R.; Burlingame, A. L.; Kuntz, I. D.; Craik, C. S.; Ortiz de Montellano, P. R. J. Am Chem. Soc. 1996, 118, 5846.
10. Finn, M. G.; Sharpless, K. B. In Asymmetrie Synthesis; Morrison, J. D., Ed.; Academic: New York, 1985; Vol. 5, Chapter 8, p 247.
11. Mitsunobu, O. Synthesis 1981, 1.
12. Bergman, D. A.; Alewood, D.; Alewood, P. F.; Andrews, J. L.; Brinkworth, R. I.; Englebretsen, D. R.; Kent, S. B. H. Lett. Pept. Sci. 1995, 2, 99.
13. Lam, P. Y. S.; Jadhav, P. K.; Eyermann, C. J.; Hodge, C. N.; Ru, Y.; Bacheler, L. T.; Meek, J. L.; Otto, M. J.; Rayner, M. M.; Wong, Y. N.; Chang, C.; Weber, P. C.; Jackson, D. A.; Sharpe, T. R.; Erickson-Viitanen, S. Science 1994, 263, 380.