Dominant negative activity of mutant thyroid hormone receptors from patients with hepatocellular carcinoma

Endocrinology

Volumn 138, Issue 12, 1997, Pages 5308-5315

  Lin, Kwang Huei ^a   Zhu, Xu Guang ^c   Hsu, Hai Chu ^a   Chen, Shen Liang ^a   Shieh, Hsing Ying ^a   Chen, Szu Tah ^a   McPhie, Peter ^b   Cheng, Sheue Yann ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR;

ARTICLE; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; POINT MUTATION; PRIORITY JOURNAL; THYROID HORMONE RESISTANCE;

EID: 0030670070     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.12.5625     Document Type: Article

References (39)

1. Cheng S-y 1995 New insights into the structure and function of the thyroid hormone receptor. J Biomed Sci 2:77-89
2. Oppenheimer JH, Schwartz HL, Strait KA 1994 Thyroid hormone action 1994: the plot thickens. Eur J Endocrinol 130:15-24
3. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG 1995 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404
4. Chen JD, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
5. Burris TP, Nawaz Z, Tsai MJ, O'Malley BW 1995 A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors. Proc Natl Acad Sci USA 92:9525-9529
6. Seol W, Choi H-S, Moore DD 1996 An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272:1336-1339
7. 3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol Endocrinol 10:813-825
8. Onate SA, Tsai SY, Tsai M-J, O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357
9. Yap N, Yu C-L, Cheng S-y 1996 Modulation of the transcriptional activity of thyroid hormone receptors by the tumor suppressor p53. Proc Natl Acad Sci USA 93:4273-4277
10. Refetoff S, Weiss RE, Usala SJ 1993 The syndromes of resistance to thyroid hormone. Endocr Rev 14:348-399
11. Usala SJ 1995 New developments in clinical and genetic aspects of thyroid hormone resistance syndromes. Endocrinologist 5:68-76
12. Brucker-Davis F, Skarulis MC, Grace MB, Benichou J, Hauser P, Wiggs E, Weintraub BD 1995 Genetic and clinical features of 42 kindreds with resistance to thyroid hormone: the NIH prospective study. Ann Intern Med 123:572-583
13. Yen PM, Chin WW 1994 Molecular mechanisms of dominant negative activity by nuclear hormone receptors. Mol Endocrinol 8:1450-1454
14. Lin KH, Zhu X-G, Shieh, H-y, Hsu, H-C, Chen, S-T, McPhie, P, Cheng, S-y 1996 Identification of naturally occurring dominant negative mutants of thyroid hormone α1 and β1 receptors in a human hepatocellular carcinoma cell line. Endocrinology 137:4073-4081
15. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
16. Cook CB, Kakucska I, Lechan RM, RJ Koening 1992 Expression of thyroid hormone receptor beta 2 in rat hypothalamus. Endocrinology 130:1077-1079
17. Meyers RM, Larin Z, Maniatis T 1985 Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science 230:1242-1246
18. Zhu XG, Yu CL, McPhie P, Wong R, Cheng S-y 1996 Understanding the molecular mechanism of dominant negative action of mutant thyroid hormone beta 1-receptors: the important role of the wild-type/mutant receptor heterodimer. Endocrinology 137:712-721
19. Lin K-H, Fukuda T, Cheng S-y 1990 Hormone and DNA binding activity of a purified thyroid hormone nuclear receptor expressed in Escherichia coli. J Biol Chem 265:5161-5165
20. Bhat MK, McPhie P, Ting YT, Zhu XG, Cheng S-y 1995 The structure of the carboxy-terminal region of thyroid hormone nuclear receptors and its possible role in hormone-dependent intermolecular interactions. Biochemistry 34:10591-10599
21. Parrilla R, Mixson AJ, McPherson JA, McClaskey JH, Weintraub BD 1991 Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain. J Clin Invest 88:2123-2130
22. Sap J, Munoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennstrom B 1986 The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 324:635-640
23. 3 response element-dependent dominant negative potency. J Clin Invest 92:1986-1993
24. Perlmann T, Rangarajan PN, Umesono K, Evans RM 1993 Determinants for selective RAR and TR recognition of direct repeat HREs. Genes Dev 7:1411-1422
25. Schrader M, Danielsson C, Wiesenberg I, Carlberg C 1996 Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers. J Biol Chem 271:19732-19736
26. Katz RW, Koenig RJ 1994 Specificity and mechanism of thyroid hormone induction from an octamer response element. J Biol Chem 269:18915-18920
27. Rastinejad, F, Perlmann T, Evans RM, Sigler PB 1995 Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature 375:203-211
28. Zhu X-G, McPhie P, Lin K-h, Cheng, S-y 1997 The differential hormone-dependent transcriptional activation of thyroid hormone receptor isoforms is mediated by interplay of their domains. J Biol Chem 272:9048-9054
29. Yaoita Y, Shi Y, Brown D 1990 Xenopus laevis alpha and beta thyroid hormone receptors. Proc Natl Acad Sci USA 87:8684-8688
30. Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ 1995 A structural role for hormone in the thyroid hormone receptor. Nature 378:690-697
31. Wurtz JM, Bourguet W, Renaud JP, Vivat V, Chambon P, Moras D, Gronemeyer H 1996 A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol 3:87-94 [published erratum appears in Nat Struct Biol, 1996 3:206]
32. Parker MG, White R 1996 Nuclear receptors spring into action. Nat Struct Biol 3:113-115
33. Kitajima K, Nagaya T, Jameson L 1995 Dominant negative and DNA-binding properties of mutant thyroid hormone receptors that are defective in homodimerization but not heterodimerization. Thyroid 5:343-353
34. Hao E, Menke JB, Smith AM, Jones C, Geffner ME, Hershman JM, Wuerth JP, Samnels HJ, Ways DK, Usala SJ 1994 Divergent dimerization properties of mutant beta 1 thyroid hormone receptors are associated with different dominant negative activities. Mol Endocrinol 8:341-851
35. Barlow C, Meister B, Lardelli M, Lendahl U, Vennstrom B 1994 Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. EMBO J 13:4241-50
36. Strait KA, Zou L, Oppenheimer JH 1992 Beta 1 isoform-specific regulation of a triiodothyronine-induced gene during cerebella development. Mol Endocrinol 6:1874-1880
37. Lezoualc'h F, Hassan AH, Giraud P, Loeffler JP, Lee SL, Demeneix BA 1992 Assignment of the beta-thyroid hormone receptor to 3,5,3′-triiodothyronine-dependent inhibition of transcription from the thyrotropin-releasing hormone promoter in chick hypothalamic neurons. Mol Endocrinol 6:1797-1804
38. Lebel JM, Dussault JH, Puymirat J 1994 Overexpression of the beta 1 thyroid receptor induces differentiation in neuro-2a cells. Proc Natl Acad Sci USA 91:2644-2648
39. Forrest D, Hanebuth E, Smeyne RJ, Everds N, Stewart CL, Wehner JM, Curran T 1996 Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. EMBO J 15:3006-3015