Understanding the Molecular Mechanism of Dominant Negative Action of Mutant Thyroid Hormone β1-Receptors: The Important Role of the Wild-Type/Mutant Receptor Heterodimer

Endocrinology

Volumn 137, Issue 2, 1996, Pages 712-721

  Zhu, Xu Guang ^c   Yu, Chia Lin ^c   Mcphie, Peter ^a   Wong, Rosemary ^b   Cheng, Sheue Yann ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; LIOTHYRONINE; RECEPTOR SUBTYPE; THYROID HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; FRAMESHIFT MUTATION; GENE DELETION; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSIVE ELEMENT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; BINDING SITES; GENES, DOMINANT; MOLECULAR SEQUENCE DATA; MUTATION; OLIGONUCLEOTIDE PROBES; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, THYROID HORMONE; THYROID HORMONES; TRIIODOTHYRONINE;

EID: 0030023159     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.2.8593822     Document Type: Article

References (38)

1. Cheng S-y 1995 New insights into the structure and function of the thyroid hormone receptor. J Biomed Sci 2:77-89
2. Oppenheimer JH, Schwartz HJ, Strait KA 1994 Thyroid hormone action 1994: the plot thickens. Eur J Endocrinol 130:15-24
3. 3 receptor. Mol Endocrinol 5:73-84
4. Beebe JS, Darling DS, Chin WW 1991 3,5,3′-Triiodothyronine receptor auxiliary protein (TRAP) enhances receptor binding by interactions within the thyroid hormone response element. Mol Endocrinol 5:85-93
5. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boulin JM, Glass CK, Rosenfeld MG 1991 RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266
6. Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM 1992 Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 355:446-449
7. Marks MS, Hallenbeck PL, Nagata T, Segars JH, Appella E, Nikodem VM, Ozato K 1992 H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBOJ 11:1419-1435
8. Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Gamier JM, Mader S, et al 1992 Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68:377-395
9. 3-recep-tor/retinoid x receptor heterodimer binding to DNA. J Biol Chem 267:23248-28252
10. 3 response element-dependent dominant negative potency. J Clin Invest 92:1986-1993
11. Zhang XK, Pfahl M 1993 Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors. Trends Endocrinol Metab 4:10-16
12. Zhang XK, Wills KN, Graupner G, Tzukerman M, Hermann T, Pfahl M 1991 Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles. New Biol 3:169-181
13. 3-receptor homodimers but not receptor-auxiliary protein heterodimers. J Biol Chem 267:3565-3568
14. Refetoff S, Weiss RE, Usala SJ 1993 The syndromes of resistance to thyroid hormone. Endocr Rev 14:348-399
15. Usala SJ 1995 New developments in clinical and genetic aspects of thyroid hormone resistance syndromes. Endocrinologist 5:68-76
16. Meier CA, Dickstein BM, Ashizawa K, McClaskey JH, Muchmore P, Ransom SC, Menke JB, Hao EH, Usala SJ, Bereu BB, et al 1992 Variable transcriptional activity and ligand binding of mutant β1 3,5,3′-triiodothyronine receptors from four families with generalized resistance to thyroid hormone. Mol Endocrinol 6:248-258
17. Nagaya T, Madison LD, Jameson JL 1992 Thyroid hormone receptor mutants that cause resistance to thyroid hormone. J Biol Chem 267:13014-13019
18. 3)-binding domain of the thyroid hormone receptor (TR) β gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone. J Clin Invest 94:607-615
19. Hao E, Menke JB, Smith AM, Jones C, Geffner ME, Hershman JM, Wuerth JP, Samuels HH, Ways DK, Usala SJ 1994 Divergent dimerization properties of mutant β1 thyroid hormone receptors are associated with different dominant negative activities. Mol Endocrinol 8:841-851
20. Nagaya T Jameson JL 1993 Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance. J Biol Chem 268:15766-15771
21. Zavacki AM, Harney JW, Brent GA, Larsen PR 1993 Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. Mol Endocrinol 7:1319-1330
22. Wong R, Zhu XG, Pineda MA, Cheng SY, Weintraub BD 1995 Cell type-dependent modulation of the dominant negative action of human mutant thyroid hormone β1 receptors. Mol Med 1:306-319
23. Forman BM, Yang CR, Au M, Casanova J, Ghysdael J, Samuels HH 1989 A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors. Mol Endocrinol 3:1610-1626
24. Yen P, Chin WW 1994 Molecular mechanisms of dominant negative activity by nuclear hormone receptors. Mol Endocrinol 8:1450-1454
25. Meier-Heusler SC, Zhu XG, Juge-Aubry C, Pernin A, Burger AG, Cheng SY, Meier CA 1995 Modulation of thyroid hormone action by mutant thyroid hormone receptors, c-erbAa2 and peroxisome proliferation-activated receptor: evidence for different mechanisms of inhibition. Mol Cell Endocrinol 107:55-66
26. Lin KH, Parkison C, McPhie P, Cheng SY 1991 An essential role of domain D in the hormone-binding activity of human β1 thyroid hormone nuclear receptor. Mol Endocrinol 5:485-492
27. Brent GA, Williams GR, Harney JW, Forman BM, Samuels HH, Moore DD, Larsen PR 1991 Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulations by 3,5,3′-triiodothyronine. Mol Endocrinol 5:542-548
28. Lin KH, Ashizawa K, Cheng SY 1992 Phosphorylation stimulates the transcriptional activity of the human β1 thyroid hormone nuclear receptor. Proc Natl Acad Sci USA 89:7737-7741
29. Bhat MK, Ashizawa K, Cheng SY 1994 Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with the retinoid X receptor. Proc Natl Acad Sci USA 91:7927-7931
30. Yen PM, Sugawara A, Refetoff S, Chin WW 1992 New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone. J Clin Invest 90:1825-1831
31. Parrilla R, Mixson AJ, McPherson JA, McClaskey JH, Weintraub BD 1991 Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two hot spot regions of the ligand binding domain. J Clin Invest 88:2123-2130
32. Hayashi Y, Janssen OE, Weiss RE, Murata Y, Seo H, Refetoff S 1993 The relative expression of mutant and normal thyroid hormone receptor genes in patients with generalized resistance to thyroid hormone determined by estimation of their specific messenger ribonucleic acid products. J Clin Endocrinol Metab 76:64-69
33. 3 receptor alleles in kindreds with generalized resistance to thyroid hormone. J Clin Invest 91:2296-2300
34. Bhat MK, McPhie P, Ting YT, Zhu XG, Cheng SY 1995 The structure of the carboxyl-terminal region of thyroid hormone nuclear receptor and its role in hormone dependent intermolecular interactions. Biochemistry 34:10591-10599
35. Yen PM, Wilcox EC, Hayashi Y, Refetoff S, Chin WW 1995 Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-β mutants. Endocrinology 136:2845-2851
36. Bunn HF, McDonough M 1974 Asymmetrical hemoglobin hybrids. An approach to the study of subunit interactions. Biochemistry 13:988-993
37. Strait KA, Schwartz HL, Perez-Castillo A, Oppenheimer JH 1990 Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats. J Biol Chem 265:10514-10521
38. Schwartz HL, Strait KA, Ling NC, Oppenheimer JH 1992 Quantitation of rat tissue thyroid hormone binding receptor isoforms by immunoprecipitation of nuclear triiodothyronine binding capacity. J Biol Chem 267:11794-11799