Neurokinin A increases duodenal mucosal permeability, bicarbonate secretion, and fluid output in the rat

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 5 36-5, 1997, Pages

  Hällgren, Anneli ^a   Flemström, Gunnar ^a   Hellström, Per M ^b   Lördal, Mikael ^b   Hellgren, Sandra ^a   Nylander, Olof ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cyclooxygenase inhibitor; Duodenum; Motility; Neurokinin 2 receptor antagonist; Tachykinin

Indexed keywords

BICARBONATE; HEXAMETHONIUM; INDOMETACIN; MEN 10627; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; NEUROPEPTIDE; NICOTINIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DUODENUM FLUID; DUODENUM MOTILITY; DUODENUM MUCOSA; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030669577     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.5.g1077     Document Type: Article

References (22)

1. Allen, A., G. Flemström, A. Garner, and E. Kivilaakso. Gastroduodenal mucosal protection. Physiol. Rev. 73: 823-857, 1993.
2. Bentzel, C. J., C. E. Palant, and M. Fromm. Physiological and pathological factors affecting the tight junction. In: Tight Junctions, edited by M. Cereijido. Boca Raton, FL: CRC, 1992, p. 151-173.
3. 3H-neurokinin A labels a specific tachykinin-binding site in the rat duodenal smooth muscle. Mol. Pharmacol. 32: 764-771, 1987.
4. Buck, S. H., E. Burcher, C. W. Shults, W. Lovenberg, and T. L. O'Donohue. Novel pharmacology of substance K-binding sites: a third type of tachykinin receptor. Science 226: 987-989, 1984.
5. Burcher, E., S. H. Buck, W. Lovenberg, and T. L. O'Donohue. Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder. J. Pharmacol. Exp. Ther. 236: 819-831, 1986.
6. Dockray, G. J. Physiology of enteric neuropeptides. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by L. R. Johnson. New York: Raven, 1994, p. 169-209.
7. Eistetter, H. R., D. J. Church, A. Mills, P. P. Godfrey, A. M. Capponi, R. Brewster, M. F. Schulz, E. Kawashima, and S. J. Arkinstall. Recombinant bovine neurokinin-2 receptor stably expressed in Chinese hamster ovary cells couples to multiple signal transduction pathways. Cell Regul. 2: 767-779, 1991.
8. Flemström, G. Gastric and duodenal mucosal secretion of bicarbonate. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by L. R. Johnson. New York: Raven, 1994, p. 1285-1310.
9. 3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract. J. Neurosci. 16: 6975-6986, 1996.
10. Hällgren, A., G. Flemström, M. Sababi, and O. Nylander. Effects of nitric oxide inhibition on duodenal function in rat: involvement of neural mechanisms. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G246-G254, 1995.
11. Kim, Y. C., and P. M. Hellström. Identification of mechanisms for duodenal contraction induced by tachykinins in the rat. J. Gastrointest. Motil. 5: 97-106, 1993.
12. Lördal, M., A. Hällgren, O. Nylander, and P. M. Hellström. Tachykinins increase vascular permeability in the gastrointestinal tract of the rat. Acta Physiol. Scand. 156: 489-494, 1996.
13. Lördal, M., C. Johansson, and P. M. Hellström. Myoelectric pattern and effects of small bowel transit induced by the tachykinins neurokinin A, neurokinin B, substance P and neuropeptide K in the rat. J. Gastrointest. Motil. 5: 33-40, 1993.
14. 2 receptors. J. Pharmacol. Exp. Ther. 271: 1489-1500, 1994.
15. Mizrahi, J., S. Dion, P. D'Orleans-Juste, E. Escher, G. Drapeau, and D. Regoli. Tachykinin receptors in smooth muscles: a study with agonists (substance P, neurokinin A) and antagonists. Eur. J. Pharmacol. 118: 25-36, 1985.
16. Nylander, O., P. Kvietys, and D. N. Granger. Effects of hydrochloric acid on duodenal and jejunal mucosal permeability in the rat. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20): G653-G660, 1989.
17. Osakada, F., K. Kubo, K. Goto, I. Kanazawa, and E. Munekata. The contractile activities of neurokinin A, B and related peptides on smooth muscles. Eur. J. Pharmacol. 120: 201-208, 1986.
18. Sababi, M., A. Hällgren, and O. Nylander. Interaction between prostanoids, NO and VIP in the modulation of duodenal alkaline secretion and motility. Am. J. Physiol. 271 (Gastrointest. Liver Physiol. 34): G582-G590, 1996.
19. Sababi, M., and O. Nylander. Elevation of intraluminal pressure and cyclooxygenase inhibitors increases duodenal alkaline secretion. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G22-G30, 1994.
20. Sharkey, K. A. Substance P and calcitonin gene-related peptide (CGRP) in gastrointestinal inflammation. Ann. NY Acad. Sci. 664: 425-442, 1992.
21. Tateishi, K., S. Kishimoto, H. Kobayashi, K. Kobuke, and Y. Matsuoka. Distribution and localization of neurokinin A-like immunoreactivity and neurokinin B-like immunoreactivity in rat peripheral tissue. Regul. Pept. 30: 193-200, 1990.
22. Tien, X.-Y., L. J. Wallace, J. F. Kachur, K. S. Won, and T. S. Gaginella. Neurokinin A increases short-circuit current across rat colonic mucosa: a role for vasoactive intestinal polypeptide. J. Physiol. (Lond.) 437: 341-350, 1991.