Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein

Genetics

Volumn 147, Issue 3, 1997, Pages 1025-1041

  Forsburg, Susan L ^a   Sherman, Daniel A ^b   Ottilie, Sabine ^a,c   Yasuda, J Randy ^a,d   Hodson, Jeffrey A ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PFIZER INC   (United States)

^d INVITROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE;

ANIMAL CELL; ARTICLE; DNA DETERMINATION; DNA SEQUENCE; ENZYME ACTIVITY; GENE DELETION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; SEQUENTIAL ANALYSIS;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; DNA REPLICATION; DNA, FUNGAL; FUNGAL PROTEINS; MUTATION; PHENOTYPE; RABBITS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; SCHIZOSACCHAROMYCES POMBE;

EID: 0030664449     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (84)

1. ALFA, C., P. FANTES, J. HYAMS, M. MCLEOD and E. WARBRICK, 1993 Experiments With Fission Yeast. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
2. BASI, G., E. SCHMID and K. MAUNDRELL, 1993 TATA box mutations in the Schizosaccharomyces pombe nmt1 promoter affect transcription efficiency but not the transcription start point or thiamine repressibility. Gene 123: 131-136.
3. BURGERS, P. M., 1996 Enzymology of the replication fork, pp. 1-28 in Eukaryotic DNA Replication, edited by J. J. BLOW. Oxford University Press, Oxford.
4. BURKHART, R., D. SCHULTE, B. Hu, C. MUSAHL, F. GOHRING et al., 1995 Interations of human nuclear proteins PIMcm3 and P1Cdc46. Eur. J. Biochem. 228: 431-438.
5. CARPENTER, P. B., P. R. MUELLER and W. G. DUNPHY, 1996 Role for a Xenopus Orc2-related protein in controlling DNA replication. Nature 379: 357-360.
6. CHONG, J. P. J., H. M. MAHBUBANI, C.-Y. KHOO and J. J. BLOW, 1995 Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375: 418-421.
7. CHONG, J. P. J., P. THOMMES and J. J. BLOW, 1996 The role of MCM/ P1 proteins in the licensing of DNA replication. Trends Biochem. 21: 102-106.
8. COLEMAN, T. R., P. B. CARPENTER and W. G. DUNPHY, 1996 The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87: 53-64.
9. + belongs to a family of proteins involved in an early step of chromosome replication. Nucleic Acids Res. 20: 5571-5577.
10. DALTON, S., and L. WHITBREAD, 1995 Cell cycle-regulated nuclear import and export of CDC47, a protein essential for initiation of DNA replication in budding yeast. Proc. Natl. Acad. Sci. USA 92: 2514-2518.
11. FANTES, P., 1979 Epistatic gene interactions in the control of division in fission yeast. Nature 279: 428-430.
12. FENECH, M., A. M. CARR, J. MURRAY, F. Z. WATTS and A. R. LEHMANN, 1991 Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe: a gene showing short regions of sequence similarity to the human XRCC1 gene. Nucleic Acids Res. 19: 6737-6741.
13. FORSBURG, S. L., 1993 Comparison of different Schizosaccharomyces pombe expression systems. Nucleic Acids Res. 21: 2955-2956.
14. FORSBURG, S. L., 1996 Regulation of S phase in the fission yeast Schizosaccharomyces pombe, pp. 197-228 in Eukaryotic DNA Replication, edited by J. J. BLOW. Oxford University Press, Oxford.
15. + in the fission yeast Schizosaccharomyces pombe. Nature 351: 245-248.
16. FORSBURG, S. L., and P. NURSE, 1994a Analysis of the Schizosaccharomyces pombe cyclin puc 1: evidence for a role in cell cycle exit. J. Cell Sci. 107: 601-613.
17. + gene encodes a member of the MCM family of replication proteins. J. Cell Sci. 107: 2779-2788.
18. FORSBURG, S. L., and D. A. SHERMAN, 1997 General purpose tagging vectors for fission yeast. Gene 191: 191-195.
19. FRANCESCONI, S., H. PARK and T. S. F. WANG, 1993 Fission yeast with DNA polymerase delta temperature sensitive alleles exhibits cell division cycle phenotype. Nucleic Acids Res. 21: 3821-3828.
20. GIBSON, S. I., R. T. SUROSKY and B.-K. TYE, 1990 The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication. Mol. Cell. Biol. 10: 5707-5720.
21. HENNESSY, K. M., C. D. CLARK and D. BOTSTEIN, 1990 Subcellular localization of yeast CDC46 varies with the cell cycle. Genes Dev. 4: 2252-2263.
22. HENNESSY, K. M., A. LEE, E. CHEN and D. BOTSTEIN, 1991 A group of interacting yeast DNA replication genes. Genes Dev. 5: 958-969.
23. + that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J. Cell Biol. 106: 1171-1183.
24. + gene encodes the catalytic subunit of DNA polymerase delta. Mol. Gen. Genet. 254: 93-97.
25. ISHIMI, Y., S. ICHINOSE, A. OMORI, K. SATO and H. KIMURA, 1996 Binding of human minichromosome maintenance preins with histone H3. J. Biol. Chem. 271: 24115-24122.
26. JOHNSTON, L., D. BARKER and P. NURSE, 1986 Molecular cloning of the Schizosaccharomyces pombe DNA ligase gene cdc17 and an associated sequence promoting high frequency plasmid transformation. Gene 41: 321-325.
27. KEARSEY, S. E., D. MAIORANO, E. C. HOLMES and I. T. TODOROV, 1996 The role of MCM proteins in the cell cycle control of genome duplication. Bioessays 18: 183-190.
28. + gene product couples S phase to START and mitosis. Cell 74: 371-382.
29. KIMURA, H., N. NOZAKI and K. SUGIMOTO, 1994 DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period. EMBO J. 13: 4311-4320.
30. KOONIN, E. V., 1993 A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Nucleic Acids Res. 21: 2541-2547.
31. KRAUSE, T., W. H. KUNAU and R. ERDMANN, 1994 Effect of site-directed mutagenesis of conserved lysine residues upon Pas1 protein function in peroxisome biogenesis. Yeast 10: 1613-1620.
32. KROLL, E. S., K. M. HYLAND, P. HIETER and J. J. LI, 1996 Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 143: 95-102.
33. KRUDE, T., C. MUSAHL, R. A. LASKEY and R. KNIPPERS, 1996 Human replication proteins hcdc21, hcdc46 and P1mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication. J. Cell Sci. 109: 309-318.
34. KUBOTA, Y., S. MIMURA, S.-I. NISHIMOTO, H. TAKISAWA and H. NOJIMA, 1995 Identification of the yeast MCM3 related protein as a component of Xenopus DNA replication licensing factor. Cell 81: 601-609.
35. LANFORD, R. E., and J. S. BUTEL, 1984 Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell 37: 801-813.
36. LAURENT, B. C., X. YANG and M. CARLSON, 1992 An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a lielicase-related protein in a new family. Mol. Cell. Biol. 12: 1893-1902.
37. LEI, M., Y. KAWASAKI and B. K. TYE, 1996 Physical interactions among MCM proteins and effects of MCM dosage on DNA replication in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: 5081-5090.
38. LI, J. J., and I. HERSKOWITZ, 1993 Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Science 262: 1870-1874.
39. +. Nature 355: 449-452.
40. MA, L., A. WESTBROEK, A. G. JOCHEMSEN, G. WEEDA, A. BOSCH et al., 1994 Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function. Mol. Cell. Biol. 14: 4126-4134.
41. MACNEILL, S. A., S. MORENO, N. REYNOLDS, P. NURSE and P. A. FANTES, 1996 The fission yeast cdc1 protein, a homologue of the small subunit of DNA polymerase δ, binds to pol3 and cdc27. EMBO J. 15: 4613-4628.
42. MADINE, M. A., C.-Y. KHOO, A. D. MILLS and R. A. LASKEY, 1995a MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375: 421-424.
43. MADINE, M. A., C. Y. KHOO, A. D. MILLS, C. MUSAHL and R. A, LASKEY, 1995b The nuclear envelope prevents reinitiation of replication by regulating the binding of Mcm3 to chromatin in Xenopus egg extracts. Curr. Biol. 5: 1270-1279.
44. MAINE, G. T., O. SUBGAM and B.-K. TYE, 1984 Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106: 365-385.
45. MAIORANO, D., G. BLOM VAN ASSENDELFT and S. E. KEARSEY, 1996 Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and located in the nucleus through-out the cell cycle. EMBO J. 15: 861-872.
46. MAUNDRELL, K, 1990 nmt1 of fission yeast: a highly transcribed gene completely repressed by thiamine. J. Biol. Chem. 265: 10857-10864.
47. MAUNDRELL, K., 1993 Thiamine-repressible expression vectors prep and prip for fission yeast. Gene 123: 127-130.
48. 2+ suppression, are members of the CDC46/MCM2 family. Mol. Biol. Cell 4: 1003-1015.
49. MIYAKE, S., I. SAITO, H. KOBAYASHI and S. YAMASHITA, 1996 Identification of two Xenopus laevis genes, xMCM2 and xCDC46, with sequence homology to MCM genes involved in DNA replication. Gene 175: 71-75.
50. MORENO, S., A. KLAR and P. NURSE, 1991 Molecular genetic analysis of the fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194: 795-823.
51. MUSAHL, C., D. SCHULTE, R. BURKHART and R. KNIPPERS, 1995 A human homologue of the yeast replication protein Cdc21 interactions with other Mem proteins. Eur. J. Biochem. 230: 1096-1101.
52. + regulates initiation of DNA replication in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 93: 1566-1570.
53. NASMYTH, K., 1977 Temperature-sensitive lethal mutants in the structural gene for DNA ligase in the yeast Schizosaccharomyces pombe. Cell 12: 1109-1120.
54. NASMYTH, K., and P. NURSE, 1981 Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 182: 119-124.
55. NISHITANI, H., and P. NURSE, 1995 p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell 83: 397-405.
56. OKISHIO, N., Y. ADACHI and M. YANAGIDA, 1996 Fission yeast nda1 and nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins. J. Cell Sci. 109: 319-326.
57. PIGNEDE, G., D. BOUVIER, A. M. DERECONDO and G. BALDACCI, 1991 Characterization of the po13 gene product from Schizosaccharomyces pombe indicates interspecies conservation of the catalytic subunit of DNA polymerase delta. J. Mol. Biol. 222: 209-218.
58. cdc10 function. Mol. Gen. Genet. 234: 449-456.
59. RIKKONEN, M., 1996 Functional significance of the nuclear-targeting and NTP-binding motifs of Semliki Forest virus nonstructural protein nsP2. Virology 218: 352-361.
60. ROMANOWSKI, P., M. A. MADINE, A. ROWLES, J. J. BLOW and R. A. LASKEY, 1996 The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol. 6: 1416-1425.
61. ROWLES, A., J. P. J. CHONG, L. BROWN, M. HOWELL, G. I. EVAN et al., 1996 Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 87: 287-296.
62. + functions as an inducer in the mitotic control of fission yeast. Cell 45: 145-153.
63. +. Cell 74: 383-393.
64. + of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet. 238: 241-251.
65. SAZER, S., and S. W. SHERWOOD, 1990 Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast. J. Cell Sci. 97: 509-516.
66. SCHULTE, D., A. RICHTER, R. BURKHART, C. MUSAHL and R. KNIPPERS, 1996 Properties of the human nuclear protein p85MCM - expression, nuclear localization and interaction with other MCM proteins. Eur. J. Biochem. 235: 144-151.
67. + of fission yeast encodes a protein kinase potentially regulated by phosphorylation. Cell 45: 261-268.
68. SINGH, S. K., and M. R. MAURIZI, 1994 Mutational analysis demonstrates different functional roles for the two ATP-binding sites in CpA protease from Escherichia coli. J. Biol. Chem. 269: 29537-29545.
69. SINHA, P., V. CHANG and B.-K. TYE, 1986 A mutant that affects the function of autonomously replicating sequences in yeast. J. Mol. Biol. 192: 805-814.
70. STARBORG, M., E. BRUNDELL, K. GELL, C. LARSSON, I. WHITE et al., 1995 A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication. J. Cell. Sci. 108: 927-934.
71. SU, T. T., G. FEGER and P. H. OFARRELL, 1996 Drosophila Mcm protein complexes. Mol. Biol. Cell 7: 319-329.
72. TAKAHASHI, K., H. YAMADA and M. YANAGIDA, 1994 Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality. Mol. Biol. Cell 5: 1145-1158.
73. THÖMMES, P., R. FETT, B. SCHRAY, R. BURKHART, M. BARNES et al., 1992 Properties of the nuclear P1 protein, a mammalian homologue of the yeast MCM3 replication protein. Nucleic Acids Res. 20: 1069-1074.
74. TODA, T., K. UMESONO, A. HIRATA and M. YANAGIDA, 1983 Cold sensitive nuclear division arrest mutants of the fission yeast Schizosaccharomyces pombe. J. Mol. Biol. 168: 251-270.
75. TODOROV, I. T., A. ATTARAN and S. E. KEARSEY, 1995 BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication. J. Cell Biol. 129: 1433-1445.
76. TODOROV, I. T., R. PEPPERKOK, R. PHILIPOVA, S. E. KEARSEY, W. ANSORGE et al., 1994 A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division. J. Cell Sci. 107: 253-265.
77. TREISMAN, J. E., P. J. FOLLETTE, P. H. OFARRELL and G. M. RUBIN, 1995 Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes Dev. 9: 1709-1715.
78. TYE, B.-K., 1994 The MCM2-3-5 proteins: are they replication licensing factors? Trends Cell Biol. 4: 160-166.
79. WALKER, J. E., M. SARAVSTE, M. J. RUNSWICK and N. J. GAY, 1982 Distantly related sequences in the alpha-and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1: 945-951.
80. WHITBREAD, L. A., and S. DALTON, 1995 Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initakion of eukaryotic DNA replication. Gene 155: 113-117.
81. WHITEHEART, S. W., K. ROSSNAGEL, S. A. BUHROW, M. BRUNNER, R. JAENICKE et al., 1994 N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion. J. Cell Biol. 126: 945-954.
82. YAHRAUS, T., N. BRAVERMAN, G. DODT, J. E. KALISH, J. C. MORRELL et al., 1996 The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor. EMBO J. 15: 2914-2923.
83. YAN, H., S. GIBSON and B. K. TYE, 1991 MCM2 and MCM3, two proteins important for ARS activity, are related in structure and function. Genes Dev. 4: 968-977.
84. YAN, H., A. M. MERCHANT and B. K. TYE, 1993 Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev. 7: 2149-2160.