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Volumn 7, Issue 20, 1997, Pages 2645-2650

Resolution and biological activities of optical isomers of 1,4-diethyl-3,6-epidithiopiperazine-2,5-dione

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; GLIOTOXIN; PIPERAZINEDIONE;

EID: 0030660207     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10052-X     Document Type: Article
Times cited : (3)

References (30)
  • 1
    • 0001292030 scopus 로고
    • Kadis, S.; Ciegler, A.; Ajl, S., Eds.; Academic: New York
    • Taylor, A. In Microbial Toxins; Kadis, S.; Ciegler, A.; Ajl, S., Eds.; Academic: New York, 1971; Vol 7, pp 337-376.
    • (1971) Microbial Toxins , vol.7 , pp. 337-376
    • Taylor, A.1
  • 11
    • 0342681892 scopus 로고    scopus 로고
    • 2 : C 41.36; H 5.21; N 12.06; S 27.60 Found C 41.55; H 5.06; N 11.71; S 27.68
    • 2 : C 41.36; H 5.21; N 12.06; S 27.60. Found C 41.55; H 5.06; N 11.71; S 27.68.
  • 14
    • 0343988144 scopus 로고    scopus 로고
    • note
    • 1,4-Diethylpiperazine-2,5-dione was dibrominated at the α-carbon positions under radical conditions using N-bromosuccinimide (2 equiv) and catalytic amounts of the radical initiator azo-(bis)-isobutyronitrile (AIBN). The dibromide was then subjected to nucleophilic displacement with potassium thioacetate (2 equiv) and only the cis - isomer was isolated. The dithioacetate derivative was subsequently hydrolysed to the dithiol under acidic conditions and finally oxidised to the disulfide (3) using a two-phase system of water/chloroform with KI3/I2.
  • 15
    • 0343552160 scopus 로고    scopus 로고
    • note
    • The HPLC was from Beckman using System Gold equipment with the online 166 UV detector tuned to 220 nm and data was analysed using System Gold Chromatography Software.
  • 19
    • 0343116222 scopus 로고    scopus 로고
    • note
    • The CD measurements were obtained using a 0.1 cm cell in a Jobin Yvon CD6 machine and analysed using Dichro Software Version 1.2.
  • 28
    • 0342681887 scopus 로고    scopus 로고
    • note
    • The FACSCAN flow cytometer was from Becton Dickinson, San Jose, CA, USA and data was analysed using winMDI version 2.5, kindly supplied by Joseph Trotter, Scripps Research Institute, La Jolla, California, USA.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.