Airway responsiveness in transgenic mice overexpressing platelet- activating factor receptor: Roles of thromboxanes and leukotrienes

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 5, 1997, Pages 1621-1627

  Nagase, Takahide ^a   Ishii, Satoshi ^a   Katayama, Hirofumi ^a   Fukuchi, Yoshinosuke ^a   Ouchi, Yasuyoshi ^a   Shimizu, Takao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5 [2 (2 CARBOXYETHYL) 3 [6 (4 METHOXYPHENYL) 5 HEXENYLOXY]PHENOXY]VALERIC ACID; APAFANT; INDOMETACIN; LEUKOTRIENE B4 RECEPTOR ANTAGONIST; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; METHACHOLINE; OZAGREL; PEPTIDOLEUKOTRIENE; PRANLUKAST; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; THROMBOXANE A2; THROMBOXANE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOSPASM; BRONCHUS MUSCLE; BRONCHUS REACTIVITY; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SMOOTH MUSCLE CONTRACTION; TRANSGENIC MOUSE;

EID: 0030657005     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.5.9703016     Document Type: Article

References (35)

1. Prescott, S. M., G. A. Zimmerman, and T. M. McIntyre. 1990. Platelet-activating factor. J. Biol. Chem. 265:17381-17384.
2. Chao, W., and M. S. Olson. 1993. Platelet-activating factor: receptors and signal transduction. Biochem. J. 292:617-629.
3. Izumi, T., and T. Shimizu. 1995. Platelet-activating factor receptor: gene expression and signal transduction. Biochim. Biophys. Acta 1259:317-333.
4. Honda, Z.-i., M. Nakamura, I. Miki, M. Minami, T. Watanabe, Y. Seyama, H. Okado, H. Toh, K. Ito, T. Miyamoto, and T. Shimizu. 1991. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature 349:342-346.
5. Nakamura, M., Z.-i. Honda, T. Izumi, C. Sakanaka, H. Mutoh, M. Minami, H. Bito, Y. Seyama, T. Matsumoto, M. Noma, and T. Shimizu. 1991. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J. Biol. Chem. 266:20400-20405.
6. Ye, R. D., E. R. Prossnitz, A. H. Zou, and C. G. Cochrane. 1991. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochem. Biophys. Res. Commun. 180:105-111.
7. Kunz, D., N. P. Gerard, and C. Gerard. 1992. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-hearing analog. J. Biol. Chem. 267: 9101-9106.
8. Sugimoto, T., H. Tsuchimochi, C. G. McGregor, H. Mutoh, T. Shimizu, and Y. Kurachi. 1992. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. Biochem. Biophys. Res. Commun. 189:617-624.
9. Bito, H., Z.-i. Honda, M. Nakamura, and T. Shimizu. 1994. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. Eur. J. Biochem. 221:211-218.
10. Ishii, S., Y. Matsuda, M. Nakamura, I. Waga, K. Kume, T. Izumi, and T. Shimizu. 1996. A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem. J. 314: 671-678.
11. Ishii, S., T. Nagase, F. Tashiro, K. Ikuta, S. Sato, I. Waga, K. Kume, J. Miyazaki, and T. Shimizu. 1997. Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J. 16:133-142.
12. Cuss, F. M., C. M. Dixon, and P. J. Barnes. 1986. Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet 2:189-192.
13. Page, C. P. 1992. Mechanism of hyperresponsiveness: platelet-activating factor. Am. Rev. Respir. Dis. 145:S31-S33.
14. Shirasaki, H., M. Nishikawa, I. M. Adcock, J. C. Mak, T. Sakamoto, T. Shimizu, and P. J. Barnes. 1994. Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. Am. J. Respir. Cell Mol. Biol. 10:533-537.
15. Stafforini, D. M., K. Satoh, D. L. Atkinson, L. W. Tjoelker, C. E. Eberhardt, H. Yoshida, T. Imaizumi, S. Takamatsu, G. A. Zimmerman, T. M. McIntyre, P. W. Gray, and S. M. Prescott. 1996. Platelet-activating factor acetylhydrolase deficiency: a missense mutation near the active site of an anti-inflammatory phospholipase. J. Clin. Invest. 97:2784-2791.
16. Miwa, M., T. Miyake, T. Yamanaka, J. Sugatani, Y. Suzuki, S. Sakata, Y. Araki, and M. Matsumoto. 1988. Characterization of serum platelet-activating factor (PAF) acetylhydrolase: correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children. J. Clin. Invest. 82:1983-1991.
17. Rubin, A.-H. E., L. J. Smith, and R. Patterson. 1987. The bronchoconstrictor properties of platelet-activating factor in humans. Am. Rev. Respir. Dis. 136:1145-1151.
18. Nagase, T., Y. Fukuchi, T. Matsuse, E. Sudo, H. Matsui, and H. Orimo. 1995. Antagonism of ICAM-1 attenuates airway and tissue responses to antigen in sensitized rats. Am. J. Respir. Crit. Care Med. 151:1244-1249.
19. Nagase, T., H. Matsui, T. Aoki, Y. Ouchi, and Y. Fukuchi. 1996. Lung tissue behaviour in the mouse during constriction induced by methacholine and endothelin-1. J. Appl. Physiol. 81:2373-2378.
20. Mead, J. 1961. Mechanical properties of lungs. Physiol. Rev. 41:281-330.
21. James, A. L., J. C. Hogg, L. A. Dunn, and P. D. Paré. 1988. The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am. Rev. Respir. Dis. 138:136-139.
22. Martin, T. R., N. P. Gerard, S. J. Galli, and J. M. Drazen. 1988. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64:2318-2323.
23. Chen, X.-S., J. R. Sheller, E. N. Johnson, and C. D. Funk. 1994. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 372:179-182.
24. Tokuyama, K., J. O. Lötvall, P. J. Barnes, and K. F. Chung. 1991. Mechanism of airway narrowing caused by inhaled platelet-activating factor: role of airway microvascular leakage. Am. Rev. Respir. Dis. 143:1345-1349.
25. Stewert, A. G., P. N. Dubbin, T. Harris, and G. J. Dusting. 1990. Platelet-activating factor may act as a second messenger in the release of icosanoids and superoxide anions from leukocytes and endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 87:3215-3219.
26. Goulet, J. L., J. N. Snouwaert, A. M. Latour, T. M. Coffman, and B. H. Koller. 1994. Altered inflammatory responses in leukotriene-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 91:12852-12856.
27. 4 induces airway hyperresponsiveness in dogs. J. Appl. Physiol. 59:1941-1946.
28. Mazzoni, L., J. Morley, C. P. Page, and S. Sanjar. 1985. Introduction of airway hyperreactivity by platelet activating factor in the guinea-pig. J. Physiol. (Lond.) 365:107.
29. Hozawa, S., Y. Haruta, S. Ishioka, and M. Yamakido. 1995. Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma. Am. J. Respir. Crit. Care Med. 152:1198-1202.
30. 4 in allergen-induced increases in airway smooth muscle in the rat. Am. Rev. Respir. Dis. 148:413-417.
31. Sandford, A., T. Weir, and P. Paré. 1996. The genetics of asthma. Am. J. Respir. Crit. Care Med. 153:1749-1765.
32. DeSanctis, G. T., M. Merchant, D. R. Beier, R. D. Dredge, J. K. Grobholz, T. R. Martin, E. S. Lander, and J. M. Drazen. 1995. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat. Genet. 11:150-154.
33. Mutoh, H., H. Bito, M. Minami, M. Nakamura, Z. Honda, T. Izumi, R. Nakata, Y. Kurachi, A. Terano, and T. Shimizu. 1993. Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor. FEBS Lett. 322:129-134.
34. Hattori, M., H. Adachi, M. Tsujimoto, H. Arai, and K. Inoue. 1994. Miller-Dicker lissencephalopathy gene encodes a subunit of brain platelet-activating factor acetylhydrolase. Nature 370:216-218.
35. Tjoelker, L. W., C. Wilder, C. Eberhardt, D. M. Stafforini, G. Dietsch, B. Schimpf, S. Hooper, H. L. Trong, L. S. Cousens, G. A. Zimmerman, Y. Yamada, T. M. McIntyre, S. M. Prescott, and P. W. Gray. 1995. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374:549-553.