메뉴 건너뛰기




Volumn 58, Issue 6, 1997, Pages 520-528

Role of matrix metalloproteinases and their inhibitors in pancreatic cancer

Author keywords

Batimastat; Marimastat; Matrix metalloproteinases; Pancreatic cancer; Tissue inhibitors, metalloproteinases

Indexed keywords

BATIMASTAT; CDP 845; CGS 27023A; CIPEMASTAT; COLLAGENASE; CYCLOPHOSPHAMIDE; D 5410; GELATINASE A; GELATINASE B; GELATINASE INHIBITOR; GEMCITABINE; MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; N1 (1 CARBAMOYL 2,2 DIMETHYLPROPYL) 2 [3 (4 CHLOROPHENYL)PROPYL] N4 HYDROXYBUTANEDIAMIDE; PRINOMASTAT; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; UNCLASSIFIED DRUG;

EID: 0030656475     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000201495     Document Type: Article
Times cited : (28)

References (106)
  • 1
    • 0002357594 scopus 로고
    • Proteolytic enzymes in tumour invasion and degradation of host extracellular matrices'
    • Honn KV, Powers WE, Sloane BF (eds), Boston, NijhoIT
    • Goldfarb RH: Proteolytic enzymes in tumour invasion and degradation of host extracellular matrices', in Honn KV, Powers WE, Sloane BF (eds): Mechanisms of Cancer Metastasis, Boston, NijhoIT, 1986, pp 341-375.
    • (1986) Mechanisms of Cancer Metastasis , pp. 341-375
    • Goldfarb, R.H.1
  • 2
    • 0019195010 scopus 로고
    • Metastatic potential correlates with enzymatic degradation of basement membrane collagen
    • Liotta LA, Trvggvason K, Garbisa S, Hart I, Foltz CM, Shafdic S: Metastatic potential correlates with enzymatic degradation of basement membrane collagen, Nature 1980:284: 67-68.
    • (1980) Nature , vol.284 , pp. 67-68
    • Liotta, L.A.1    Trvggvason, K.2    Garbisa, S.3    Hart, I.4    Foltz, C.M.5    Shafdic, S.6
  • 4
    • 0022521573 scopus 로고
    • Tumour basement membrane laminin in adenocarcinoma of the rectum: An immunohistochemical study of biological and clinical significance
    • Forster SJ, Talbot IC, Clayton DG, Critchley DR: Tumour basement membrane laminin in adenocarcinoma of the rectum: An immunohistochemical study of biological and clinical significance, Int J Cancer 1986:37:813-817.
    • (1986) Int J Cancer , vol.37 , pp. 813-817
    • Forster, S.J.1    Talbot, I.C.2    Clayton, D.G.3    Critchley, D.R.4
  • 5
    • 0002324979 scopus 로고
    • Pathology of non-endocrine pancreas tumours
    • Go LW, DiMagno EP, Gardner HD, Lebenthal E, Reber HA, Scheele GA (eds), New York, Raven Press
    • Kioppcl G: Pathology of non-endocrine pancreas tumours; in Go LW, DiMagno EP, Gardner HD, Lebenthal E, Reber HA, Scheele GA (eds): The Pancreas: Biology, Pathobiology and Disease, cd 2, New York, Raven Press, 1993, pp 871-897.
    • (1993) The Pancreas: Biology, Pathobiology and Disease, Cd 2 , pp. 871-897
    • Kioppcl, G.1
  • 6
    • 0028363866 scopus 로고
    • Distribution of type IV collagen in pancreatic adenocarcinoma and chronic pancreatitis
    • Lee CS, Montebello J, Gcorgiou T, Rode J: Distribution of type IV collagen in pancreatic adenocarcinoma and chronic pancreatitis, Int J Exp Pathol 1994:75:79-83.
    • (1994) Int J Exp Pathol , vol.75 , pp. 79-83
    • Lee, C.S.1    Montebello, J.2    Gcorgiou, T.3    Rode, J.4
  • 7
    • 0022656975 scopus 로고
    • Tumour invasion and metastasis: Role of the extracellular matrix
    • Liotta LA: Tumour invasion and metastasis: Role of the extracellular matrix, Cancer Res 1986:46:1-7.
    • (1986) Cancer Res , vol.46 , pp. 1-7
    • Liotta, L.A.1
  • 8
    • 0002522994 scopus 로고
    • The role of protcases in cancer
    • Gotlesman M: The role of protcases in cancer, Semin Cancer Biol 1990; 1:97-100.
    • (1990) Semin Cancer Biol , vol.1 , pp. 97-100
    • Gotlesman, M.1
  • 9
    • 0021045628 scopus 로고
    • Antibodies to plasminogen activator inhibit human tumour metastasis
    • Ossawski L, Reisch E: Antibodies to plasminogen activator inhibit human tumour metastasis, Cell 1983:35:611-619.
    • (1983) Cell , vol.35 , pp. 611-619
    • Ossawski, L.1    Reisch, E.2
  • 10
    • 0019797924 scopus 로고
    • Lysosomal cathepsin B: Correlation with metastatic potential
    • Sloane BF, Dunn JR, Huon KV: Lysosomal cathepsin B: Correlation with metastatic potential, Science 1981:212:1 151-1153.
    • (1981) Science , vol.212 , Issue.1 , pp. 151-1153
    • Sloane, B.F.1    Dunn, J.R.2    Huon, K.V.3
  • 11
    • 0026522287 scopus 로고
    • The role of proteolytic enzymes in cancer invasion and metastasis
    • Duffy MJ: The role of proteolytic enzymes in cancer invasion and metastasis, Clin Exp Metastasis 1992:10:145-155.
    • (1992) Clin Exp Metastasis , vol.10 , pp. 145-155
    • Duffy, M.J.1
  • 12
    • 0026425631 scopus 로고
    • Tumour invasion and metastasis: An imbalance of positive and negative regulation
    • Liotta LA, Stetler Stevenson WG: Tumour invasion and metastasis: An imbalance of positive and negative regulation, Cancer Res 1991: 51:5054-5059.
    • (1991) Cancer Res , vol.51 , pp. 5054-5059
    • Liotta, L.A.1    Stetler Stevenson, W.G.2
  • 13
    • 0027223141 scopus 로고
    • Regulation of matrix metalloproteinases: Their role in tumour invasion and metastasis
    • Cottam DW, Rees RC: Regulation of matrix metalloproteinases: Their role in tumour invasion and metastasis, Int J Oncol 1993:2:861-872.
    • (1993) Int J Oncol , vol.2 , pp. 861-872
    • Cottam, D.W.1    Rees, R.C.2
  • 14
    • 0002801861 scopus 로고
    • Mechanism of mineral solubilisation and matrix degradation in ocsto-clastic bone resorption
    • Rifkin BR, Gay CV (eds), Boea Raton, CRC Press
    • Délaisse JM, Vacs G: Mechanism of mineral solubilisation and matrix degradation in ocsto-clastic bone resorption: in Rifkin BR, Gay CV (eds): Biology and Physiology of the Osteoclast, Boea Raton, CRC Press, 1992, pp 290-314.
    • (1992) Biology and Physiology of the Osteoclast , pp. 290-314
    • Délaisse, J.M.1    Vacs, G.2
  • 15
    • 0024503589 scopus 로고
    • Prolonged activation of jun and colta-gcnasc genes by tumour necrosis factor alpha
    • Brenner DA, Ohara M, Angel P, Chojkicr M, Karin M: Prolonged activation of jun and colta-gcnasc genes by tumour necrosis factor alpha, Nature 1989:337:661-663.
    • (1989) Nature , vol.337 , pp. 661-663
    • Brenner, D.A.1    Ohara, M.2    Angel, P.3    Chojkicr, M.4    Karin, M.5
  • 16
    • 0026621123 scopus 로고
    • Breast-canccr-associatcd stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing
    • Wolf C, Chenard MP, Durand de Grossouvre P, Bcllocq JP, Chambon P, Basset P: Breast-canccr-associatcd stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing, J Invest Dermatol 1992:99:870-872.
    • (1992) J Invest Dermatol , vol.99 , pp. 870-872
    • Wolf, C.1    Chenard, M.P.2    Durand De Grossouvre, P.3    Bcllocq, J.P.4    Chambon, P.5    Basset, P.6
  • 17
    • 0025304539 scopus 로고
    • Rheumatoid arthritis: Pathophysiology and implications for therapy
    • Harris E: Rheumatoid arthritis: Pathophysiology and implications for therapy, N Engl J Med 1990:322:1277-1289.
    • (1990) N Engl J Med , vol.322 , pp. 1277-1289
    • Harris, E.1
  • 18
    • 0019942852 scopus 로고
    • Correlation of collagenase secretion with metastatic colonisation potential in naturally occurring murine mammary tumours
    • Tarin D, Hoyt BJ, Evans DJ: Correlation of collagenase secretion with metastatic colonisation potential in naturally occurring murine mammary tumours, Br J Cancer 1982:46:266-278.
    • (1982) Br J Cancer , vol.46 , pp. 266-278
    • Tarin, D.1    Hoyt, B.J.2    Evans, D.J.3
  • 19
    • 0025799478 scopus 로고
    • The origin of matrix metalloproteinases and their familial relationships
    • Murphy GJP, Murphy G, Reynolds JJ: The origin of matrix metalloproteinases and their familial relationships, FEBS Lett 1991:289:4-7.
    • (1991) FEBS Lett , vol.289 , pp. 4-7
    • Murphy, G.1    Murphy, G.2    Reynolds, J.J.3
  • 20
    • 0016819074 scopus 로고
    • Purification and characterisation of a collagenase extracted from rabbit tumours
    • McCroskery PA, Richards JF, Harris ED: Purification and characterisation of a collagenase extracted from rabbit tumours, Biochem J 1975:152:131-142.
    • (1975) Biochem J , vol.152 , pp. 131-142
    • McCroskery, P.A.1    Richards, J.F.2    Harris, E.D.3
  • 21
    • 0024545345 scopus 로고
    • Identification of a mctalloproteinase co-purifving with rat tumour collagenase and the characteristics of fragments of both enzymes
    • Ncthery A, O'Grady RL: Identification of a mctalloproteinase co-purifving with rat tumour collagenase and the characteristics of fragments of both enzymes, Biochim Biophys Acta 1989: 994:149-160.
    • (1989) Biochim Biophys Acta , vol.994 , pp. 149-160
    • Ncthery, A.1    O'grady, R.L.2
  • 23
    • 0025230509 scopus 로고
    • Metalloproteinases and their inhibitors in matrix remodelling
    • Matr sian LM: Metalloproteinases and their inhibitors in matrix remodelling, Trends Genet 1990;6:121-125.
    • (1990) Trends Genet , vol.6 , pp. 121-125
    • Matr Sian, L.M.1
  • 24
    • 0028116127 scopus 로고
    • Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3
    • Pei D, Majmudar G, Weiss SJ: Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3, J Biol Chem 1994:269:25849-25855.
    • (1994) J Biol Chem , vol.269 , pp. 25849-25855
    • Pei, D.1    Majmudar, G.2    Weiss, S.J.3
  • 25
    • 0028291737 scopus 로고
    • A matrix mctallopro-tcinase expressed on the surface of invasive tumour cells
    • Sato H, Takin T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Sciki M: A matrix mctallopro-tcinase expressed on the surface of invasive tumour cells, Nature 1994;370:61-65.
    • (1994) Nature , vol.370 , pp. 61-65
    • Sato, H.1    Takin, T.2    Okada, Y.3    Cao, J.4    Shinagawa, A.5    Yamamoto, E.6    Sciki, M.7
  • 26
    • 0029133344 scopus 로고
    • CDNA sequence and rnRNA tissue distribution of a novel human matrix mctalloproteinase with a potential transmembranc segment
    • Will H, Hinzman B: cDNA sequence and rnRNA tissue distribution of a novel human matrix mctalloproteinase with a potential transmembranc segment, Eur J Biochem 1995: 231:602-608.
    • (1995) Eur J Biochem , vol.231 , pp. 602-608
    • Will, H.1    Hinzman, B.2
  • 27
    • 0029118269 scopus 로고
    • Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library
    • Takino T, Sao H, Shinagawa A, Seiki M: Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library, J Biol Chem 1995;270:23013-23020.
    • (1995) J Biol Chem , vol.270 , pp. 23013-23020
    • Takino, T.1    Sao, H.2    Shinagawa, A.3    Seiki, M.4
  • 28
    • 0030022539 scopus 로고    scopus 로고
    • Molecular cloning of a novel membrane-type matrix metalloprotcinase form a human breast carcinoma
    • Puente XS, Pendas AM, Llano E, Velasco G, Ldpez-Otin C: Molecular cloning of a novel membrane-type matrix metalloprotcinase form a human breast carcinoma, Cancer Res 1996; 56:944-949.
    • (1996) Cancer Res , vol.56 , pp. 944-949
    • Puente, X.S.1    Pendas, A.M.2    Llano, E.3    Velasco, G.4    Ldpez-Otin, C.5
  • 30
    • 0024318368 scopus 로고
    • PUMP I cDNA codes for a protein with characteristics similar to those of classical collagenase family members
    • Quantin B, Murphy G, Brcathnach R: PUMP I cDNA codes for a protein with characteristics similar to those of classical collagenase family members, Biochemistry 1989;28:5325-5334.
    • (1989) Biochemistry , vol.28 , pp. 5325-5334
    • Quantin, B.1    Murphy, G.2    Brcathnach, R.3
  • 31
    • 0027515289 scopus 로고
    • Cloning and characterisation of a unique elastolytic mc-talloprolcinase produced by human alveolar macrophages
    • Shapiro SD, Kobayashi DK, Ley TJ: Cloning and characterisation of a unique elastolytic mc-talloprolcinase produced by human alveolar macrophages, J Biol Chem 1993:268:23824-23829.
    • (1993) J Biol Chem , vol.268 , pp. 23824-23829
    • Shapiro, S.D.1    Kobayashi, D.K.2    Ley, T.J.3
  • 33
    • 0025611427 scopus 로고
    • Type IV collagcnascs in tumour invasion and metastasis
    • Stetler-Stevenson WG: Type IV collagcnascs in tumour invasion and metastasis, Cancer Metastasis Rev 1990:9:289-303.
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 289-303
    • Stetler-Stevenson, W.G.1
  • 34
    • 0027409432 scopus 로고
    • Role of zinc binding and hemopcxin-domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins
    • Sanchez-Ldpez R, Alexander CM, Bchrendtscn O, Breathnach R, Werb Z: Role of zinc binding and hemopcxin-domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins, J Biol Chem 1993:268:7238-7247.
    • (1993) J Biol Chem , vol.268 , pp. 7238-7247
    • Sanchez-Ldpez, R.1    Alexander, C.M.2    Bchrendtscn, O.3    Breathnach, R.4    Werb, Z.5
  • 35
    • 0026462778 scopus 로고
    • Over-expression of the epidermal growth factor receptor in human pancreatic cancer is associated with coneom-mitant increases in the levels of epidermal growth factor and transforming growth factor alpha
    • Korc M, Chandreskar B, Yamanaka Y, Frciss H, Biichlcr M, Bcger HG: Over-expression of the epidermal growth factor receptor in human pancreatic cancer is associated with coneom-mitant increases in the levels of epidermal growth factor and transforming growth factor alpha, J Clin Invest 1992:90:1352-1360.
    • (1992) J Clin Invest , vol.90 , pp. 1352-1360
    • Korc, M.1    Chandreskar, B.2    Yamanaka, Y.3    Frciss, H.4    Biichlcr, M.5    Bcger, H.G.6
  • 36
    • 0027418434 scopus 로고
    • Production of matrix metalloprotcinase 9 (92 kDa gelatinasc) by human oesophageal squamous cell carcinoma in response to epidermal growth factor
    • Shima I, Sasaguri Y, Kasukawa J, Nakano R, Yamana H, Fujita H, Kakegawa T, Morimatsu M: Production of matrix metalloprotcinase 9 (92 kDa gelatinasc) by human oesophageal squamous cell carcinoma in response to epidermal growth factor, Br J Cancer 1993:67:721-727.
    • (1993) Br J Cancer , vol.67 , pp. 721-727
    • Shima, I.1    Sasaguri, Y.2    Kasukawa, J.3    Nakano, R.4    Yamana, H.5    Fujita, H.6    Kakegawa, T.7    Morimatsu, M.8
  • 37
    • 0023718397 scopus 로고
    • Fos-associated cellular p39 is related to nuclear transcription factor AP-I
    • Sassonc-Corsi P, Lamph WW, Kamps M, Ver-ma IM: Fos-associated cellular p39 is related to nuclear transcription factor AP-I, Cell 1988; 54:553-563.
    • (1988) Cell , vol.54 , pp. 553-563
    • Sassonc-Corsi, P.1    Lamph, W.W.2    Kamps, M.3    Ver-Ma, I.M.4
  • 38
    • 0025346113 scopus 로고
    • The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites
    • Gutman A, Wasylyk B: The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites, EMBO J 1990:9:2241-2246.
    • (1990) EMBO J , vol.9 , pp. 2241-2246
    • Gutman, A.1    Wasylyk, B.2
  • 39
    • 0024330327 scopus 로고
    • SV40 transformed human lung fibroblasts secrete a 92 kDa type IV collagenase which is identical to that secreted by normal human macrophages
    • Wilhelm SM, Collier IE, Mariner BL, Eisen AZ, Grant GA, Goldberg GL: SV40 transformed human lung fibroblasts secrete a 92 kDa type IV collagenase which is identical to that secreted by normal human macrophages, J Biol Chem 1989:264:17213-17221.
    • (1989) J Biol Chem , vol.264 , pp. 17213-17221
    • Wilhelm, S.M.1    Collier, I.E.2    Mariner, B.L.3    Eisen, A.Z.4    Grant, G.A.5    Goldberg, G.L.6
  • 40
    • 0022574622 scopus 로고
    • Interleukin I stimulation of synovial cell plasminogen activator production
    • Mochan E, Uhl J, Nowlon R: Interleukin I stimulation of synovial cell plasminogen activator production, J Rheumatol 1986:13:15-19.
    • (1986) J Rheumatol , vol.13 , pp. 15-19
    • Mochan, E.1    Uhl, J.2    Nowlon, R.3
  • 43
    • 0025616093 scopus 로고
    • Matrix metalloprotcinase 2 from human rheumatoid synovial fibroblasts: Purification and activation of the precursor and enzymic properties
    • Okada Y, Morodomi T, Enghild J, Suzuki K, Yasui A, Nakanishi I, Salvcson G, Nagasc H: Matrix metalloprotcinase 2 from human rheumatoid synovial fibroblasts: Purification and activation of the precursor and enzymic properties, Eur J Biochem 1990:194:721-730.
    • (1990) Eur J Biochem , vol.194 , pp. 721-730
    • Okada, Y.1    Morodomi, T.2    Enghild, J.3    Suzuki, K.4    Yasui, A.5    Nakanishi, I.6    Salvcson, G.7    Nagasc, H.8
  • 44
    • 0026795140 scopus 로고
    • Matrix metalloprotcinase 9 (92 kDa gelatinasc/ type IV collagenase) from HTI080 human fibrosarcoma cells
    • Okada Y, Gonoji Y, Naka K, Tomita K, Nakanishi I, iwata K, Yamashita K, Hayakawa T: Matrix metalloprotcinase 9 (92 kDa gelatinasc/ type IV collagenase) from HTI080 human fibrosarcoma cells, J Biol Chem 1992:267: 21712-21719.
    • (1992) J Biol Chem , vol.267 , pp. 21712-21719
    • Okada, Y.1    Gonoji, Y.2    Naka, K.3    Tomita, K.4    Nakanishi, I.5    Iwata, K.6    Yamashita, K.7    Hayakawa, T.8
  • 45
    • 0025074287 scopus 로고
    • Induction and stimulation of 92 kD gelatinasc/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by-tumour necrosis factor alpha
    • Okada Y, Tsuchiya H, Shimizu H, Tomita K, Nakanishi I, Sato H, Seiki M, Yamashita K, Hayakawa T: Induction and stimulation of 92 kD gelatinasc/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by-tumour necrosis factor alpha, Biochem Bio-phvsRcsCommun 1990:171:610-617.
    • (1990) Biochem Bio-Phvsrcscommun , vol.171 , pp. 610-617
    • Okada, Y.1    Tsuchiya, H.2    Shimizu, H.3    Tomita, K.4    Nakanishi, I.5    Sato, H.6    Seiki, M.7    Yamashita, K.8    Hayakawa, T.9
  • 46
    • 0025853770 scopus 로고
    • Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells are invasive foci in human colon adenocarcinomas
    • Pyke C, Kristensen P, Ralfiaer E, Grandahl-hanscn J, Eriksen J, Brasi F, Dano K: Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells are invasive foci in human colon adenocarcinomas, Am J Pathol 1991:138:1059-1067.
    • (1991) Am J Pathol , vol.138 , pp. 1059-1067
    • Pyke, C.1    Kristensen, P.2    Ralfiaer, E.3    Grandahl-Hanscn, J.4    Eriksen, J.5    Brasi, F.6    Dano, K.7
  • 47
    • 0004553618 scopus 로고
    • Tissue cooperation in a proteolytic cascade activating human intestinal collagenase
    • He C, Wilhelm SM, Pentland AP, et al: Tissue cooperation in a proteolytic cascade activating human intestinal collagenase, Proc Natl Acad Sci USA 1989:86:2632-2636.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2632-2636
    • He, C.1    Wilhelm, S.M.2    Pentland, A.P.3
  • 48
    • 0025193320 scopus 로고
    • Basement membrane type IV collagen degradation: Evidence for the involvement of a proteolytic cascade independent of metalloproteinases
    • Mackey AR, Corbitt RH, Hartzler JL, Thorgeirsson UP: Basement membrane type IV collagen degradation: Evidence for the involvement of a proteolytic cascade independent of metalloproteinases, Cancer Res 1990:50:5997-6001
    • (1990) Cancer Res , vol.50 , pp. 5997-6001
    • Mackey, A.R.1    Corbitt, R.H.2    Hartzler, J.L.3    Thorgeirsson, U.P.4
  • 49
    • 0025026410 scopus 로고
    • Mechanisms of activation of tissue procollagenase by matrix mctalloprolci-nasc3 (Stromelysin)
    • Suzuki K, Enghild JJ, Morodomi T, Salvcson G, Nagase H: Mechanisms of activation of tissue procollagenase by matrix mctalloprolci-nasc3 (stromelysin), Biochemistry 1990:29: 10261-10270.
    • (1990) Biochemistry , vol.29 , pp. 10261-10270
    • Suzuki, K.1    Enghild, J.J.2    Morodomi, T.3    Salvcson, G.4    Nagase, H.5
  • 50
    • 0029103394 scopus 로고
    • Proteolytic and non-proteolytic activation of human neutrophil progelatinase
    • Sang QX, Birkedel-Hanson H, Van Wart LIE: Proteolytic and non-proteolytic activation of human neutrophil progelatinase, Biochim Bio-physActa 1995:1251:99-108.
    • (1995) Biochim Bio-Physacta , vol.1251 , pp. 99-108
    • Sang, Q.X.1    Birkedel-Hanson, H.2    Van Wart, L.3
  • 51
    • 0028291374 scopus 로고
    • Human procollagenase A can be activated by matrilysin
    • Crabbe T, Smith B, O'connell JP, Dochcrty A: Human procollagenase A can be activated by matrilysin, FEBS Lett 1994;345:14-16.
    • (1994) FEBS Lett , vol.345 , pp. 14-16
    • Crabbe, T.1    Smith, B.2    O'connell, J.P.3    Dochcrty, A.4
  • 52
    • 0018360377 scopus 로고
    • Rabbit bone collagenase inhibitor blocks the activity of other neutral metalloproteinases
    • Sellers A, Murphy G, Mcickle MC, Reynolds JJ: Rabbit bone collagenase inhibitor blocks the activity of other neutral metalloproteinases, Biochem Biphys Res Commun 1979:87:581-587.
    • (1979) Biochem Biphys Res Commun , vol.87 , pp. 581-587
    • Sellers, A.1    Murphy, G.2    McIckle, M.C.3    Reynolds, J.J.4
  • 53
    • 0024394212 scopus 로고
    • Tissue inhibitor of mc-talloproteinasc (TIMP 2)
    • Stetler Stevenson WG: Tissue inhibitor of mc-talloproteinasc (TIMP 2), J Biol Chem 1989; 264:17374-17378.
    • (1989) J Biol Chem , vol.264 , pp. 17374-17378
    • Stetler Stevenson, W.G.1
  • 54
    • 0028355246 scopus 로고
    • Structure and expression in breast tumours of human TIMP 3, a new- mem-her of the metalloprotcinase inhibitor family
    • Uria JA, Ferrando AA, Velasco G, Freije JMP, Lopez-Otin C: Structure and expression in breast tumours of human TIMP 3, a new- mem-her of the metalloprotcinase inhibitor family, Cancer Res 1994;54:2091-2094.
    • (1994) Cancer Res , vol.54 , pp. 2091-2094
    • Uria, J.A.1    Ferrando, A.A.2    Velasco, G.3    Freije, J.4    Lopez-Otin, C.5
  • 55
    • 0029806813 scopus 로고    scopus 로고
    • Molecular cloning and characterisation of human tissue inhibitor of mctal-loproteinase 4
    • Greene J, Wang M, I-iu YE, Raymond LA, Rosen C, Chi YE: Molecular cloning and characterisation of human tissue inhibitor of mctal-loproteinase 4, J Biol Cheni 1996:271:30375-30380.
    • (1996) J Biol Cheni , vol.271 , pp. 30375-30380
    • Greene, J.1    Wang, M.2    I-Iu, Y.E.3    Raymond, L.A.4    Rosen, C.5    Chi, Y.E.6
  • 57
    • 0025825501 scopus 로고
    • Decreased expression of tissue inhibitor of the mctallopro-teinascs in metastatic tumour cells leading to increased levels of collagenase activity
    • Ponton A, Coulombe B, Skup D: Decreased expression of tissue inhibitor of the mctallopro-teinascs in metastatic tumour cells leading to increased levels of collagenase activity, Cancer Res 1991:51:2138-2143.
    • (1991) Cancer Res , vol.51 , pp. 2138-2143
    • Ponton, A.1    Coulombe, B.2    Skup, D.3
  • 58
    • 0022382006 scopus 로고
    • Sequence of human tissue inhibitor of the metalloprotcinase and its identity to crythroid-potentiating activity
    • Dochcrty AJP, Lyons A, Smith BJ, Wright EM, Stephens PE, Harris TJR: Sequence of human tissue inhibitor of the metalloprotcinase and its identity to crythroid-potentiating activity, Nature 1985;318:66-69.
    • (1985) Nature , vol.318 , pp. 66-69
    • Dochcrty, A.1    Lyons, A.2    Smith, B.J.3    Wright, E.M.4    Stephens, P.E.5    Harris, T.6
  • 59
    • 0024013243 scopus 로고
    • A primary genetic map of the pericentromcric region of the human X chromosome
    • Mahtani MM, Willard HF: A primary genetic map of the pericentromcric region of the human X chromosome, Genomics 1988:2:294-301.
    • (1988) Genomics , vol.2 , pp. 294-301
    • Mahtani, M.M.1    Willard, H.F.2
  • 60
    • 0020974880 scopus 로고
    • Human skin fibroblast collagenase inhibitor
    • Welgus HG, Stricklin GP: Human skin fibroblast collagenase inhibitor, J Biol Chem 1983; 258:12259-12264.
    • (1983) J Biol Chem , vol.258 , pp. 12259-12264
    • Welgus, H.G.1    Stricklin, G.P.2
  • 62
    • 0021999008 scopus 로고
    • Biosynthesis of tissue inhibitor of the metalloproteinases by human fibroblasts in culture
    • Murphy GJ P, Reynolds JJ, Wcrb Z: Biosynthesis of tissue inhibitor of the metalloproteinases by human fibroblasts in culture, J Biol Chem 1985:260:3079-3083.
    • (1985) J Biol Chem , vol.260 , pp. 3079-3083
    • Murphy, G.1    Reynolds, J.J.2    Wcrb, Z.3
  • 63
    • 0026568011 scopus 로고
    • Growth-promoting activity of tissue inhibitor of the metalloproteinases-1 (LIMP I) for a wide range of cells: A possible new growth factor in serum
    • Hayakawa T, Yamashita K, Tanzawa K, Uchi-jima E, Iwata K: Growth-promoting activity of tissue inhibitor of the metalloproteinases-1 (LIMP I) for a wide range of cells: A possible new growth factor in serum, FEBS Lett 1992; 298:29-32.
    • (1992) FEBS Lett , vol.298 , pp. 29-32
    • Hayakawa, T.1    Yamashita, K.2    Tanzawa, K.3    Uchi-Jima, E.4    Iwata, K.5
  • 64
    • 0024325265 scopus 로고
    • Purification and characterisation of two related but distinct metalloprotcinase inhibitors secreted by bovine aortic endothelial cells
    • DcClcrck Y, Yean TD, Ratzkin BJ, Lu HS, Langley KE: Purification and characterisation of two related but distinct metalloprotcinase inhibitors secreted by bovine aortic endothelial cells, J Biol Chem 1989:264:17445-17453.
    • (1989) J Biol Chem , vol.264 , pp. 17445-17453
    • Dcclcrck, Y.1    Yean, T.D.2    Ratzkin, B.J.3    Lu, H.S.4    Langley, K.E.5
  • 65
    • 0026005135 scopus 로고
    • Distribution of collagenase and tissue inhibitor of the metallopro-tcinases (TIMP) in colorectal tumours
    • Hewitt RE, Leach IH, Powc DG, Clarke IM, Cawston TE, Turner DR: Distribution of collagenase and tissue inhibitor of the metallopro-tcinases (TIMP) in colorectal tumours, Int J Cancer 1991;49:666-672.
    • (1991) Int J Cancer , vol.49 , pp. 666-672
    • Hewitt, R.E.1    Leach, I.H.2    Powc, D.G.3    Clarke, I.M.4    Cawston, T.E.5    Turner, D.R.6
  • 66
    • 0029129995 scopus 로고
    • Distinct pattern of matrix metalloprotcinase 9 and tissue inhibitor of metalloproteinase I mRNA expression in human colorectal cancer and liver metastasis
    • Zeng ZS, Guillem JG: Distinct pattern of matrix metalloprotcinase 9 and tissue inhibitor of metalloproteinase I mRNA expression in human colorectal cancer and liver metastasis, Br J Cancer 1995;72:575-582.
    • (1995) Br J Cancer , vol.72 , pp. 575-582
    • Zeng, Z.S.1    Guillem, J.G.2
  • 68
    • 0024534977 scopus 로고
    • Independent regulation of collagenase, 72 kDa progelati-nase, and mctalloendoprotcinase inhibitor expression in human fibroblasts by transforming growth factor-beta
    • Overall CM, Wrana JL, Sodek J: Independent regulation of collagenase, 72 kDa progelati-nase, and mctalloendoprotcinase inhibitor expression in human fibroblasts by transforming growth factor-beta, J Biol Chem 1989:264: 1860-1869.
    • (1989) J Biol Chem , vol.264 , pp. 1860-1869
    • Overall, C.M.1    Wrana, J.L.2    Sodek, J.3
  • 69
    • 1842288608 scopus 로고
    • Enhanced expression of matrix metal-loproteinases is often unopposed by their inhibitors (Tissue inhibitors of metalloprotci-nases) in pancreatic cancer
    • Bramhall SR, Lemoinc N, Stamp G, Neoplole-mos JP: Enhanced expression of matrix metal-loproteinases is often unopposed by their inhibitors (tissue inhibitors of metalloprotci-nases) in pancreatic cancer, Br J Surg 1995:82: 707-708.
    • (1995) Br J Surg , vol.82 , pp. 707-708
    • Bramhall, S.R.1    Lemoinc, N.2    Stamp, G.3    Neoplole-Mos, J.P.4
  • 70
    • 0025292162 scopus 로고
    • Correlation between collagenolytic activity and grade of histological differentiation in colorectal tumours
    • Van Der Stappcn JWJ, Hendricks T, Wobbes T: Correlation between collagenolytic activity and grade of histological differentiation in colorectal tumours, Int J Cancer 1990:45: 1071-1078.
    • (1990) Int J Cancer , vol.45 , pp. 1071-1078
    • Van Der Stappcn, J.1    Hendricks, T.2    Wobbes, T.3
  • 71
    • 0028925243 scopus 로고
    • The distribution of matrix metalloproteinases and tissue inhibitor of the metalloproteinases in colorectal cancer
    • Gallegos NC, Smales C, Savage FJ, Hembry RM, Boulos PB: The distribution of matrix metalloproteinases and tissue inhibitor of the metalloproteinases in colorectal cancer, Surg Oncol 1995;4:21-29.
    • (1995) Surg Oncol , vol.4 , pp. 21-29
    • Gallegos, N.C.1    Smales, C.2    Savage, F.J.3    Hembry, R.M.4    Boulos, P.B.5
  • 72
    • 0009632340 scopus 로고    scopus 로고
    • Colorectal cancers overexpress ge-latinascs (Matrix metalloproteinases 2 and 9) (abstract)
    • Parsons SL, Watson SA, Collins H, Clarke P, Steele RJC: Colorectal cancers overexpress ge-latinascs (matrix metalloproteinases 2 and 9) (abstract), Gastroenterology 1996:110:574.
    • (1996) Gastroenterology , vol.110 , pp. 574
    • Parsons, S.L.1    Watson, S.A.2    Collins, H.3    Clarke, P.4    Steele, R.5
  • 73
    • 0026131489 scopus 로고
    • Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression
    • D'Errico A, Garbisa S, Liolta L, Astronova V, Stetler-Stevenson W, Grigioni W: Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression, Mod Pathol 1991:4:239-246.
    • (1991) Mod Pathol , vol.4 , pp. 239-246
    • D'errico, A.1    Garbisa, S.2    Liolta, L.3    Astronova, V.4    Stetler-Stevenson, W.5    Grigioni, W.6
  • 74
    • 0029103339 scopus 로고
    • Expression of membrane-type matrix metallo-protcinase in human gastric carcinomas
    • Nomura H, Sato H, Seiki M, Mai M, Okada Y: Expression of membrane-type matrix metallo-protcinase in human gastric carcinomas, Cancer Res 1995;55:3263-3266.
    • (1995) Cancer Res , vol.55 , pp. 3263-3266
    • Nomura, H.1    Sato, H.2    Seiki, M.3    Mai, M.4    Okada, Y.5
  • 78
    • 0027469921 scopus 로고
    • Association between expression of activated 72-kilodalton gelatinasc and tumour spread in non-small-cell lung carcinoma
    • Brown PD, Bloxidge RE, Stuart NSE, Gattcr KC, Carmichael J: Association between expression of activated 72-kilodalton gelatinasc and tumour spread in non-small-cell lung carcinoma, J Natl Cancer Inst 1993:85:574-578.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 574-578
    • Brown, P.D.1    Bloxidge, R.E.2    Stuart, N.3    Gattcr, K.C.4    Carmichael, J.5
  • 80
    • 0026780346 scopus 로고
    • Correlation between spontaneous metastatic potential and type 1 collagenolytic activity in a human pancreatic cancer cell line (SUIT 2) and sub-lines
    • Taniguchi S, Iwamura T, Katsuki T: Correlation between spontaneous metastatic potential and type 1 collagenolytic activity in a human pancreatic cancer cell line (SUIT 2) and sub-lines, Clin Exp Metastasis 1992:10:259-266.
    • (1992) Clin Exp Metastasis , vol.10 , pp. 259-266
    • Taniguchi, S.1    Iwamura, T.2    Katsuki, T.3
  • 81
    • 0030801093 scopus 로고    scopus 로고
    • Neoptole-mosJP: Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic cancer
    • Bramhall SR, Lemoine N, Stamp G, Neoptole-mosJP: Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic cancer, J Pathol 1997;182: 347-355.
    • (1997) J Pathol , vol.182 , pp. 347-355
    • Bramhall, S.R.1    Lemoine, N.2    Stamp, G.3
  • 82
    • 0025375927 scopus 로고
    • DiMassimo EL Stetler-Stevenson WG, Liotta LA, Schwcdes JW: Extraction of type-IV collagenase/gelati-nase from plasma membranes of human cancer cells
    • Zucker S, Moll UM, Lysik RM, DiMassimo EL Stetler-Stevenson WG, Liotta LA, Schwcdes JW: Extraction of type-IV collagenase/gelati-nase from plasma membranes of human cancer cells, Int J Cancer 1990:45:1137-1142.
    • (1990) Int J Cancer , vol.45 , pp. 1137-1142
    • Zucker, S.1    Moll, U.M.2    Lysik, R.M.3
  • 83
    • 0028063340 scopus 로고
    • Ohtani 11, Shimosegawa T, Koizumi M, Sawai T, Toyota T: Infrequent stromal expression of gelatinasc A and intact basement membrane in intraductal neoplasms of the pancreas
    • Satoh K, Ohtani 11, Shimosegawa T, Koizumi M, Sawai T, Toyota T: Infrequent stromal expression of gelatinasc A and intact basement membrane in intraductal neoplasms of the pancreas, Gastroenterology 1994:107:1488-1495.
    • (1994) Gastroenterology , vol.107 , pp. 1488-1495
    • Satoh, K.1
  • 84
    • 0029080314 scopus 로고
    • Expression and in-situ localisation of genes coding for extracellular matrix proteins and extracellular matrix degrading protcases in pancreatic cancer
    • Gress TM, MUUer-Pillasch F, Lcrch MM, Freiss H, Büchler M, Alder G: Expression and in-situ localisation of genes coding for extracellular matrix proteins and extracellular matrix degrading protcases in pancreatic cancer, Int J Cancer 1995:62:407-413.
    • (1995) Int J Cancer , vol.62 , pp. 407-413
    • Gress, T.M.1    Muuer-Pillasch, F.2    Lcrch, M.M.3    Freiss, H.4    Büchler, M.5    Alder, G.6
  • 85
    • 0029979467 scopus 로고    scopus 로고
    • Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of metalloproteinases (TIMP1) in pancreatic and ampullary disease
    • Bramhall SR, Stamp G, Dunn J, Lemoine N, Neoptolemos JP: Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of metalloproteinases (TIMP1) in pancreatic and ampullary disease, Br J Cancer 1996;73:972-978.
    • (1996) Br J Cancer , vol.73 , pp. 972-978
    • Bramhall, S.R.1    Stamp, G.2    Dunn, J.3    Lemoine, N.4    Neoptolemos, J.P.5
  • 86
    • 0005714980 scopus 로고
    • 72 kDa collagenase, stromelysin I and tissue inhibitor of me-talloproteinasc I expression in pancreatic cancer
    • Bramhall SR, Lemoinc N, Stamp G, Donovan IA, Dunn J, Neoptolemos JP: 72 kDa collagenase, stromelysin I and tissue inhibitor of me-talloproteinasc I expression in pancreatic cancer, Digestion 1994:55:286.
    • (1994) Digestion , vol.55 , pp. 286
    • Bramhall, S.R.1    Lemoinc, N.2    Stamp, G.3    Donovan, I.A.4    Dunn, J.5    Neoptolemos, J.P.6
  • 87
    • 0027516026 scopus 로고
    • Tissue inhibitor of the metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo
    • Tsuchiva Y, Satro H, Endo Y, Okada Y, Mai M, Sasaki T, Sciki M: Tissue inhibitor of the metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo, Cancer Res 1993;53:1397-1402.
    • (1993) Cancer Res , vol.53 , pp. 1397-1402
    • Tsuchiva, Y.1    Satro, H.2    Endo, Y.3    Okada, Y.4    Mai, M.5    Sasaki, T.6    Sciki, M.7
  • 88
    • 0026573378 scopus 로고
    • Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases
    • DeClerck Y, Perez N, Shimada H, Boone TC, Langley KE, Taylor SM: Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases, Cancer Res 1992;52:701-708.
    • (1992) Cancer Res , vol.52 , pp. 701-708
    • Declerck, Y.1    Perez, N.2    Shimada, H.3    Boone, T.C.4    Langley, K.E.5    Taylor, S.M.6
  • 89
    • 0028886516 scopus 로고
    • Overexprcssion of tissue inhibitor of the metalloproteinases (TIM P I and TIMP 2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma
    • Kawamata H, Kawai K, Kameyama S, Johnson MD, Stetler-Stevenson WG, Ovasu R: Overexprcssion of tissue inhibitor of the metalloproteinases (TIM P I and TIMP 2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma, Int J Cancer 1995:63:680-687.
    • (1995) Int J Cancer , vol.63 , pp. 680-687
    • Kawamata, H.1    Kawai, K.2    Kameyama, S.3    Johnson, M.D.4    Stetler-Stevenson, W.G.5    Ovasu, R.6
  • 90
    • 0027251836 scopus 로고
    • A synthetic matrix metalloprotci-nasc inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
    • Davies B, Brown PD, Eats N, Crimmin MJ, Balkwill FR: A synthetic matrix metalloprotci-nasc inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenografts, Cancer Res 1993:53: 2087-2091.
    • (1993) Cancer Res , vol.53 , pp. 2087-2091
    • Davies, B.1    Brown, P.D.2    Eats, N.3    Crimmin, M.J.4    Balkwill, F.R.5
  • 91
    • 0029841408 scopus 로고    scopus 로고
    • Therapeutic effect of the matrix metalloproteinase inhibitor batimaslat in a human colorectal cancer ascites model
    • Watson SA, Morris TM, Parsons SL, Steele RJC, Brown PB: Therapeutic effect of the matrix metalloproteinase inhibitor batimaslat in a human colorectal cancer ascites model, Br J Cancer 1996;74:1354-1358.
    • (1996) Br J Cancer , vol.74 , pp. 1354-1358
    • Watson, S.A.1    Morris, T.M.2    Parsons, S.L.3    Steele, R.4    Brown, P.B.5
  • 92
    • 0028889359 scopus 로고
    • Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice
    • Sledge GW, Qualali M, Goulet R, Bone EA, Thomas W, Brown PD: Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice, J Natl Cancer Res 1995;87:1546-1550.
    • (1995) J Natl Cancer Res , vol.87 , pp. 1546-1550
    • Sledge, G.W.1    Qualali, M.2    Goulet, R.3    Bone, E.A.4    Thomas, W.5    Brown, P.D.6
  • 93
    • 0027994031 scopus 로고
    • Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumour growth and spread in a patient-like orthotopic model in nude mice
    • Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM: Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumour growth and spread in a patient-like orthotopic model in nude mice, Cancer Res 1994:54: 4726-4728.
    • (1994) Cancer Res , vol.54 , pp. 4726-4728
    • Wang, X.1    Fu, X.2    Brown, P.D.3    Crimmin, M.J.4    Hoffman, R.M.5
  • 94
    • 0029165411 scopus 로고
    • Inhibition of organ invasion by the matrix mctallo-proteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastases models
    • Watson SA, Morris TM, Robinson G, Crimmin MJ, Brown PD, Hardcastle JD: Inhibition of organ invasion by the matrix mctallo-proteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastases models, Cancer Res 1995:55:3629-3633.
    • (1995) Cancer Res , vol.55 , pp. 3629-3633
    • Watson, S.A.1    Morris, T.M.2    Robinson, G.3    Crimmin, M.J.4    Brown, P.D.5    Hardcastle, J.D.6
  • 95
    • 0027956746 scopus 로고
    • Inhibition of angiogcnesis by the matrix metalloproteinase inhibitor N-[2R-2-(Hydroxamidocarbonylmethyl)-4-methylpen-tanoyl)]-/.-tryptophan mclhylamide
    • Galardy RE, Grobelnv D, Foellmcr HG, Fernandez LA: Inhibition of angiogcnesis by the matrix metalloproteinase inhibitor N-[2R-2-(hydroxamidocarbonylmethyl)-4-methylpen-tanoyl)]-/.-tryptophan mclhylamide, Cancer Res 1994:54:4715-4718.
    • (1994) Cancer Res , vol.54 , pp. 4715-4718
    • Galardy, R.E.1    Grobelnv, D.2    Foellmcr, H.G.3    Fernandez, L.A.4
  • 97
    • 0030042145 scopus 로고    scopus 로고
    • Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma
    • Anderson IC, Shipp MA, Docherty AJP, Teicher BA: Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma, Cancer Res 1996;56: 715-718.
    • (1996) Cancer Res , vol.56 , pp. 715-718
    • Erson, I.C.1    Shipp, M.A.2    Docherty, A.3    Teicher, B.A.4
  • 99
    • 0009567641 scopus 로고    scopus 로고
    • Phase I/II trial of a matrix metalloproteinase inhibitor in patients with malignant ascites (Abstract)
    • Parsons S, Watson S, Amar S, Steele R: Phase I/II trial of a matrix metalloproteinase inhibitor in patients with malignant ascites (abstract), Gastroenterology 1996:110:575.
    • (1996) Gastroenterology , vol.110 , pp. 575
    • Parsons, S.1    Watson, S.2    Amar, S.3    Steele, R.4
  • 101
    • 0003099286 scopus 로고
    • BB-2516: An orally bioavailable matrix metalloproteinase inhibitor with efficacy in animal cancer models (abstract)
    • Drummond A, Beckett P, Bone EA: BB-2516: An orally bioavailable matrix metalloproteinase inhibitor with efficacy in animal cancer models (abstract), Proc Am Assoc Cancer Res 1995:36:100.
    • (1995) Proc am Assoc Cancer Res , vol.36 , pp. 100
    • Drummond, A.1    Beckett, P.2    Bone, E.A.3
  • 102
    • 0002635973 scopus 로고    scopus 로고
    • An open phase 1/11 study of the oral matrix metalloproteinase inhibitor marimas-tat in patients with inoperable gastric cancer (Abstract)
    • Parsons SL, Watson SA, Grifin NR, Steele RJC: An open phase 1/11 study of the oral matrix metalloproteinase inhibitor marimas-tat in patients with inoperable gastric cancer (abstract), Ann Oncol 1996:7:47.
    • (1996) Ann Oncol , vol.7 , pp. 47
    • Parsons, S.L.1    Watson, S.A.2    Grifin, N.R.3    Steele, R.4
  • 103
    • 0001176281 scopus 로고    scopus 로고
    • A dose-finding study of marimastat, an oral matrix metalloproteinase inhibitor, in patients with advanced colorectal cancer (Abstract)
    • Primrose J, Bleiberg H, Daniel F, Johnson P, Mansi J, Neoptolemos J, Seymour M, Van Belle S: A dose-finding study of marimastat, an oral matrix metalloproteinase inhibitor, in patients with advanced colorectal cancer (abstract), Ann Oncol 1996;7:35.
    • (1996) Ann Oncol , vol.7 , pp. 35
    • Primrose, J.1    Bleiberg, H.2    Daniel, F.3    Johnson, P.4    Mansi, J.5    Neoptolemos, J.6    Seymour, M.7    Van Belle, S.8
  • 104
    • 0002750508 scopus 로고    scopus 로고
    • A dose-finding study of marimastat, an oral matrix metalloproteinase inhibitor, in patients with advanced ovarian cancer (Abstract)
    • Peole C, Adams M, Barley V, Graham J, Kerr D, Louviaux I, Pcrren T, Piccar! M, Thomas H: A dose-finding study of marimastat, an oral matrix metalloproteinase inhibitor, in patients with advanced ovarian cancer (abstract), Ann Oncol 1996:7:68.
    • (1996) Ann Oncol , vol.7 , pp. 68
    • Peole, C.1    Adams, M.2    Barley, V.3    Graham, J.4    Kerr, D.5    Louviaux, I.6    Pcrren, T.7    Piccar!, M.8    Thomas, H.9
  • 106
    • 0029943675 scopus 로고    scopus 로고
    • Activity of gemcitabine in patients with advanced pancreatic cancer
    • Moore M: Activity of gemcitabine in patients with advanced pancreatic cancer, Cancer 1996;78:633-638.
    • (1996) Cancer , vol.78 , pp. 633-638
    • Moore, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.