Analysis of the Contact Sites on the CD4 Molecule with Class II MHC Molecule: Co-Ligand Versus Co-Receptor Function

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 216-225

  Huang, Bei ^a,b   Yachou, Abdelkader ^a,d   Fleury, Sylvain ^a,c,f   Hendrickson, Wayne A ^e   Sekaly, Rafick Pierre ^a,b,c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d FACULTÉ DES SCIENCES BEN M SIK   (Morocco)

^e Columbia University ^*  (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN RECEPTOR; LIGAND;

ARTICLE; BIOSYNTHESIS; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION;

ANTIGENS, CD4; HLA-DR ANTIGENS; HUMANS; LIGANDS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, IMMUNOLOGIC;

EID: 0030638941     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Maddon, P. J., D. R. Littman, M. Godfrey, D. E. Maddon, L. Chess, and R. Axel. 1985. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell 42:93.
2. lck. Cell 55:301.
3. Janeway, C. A. 1992. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10:645.
4. Dalgleish, A. G., P. C. L. Beverley, P. R. Clapham, D. H. Crawford, M. F. Greaves, and R. A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763.
5. Klatzmann, D., E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. Hercend, J. C. Gluckman, and L. Montagnier. 1984. T-lymphocyte T4 molecule behaves as a the receptor for human retrovirus LAV. Nature 312:767.
6. Maddon P. J., A. G. Dalgleish, J. S. McDougal, P. R. Clapham, R. A. Weiss, and R. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333.
7. Konig, R., L. Y. Huang, and R. N. Germain. 1992. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature 316:796.
8. 2 domain of HLA-DR molecules. Nature 356:799.
9. Konig, R., X. Shen, and R. N. Germain. 1995. Involvement of both major histocompatibility complex class II α and β chains in CD4 function indicates a role for ordered oligomerization in T cell activation. J. Exp. Med. 182:779.
10. Fleury, S., D. Lamarre, S. Meloche, S.-E. Ryu, C. Cantin, W. A. Hendrickson, and R.-P. Sekaly. 1991. Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite to the gp120-binding site. Cell 66:1037.
11. Fleury, S., B. Huang, A. Zerbib, G. Croteau, E. O. Long, and R. P. Sekaly. 1996. Mutations in human CD4 impair the functional interaction with different human and mouse class II isotypes and alleles. J. Immunol. 156:1848.
12. Gustafson, K., S. Germana, T. M. Sundt III, D. H. Sachs, and C. LeGuern. 1993. Extensive allelic polymorphism in the CDR2-like region of the miniature swine CD4 molecule. J. Immunol. 151:1365.
13. Piatier-Tonneau, D., L. N. Gastinel, G. Moussy, B. Benichou, F. Amblard, P. Vaigot, and C. Auffray. 1991. Mutation in the D strand of the human CD4 V1 domain affect CD4 interaction with the human immunodeficiency virus envelop glycoprotein gp120 and HLA class II antigens similarly. Proc. Natl. Acad. Sci. USA 88:6858.
14. Moebius, U., L. L. Clayton, S. Abraham, A. Diener, J. J. Yunis, S. C. Harrison, and E. L. Reinherz. 1992. Human immunodeficiency virus gp120 binding C′C″ ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA 89:12008.
15. Moebius, U., P. Pallai, S. C. Harrison, and E. L. Reinherz. 1993. Delineation of an extended surface contact area on human CD4 involved in class II major complex binding. Proc. Natl. Acad. Sci. USA 90:8259.
16. Wang, J., Y. Yan, T. P. J. Garrett, J. Liu, D. W. Rodgers, R. L. Garlick, G. E. Tarr, Y. Husain, E. L. Reinherz, and S. C. Harrison. 1990. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 348:411.
17. Ryu, S., P. D. Kwong, A. Truneh, T. G. Porter, J. Arthos, M. Rosenberg, X. Dai, N. Xuong, R. Axel, R. W. Sweet, and W. A. Hendrickson. 1990. Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature 348:419.
18. 2-terminal domains. Science 260:979.
19. Hendrickson, W. A., P. D. Kwong, D. J. Leahy, S. E. Ryu, H. Yamaguchi, S. Fleury, and R. P. Sekaly. 1992. Structural aspects of CD4 and CD8 involvement in the cellular immune response. Cold Spring Harbor Symp. Quant. Biol. 57:549.
20. Kwong, P. D., S. E. Ryu, W. A. Hendrickson, R. Axel, R. M. Sweet, G. Folena-Wasserman, P. Hensley, and R. W. Sweet. 1990. Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals. Proc. Natl. Acad. Sci. USA 87:6423.
21. 2-terminal region of T4 (CD4) and requires the intact variable region-like domains. Proc. Natl. Acad. Sci. USA 85: 6102.
22. Ibegbu, C. C., M. S. Kennedy, P. J. Maddon, K. G. Deen, S. D. Hicks, R. W. Sweet, and J. S. McDougal. 1989. Structural features of CD4 required for binding to HIV. J. Immunol 142:2250.
23. + cells from virus binding. J. Exp. Med. 172:1233.
24. Hart, T. K., R. Kirsh, H. Ellens, R. W. Sweet, D. M. Lambert, S. R. Petteway, Jr., J. Leary, and P. J. Bugelski. 1991. Binding of soluble CD4 proteins to human immunodeficiency virus type I and infected cells induces release of envelop glycoprotein gp120. Proc. Natl. Acad. Sci. USA 88:2189.
25. Sattentau, Q. J., and J. P. Moore. 1991. Conformational changes induced in the human immunodeficiency virus envelop glycoprotein by soluble CD4 binding. J. Exp. Med. 174:407.
26. Burkly, L. C., D. Olson, R. Shapiro, G. Winkler, J. J. Rosa, D. M. Thomas, C. Williams, and P. Chisholm. 1992. Inhibition of HIV infection by a usual CD4 domain 2-specific monoclonal antibody. J. Immunol. 149:1779.
27. Ashkenazi, A., L. G. Presta, S. A. Marsters, T. R. Camerato, K. A. Rosenthal, B. M. Fendly, and D. J. Capon. 1990. Mapping the CD4 binding site for human immunodeficiency virus by alanine scanning mutagenesis. Proc. Natl. Acad. Sci. USA 87:7150.
28. Peterson, A., and B. Seed. 1988. Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4. Cell 54:65.
29. Mizukami, T., T. R. Fuerst, E. A. Berger, and B. Moss. 1988. Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis. Proc. Natl. Acad. Sci. USA 85:9273.
30. Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap expression using the polymerase chain reaction. Gene 77:51.
31. Sleckman, B. P., A. Peterson, J. A. Foran, J. C. Gorga, C. J. Kara, J. L. Strominger, S. J. Burakoff, and J. L. Greenstein. 1988. Functional analysis of a cytoplasmic domain-related mutant of the CD4 molecule. J. Immunol. 141:49.
32. Takebe, Y. 1988. Sra promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8:466.
33. Graham, F. L., and A. J. van der Eb. 1973. Transformation of rat cells by DNA of human adenovirus 5. Virology 52:456.
34. Lamarre, D., A. Ashkenazi, S. Fleury, D. H. Smith, R. P. Sekaly, and D. J. Capon. 1989. The MHC-binding and gp120-binding functions of CD4 are separable. Science 245:743.
35. Sakihama, T., A. Smolyar, and E. L. Reinherz. 1995. Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120. Proc. Natl. Acad. Sci. USA 92:6444.
36. Kupfer, A., S. J. Singer, C. A. J. Janeway, and S. L. Swain. 1987. Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc. Natl. Acad. Sci. USA 84:5888.
37. Vignali, D. A. A., R. T. Carson, B. Chang, R. S. Mittler, and J. L. Strominger. 1996. The two membrane proximal domains of CD4 interact with the T cell receptor. J. Exp. Med. 183:2097.
38. Bowman, M. R., K. D. MacFerrin, S. L. Schreiber, and S. J. Burakoff. 1990. Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA 87:9052.
39. Zhang X., D. Piatier-Tonneau, C. Auffray, R. Murali, A. Mahapatra, F. Zhang, C. C. Maier, H. Saragovi, and M. I. Greene. 1996. Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T cell activation. Nat. Biotechnol. 14:472.
40. Brown, J. H., T. S. Jardetzky, J. C. Gorga, L. J. Stern, R. G. Urban, J. L. Strominger, and D. C. Wiley. 1993. Three-dimensional structures of the human class II antigen HLA-DR1. Nature 364:33.
41. Giblin, P. A., D. J. Leahy, J. Mennone, and P. B. Kavathas. 1994. The role of charge and multiple faces of the CD8 alpha/alpha homodimers in binding to major histocompatibility complex class I molecules: support for a bivalent model. Proc. Natl. Acad. Sci. USA 91:1716.