Gastroprotection by an antacid and mucosal coating agent in the rat. Role of prostaglandins, afferent neurons and nitric oxide;Etude de l'effet gastroprotecteur d'un pansement antiacide chez le rat. Role des prostaglandines endogenes, des neurones afferents sensibles a la capsaicine et du monoxyde d'azote

Gastroenterologie Clinique et Biologique

Volumn 21, Issue 5, 1997, Pages 370-376

  Ramaholimihaso, Fidy ^a   Duchateau, Alain ^a   Scheck, Florence ^b   Thiefin, Gérard ^a,c  

^a Lab de Morpholugie Cell Digestive   (France)

^b UPSA Laboratories   (France)

^c SERVICE DE DERMATOLOGIE   (France)

Author keywords

afferent nerves; antacids; capsaicin; indomethacin; mucosal protection; nitric oxide; rat; stomach

Indexed keywords

ALUMINUM GLYCINATE; ALUMINUM HYDROXIDE; ANTACID AGENT; CAPSAICIN; GASTRALGINE; INDOMETACIN; MAGNESIUM TRISILICATE; NITRIC OXIDE; SIMETICONE; UNCLASSIFIED DRUG; GASTROINTESTINAL AGENT; PROSTAGLANDIN; SIMETHICONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SENSORY NERVE; STOMACH MUCOSA INJURY; STOMACH PROTECTION; ANIMAL; DRUG EFFECT; PHYSIOLOGY; SENSORY NERVE CELL; STOMACH MUCOSA; VASCULARIZATION; WISTAR RAT;

ANIMALS; ANTACIDS; CAPSAICIN; GASTRIC MUCOSA; GASTROINTESTINAL AGENTS; MALE; NEURONS, AFFERENT; NITRIC OXIDE; PROSTAGLANDINS; RATS; RATS, WISTAR; SIMETHICONE;

EID: 0030634712     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Peterson WL, Sturdevant RAL, Frankl HD, Richardson CT, Isenberg JI, Elashoff JD et al. Healing of duodenal ulcer with an antacid regimen. N Engl J Med 1977;297:341-5.
2. Rydning A, Weberg R, Lange, Berstad A. Healing of benign gastric ulcer with low-dose antacids and fiber diel. Gastroenterology 1986;91:56-61.
3. Weberg R, Berstad A, Lange O, Schultz T, Aubert E. Duodenal ulcer healing with four antacid tablets daily. Scand J Gastroenterol 1985;20:1041-5.
4. Borrela LE, DiJoseph JF, Mir GN. Cytoprotective and antiulcer activities of the antacid ES Riopan in the rat (abstract). Gastroenterology 1986;90:A1351.
5. Duchateau A, Thiéfin G, Varin-Bishoff S, Garbe E, Zeitoun P. Prevention by aluminium phosphate of gastric lesions induced by ethanol in the rat: role of endogenous prostaglandins and sulfhydryls. Histol Histopathol 1990, 5, 89-94.
6. Hagel J, Renner H, Hirsch M, Weig G, Kaduk B, Ruppin H, Domschke W. Gastric cytoprotection by antacids and papaverine in rats. Hepatogastroenterology 1982;29:271-4.
7. Kontürek SJ, Brzozowski T, Drozdowicz D, Nauert C. Gastroprotection by an aluminium and magnesium hydroxide-containing antacid in rats. Scand J Gastroenterol 1989:24:1113-20.
8. Szelenyi I. Functional cytoprotection by certain antacids. Acta Physiol Hung 1984;64:259-68.
9. Tarnawski A, Hollander D, Gergely H, Stachura J. Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury. Am J Med 1985;79:19-23.
10. DiJoseph JF, Borrella LE, Mir GN. Activated aluminium complex derived from solubilized antacids exhibits enhanced cytoprotective activity in the rat. Gastroenterology 1989;96:730-5.
11. DiJoseph JF, Borrella LE, Wells CL, Mir GN. Mucosal protective activity of activated aluminium complex. Digestion 1990;45:19-25.
12. Kontürek SJ, Brzozowski T, Drozdowicz D, Nauert C. Role of intragastric pH in cytoprotection by antacids in rats. Eur J Pharmacol 1990;176:187-95.
13. Kontürek SJ, Brzozowski T, Majka J, Szlachcic A, Nauert C, Slomiany B. Nitric oxide in gastroprotection by aluminium-containing antacids. Eur J Pharmacol 1992;229:155-62.
14. Lambrecht N, Trautmann M, Korolkiewicz R, Liszkay M, Peskar BM. Role of eicosanoids, nitric oxide, and afferent neurons in antacid induced protection in the rat stomach. Gut 1993;34:329-37.
15. Szelenyi I, Brune K. Possible role of sulfhydryls in mucosal protection induced by aluminium hydroxide. Dig Dis Sci 1986;31:1207-10.
16. Holzer P, Sametz W. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons. Gastroenterology 1986;91:975-81.
17. Holzer P, Lippe IT. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 1988;27:981-7.
18. Holzer P, Pabst MA, Lippe IT. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa. Gastroenterology 1989;96:1425-33.
19. Holzer P, Peskar BM, Peskar BA, Amann R. Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach. Neurosci Lett 1990;108:195-200.
20. Peskar BM, Respondek M, Müller KM, Peskar BA. A role of nitric oxide in capsaicin-induced gastroprotection. Eur J Pharmacol 1991;198:113-4.
21. Lambrecht N, Burchert M, Respondek M, Müller KM, Peskar BM. Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat. Gastroenterology 1993;104:1371-80
22. Holzer P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 1991;43:144-201.
23. Moore PK, Al-Swayeh OA, Chong NWS, Evans RA, Gibson A. L-NG-Nitro-arginine (L-NOARG), a novel L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br J Pharmacol 1990;99:408-12.
24. Szelenyi I, Postius S. Further evidence for gastroprotection induced by aluminium hydroxyde in the rat. Z Gastroenterologie 1986;24:717-21.
25. Szelenyi I, Postius S, Engler H. Evidence for a functional cytoprotective effect produced by antacids in the rat stomach. Eur J Pharmacol 1983;88:403-6.
26. Vergin H, Kori-Lindner C. Putative mechanisms of cytoprotective effect of certain antacids and sucralfate. Dig Dis Sci 1990;11:1320-7.
27. Szelenyi I, Postius S. Functional cytoprotection by certain antacids and sucralfate in the rat stomach. Gastroenterology 1985;88:1604.
28. Tarnawski A, Hollander D, Cummings D, Krause WJ, Gergely H, Zipser RD. Are antacids acid neutralizers only ? Histology, ultrastructural and functional changes in normal gastric mucosa induced by antacids. Gastroenterology 1984,86;1276.
29. Berstad K, Vergin H, Postius R, Weberg R, Szelenyi I, Berstad A. Gastric prostaglandin E2 release induced by aluminium hydroxide and aluminium hydroxide-containing antacids in rats. Effect of low doses and citric acid. Scand J Gastroenterol 1987;22:884-8.
30. Kontürek SJ, Kwiecen N, Obtulowicz W, Hebzda Z, Oleksy J. Effects of protective drugs on gastric alkaline secretion in man. Scand J Gastroenterol 1987;22:1059-63.
31. Preclik G, Stange EF, Gerber K, Fetzer G, Horn H, Ditschuneit H. Stimulation of mucosal prostaglandin synthesis in human stomach and duodenum by antacid treatment. Gut 1989;30:148-51.
32. Quadros E, Johnson JV, Wilson DE. Antacids stimulate prostaglandin (PG) release from gastric mucosa. Gastroenterology 1986;90:1595.
33. Szelenyi I, Lanz R. Release of cytoprotective PGE2 from cultured macrophages induced by antacids and sucralfate. Agents Actions 1986;18:375-80.
34. Satoh H, Inada I, Hirata T, Maki Y. Indomethacin produces gastric antral ulcers in the refed rat. Gastroenterology 1981;81:719-25.
35. Sternini C, Reeve JR, Brecha N. Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats. Gastroenterology 1987;93:852-862.
36. Li DS, Raybould HE, Quintero E, Guth PH. Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin. Am J Physiol 1991;261:G657-G661.
37. Holzer P, Guth PH. Neuropeptide control of ral gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A, Circ Res 1991;68:100-5.
38. Lippe IT, Lorbach M, Holzer P. Close arterial infusion of calcitonin gene-related peptide into the rat stomach inhibits aspirin- and ethanol-induced hemorrhaggic damage. Regul Pept 1989;26:35-46.
39. Tepperman BL, Whittle BJR. Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat microcirculation. Br J Pharmacol;105:171-5.
40. Whittle BJR, Lopez-Belmonte J, Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 1990;99:607-11.
41. Masuda E, Kawano S, Nagano K, Tsuji S, Takei Y, Tsujii M et al. Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats. Gastroenterology 1995;108:58-64.
42. Vatier J, Vitre MT, Mignon M. Activité antiacide d'un mélange d'hydroxyde d'aluminium, de trisilicate de magnésium et de diméticone in vitro dans le modèle de « l'estomac duodénum artificiels » incluant ou non un fragment de muqueuse antrale de porc. Med Chir Dig 1992;21:471-474.