Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat gastric microcirculation

British Journal of Pharmacology

Volumn 105, Issue 1, 1992, Pages 171-175

  Tepperman, B L ^a   Whittle, B J R ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

capsaicin; gastric mucosal blood flow; NG nitro l arginine methyl ester; Nitric oxide; primary afferent neurones; sensory neuropeptides

Indexed keywords

AMINOPHYLLINE; ARGININE; CAPSAICIN; INDOMETACIN; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; NEUROPEPTIDE; NITRIC OXIDE; TERBUTALINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOPPLER FLOWMETRY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; STEREOSPECIFICITY; STOMACH MUCOSA BLOOD FLOW;

ANIMAL; ARGININE; BLOOD PRESSURE; CAPSAICIN; COMPARATIVE STUDY; GASTRIC MUCOSA; INDOMETHACIN; MALE; MICROCIRCULATION; NEURONS, AFFERENT; NEUROPEPTIDES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OMEGA-N-METHYLARGININE; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0026570451     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1992.tb14230.x     Document Type: Article

References (41)

1. Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus
2. Protective effect of S‐nitroso‐N‐acetyl‐penicillamine in endotoxin‐induced acute intestinal damage in the rat
3. Calcitonin gene‐related peptide is a potent vasodilator
4. Localization of nitric oxide synthase indicating a neural role for nitric oxide
5. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid
6. Peptide‐containing nerve fibres in the stomach wall of rat and mouse
7. Local opioid‐sensitive afferent sensory neurones in the modulation of gastric damage induced by PAF.
8. Role of endothelium in responses of vascular smooth muscle
9. G‐nitro‐l‐arginine methyl ester in conscious, Long Evans rats
10. Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea‐pig
11. Pentagastrin and gastric mucosal blood flow
12. Local effector functions of capsaicin‐sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene‐related peptide and other neuropeptides
13. Capsaicin: Cellular targets, mechanism of action, and selectivity for thin sensory neurons
14. Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene‐related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A.
15. Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat
16. Endothelium‐derived relaxing factor produced and released from artery and vein is nitric oxide
17. ω‐Nitro‐l‐arginine: a potent inhibitor of endothelium‐derived relaxing factor formation
18. Additional evidence that endothelium‐derived relaxing factor is nitric oxide
19. Gastric mucosal blood flow measured by laser‐Doppler velocimetry
20. Nitric oxide and vasoactive intestinal polypeptide mediate non‐adrenergic, non‐cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus
21. G‐nitro arginine (l‐NOARG), a novel, l‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro
22. 5‐[imino‐(nitroamino)methyl]‐l‐ornithine) impairs endothelium‐dependent dilations by inhibiting cytosolic nitric oxide synthesis from l‐arginine
23. Nitric oxide from l‐arginine stimulates the soluble guanylate cyclase in adrenal glands
24. Nitric oxide release accounts for the biological activity of endothelium‐derived relaxing factor
25. Vascular endothelial cells synthesize nitric oxide from l‐arginine
26. l‐arginine is the physiological precursor for the formation of nitric oxide in endothelium‐dependent relaxation
27. Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF.
28. The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation
29. Endogenous nitric oxide as a mediator of gastric mucosal vasodilatation during acid secretion: effects of nitric oxide inhibition on pentagastin‐stimulated acid secretion and mucosal blood flow in the rat
30. Involvement of endogenous nitric oxide in the regulation of the rat splanchnic circulation
31. Role of endothelium‐derived nitric oxide in the regulation of blood pressure
32. Characterization of three inhibitors of endothelial nitric oxide synthases in vitro and in vivo
33. Distribution and characterisation of calcitonin gene‐related peptide immunoreactivity in the digestive system of normal and capsaicin‐treated rats
34. Comparison of the effects of neuropeptide Y and noradrenaline on rat gastric mucosal blood flow and integrity
35. Endothelium‐derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa
36. Role of endogenous nitric oxide in the mechanisms underlying gastric mucosal integrity
37. Interactions between the vascular peptide endothelin‐1 and sensory neuropeptides in gastric mucosal injury
38. Prostanoids as regulators of gastrointestinal function
39. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat
40. Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation
41. Detection of the synthase enzyme that forms the endogenous vasodilator, nitric oxide in the rat gastric mucosa