CD8+ T cells and not CD4+ T cells are hyporesponsive to CD28- and CD40L-mediated activation in HIV-infected subjects

Clinical and Experimental Immunology

Volumn 107, Issue 3, 1997, Pages 440-447

  Vingerhoets, J ^a   Kestens, L ^a   Penne, G ^a   De Vuyst, H ^a   Vandenbruaene, M ^a   Pelgrom, Y ^a   Bosmans, E ^b   De Boer, M ^c   Kasran, A ^d   Azuma, M ^e   Colebunders, R ^a   Ceuppens, J L ^d   Vanham, G ^a  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b Eurogenetics   (Belgium)

^c PanGenetics BV   (Netherlands)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e JUNTENDO UNIVERSITY   (Japan)

Author keywords

CD28; CD40L; CD8+; Cytokines; HIV; T lymphocyte

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GLYCOPROTEIN GP 39; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; PHORBOL 13 ACETATE 12 MYRISTATE; CD40 LIGAND; LIGAND; MEMBRANE PROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DRUG EFFECT; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; SERODIAGNOSIS; TH1 CELL; TH2 CELL;

ADULT; ANTIGENS, CD28; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; HIV INFECTIONS; HIV SERONEGATIVITY; HUMANS; LIGANDS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; TH1 CELLS; TH2 CELLS;

EID: 0030615096     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.d01-964.x     Document Type: Article

References (50)

1. Fahey JL, Taylor JMG, Detels R et al. The prognostic vale of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med 1990; 322:166-72.
2. Prince HE, Jensen ER. Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection. J Acquir Immun Defic Syndr 1991; 4:1227-32.
3. Kestens L, Vanham G, Gigase P et al. Expression of activation antigens, HLA-DR and CD38 on CD8 lymphocytes during HIV-1 infection. AIDS 1992; 6:793-7.
4. + T lymphocytes during HIV-1 infection. Clin Exp Immunol 1994; 95:436-41.
5. Vanham G, Kestens L, Gigase P et al. Evidence for circulating activated cytotoxic T cells in HIV-infected subjects before the onset of opportunistic infections. Clin Exp Immunol 1990; 82:3-9.
6. Cayota A, Vuillier F, Scottalgara D, Feuillie V, Dighiero G. Impaired proliferative capacity and abnormal cytokine profile of naive and memory CD4 T-cells from HIV-seropositive patients. Clin Exp Immunol 1992; 88:478-83.
7. Clerici M, Stocks NI, Zajac RA et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. J Clin Invest 1989; 84:1892-9.
8. Gruters RA, Terpstra FG, De Jong R, van Noesel CJM, van Lier RAW, Miedema F. Selective loss of T cell functions in different stages of HIV infection. Eur J Immunol 1990; 20:1039-44.
9. Clerici M, Shearer GM. A Th1/Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993; 14:107-11.
10. + T-cell clones in human immunodeficiency virus infection. Blood 1994; 84:4262-8.
11. Maggi E, Mazzetti M, Ravina A et al. Ability of HIV to promote a Ti (H)1 to T (H)0 shift and to replicate preferentially in T (H)2 and T (H)0 cells. Science 1994; 265:244-8.
12. Graziosi C, Pantaleo G, Gantt KR et al. Lack of evidence for the dichotomy of T (H)1 and T (H)2 predominance in HIV-infected individuals. Science 1994; 265:248-52.
13. Schwartz RH. Costimulation of lymphocytes-T - the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71:1065-8.
14. Linsley PS, Ledbetter JA. The role of the CD28 receptor during T-cell responses to antigen. Annu Rev Immunol 1993; 11:191-212.
15. Lane P, Traunecker A, Hubele S, Inui S, Lanzavecchia A, Gray D. Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur J Immunol 1992; 22:2573-8.
16. Ledbetter JA, Shu G, Gallagher M, Clark EA. Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40). J Immunol 1987; 138:788-94.
17. Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992; 357:80-82.
18. Cayabyab M, Phillips JH, Lanier LL. CD40 preferentially costimulates activation of CD4 (+) T lymphocytes. J Immunol 1994; 152:1523-31.
19. Armitage RJ, Tough TW, Macduff BM et al. CD40 ligand is a T cell growth factor. Eur J Immunol 1993; 23:2326-31.
20. Lanier LL, Ofallon S, Somoza C et al. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol 1995; 154:97-105.
21. Webb LMC, Feldmann M. Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. Blood 1995; 86:3479-86.
22. Kuchroo VK, Das MP, Brown JA et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 1995; 80:707-18.
23. Gruters RA, Terpstra FG, de Goede REY et al. Immunological and virological markers in individuals progressing from seroconversion to AIDS. AIDS 1991; 5:837-44.
24. - cell population in the blood and lung of HIV-positive patients. J Acquir Immun Defic Syndr 1993; 6:1194-204.
25. + T-cell phenotype correlates with anti-HIV activity and asymptomatic clinical status. Clin Immunol Immunopathol 1993; 69:106-16.
26. + T cells from HIV-infected persons. J Immunol 1994; 153:412-20.
27. - T-cells. AIDS 1994; 8:431-41.
28. + T cells from HIV-infected subjects. Clin Exp Immunol 1995; 100:425-33.
29. Meyaard L, Kuiper H, Otto SA, Wolthers KC, Vanlier RAW, Miedema F. Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals. Eur J Immunol 1995; 25:232-7.
30. Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J Infect Dis 1994; 169:730-8.
31. CDC. 1993 revised classification system for HIV infection. MMW R 1992; 41:1-17.
32. de Boer M, Parren P, Dove P, Ossendorp G, van der Horst G, Reeder J. Functional characterization of a novel anti-B7 monoclonal antibody. Eur J Immunol 1992; 22:3071-5.
33. Azuma M, Ito D, Yagita H et al. B70 antigen is a 2nd ligand for CTLA-4 and CD28. Nature 1993; 366:76-79.
34. + naive T-cells can be efficiently activated by remote co-stimulation with B7. Int Immunol 1993; 5:1483-7.
35. Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL. CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J Exp Med 1992; 175:353-60.
36. - T-cell population. J Immunol 1990; 144:1696-704.
37. + CD8 cell subsets during in vitro culture of mononuclear cells from human immunodeficiency virus type-I (HIV)-seropositive former blood donors. J Clin Immunol 1989; 9:421-8.
38. + individuals to express CD40 ligand after in vitro stimulation is not impaired. Clin Immunol Immunopathol 1995; 74:112-4.
39. Hickey TE, Blair PJ, Perfetto S et al. Intact antigen receptor-mediated calcium signals in patients with early stage HIV-1 infection. J Immunol 1996; 156:4012-7.
40. Meyaard L, Schuitemaker H, Miedema F. T-cell dysfunction in HIV infection - anergy due to defective antigen-presenting cell function. Immunol Today 1993; 14:161-4.
41. + T-cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992; 175:331-40.
42. Hagiwara E, Sacks T, Leitman-Klinman SF, Klinman DM. Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood. AIDS Res Hum Retrovir 1996; 12:127-32.
43. Fan J, Bass HZ, Fahey JL. Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection. J Immunol 1993; 151:5031-40.
44. Fuchs D, Hausen A, Reibnegger G et al. Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1. J Acquir Immun Defic Syndr 1989; 2:158-62.
45. Seder RA, Grabstein KH, Berzofsky JA, Mcdyer JF. Cytokine interactions in human immunodeficiency virus- infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15. J Exp Med 1995; 182:1067-77.
46. Chehimi J, Starr SE, Frank I et al. Impaired interleukin-12 production in human immunodeficiency virus-infected patients. J Exp Med 1994; 179:1361-6.
47. Clerici M, Lucey DR, Berzofsky JA et al. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993; 262:1721-4.
48. Daftarian MP, Diaz-Mitoma F, Creery WD, Cameron W, Kumar A. Dysregulated production of interleukin-10 (IL-10) and IL-12 by peripheral blood lymphocytes from human immunodeficiency virus-infected individuals is associated with altered proliferative responses to recall antigens. Clin Diagn Lab Immunol 1995; 2:712-8.
49. + T cell function in the course of human immunodeficiency virus infection. J Clin Invest 1994; 94:1947-52.
50. Clerici M, Landay AL, Kessler HA et al. Multiple patterns of alloantigen presenting/stimulating cell dysfunction in patients with AIDS. J Immunol 1991; 146:2207-13.