G(i) protein activation of gonadotropin-releasing hormone-mediated protein dephosphorylation in human endometrial carcinoma

American Journal of Obstetrics and Gynecology

Volumn 176, Issue 2, 1997, Pages 371-376

  Imai, A ^a   Horibe, S ^a   Takagi, A ^a   Tamaya, T ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

endometrial cancer; gonadotropin releasing hormone analog; gonadotropin releasing hormone receptor; Guanosine triphophate binding protein; protein dephosphorylation

Indexed keywords

GONADORELIN; 1 (2 NITRO)PHENYLETHYL P(3) GUANOSINE 5' O (3 THIO)TRIPHOSPHATE; 1-(2-NITRO)PHENYLETHYL-P(3)-GUANOSINE 5'-O-(3-THIO)TRIPHOSPHATE; ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; BORDETELLA VIRULENCE FACTOR; BUSERELIN; DRUG DERIVATIVE; GONADORELIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PERTUSSIS TOXIN;

ARTICLE; DEPHOSPHORYLATION; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; FEMALE; GONADOTROPIN RELEASE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; CARCINOMA; DRUG ANTAGONISM; DRUG EFFECT; ENDOMETRIUM TUMOR; ENZYME ACTIVATION; METABOLISM; PHOSPHORYLATION;

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS, HORMONAL; BUSERELIN; CARCINOMA; ENDOMETRIAL NEOPLASMS; ENZYME ACTIVATION; FEMALE; GONADOTROPIN-RELEASING HORMONE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; PERTUSSIS TOXIN; PHOSPHORYLATION; RECEPTORS, LHRH; VIRULENCE FACTORS, BORDETELLA;

EID: 0030614823     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(97)70501-5     Document Type: Article

References (25)

1. G Emons AV Schally The use of luteinizing hormone releasing hormone agonists and antagonists in gynecological cancers Hum Reprod Update 9 1994 1364 1379
2. A Imai S Horibe H Takagi T Fuseya T Tamaya Signal transduction of Gn-RH receptor in the reproductive tract tumor Endocrinol J 43 1996 249 260
3. C Gallagher R Oliver D Oram C Fowler P Blanke B Mantell A new treatment for endometrial cancer with gonadotropin releasing-hormone analogue Br J Obstet Gynaecol 98 1991 1037 1041
4. A Imai T Ohno K Iida T Fuseya T Furui T Tamaya Gonadotropin-releasing hormone receptor in gynecologic tumors: frequent expression in adenocarcinoma histologic types Cancer 74 1994 2555 2561
5. G Irmer C Bürger O Ortmann K Schulz G Emons Expression of luteinizing hormone releasing hormone and its mRNA in human endometrial cancer cell lines J Clin Endocrinol Metab 79 1994 916 919
6. SS Stojilkovic J Reinhart KJ Catt Gonadotropin-releasing hormone receptors: structure and signal transduction pathways Endocr Rev 15 1994 462 499
7. HT Keutmann Receptor-binding regions in human glycoprotein hormones Mol Cell Endocrinol 88 1992 C1 C67
8. N Dhanasekaran L Heasley G Johnson G protein–coupled receptor systems involved in cell growth and oncogenesis Endocr Rev 16 1995 259 270
9. A Imai H Takagi T Furui S Horibe T Fuseya T Tamaya Evidence for coupling of phosphotyrosine phosphatase to gonadotropin-releasing hormone receptor in ovarian carcinoma membrane Cancer 77 1996 132 137
10. T Ohno A Imai T Furui K Takahashi T Tamaya Presence of gonadotropin-releasing hormone and its messenger ribonucleic acid in human ovarian epithelial carcinoma Am J Obstet Gynecol 169 1993 605 610
11. A Imai MJ Rebecchi MC Gershengorn Differential regulation by phosphatidylinositol 4,5-bisphosphate of pituitary plasma membrane and cytosolic phosphoinositide kinases Biochem J 240 1986 341 348
12. A Imai MC Gershengorn Independent phosphatidylinositol synthesis in rat pituitary plasma membrane and endoplasmic reticulum Nature 325 1987 725 728
13. OH Lowry N Rosebrough AL Farr RJ Randall Protein measurement with the Folin phenol reagent J Biol Chem 193 1951 265 275
14. WK Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage lambda Nature 227 1970 680 685
15. D Jones S Masters H Bourne R Reed Biochemical characterization of three stimulatory GTP-binding proteins J Biol Chem 265 1990 2671 2676
16. G Europe-Finner S Phaneuf A Tolkovsky S Watson A Bernal Down-regulation of Gas in human myometrium in term and preterm labor: a mechanism for parturition J Clin Endocrinol Metab 79 1994 1835 1839
17. M Ui T Katada Bacterial toxins as probe for receptor-G coupling Y Nishizuka The biology and medicine of signal transductions 1990 : Raven New York 63 69
18. J Middlebrook R Dorland Bacterial toxins: cellular mechanisms of action Microbiol Rev 48 1984 199 221
19. KM Walton JE Dixon Protein tyrosine phosphatases Annu Rev Biochem 62 1993 20
20. MG Pan T Florio PJS Stork G protein activation of a hormone-stimulated phosphatase in human tumor cells Science 256 1992 1215 1217
21. CD Strader TM Fong MR Tota D Underwood RAF Dixon Structure and function of G protein–coupled receptors Annu Rev Biochem 63 1994 101 132
22. L Birnbaumer Receptor to effector coupling through G proteins: roles for bg dimers as well as a subunits Cell 71 1992 1063 1072
23. BR Conklin HR Bourne Structural elements of Gα subunits that interact with Gβγ, receptors and effectors Cell 73 1993 631 641
24. U Kaiser R Katzenellenbogen P Conn W Chin Evidence that signalling pathways by which thyrotropin-releasing hormone and gonadotropin-releasing hormone act are both common and distinct Mol Endocrinol 8 1994 1038 1048
25. K Hsieh T Martin Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to guanosine triphosphate-binding proteins Gq and G11 Mol Endocrinol 6 1992 1673 1681