Signal transduction of GnRH receptor in the reproductive tract tumor

Endocrine Journal

Volumn 43, Issue 3, 1996, Pages 249-260

  Imai, Atsushi ^a   Horibe, Shinnji ^a   Takagi, Hiroshi ^a   Fuseya, Tatsuo ^a   Tamaya, Teruhiko ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADORELIN RECEPTOR;

FEMALE; FEMALE GENITAL TRACT TUMOR; GENETICS; HUMAN; METABOLISM; REVIEW; SIGNAL TRANSDUCTION;

FEMALE; GENITAL NEOPLASMS, FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; RECEPTORS, LHRH; SIGNAL TRANSDUCTION;

EID: 0030155790     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.43.249     Document Type: Review

References (139)

1. Imai A, Furui T, Tamaya T (1992) Is extrapituitary action of gonadotropin-releasing hormone biologically significant? Ann Clin Biochem 29: 477-480.
2. Leung PCK, Steele GL (1992) Intracellular signaling in the gonads. Endocrine Rev 13: 476-498.
3. Schally AV, Comarus-Schally AM, Redding TW (1992) Antitumor effects of analogs of hypothalamic hormones in endocrine-dependent cancers. Proc Soc Exp Biol Med 175: 259-81.
4. Emons G, Schally AV (1994) The use of luteinizing hormone releasing hormone agonists and antagonists in gynecological cancers. Human Reprod Update 9: 1364-1379.
5. Stojilkovic SS, Reinhart J, Catt KJ (1994) Gonadotropin-releasing hormone receptors: Structure and signal transduction pathways. Endocr Rev 15: 462-499.
6. Ohno T, Imai A, Furui T, Takahashi K, Tamaya T (1993) Presence of gonadotropin-releasing hormone and its messenger ribonucleic acid in human ovarian epithelial carcinoma. Am J Obstet Gynecol 169: 605-610.
7. Harris N, Dutlow C, Eidne K, Dong KW, Roberts J, Millar R (1991) Gonadotropin-releasing hormone gene expression in MDA-MB-231 and ZR-75-1 breast carcinoma cell lines. Cancer Res 51: 2577-2581.
8. Hsueh AJW, Jones PBC (1981) Extrapituitary actions of gortadotropin-releasing hormone. Endocr Rev 2: 437-461.
9. Manni A, Santen R, Harvey H, Lipton A, Max D (1986) Treatment of breast cancer with gonadotropin-releasing hormone. Endocrine Rev 7: 89-113.
10. Klijn JGM (1992) LH-RH agonists in the treatment of metastatic breast cancer: Ten years' experience. Recent Results Cancer Res 124: 76-90.
11. Höffken K (1992) LH-RH agonists in the treatment of premenopausal patients with advanced breast cancer. Recent Results Cancer Res 124: 91-104.
12. +, hormonal untreated breast cancer patients. Gynecol Endocrinol 7 (Suppl 2): 68.
13. Santen RJ, Manni A, Harvey H (1986) Gonadotropin releasing hormone (Gn-RH) analogs for the treatment of breast and prostaric carcinoma. Breast Cancer Res Treatment 7: 129-145.
14. Béland G, Elhilali M, Frader Y, Laroche B, Ramsey EW, Trachtenberg J (1990) A controlled trial of castration with and without nilutamide in metastatic prostaric carcinoma. Cancer 66: 1074-1079.
15. 2 cancer of the prostate. Cancer 62: 1881-1887.
16. Iversen P, Sucius S, Sylvester R, Christensen I, Denis L (1990) Zolandex and flutamide versus orchiectomy in the treatment of advanced prostatic cancer. Cancer 66: 1067-1073.
17. Schröder FH (1989) Hormonal manipulation of prostatic cancer: Too soon for total androgen blockade? Br Med J 303: 1489-1490.
18. Gonzalez-Barcena D, Ibarro-Olmos MA, Garcia-Carrasco F, Gutierez-Samperio C, Comarus-Schally AM, Schally AV (1989) Influence of D-Trp-6-LH-RH on the survival time in patients with advanced pancreatic cancer. Biomed Pharmacother 43: 313-317.
19. Greenway BA (1987) Carcinoma of the exocrine pancreas: A sex hormone responsive tumour? Br J Surg 74: 441-442.
20. Gallagher CJ, Oliver RTD, Oram DH, Fowler CG, Blake PR, Mantell, BS (1991) A new treatment for endometrial cancer with gonadotrophin releasing-hormone analogue. Br J Obstet Cynecol 98: 1037-1041.
21. Kullander S (1992) Treatment of endometrial cancer with GnRH analogs. Recent Results Cancer Res 124: 69-73.
22. Kauppila A, Martikainen H, Pentinen J, Reinil* M (1990) GnRH agonist analogue treatment of ovarian granulosa cell malignancies. Cynecol Endocrinol 4 (Suppl 2): 97.
23. Emons G, Ortmann O, Pahwa GS, Löhrs U, Weiterung T, Dilling H, Oberheuser F, Knuppen R (1992) In-vivo and in-vitro effects of GnRH analogues on an ovarian Leydig cell tumor. Geburtshilfe Frauenheilkd 52: 487-493.
24. Parmar H, Rustin G, Lightman SL, Phillips RH, Hanham IW, Schally AV (1988) Response to D-Try-6-luteinizing hormone releasing hormone (Decapeptyl) microcapsules in advanced ovarian cancer. Br Med J 296: 1229.
25. Emons G, Ortmann O, Pahwa GP, Hackenberg R, Oberheuser F, Schultz KD (1992) Intracellular actions of gonadotropic and peptide hormones and the therapeutic value of Gn-RH agonist in ovarian cancer. Acta Obstet Gynecol Scand 71 (Suppl 155): 31-38.
26. Pour PM, Redding TW, Paz Bouza JI, Schally AV (1988) Treatment of experimental ovarian carcinoma with monthly injection of the agonist D-Trp-6-LH-RH: A preliminary report. Cancer Lett 41: 105-110.
27. Mortel R, Stayaswaroop PG, Schally AV (1986) Inhibitory effect of GnRH superagonist on the growth of human ovarian carcinoma NIH: OVCAR 3 in the nude mouse. Gynecol Oncol 23: 254-255.
28. Petreson CM, Zimniski SJ (1990) A long acting gonadotropin-releasing hormone agonist inhibits the growth of a human epithelial ovarian carcinoma (BG-1) heterotransplanted in the nude mouse. Obstet Gynecol 76: 264-267.
29. Parmar H, Phillips RH, Rustin F, Lightman SL, Hanham JW, Serially AV (1988) Therapy of advanced ovarian cancer with D-Trp-6 LH-RH (Decapeptyl) microcapsules. Biomed Pharmacother 42: 531-538.
30. Parmar H, Nicholl J, Stockgale A, Cassoni A, Phillips RH, Lightman SL, Schally AV (1985) Advanced ovarian carcinoma; response to the agonist D-Trp-6-LH-RH. Cancer Treatment Rep 69: 1341-1342.
31. Jäger W, Wildt L, Lang N (1989) Some observations on the effects of GnRH analog in ovarian cancer. Eur J Obstet Gynecol Reprod Biol 32: 137-148.
32. Kavanagh JJ, Roberts W, Townsend P, Hewitt S (1989) Luprolide acetate in the treatment of refractory or persistent epithelial ovarian cancer. J Clin Oncol 7: 115-118.
33. Foekens JA, Klijn JGM (1992) Direct anti-tumor effects of LH-RH analogs. Recent Results Cancer Res 124: 7-17.
34. Bruckner HW, Motwani BT (1992) Treatment of advanced refractory ovarian carcinoma with a gonadotropin-releasing hormone analogue. Am J Obstet Gynecol 161: 1216-1218.
35. Emons G, Ortmann O, Pahwa GS, Oberheuser F, Schulz KD (1992) LH-RH agonists in the treatment of ovarian cancer. Recent Results Cancer Res 124: 55-68.
36. Kleinman D, Douvdevani A, Schally AV, Levy J, Sharoni Y (1994) Direct growth inhibition of human endometrial cancer cells by the gonadotropin-releasing hormone antagonist SB-75: Role of apoptosis. Am J Obstet Gynecol 170: 96-102.
37. Levy J, Kleinman D, Hershkovitz E, Bosin E, Segal-Abamson T, Kitoroser H, Marbach M, Scharoni Y (1993) A mechanism for direct growth inhibition of human breast and endometrial cancer cells by GnRH antagonist, SB-75. Gynecol Endocrinol 7 (Suppl 2): 26.
38. Slotman BJ, Poels LG, Rao BR (1989) A direct LH-RH-agonist action on cancer cells is unlikely to be the cause of response to LH-RH agonist treatment. Anticancer Res 9: 77-80.
39. Thompson MA, Adelson MD, Kaufman LM (1991) Lupron retards proliferation of ovarian epithelial tumor cells, cultured in serum free medium. J Clin Endocrinol Metab 72: 1036-1041.
40. Emons G, Ortmann O, Becker M, Inner G, Springer B, Laun R, Hölzel F, Schulz KD, Schally AV (1993) High affinity binding and direct antiproliferative effects of LH-RH analogues in human ovarian cancer cell lines. Cancer Res 54: 5439-5446.
41. Sharoni Y, Bosin E, Levy MJ, Schally AV (1989) Inhibition of growth of human mammary tumor cells by potent antagonists of luteinizing hormone-releasing hormone. Proc Natl Acad Sci USA 86: 1648-1651.
42. Foekens JA, Henkelman MS, Fukkink JF, Blankenstein MA, Klijn JMG (1986) Combined effects of buserelin, estradiol and tamoxifen on the growth of MCF-7 human breast cancers in vitro. Biochem Biophys Res Commun 140: 50-56.
43. Millar WR, Scott WN, Morris R, Fraser HM, Sharpe RM (1985) Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist. Nature 313: 231-233.
44. Kéri G, Balogh A, Szöke B, Téplan I, Csuka O (1991) Gonadotropin-releasing hormone analogues inhibit cell proliferation and activate signal transduction pathways in MDA-MB-231 human breast cancer cell line. Tumor Biol 12: 61-67.
45. 1 phase of the cell cycle. Br J Cancer 63: 930-932.
46. Scambia G, Panici PB, Baiocchi G, Perrone L, Gaggird C, Iacobelli S, Mancuso S (1988) Growth inhibitory effect of LH-RH analogs on human breast cancer cells. Anticancer Res 8: 187-190.
47. Schally AV, Redding TW (1987) Somatostatin analogs as adjunction to agonists of luteinizing hormone in the treatment of experimental prostate cancer. Proc Natl Acad Sci USA 84: 7275-7279.
48. Limonta P, Dondi D, Moretti RM, Maggi R, Motta R (1992) Antiproliferative effects of luteinizing hormone releasing hormone agonists on the human prostatic cancer cell line LNCaP. J Clin Endocrinol Metab 75: 207-212.
49. Szende B, Zalatnai A, Schally AV (1989) Programmed cell death (apoptosis) in pancreatic cancers of hamsters after treatment with analogs of both luteinising hormone-releasing hormone and somatostatin. Proc Natl Acad Sci USA 86: 1613-16137.
50. Szende B, Srkalovic G, Schally AV, Lapis K, Groot K (1990) Inhibitory effects of analogs of luteinizing hormone-releasing hormone and somatostatin on pancreatic cancers. Cancer 65: 2279-90.
51. Imai A, Ohno T, Iida K, Fuseya T, Furui T, Tamaya T (1994) Gonadotropin-releasing hormone receptor in gynecologic tumor: Frequent expression in adenocarcinoma histologic types. Cancer 74: 2555-2561.
52. Imai A, Ohno T, Ohsue K, Tamaya T (1994) Expression of gonadotropin-releasing hormone receptors in human epithelial ovarian carcinoma. Ann Clin Biochem 31: 65-71.
53. Imai A, Ohno T, Furui T, Takahashi K, Matsuda T, Tamaya T (1993) Gonadotropin-releasing hormone stimulates phospholipase C but not protein phosphorylation/dephosphorylation in plasma membrane from human epithelial ovarian cancer. Int J Gynecol Cancer 3: 311-317.
54. Emons G, Pahma GS, Brack C, Sturm R, Oberheuser F, Knuppen R (1989) Gonadotropin-releasing hormone binding sites in human epithelial ovarian carcinoma. Eur J Cancer Clin Oncol 25: 215-221.
55. Pahwa GS, Vollmer G, Knuppen R, Emons G (1989) Photoaffinity labelling of gonadotropin-releasing hormone binding sites in human epithelial ovarian carcinomata. Biochem Biophys Res Commun 161: 1086-1092.
56. Emons G, Pahwa GS, Ortmann O, Knuppen R, Oberheuser F, Schulz KD (1990) LH-RH receptors and LH-RH-agonist treatment in ovarian cancer: An overview. J Steroid Biochem Mol Biol 37: 1003-1006.
57. Emons G, Ortmann O, Backer M, Irmer G, Springer B, Laun R, Hölzel F, Schulz KD, Schally AV (1993) High affinity binding and direct antiproliferative effects of LH-RH analogues in human ovarian cancer cell lines. Cancer Res 54: 5439-5446.
58. Beisle S, Guevin JF, Bellabarba D, Lehoux JG (1984) Luteinizing hormone-releasing hormone binds to enriched human placental membranes and stimulates in vitro the synthesis of bioactive human chorionic gonadotropin. J Clin Endocrinol Metab 59: 119-124.
59. Iwashita M, Evans MI, Catt KJ (1986) Characterization of a gonadotropin-releasing hormone receptor site in term placenta and chorionic villi. J Clin Endocrinol Metab 62: 127-134.
60. Keutmann HT (1992) Receptor-binding regions in human glycoprotein hormones. Mol Cell Endocrinol 88: C1-C67.
61. Imai A, Ohno T, Iida K, Fuseya T, Furui T, Tamaya T (1994) Presence of gonadotropin-releasing hormone receptor and its messenger ribonucleic acid in endometrial carcinoma and endometrium. Gynecol Oncol 55: 144-148.
62. Emons G, Schröder B, Ortmann O, Westphalen S, Schulz KD, Schally AV (1993) High affinity binding and direct antiproliferative effects of luteinizing hormone-releasing hormone analogs in human endometrial cancer cell lines. J Clin Endocrinol Metab 77: 1458-1464.
63. Srkalovic G, Wittliff JL, Schally AV (1990) Detection and partial characterization of receptors for [D-Trp6]-luteiruzing hormone-releasing hormone and epidermal growth factor in human endometrial carcinoma. Cancer Res 50: 1841-1846.
64. Pahwa GS, Kullander S, Vollmer G, Oberheuser F, Knuppen R, Emons G (1991) Specific low affinity binding sites for gonadotropin-releasing hormone in human endometrial carcinomata. Eur J Obstet Gynecol Reprod Biol 41: 135-142.
65. Eidne KA, Flanagan CA, Harris NS, Millar RP (1987) Gonadotropin-releasing hormone (Gn-RH)-binding sites in human breast cancer cell lines and inhibitory effects of Gn-RH antagonists. J Clin Endocrinol Metab 64: 425-432.
66. Eidne KA, Flanagan CA, Millar RP (1985) Gonadotropin-releasing hormone binding sites in human breast carcinoma. Science 229: 989-991.
67. Milovanovic SR, Radulovic S, Schally AV (1992) Evaluation of binding of cytotoxic analogs of luteinizing hormone-releasing hormone to human breast cancer and mouse MXT mammary tumor. Breast Cancer Res Treatment 24: 147-158.
68. Eidne KA, Flanagan CA, Harris NS, Millar RP (1987) Gonadotropin-releasing hormone (Gn-RH)-binding sites in human breast cancer cell lines and inhibitory effects of Gn-RH antagonists. J Clin Endocrinol Metab 64: 425-432.
69. Fekete M, Bajusz S, Groot K, Csernus VJ, Schally AV (1989) Comparison of different agonists and antagonists of luteinizing hormone-releasing hormone for receptor-binding ability to rat pituitary and human breast cancer membrane. Endocrinology 124: 946-955.
70. 6]-luteinizing hormone-releasing hormone, somatostatin, epidermal growth factor, and sex steroids in 500 biopsy samples of human breast cancer. J Clin Lab Anal 3: 137-147.
71. Fekete M, Redding TW, Comaru-Schally AM, Pontes JE, Connelly RW, Srkalovic G (1989) Receptors for luteinizing hormone-releasing hormone, somatostatin, prolactin and epidermal growth factor in cat and human prostate cancers and in benign prostate hyperplasia. Prostate 14: 191-208.
72. Kadar T, Ben-David M, Pontes JE, Fekete M, Schally AV (1988) Prolactin and luteinizing hormone-releasing hormone receptors in human benign prostatic hyperplasia and prostate cancer. Prostate 12: 299-307.
73. Fekete M, Zalatnai A, Comaru-Schally AM, Schally AV (1989) Membrane receptors for peptides in experimental and human pancreatic cancers. Pancreas 4: 521-528.
74. Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo, M, Illing N, Millar RP, Sealfon SC (1993) Cloning and characterization of the human GnRH receptor. Mol Cell Endocrinol 91: R1-R5.
75. Kakar SS, Musgrove LC, Devar DC, Sellers JC, Neill JD (1992) Cloning, sequencing and expression of human gonadotropin releasing hormone (Gn-RH) receptor. Bicochem Biophys Res Commun 189: 289-295.
76. Stojilkovic SS, Reinhart J, Catt KJ (1994) Gonadotropin-releasing hormone receptors: Structure and signal transduction pathways. Endocr Rev 15: 462-499.
77. Neer EJ (1995) Heterotrimetric G proteins: Organizers of transmembrane signals. Cell 80: 249-257.
78. Heldin CH (1995) Dimerization of cell surface receptors in signal transduction. Cell 80: 213-233.
79. Bairon A (1991) Prosite: A dictionary of sites and patterns of proteins. Nucleic Acids Res 19: 2241-2245.
80. Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC (1992) Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol 11: 1-20.
81. Dolman HG, Thorner J, Caron MG, Lefkowitz RJ (1991) Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem 60: 653-688.
82. Kaiser UB, Katzenellenbogen P, Conn M, Chin WW (1994) Evidence that signalling pathways by which thyrotropin-releasing hormone and gonadotropin-releasing hormone act are both common and distinct. Mol Endocrinol 8: 1038-1048.
83. Segal-Abramson T, Giant J, Sharoni Y (1992) Guanosine nucleotide modulation of high affinity gonadotropin-releasing hormone receptors in rat mammary tumors. Mol Cell Endocrinol 85: 109-116.
84. Imai A, Takagi H, Furui T, Horibe S, Fuseya T, Tamaya T (1996) Evidence for coupling of phosphotyrosine phosphatase to gonadotropin-releasing hormone receptor in ovarian carcinoma membrane. Cancer 77: 132-137.
85. Divecha N, Irvine RF (1995) Phospholipid signaling. Cell 80: 269-278.
86. Gershengorn MC (1989) Mechanism of signal transduction by TRH. Ann NY Acad Sci 553: 191-196.
87. Clapham DE (1995) Calcium signaling. Cell 80: 259-268.
88. Cohen GB, Ren R, Baltimore D (1995) Modular binding domains in signal transduction proteins. Cell 80: 237-248.
89. Fantl WJ, Johnoson DE, Williams LT (1993) Signalling by receptor tyrosine kinases. Annu Rev Biochem 62: 453-481.
90. Walton KM, Dixon JE (1993) Protein tyrosine phosphatases. Annu Rev Biochem 62: 101-120.
91. Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185.
92. Hunter T (1995) Protein kinases and phosphatases: the Yin and Yang of protein phosphorylation and signaling. Cell 80: 225-236.
93. 11. Mol Endocrinol 6: 1673-1681.
94. Segal-Abramson T, Giat J, Levy J, Sharoni Y (1992) Guanine nucleotide modulation of high affinity gonadotropin-releasing hormone receptors in rat mammary tumors. Mol Cell Endocrinol 85: 109-116.
95. Hirota K, Hirota T, Auguilera G, Catt KJ (1985) Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs. J Biol Chem 260: 3243-3246.
96. Iida K, Imai A, Tamaya T (1991) Stimulatory effects of estrogen on gonadotropin-releasing hormone-induced phosphoinositide turnover in granulosa cells. J Steroid Biochem 38: 583-586.
97. Imai A, Iida K, Tamaya T (1993) Gonadotropin-releasing hormone has a biphasic action on aromatase activity through protein kinase C in granulosa cells. Int J Fertil 38: 50-56.
98. Noar Z, Yavin E (1982) Gonadotropin-releasing hormone stimulates phospholipid labeling in cultured granulosa cells. Endocrinology 111: 1615-1619.
99. Wang J, Lee V, Leung PCK (1989) Differential role of protein kinase C in the action of luteinizing hormone-releasing hormone on hormone production in rat ovarian cells. Am J Obstet Gynecol 160: 984-988.
100. Davis JS, West LA, Farese RV (1986) Gonadotropin-releasing hormone (Gn-RH) rapidly stimulates the formation of inositol phosphates and diacylglycerol in rat granulosa cells. Endocrinology 118: 2561-2571.
101. Imai A, Iida K, Tamaya T (1992) Tight coupling of gonadotropin-releasing hormone receptor to stimulated phosphoinositide turnover and antigonadotropic action. Obstet Gynecol Invest 33: 36-41.
102. Imai A, Iida K, Tamaya T (1991) Direct action of gonadotropin-releasing hormone (Gn-RH) analogue on ovary: An alternative acting mechanism of buserelin. Arch Gynecol Obstet 248: 117-121.
103. Yano T, Pinski P, Groot K, Serially AV (1992) Stimulation by bombesin and inhibition by bombesin/ gastrin-releasing peptide antagonists RC-3095 of growth of human breast cancer cell lines. Cancer Res 52: 4545-4547.
104. Ban E, Arias MC, Latouche J, Leblanc P, Heurtier JF, Drieu K, Pillion G, Haour F (1990) GnRH receptors in rat brain, pituitary and testis: Modulation following surgical and gonadotropin-releasing hormone agonist-induced castration. Mol Cell Endocrinol 70: 99-107.
105. Sundberg DK, Fawcett CP, McCann SM (1976) The involvement of cyclic AMP in the release of hormones from the anterior pituitary. Proc Soc Exp Biol Med 151: 149-154.
106. Liu TC, Wang PS, Jackson GL (1981) Effects of GnRH and drugs that affect cAMP levels on LH synthesis and release. Am J Physiol 241: E14-E21.
107. Florio T, Pan MG, Newman B, Hershberger RE, Gvelli O, Stork PJS (1992) Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity. J Biol Chem 267: 24169-24172.
108. Pan MG, Florio T, Stork PJS (1992) G protein activation of a hormone-stimulated phosphatase in human tumor cells. Science 256: 1215-1217.
109. Raid A, Oliver B, Abdelrahman A, Sháafi RI, Hajjar JJ (1993) Role of tyrosine kinase and phosphotyrosine phosphatase in growth of the intestinal crypt cell (IEC-6) line. Proc Soc Exp Biol Med 202: 435-439.
110. Klarlund JK (1985) Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins. Cell 41: 707-717.
111. Cicirelli MF, Tnks NK, Diltz CD, Weiel JE, Fischer EH, Krebs EG (1990) Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. Proc Natl Acad Sci USA 87: 5514-5518.
112. Fischer EH, Charbonneau H, Tonks NK (1991) Protein tyrosine phosphatases: A diverse family of intracellular and transmembrane enzymes. Science 253: 401-406.
113. Ingebritsen TS (1989) Phosphotyrosyl-protein phosphatases II; identification and characterization of two heat-stable protein inhibitors. J Biol Chem 264: 7754-7759.
114. Hammond KD, Bex P, Mohamed E, Levy N (1992) Phosphoamino acid phosphatases in normal and cancerous tissues of the human uterus, cervix and ovary. Arch Int Physiol Biochim Biophys 100: 105-107.
115. Maher PA (1993) Activation of phosphotyrosine phosphatase activity by reduction of cell-substrate adhesion. Proc Natl Acad Sci USA 90: 11177-11181.
116. Takagi H, Imai A, Furui T, Horibe S, Fuseya T, Tamaya T (1995) Evidence for tight coupling of gonadotropin-releasing hormone receptors to phosphatidylinositol kinase in plasma membrane from ovarian carcinomas. Gynecol Oncol 58: 110-115.
117. Furui T, Imai A, Takagi H, Horibe S, Fuseya T, Tamaya T (1995) Phosphotyrosine phosphatase activity in membranes from endometrial carcinoma. Oncol Reports 2: 1055-1057.
118. Lee MT, Liebow C, Kramer AR, Schally AV (1991) Effects of epidermal growth factor and analogues of luteinizing hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific substrates in various tumors. Proc Natl Acad Sci USA 88: 1656-1660.
119. Liebow C, Lee MT, Kramer AR, Schally AV (1991) Regulation of luteinizing hormone-releasing hormone receptor binding by heterologous receptor-stimulated tyrosine phosphorylation. Proc Natl Acad Sci USA 88: 2244-2248.
120. Hammond KD, Hohamed BE, Levy N (1992) Phosphoamino acid phosphatases in normal and cancerous tissues of the human uterus, cervix and ovary. Arch Int Physiol Biochim Biophys 100: 105-107.
121. Ozawa S, Sand O (1986) Electrophysiology of exitable endocrine cells. Physiol Rev 66: 887-952.
122. 2+ channels in pituitary gonadotrophs. Proc Natl Acad Sci USA 87: 8855-8859.
123. 12 protein have opposite effects on proliferation of NIH 3T3 cells. Proc Natl Acad Sci USA 88: 10455-10459.
124. Cui Z, Zubiaur M, Bloch DB, Michel T, Seidman JG, Neer EJ (1991) Expression of a G protein subunit, a i-1, in Balb/c 3T3 cells leads to agonist-specific changes in growth regulation. J Biol Chem 266: 20276-20282.
125. Cook JV, Faccenda E, Anderson L, Couper GC, Eidne KA, Taylor PL (1993) Effects of Asn87 and Asp318 mutations on ligand binding and signal transduction in the rat Gn-RH receptor. J Endocrinol 139: R1-R4.
126. Zhou W, Flanagan C, Ballesteros JA, Konvicka K, Davidson JS, Weinstein H, Millar RP, Sealfon SC (1994) A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol Pharmacol 45: 165-170.
127. Davidson JS, Flanagan CA, Zhou W, Becker II, Elario R, Emeran W, Sealfon SC, Millar RP (1995) Identification of N-glycosylation sites in the gonadotropin-releasing hormone receptor: role in receptor expression but not ligand binding. Mol Cell Endocrinol 107: 241-245.
128. Fan NC, Peng, C, Krisinger J, Leung PCK (1995) The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals. Mol Cell Endocrinol 107: R1-R8.
129. Clapham DE (1994) Mutations in G protein-linked receptors: Novel insights on disease. Cell 75: 1237-1239.
130. Sharif M, Sasakawa N, Hanley MR (1994) Malignant transformation by G protein-coupled hormone receptors. Mol Cell Endocrinol 100: 115-119.
131. Strader CD, Fong TM, Tota MR, Underwood D (1994) Structure and function of G protein-coupled receptor. Annu Rev Biochem 63: 101-132.
132. Lyons J, Landis CA, Harsh G, Vallar L, Grünewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR, McCormick F (1992) Two G protein oncogenes in human endocrine tumors. Science 249: 655-659.
133. Raymond J (1995) Hereditary and aquired defects in signaling through the hormone-receptor-G-protein complex. Am J Physiol 266: F163-F174.
134. Imai A, Horibe B, Takagi H, Fuseya T, Tamaya T (1996) Alteration of GTP-binding proteins in ovarian tumors. Oncol Rep 3: 241-243.
135. 13 and Gz? Mol Cell Endocrinol 100: 71-74.
136. DeVivo M, Iyengar R (1994) G protein pathways: Signal processing by effectors. Mol Cell Endocrinol 100: 65-70.
137. Williamson EH, Johnson SJ, Foster S, Kendall-Taylor R, Harris PE (1995) G protein gene mutations in patients with multiple endocrinopathies. J Clin Endocrinol Metab 80: 1702-1705.
138. Imai A, Takagi H, Horibe S, Fuseya T, Tamaya T (1996) Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumor. J Clin Endocrinol Metab (In press).
139. Horibe S, Imai A, Takagi H, Fuseya T, Tamaya T (1995) Gonadorropin-releasing hormone decreases the content of estrogen receptors in endometrial cancer cells. Endocrinol Metab 2: 221-224.