Mutagenesis of an Immunodominant Y Cell Epitope can Affect Recognition of Different T and B Determinants within the same Antigen

Molecular Immunology

Volumn 34, Issue 4, 1997, Pages 315-322

  Harris, David P ^a,d   Hill, Mahmuda ^a   Vordermeier, Hans Martin ^a   Jones, Mick ^b   Hewinson, Glyn ^c   Thangaraj, Harry ^a   Ivanyi, Juraj ^a  

^a MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c VETERINARY LABORATORIES AGENCY   (United Kingdom)

^d TRUDEAU INSTITUTE   (United States)

Author keywords

Antigenic structure; Mutagenesis; Mycobacteria; Peptides; Proteins

Indexed keywords

EPITOPE; 19 KDA ANTIGEN, MYCOBACTERIUM; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; HYBRID PROTEIN; PEPTIDE FRAGMENT;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CONFORMATION; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; C57BL MOUSE; GENETICS; HYBRIDOMA; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; SITE DIRECTED MUTAGENESIS; SPLEEN;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FEMALE; HYBRIDOMAS; IMMUNODOMINANT EPITOPES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; SPLEEN; T-LYMPHOCYTES;

EID: 0030612347     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00041-2     Document Type: Article

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