[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT(4S) and 5-HT(4L)) receptors

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 671-679

  Bonhaus, D W ^a   Berger, J ^a   Adham, N ^b   Branchek, T A ^b   Hsu, S A O ^a   Loury, D N ^a   Leung, E ^a   Wong, E H F ^a,c   Clark, R D ^a   Eglen, R M ^a  

^a ROCHE BIOSCIENCE   (United States)

^b H LUNDBECK A S   (Denmark)

^c CNS Biology Pharmacia SPA   (Italy)

Author keywords

5 HT; 5 HT4 receptors; GR113808; RS 57639

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 2,3 DIHYDRO 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 6 METHOXY 3ALPHA TROPANYL ESTER; 2,3 DIHYDRO 3 ISOPROPYL 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 3ALPHA TROPANYLAMIDE; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (DIETHYLAMINO)ETHYL ESTER; 5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; ADENYLATE CYCLASE; ALPHA METHYLSEROTONIN; CISAPRIDE; CYCLIC AMP; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANYLYLIMIDODIPHOSPHATE; ISOPROTEIN; PARTIAL AGONIST; RADIOLIGAND; RECEPTOR SUBTYPE; RENZAPRIDE; RS 57639; SEROTONIN; SEROTONIN 4 AGONIST; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR; TROPISETRON; UNCLASSIFIED DRUG; ZACOPRIDE; AMINOBENZOIC ACID DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BINDING SITE; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVATION; GENE EXPRESSION; GUINEA PIG; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; RNA SPLICING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENETICS; KINETICS; MEMBRANE; METABOLISM; NEOSTRIATUM; RADIOASSAY; RAT; THERMODYNAMICS;

AMINOBENZOIC ACIDS; ANIMALS; CLONING, MOLECULAR; CYCLIC AMP; GUINEA PIGS; KINETICS; MEMBRANES; NEOSTRIATUM; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; THERMODYNAMICS; TUMOR CELLS, CULTURED;

EID: 0030610870     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00039-7     Document Type: Article

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