Methods for quantitative assessment of tissue microcirculation using dynamic contrast-enhanced MR imaging;Methodische Ansatze zur quantitativen Beurteilung der Mikrozirkulation im Gewebe mit der dynamischen Magnetresonanztomographie

Radiologe

Volumn 37, Issue 6, 1997, Pages 470-480

  Brix, G ^a   Schreiber, W ^a   Hoffmann, U ^a   Guckel F ^b   Hawighorst, H ^a   Knopp, M V ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Blood flow; Blood volume; Capillary permeability; Dynamic MRI; Tracer kinetic modeling

Indexed keywords

CONTRAST MEDIUM; DIAGNOSTIC AGENT; DRUG DERIVATIVE; GADODIAMIDE; GADOLINIUM PENTETATE; ORGANOMETALLIC COMPOUND; PENTETIC ACID;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD FLOW; BLOOD VOLUME; BRAIN; CAPILLARY; CAPILLARY PERMEABILITY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MEASUREMENT; MICROCIRCULATION; NUCLEAR MAGNETIC RESONANCE IMAGING; TISSUE; BLOOD FLOW VELOCITY; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; IMAGE PROCESSING; INSTRUMENTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; VASCULARIZATION;

BLOOD FLOW VELOCITY; BLOOD VOLUME; BRAIN; BRAIN ISCHEMIA; CAPILLARY PERMEABILITY; CEREBROVASCULAR DISORDERS; CONTRAST MEDIA; GADOLINIUM DTPA; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING, CINE; MICROCIRCULATION; ORGANOMETALLIC COMPOUNDS; PENTETIC ACID; REGIONAL BLOOD FLOW;

EID: 0030610097     PISSN: 0033832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001170050241     Document Type: Article

References (47)

1. Axel L (1980) Cerebral blood flow determination by rapid-sequence computed tomography. Radiology 137: 679-686
2. Bloembergen N (1957) Proton relaxation in paramagnetic solutions. J Chem Phys 27: 572-573
3. Brasch RC, Weinmann HJ, Wesbey GE (1984) Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex. AJR 142: 625-630
4. Brix G, Semmler W, Port R, Schad LR, Layer G, Lorenz WJ (1991) Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 15: 621-628
5. Brix G (1992) Bildgebungssequenzen und Bildkontraste. In: Reiser M, Semmler W (Hrsg) Magnetresonanztomographie. Springer, Berlin Heidelberg New York, speziell S 57-58
6. Edelman RR, Matle HP, Atkinson DJ, Hill T, Finn JP, Mayman C, Ronthal M, Hoogewoud HM, Kleefield J (1990) Cerebral blood flow: assessment with dynamic contrast-enhanced T2*-weighted MR imaging at 1.5 T. Radiology 176: 211-220
7. Fisel CR, Ackerman JL, Buxton RB, Garrido L, Belliveau JW, Rosen BR, Brady TJ (1991) MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology. Magn Reson Med 17, 336-347
8. Gadian DG, Payne JA, Bryant DJ, Young IR, Carr DH, Bydder GM (1985) Gadolinium-DTPA as a contrast agent in MR imaging - theoretical projections and practical observations. J Comput Assist Tomogr 9: 242-251
9. Gaehtgens P (1992) Physiologie des Blutes, in: Deetjem P, Speckmann EJ (Hrsg) Physiologie. Urban & Schwarzen berg, München, S 261-290
10. Goldstein EJ, Burnett KR, Hansell JR (1984) Gadolinium DTPA (an NMR proton imaging contrast agent): chemical structure, paramagnetic properties and pharmacokinetics. Physiol Chem Phys 16: 97-104
11. Guckel F, Brix G, Rempp K, Deimling M, Rbther J, Georgi M (1994) Assessment of cerebral blood volume with dynamic susceptibility contrast enhanced gradient-echo imaging. J Comp Assist Tomogr 18: 344-351
12. Gückel F, Brix G, Schmiedek P, Piepgras A, Rempp K, Kbpke J, Lammler B, Georgi M (1995) Nicht-invasive Quantifizierung des zerebralen Blutvolumens und Blutflusses mit der dynamischen MR-Tomographie: Untersuchungen an Probanden und Patienten mit cerebrovaskulärer Insuffizienz. Radiologe 35: 792-800
13. Gückel F, Brix G, Schmiedek P, Piepgras A, Backer G, Koepke J, Grass H, Georgi M (1996) Cerebrovascular reserve capacity in patients with occlusive cerebrovascular disease: assessment with dynamic susceptibility contrast-enhanced MR imaging and the acetazolamide stimulation test. Radiology 201: 405-412
14. Hawighorst H, Knapstein PG, Schäffer U, Brix G, Weikel P, Essig M, Zuna I, Knopp MV (1995) Rezidivdiagnostik beim Zervixkarzinom mittels dynamischer MRT: Korrelation von pharmakokinetischer Analyse und Histopathologie. Radiologe 35: 945-951
15. Hawighorst H, Knappstein PG, Weikel W, Knopp MV, Schaeffer U, Brix G, Essig M, Hoffmann U, Zuna I, Schonberg S, van Kaick G (1996) Cervical carcinoma: comparision of Standard and pharmacokinetic MR imaging. Radiology 201: 531-539
16. Hawighorst H, Engenhart R, Knopp MV, Brix G, Essig M, Miltner P, Zuna I, Fuß M, van Kaick G (1997) Intracranial meningeomas: time and dose dependent effects of irradiation on tumor microcirculation as monitored by dynamic MR imaging. Magn Reson Imaging (in press)
17. Hoffmann U, Brix G, Knopp MV, Heß Th, Lorenz WJ (1995) Pharmacokinetic mapping of the breast: a new method for dynamic MR mam mography. Magn Reson Med 33. 506-514
18. Horvath A, Schreiber W, Brix G, Hoffmann U, Lorenz WJ (1997) A pharmacokinetic model quantification of tissue perfusion and vascular permeability from dynamic magnetic resonance images. Proceedings of the ISMRM, Vol 3: 1789 (Abstract)
19. Koenig SH, Spiller M, Brown RD, Wolf GL (1986) Relaxation of water protons in the intra- and extracellular regions of blood containing Gd(DTPA). Magn Reson Med 3 791-795
20. Knopp MV, Brix G, Junkermann HJ, Sinn HP (1994) MR mammography with pharmakokinetic mapping for monitoring of breast cancer treatment during neoadjuvant therapy. MRI Clin North Am 2: 633-658
21. Knopp MV, Hoffmann U, Brix G, Hawighorst H, Junkermann HJ, van KaickG (1995) Schnelle MR-Kontrastmitteldynamik zur Charakterisierung von Tumoren: Erfahrungen mit der funktionellen MR-Mammographie. Radiologe 35: 964-972
22. Kuhl CK, Bieling H, Gieseke J, Ebel T, Mielcarek P, Far F, Folkers P, Elevelt A, Schild HH (1997) Breast neoplasms: T2* susceptibility-contrast, first-pass perfusion MR imaging. Radiology 202: 87-95
23. Lauffer RB (1990) Magnetic resonance contrast media: principles and progress. Magn Reson Q 6: 65-84
24. Leenders KL, Perani D, Lammertsma AA, Heather JD, Buckingham P, Healy MJR, Bibbs JM, Wise RJS, Hatazawa J, Herold S, Beaney RP, Brooks DJ, Spinks T, Rhodes C, Frackowiak RSJ, Jones T (1990) Cerabral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 113: 27-47
25. Mitchell SA, Wei H, Lee JH, Patlak CS, Springer CS (1993) Susceptibility changes following bolus injections. Magn Reson Med 29: 700-708
26. +++. J Chem Phys 31: 365-368
27. Moseley ME, Vexler Z, Asgari HS, Mintorovitch J, Derugin N, Rocklage S, Kucharczyk J (1991) Comparison of Gd- and Dy-chelates for T2* contrast-enhanced imaging. Magn Reson Med 22: 259-264
28. Muller-Schimpfle M, Brix G, Layer G, Schlag P, Engenhart R, FrohmüllerS, Heß T, Zuna I, Semmler W, van Kaick G (1993) Dynamic MRI in the diagnosis of recurrent rectal cancer. Radiology 189: 881-889
29. Østergaard L, Weiskoff RM, Chesler DA, Gyldensted C, Rosen BR (1996) High resolution measurements of cerebral blood flow using intravascular tracer bolus passages: Part I: mathematical approach and statistical analysis. Magn Reson Med 36: 715-725
30. Perman WH, Gado MH, Larson KB, Perlmutter JS (1992) Simultaneous MR acquisition of arterial and brain signal-time curves. Magn Reson Med 28: 74-83
31. Rempp K, Brix G, Wenz F, Becker C Guckel F, Lorenz WJ (1994) Quantitative assessment of cerebral blood flow and volume by dynamic susceptibility enhanced MR imaging. Radiology 193: 637-641
32. Rosen BR, Belliveau JW, Chien D (1989) Perfusion imaging by nuclear magnetic resonance. Magn Reson Q 5: 263-281
33. Runge VM, Clanton JA, Price AC (1984) Paramagnetic contrast agents in magnetic resonance imaging; Research at Vanderbilt University. Physiol Chem Phys 16. 113-122
34. Sage MR (1982) Blood-brain barrier. Phenomenon of increasing importance to the imaging clinician. AJNR 3: 127-138
35. Schreiber W, Gückel F, Brix G, Stritzke P, Schmiedek P, Rempp K, Lorenz WJ (1996) Cerebrovascular reserve capacity assessed from mapping of blood flow, mean transit time, and acetazolamide stimulation. Proceedings of the ISMRM, Vol 3: 1786 (Abstract)
36. Solomon I (1955) Relaxation processes in a system of two spins. Phys Rev 99: 559-565
37. Strich G, Hagan PL, Gerber KH, Slutsky RA (1985) Tissue distribution and magnetic resonance spin lattice relaxation effects of gadoliniumDTPA. Radiology 154: 723-726
38. Stritzke P, King MA, Vaknine R, Goldsmith SJ (1990) Deconvolution using orthogonal polynomials in nuclear medicine: a method for forming quantitative images from kinetic studies. IEEE Trans Med Imaging 9: 11-23
39. Tofts PA, Kermode AG (1991) Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. fundamental concepts. Magn Reson Med 17: 357-367
40. Tofts PS, Berkowitz B, Schnall MD (1995) Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumors using a permeability model. Magn Reson Med 33: 564-568
41. Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, van Wedeen J, Brady TJ (1988) Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 6: 164-174
42. Weinmann HJ, Brasch RC, Press WR, Wesbey GE (1984) Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. AJR 142: 619-624
43. Weinmann HJ, Laniado M, Mützel W (1984) Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers. Physiol Chem Phys 16: 167-172
44. Wenz F, Rempp K, Brix G, Knopp MV, Gückel F, Heß Th, van Kaick G (1996) Age-dependency of the regional cerebral blood volume (rCBV) measured with dynamic susceptibility contrast MR imaging. Magn Reson Imaging 14: 157-162
45. Wenz F, Rempp K, Heß T, Debus J, Brix G, Knopp MV, Engenhart R, van Kaick G, Wannenmacher M (1996) Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue: quantification with dynamic susceptibility contrast MR imaging. AJR 166: 187-193
46. Witzleb E (1985) Mikrozirkulation. In: Schmidt RF, Thews G (Hrsg) Physiologie des Menschen, 22. Aufl. Springer, Berlin Heidelberg New York, Kap. 18.6
47. Zierler KL (1962) Theoretical basis of indicatordilution methods for measuring flow and volume. Circ Res 10: 393-407